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Leuget 50 Injection 5 ml is used in cancer treatment as an antidote to reduce the toxic effects of certain cancer drugs, such as methotrexate. It contains calcium folinate, also known as Leucovorin, which is a form of vitamin B. It is folic acid in its active form. It works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells. It should be administered as soon as possible after taking methotrexate.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

GLS Pharma Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Leuget 50 Injection 5 ml

Leuget 50 Injection 5 ml is a prescription injection used to reduce the harmful side effects of specific cancer therapies, such as high-dose methotrexate. It is also used to increase the clinical effectiveness of other chemotherapy medications in treating advanced colon cancer, and to treat severe types of anaemia caused by vitamin deficiency.

Since this medicine is given as an injection or infusion into a vein or muscle, it is administered on a strict schedule by a healthcare professional in a hospital or clinic. To support your body during this treatment, eating a balanced diet rich in proteins and staying highly hydrated can significantly improve your recovery.

While receiving this injection, you may experience mild side effects like nausea, diarrhoea, or temporary skin flushing. However, if you develop serious signs such as a severe skin rash, itching, or sudden breathing difficulties, you must tell your doctor or nurse immediately.

Before starting your therapy, tell your doctor if you have a history of seizures, kidney disease, or severe dehydration. You must not receive this injection if you have a known severe allergy to it, or if you have certain types of anaemia, such as pernicious anaemia, that are not caused by folate deficiency.

This medicine can interact with alcohol, smoking, and certain epilepsy medications, which may reduce the seizure medication's effectiveness and increase your risk of fits. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, consult your doctor or pharmacist to discuss your specific safety plan.

Uses of Leuget 50 Injection 5 ml

Leuget 50 Injection 5 ml is used to treat or manage the following conditions:

  • Methotrexate toxicity prevention: Helps rescue healthy body cells from the harmful effects of high-dose cancer treatments.
  • Advanced colorectal cancer: Enhances the therapeutic effects of other chemotherapy medicines to target tumours more effectively.
  • Folate deficiency anaemia: Rebuilds healthy red blood cells when oral vitamin supplements cannot be used or are not working.

Key Benefits

Leuget 50 Injection 5 ml provides reliable support to help protect healthy tissues and manage the physical toll of intensive therapies. By supporting your body during treatment, this medicine brings several key health benefits:

  • Minimises therapy complications: By acting as a protective shield for healthy tissues, it helps prevent painful mouth sores, severe gut issues, and bone marrow suppression (a condition where your body cannot make enough healthy blood cells). This allows you to complete your scheduled cancer therapy with fewer painful interruptions.
  • Boosts treatment success: When used alongside colon cancer treatments, it helps improve the overall effectiveness of your therapy, supporting your body's fight against the disease.
  • Restores energy and strength: For patients with severe vitamin deficiencies, it directly aids the production of healthy blood cells, which helps relieve extreme fatigue, weakness, and shortness of breath.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Leuget 50 Injection 5 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer it.

How Leuget 50 Injection 5 ml Works

Leuget 50 Injection 5 ml contains calcium folinate, an active form of vitamin B9 (folate) that does not require conversion by the body's enzymes (natural proteins that help with chemical reactions). Certain chemotherapy drugs work by blocking these natural proteins, which stops healthy cells from getting the active folate they need to survive and repair themselves. By injecting Leuget 50 Injection 5 ml directly into your body, we bypass this block. This delivers the necessary active folate directly to your healthy cells, allowing them to recover and survive the harsh effects of chemotherapy. In cancer treatment, it also helps certain cancer drugs stay active inside tumour cells for longer, helping them work more effectively.
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Alcohol

Caution

Avoid the consumption of alcohol as it may cause some side effects and make the impact of Leuget 50 Injection 5 ml less effective.

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Pregnancy

Caution

Leuget 50 Injection 5 ml should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Leuget 50 Injection 5 ml.

