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  3. Mabvinra 40 mg Injection 0.4 ml

Mabvinra 40 mg Injection 0.4 ml, Pack of 1 Injection
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Santoshini Reddy G , M Pharmacy

Mabvinra 40 mg Injection is used to help reduce signs and symptoms of autoimmune disorders such as Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, Plaque psoriasis, Crohn's disease, Uveitis and Ulcerative colitis. It consists of Adalimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

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Composition :

ADALIMUMAB-40MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Mabvinra 40 mg Injection

Mabvinra 40 mg Injection  belongs to the class of monoclonal TNF (Tumor necrosis factor) inhibitors that help reduce signs and symptoms of autoimmune disorders. It is primarily used in the treatment of rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, plaque psoriasis, and psoriatic arthritis. This medicine is also used in the treatment of Crohn’s disease, ulcerative colitis, hidradenitis suppurativa, and uveitis.

Mabvinra 40 mg Injection consists of Adalimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Mabvinra 40 mg Injection may cause certain side effects such as nausea, headache, back pain, upper respiratory tract infections, vision problems, dizziness, pale skin, numbness, chest pain, rash, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor on priority. Mabvinra 40 mg Injection is a parenteral medicine. It will be administered by a trained healthcare doctor. Hence, do not self-administer. Your physician will decide the dose and duration of the medicine based on the type and severity of the condition.

Mabvinra 40 mg Injection should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, tuberculosis, optimistic infections, cancer, alcoholic hepatitis, hepatitis B virus infection, heart failure, liver, heart, or kidney diseases, or a weak immune system, as it can worsen your health condition. Mabvinra 40 mg Injection may cause dizziness, so drive only if you are alert and focused. Mabvinra 40 mg Injection should not be given to children under two years of age as safety has not been established. Consult the doctor if you are pregnant or breastfeeding.

Uses of Mabvinra 40 mg Injection

Mabvinra 40 mg Injection is used in the treatment of autoimmune inflammatory diseases. The detailed uses of Mabvinra 40 mg Injection are as follows:<br/>• Treatment of Rheumatoid arthritis (RA): Mabvinra 40 mg Injection reduces inflammation, joint pain, and stiffness in adults with moderate to severe RA, improving mobility and quality of life.<br/>• Treatment of Juvenile idiopathic arthritis (JIA): Mabvinra 40 mg Injection is used in children to control inflammation, relieve joint symptoms, and support normal growth and development.<br/>• Treatment of Crohn’s disease: Mabvinra 40 mg Injection treats moderate to severe Crohn’s disease in adults and children by reducing intestinal inflammation when other treatments fail.<br/>• Treatment of Ulcerative colitis: Mabvinra 40 mg Injection is indicated for adults and children with moderate to severe ulcerative colitis who are unresponsive to conventional therapy.<br/>• Treatment of Ankylosing spondylitis: Mabvinra 40 mg Injection helps manage chronic back pain and stiffness by reducing spinal inflammation in adults.<br/>• Treatment of Psoriatic arthritis: Mabvinra 40 mg Injection improves joint and skin symptoms in adults by decreasing swelling, pain, and the formation of psoriatic skin lesions.<br/>• Treatment of Hidradenitis suppurativa: Mabvinra 40 mg Injection is used in adults and adolescents to reduce painful lumps and inflammation in areas like the armpits and groin.<br/>• Treatment of Uveitis: Mabvinra 40 mg Injection treats non-infectious uveitis in adults and children by lowering eye inflammation and helping preserve vision.<br/>• Treatment of Chronic plaque psoriasis: Mabvinra 40 mg Injection is used in adults with moderate to severe plaque psoriasis to reduce red, scaly patches and improve skin appearance.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Mabvinra 40 mg Injection will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Mabvinra 40 mg Injection consists of Adalimumab, which belongs to the class of monoclonal TNF (Tumor necrosis factor) inhibitors. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain, redness, and inflammation (swelling) caused by various autoimmune diseases.

How Mabvinra 40 mg Injection Works

Mabvinra 40 mg Injection consists of Adalimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Mabvinra 40 mg Injection out of the sight and reach of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Mabvinra 40 mg Injection 0.4 ml
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

What if I have taken an overdose of Mabvinra 40 mg Injection

Since Mabvinra 40 mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Mabvinra 40 mg Injection should be avoided if allergic to it or any other components present. Inform your doctor if you have any history of serious infections, tuberculosis, optimistic infections, cancer, alcoholic hepatitis, hepatitis B virus infection, heart failure, liver, heart or kidney diseases, weak immune system, multiple sclerosis (nerve and muscle disease), or diabetes as it can worsen your health condition. Do not take live vaccines while being treated with Mabvinra 40 mg Injection to prevent any serious consequences. Mabvinra 40 mg Injection is not recommended for use in children below two years of age as safety and efficacy are not established. This medicine is not recommended for patients suffering from sepsis as it can worsen the condition.

Drug-Drug Interactions

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AdalimumabInfliximab
Severe
AdalimumabMercaptopurine
Severe

Drug-Drug Interactions

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AdalimumabInfliximab
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
Taking Infliximab with Mabvinra 40 mg Injection 0.4 ml can increase the risk or severity of developing an infection.

How to manage the interaction:
Taking Infliximab with Mabvinra 40 mg Injection 0.4 ml together can result in an interaction, but it can be taken if your doctor has advised it. If you have any symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AdalimumabMercaptopurine
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
When Mabvinra 40 mg Injection 0.4 ml is taken with Mercaptopurine, the effect of Mercaptopurine in the blood may decrease which may increase risk of infection.