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Breast Feeding

Caution

Leuget 50 Injection 5 ml should not be used in nursing mothers unless clearly necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Leuget 50 Injection 5 ml.

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Driving

Safe

Leuget 50 Injection 5 ml does not affect the ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before receiving the Leuget 50 Injection 5 ml if you have had a liver impairment/disorder history. Your doctor may adjust the dose of this medicine based on your condition.

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Kidney

Caution

Inform your doctor before receiving the Leuget 50 Injection 5 ml if you have had a kidney impairment/disorder history. Your doctor may adjust the dose of this medicine based on your condition.

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Children

Safe if prescribed

Your doctor will weigh the benefits and potential risks before prescribing Leuget 50 Injection 5 ml.

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Heart

Consult your doctor

If you have a heart disease or any related concerns, Please consult your doctor before using Leuget 50 Injection 5 ml.

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Geriatrics

Consult your doctor

Leuget 50 Injection 5 ml should be given to geriatrics only when prescribed by a doctor. If you have any concerns about using Leuget 50 Injection 5 ml for geriatrics, please consult a doctor.

What if I have taken an overdose of Leuget 50 Injection 5 ml

An overdose is unlikely because this medicine is administered by healthcare professionals. However, if you suspect you received too much or experience unusual symptoms, notify your medical team right away or seek emergency medical care.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of fluids (as advised by your doctor) to help your kidneys flush out chemotherapy medications efficiently.
  • Eat small, frequent meals: If you experience nausea or mouth sores from your cancer therapy, eating soft, bland foods can help maintain your nutrition.
  • Avoid self-supplementing: Do not take over-the-counter folic acid or multivitamin supplements containing folic acid unless specifically directed by your doctor. Self-supplementing can interfere with your chemotherapy and can also mask underlying vitamin B12 deficiency (pernicious anaemia) while neurological damage continues.
  • Monitor your temperature: Keep a thermometer at home and check your temperature regularly, reporting any signs of fever or infection to your oncologist immediately.
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How Soon It Starts Working

The time required for Leuget 50 Injection 5 ml to start to work: Leuget 50 Injection 5 ml ideally starts working within 5 minutes after intravenous administration and 10 to 20 minutes after intramuscular administration. The time for which the effects of Leuget 50 Injection 5 ml last: The effect of Leuget 50 Injection 5 ml lasts for 3 to 6 hours.

What if you forget to take Leuget 50 Injection 5 ml

Since this medication is given on a strict schedule by medical professionals, missing a dose can be serious. If you miss an appointment or suspect a dose was delayed, contact your healthcare team immediately to reschedule.

Storage

•Store them in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Never give into the spinal fluid: Leuget 50 Injection 5 ml is strictly for intravenous (IV, into a vein) or intramuscular (IM, into a muscle) use only. It must never be injected into the spinal fluid (intrathecally), as this can cause severe or fatal nervous system damage.
  • Verify the solution: Always inspect the liquid before injection; it should be clear and pale yellow. Do not use it if it contains particles or is cloudy.
  • Follow safety disposal protocols: If administering at home under supervision, use a puncture-proof sharps container to safely discard all needles and syringes.
  • Report kidney changes: Inform your doctor immediately if you experience a decrease in urination, as poor kidney function can slow down how fast your body clears chemotherapy.
  • Avoid immediate driving: Some patients may feel dizzy or tired after receiving this injection; avoid driving until you know how it affects you.
  • Do not mix in the same line: Ensure your healthcare provider does not mix Leuget 50 Injection 5 ml in the exact same IV line with certain other drugs, like 5-fluorouracil, at the same time unless clinically managed, as the medicines can clump together and block the IV line.

Drug-Drug Interactions

verifiedApollotooltip
  • Seizure medications: May decrease the effectiveness of medicines like phenytoin, fosphenytoin, phenobarbital, and primidone, increasing the risk of seizures.
  • Chemotherapy drugs: Can increase the toxicity of 5-fluorouracil, which must be carefully monitored by your medical team.
  • Folate-blocking antibiotics (antifolates): Medicines that block folate, such as trimethoprim or sulfamethoxazole, may interfere with the action of this medication if taken at the same time.

Drug-Drug Interactions

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How does the drug interact with Leuget 50 Injection 5 ml:
Co-administration of Leuget 50 Injection 5 ml with Trimethoprim may increase rates of treatment failure.

How to manage the interaction:
Although there is an interaction between Leuget 50 Injection 5 ml and trimethoprim, but it can be taken together if prescribed by the doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Leuget 50 Injection 5 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[DETOXIFYING AGENTS]

FAQs

Leuget 50 Injection 5 ml is used to prevent the harmful effects of methotrexate.
Leuget 50 Injection 5 ml contains calcium folinate, also known as Leucovorin. This compound prevents healthy cells from the toxic effects of methotrexate (cancer medicine) while accepting it to enter and kill cancer cells.
It is contraindicated to use if you are known for hypersensitivity to any components present in Leuget 50 Injection 5 ml or if you have Pernicious anaemia or other anaemias due to vitamin B12 deficiency.
Megaloblastic anemia is a condition where abnormal, oversized red blood cells form due to defective DNA production, typically from a lack of vitamin B12 or folate (folic acid). Symptoms include fatigue, pale skin, and sometimes neurological issues.
Your doctor may recommend specific blood tests during your treatment with Leuget 50 Injection 5 ml to check methotrexate levels especially if you are undergoing chemotherapy or in cases of overdose. A complete blood count (CBC) will also be done to check red blood cell levels if you are being treated for anemia and also calcium levels (to avoid hypercalcemia due to calcium in Leuget 50 Injection 5 ml). These tests are essential for ensuring the treatment is both safe and effective.
To promote the excretion of methotrexate during treatment with Leuget 50 Injection 5 ml, increase fluid intake to maintain urine output above 2,500 mL/day for 12 hours before and 36 hours after methotrexate infusion. Ensure urine pH is above 7.0 before the infusion and avoid acidic substances. Measure blood methotrexate levels at 24, 48 and 72 hours after infusion.
No, Leuget 50 Injection 5 ml is not a chemotherapy drug. It is a supportive care medicine (an active form of folate) used to protect healthy cells from chemotherapy toxicity or to make certain cancer treatments work better. Talk to your doctor for more details about your specific treatment plan.
This medicine is generally only used during pregnancy if your doctor determines the benefits outweigh the risks. If you are pregnant or planning to become pregnant, talk to your doctor or pharmacist before starting therapy.
It is given as an injection into a muscle (intramuscularly) or as an infusion directly into a vein (intravenously) by a trained healthcare professional. Talk to your doctor if you have questions about your administration route.
Regular folic acid must be converted by an enzyme in the body into an active form, which chemotherapy drugs can block. Leuget 50 Injection 5 ml is already in the active form, so it can bypass this block and protect your cells immediately. Talk to your doctor or pharmacist to learn more.
The timing is critical because it must be given at precise intervals relative to your chemotherapy (such as methotrexate) to rescue healthy cells before they suffer permanent damage. Talk to your doctor to understand your schedule.
Leuget 50 Injection 5 ml itself does not typically cause hair loss. However, it is often given alongside chemotherapy drugs that do cause hair loss. Talk to your doctor if you are concerned about side effects from your treatment regimen.
It is highly recommended to avoid alcohol while undergoing cancer treatment or receiving Leuget 50 Injection 5 ml, as alcohol can worsen liver strain and dehydration. Talk to your doctor or pharmacist for personalised advice.
Yes, if you are storing this medicine at home before your clinic appointment, it must be kept in a refrigerator between 2°C and 8°C (36°F to 46°F) and protected from light. Talk to your doctor or pharmacist if you have storage concerns.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

F-30, Phase-1, Okhla Industrial Estate, New Delhi - 110020, INDIA
Other Info - LEU0130
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