How to manage the interaction:
Taking Mercaptopurine with Mabvinra 40 mg Injection 0.4 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. However contact a doctor immediately, if you experience any symptoms such as infections, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AdalimumabPrednisolone
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
Co-administration of Mabvinra 40 mg Injection 0.4 ml with Prednisolone can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Prednisolone and Mabvinra 40 mg Injection 0.4 ml, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
AdalimumabTacrolimus
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
Taking Tacrolimus with Mabvinra 40 mg Injection 0.4 ml may increase the risk of serious infections.

How to manage the interaction:
Although taking tacrolimus and Mabvinra 40 mg Injection 0.4 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
AdalimumabAzathioprine
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
When Azathioprine and Mabvinra 40 mg Injection 0.4 ml are taken together, they may raise the risk of severe infections.

How to manage the interaction:
Although there is a possible interaction between Azathioprine and Mabvinra 40 mg Injection 0.4 ml, you can take these medicines together if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm (a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AdalimumabValganciclovir
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
The combined use of Mabvinra 40 mg Injection 0.4 ml and valganciclovir can increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Valganciclovir and Mabvinra 40 mg Injection 0.4 ml, but it can be taken if prescribed by a doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - reach out to your doctor right away. Do not stop using any medications without talking to your doctor.
AdalimumabClozapine
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
The combined use of Mabvinra 40 mg Injection 0.4 ml and clozapine can increase the effect of clozapine.

How to manage the interaction:
Taking Abiraterone with Clozapine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
AdalimumabMycophenolic acid
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
Taking Mycophenolic acid and Mabvinra 40 mg Injection 0.4 ml can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Mycophenolic acid and Mabvinra 40 mg Injection 0.4 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, or burning urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AdalimumabDeflazacort
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
Combining Mabvinra 40 mg Injection 0.4 ml with Deflazacort can increase the risk of severity of side effects.

How to manage the interaction:
Although there is a possibility of interaction between Deflazacort and Mabvinra 40 mg Injection 0.4 ml, it can be taken if prescribed by a doctor. If you have any symptoms like fever, chills, diarrhea, a sore throat, muscle pain, or experiencing pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
AdalimumabBusulfan
Severe
How does the drug interact with Mabvinra 40 mg Injection 0.4 ml:
Coadministration of Mabvinra 40 mg Injection 0.4 ml with Busulfan may increase the risk of developing infections.

How to manage the interaction:
Although taking Busulfan and Mabvinra 40 mg Injection 0.4 ml together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, diarrhea, sore throat, muscle aches, or pain while urinating, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well and get plenty of sleep.
  • Stay hydrated; drink plenty of water.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Mabvinra 40 mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is not known if alcohol interacts with Mabvinra 40 mg Injection . Please consult the doctor.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Mabvinra 40 mg Injection . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Mabvinra 40 mg Injection .

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Driving

Caution

Mabvinra 40 mg Injection will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

Mabvinra 40 mg Injection should be used with caution if you have liver disease. Dose adjustment may be needed in patients with liver impairment.

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Kidney

Caution

Mabvinra 40 mg Injection should be used with caution if you have kidney disease. Dose adjustment may be needed in patients with liver impairment.

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Children

Caution

Mabvinra 40 mg Injection is not recommended in children below two years of age as safety and efficacy are not established. In children above two years of age, it will be administered by the pediatrician. Mabvinra 40 mg Injection is used in children only for the treatment of juvenile idiopathic arthritis, paediatric Crohn’s disease, and uveitis.

Have a query?

FAQs

Mabvinra 40 mg Injection is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, Plaque psoriasis, Crohn’s disease, Uveitis and Ulcerative colitis.

Mabvinra 40 mg Injection contains Adalimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive.

Mabvinra 40 mg Injection affects your immune system and makes you more susceptible to infections. Hence, it is not recommended in people with active infections like tuberculosis or abnormal liver enzymes. Mabvinra 40 mg Injection can also increase the risk of developing cancers; hence, informing your doctor if you have a history of any cancer is essential.

Mabvinra 40 mg Injection is an antirheumatic medicine that belongs to the TNF (tumor necrosis factor) inhibitor class. It contains the active ingredient Adalimumab.

Treatment with Mabvinra 40 mg Injection can help reduce inflammation, pain, redness, and swelling associated with various autoimmune disorders.

Mabvinra 40 mg Injection which contains Adalimumab, can weaken your immune system. Since it affects the immune system, it may increase your risk of developing infections. It is important to follow your doctor's advice and inform them if you have any existing infections or health concerns before starting treatment.

Mabvinra 40 mg Injection can be used alongside other arthritis medicines such as methotrexate, prednisolone, naproxen, ibuprofen, and paracetamol. However, Mabvinra 40 mg Injection should not be used with other biological disease-modifying antirheumatic drugs (bDMARDs).

Mabvinra 40 mg Injection should be stopped before surgery. It can be resumed after the operation, once the wound has healed and there is no infection, as determined by your surgeon and rheumatologist.

Mabvinra 40 mg Injection causes side effects such as rash, headache, sinusitis, upper respiratory infections, fever, and application site reactions. Therefore, please contact a doctor if these do not reduce and persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - MAB0028

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Author Details

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/125057s410lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a603010.html
  3. https://go.drugbank.com/drugs/DB00051
  4. https://reference.medscape.com/drug/amjevita-humira-adalimumab-343187
  5. https://www.nhs.uk/medicines/adalimumab/
  6. https://www.humira.com/
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