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  3. Linapil-M 2.5 mg/1000 mg Tablet 10's

Linapil-M 2.5 mg/1000 mg Tablet 10's, Pack of 10 TabletS
Linapil-M 2.5 mg/1000 mg Tablet 10's, Pack of 10 TabletS
Linapil-M 2.5 mg/1000 mg Tablet 10's, Pack of 10 TabletS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Linapil-M 2.5/1000Mg Tab is used to treat Type 2 Diabetes. It contains Linagliptin and Metformin, which help the body produce more insulin only when required. It also reduces the amount of sugar produced by the liver when not needed. Also, it lowers glucose production in the liver, delays glucose absorption from the intestines and increases the body's sensitivity to insulin. Thus, it prevents blood glucose levels from rising to very high levels after meals. It may cause common side effects such as hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth, skin, etc. So to avoid hypoglycemia, you should not miss meals and should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

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Composition :

LINAGLIPTIN-2.5MG + METFORMIN-1000MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Linapil-M 2.5/1000Mg Tab

Linapil-M 2.5/1000Mg Tab is a combination drug used in the treatment of type 2 diabetes mellitus. Type 2 diabetes develops when the body does not produce enough insulin or when the body's insulin does not work as well as it should. It can also develop if the body produces too much glucagon. Insulin is a substance which helps to lower the level of sugar in your blood, especially after meals.

Linapil-M 2.5/1000Mg Tab contains metformin and vildagliptin, which help control blood sugar levels. It works by causing the pancreas to produce more insulin and less glucagon (the effect of vildagliptin) and also by helping the body utilise insulin more effectively (the effect of metformin).

Not everyone who is taking Linapil-M 2.5/1000Mg Tab will get these side effects. The most common side effect of Linapil-M 2.5/1000Mg Tab is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, hunger pangs, dry mouth and skin, etc. Other side effects include changes in taste, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Linapil-M 2.5/1000Mg Tab should be taken with food to avoid an upset stomach. It is advised to take it at the same time each day for best results. For better advice, your doctor will determine the appropriate dose, which can change quickly depending on your condition. Do not skip your meals, and also carry a form of sugar with you to prevent low blood sugar levels.

Avoid taking Linapil-M 2.5/1000Mg Tab if you are allergic to it. Linapil-M 2.5/1000Mg Tab should not be stopped even if you feel better without consulting your doctor, as sugar levels may change. If you stop taking Linapil-M 2.5/1000Mg Tab abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney damage and nerve damage. Please inform your doctor if you have any heart disease or are planning to get pregnant or breastfeed. You must continue following the diet and exercise recommended for you while on treatment with Linapil-M 2.5/1000Mg Tab .

Uses of Linapil-M 2.5/1000Mg Tab

Linapil-M 2.5/1000Mg Tab is used in the treatment of Type 2 Diabetes Mellitus. The detailed uses of Linapil-M 2.5/1000Mg Tab are as follows:

  • Management of Diabetes: Linapil-M 2.5/1000Mg Tab is commonly prescribed to help regulate blood sugar levels in patients with type 2 diabetes, particularly those who may require additional medication alongside lifestyle changes.
  • Improvement of Glycemic Control: Linapil-M 2.5/1000Mg Tab aids in improving overall glycemic control by enhancing insulin sensitivity and decreasing hepatic glucose production.
  • Weight Management: In some cases, Linapil-M 2.5/1000Mg Tab can assist in weight management for diabetic patients, as it may help reduce appetite or modify fat metabolism.
  • Prevention of Diabetes Complications: Regular use of Linapil-M 2.5/1000Mg Tab can contribute to the prevention of long-term complications associated with diabetes, such as neuropathy, nephropathy, and retinopathy.

Directions for Use

  • Take Linapil-M 2.5/1000Mg Tab with or without food as advised by your doctor.
  • It is advised to take Linapil-M 2.5/1000Mg Tab twice daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Linapil-M 2.5/1000Mg Tab as a whole with a glass of water.
  • Do not crush, chew or break it.

Medicinal Benefits

  • Linapil-M 2.5/1000Mg Tab helps your pancreas produce more insulin, effectively utilise insulin, and decrease the excess sugar that your liver makes.
  • It helps control the rise of blood sugar levels in your body after a meal.
  • Linapil-M 2.5/1000Mg Tab plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

How Linapil-M 2.5/1000Mg Tab Works

Linapil-M 2.5/1000Mg Tab contains Linagliptin (DPP4 inhibitors) and Metformin (Biguanide). Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that blocks the action of DPP-4, an enzyme that destroys the hormone incretin that helps the body produce more insulin only when required. It also reduces the amount of sugar produced by the liver when not needed. Metformin functions by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Linapil-M 2.5/1000Mg Tab

Do not take more than the prescribed dose of Linapil-M 2.5/1000Mg Tab as it may cause overdose resulting in severe low blood sugar. The symptoms include sweating, tremors, extreme weakness, nausea, trouble speaking, seizures (fits), confusion or fast heartbeats. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor if you are allergic to Linapil-M 2.5/1000Mg Tab .
  • This medicine should not be used in patients with type 1 diabetes or with diabetic ketoacidosis.
  • Some diabetic patients, while taking Linapil-M 2.5/1000Mg Tab , might develop a rare but serious condition called lactic acidosis (too much lactic acid accumulated in the blood) that can damage the working of your liver and kidneys, which are required for the elimination of excess lactic acid from the blood.
  • Before you start taking Linapil-M 2.5/1000Mg Tab , tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, or a low vitamin B12 level.
  • Linapil-M 2.5/1000Mg Tab , when used with insulin, may significantly lower the blood sugar level, leading to a hypoglycemic condition, which can be fatal.
  • Inform your doctor if you are pregnant, planning for a pregnancy or breastfeeding before starting the treatment.
  • Prolonged intake of Linapil-M 2.5/1000Mg Tab may lower your thyroid-stimulating hormone (TSH); hence, an annual checkup of TSH is recommended.
  • In rare cases, you may also develop a severe skin reaction known as bullous pemphigoid that requires immediate medical attention.
  • Inform your doctor if you are scheduled to undergo a diagnostic test that involves an injection of dye or an X-ray contrast agent. The use of Linapil-M 2.5/1000Mg Tab should be stopped for a short time before having an X-ray procedure.
  • It is always important to check for the expiry of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

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MetforminIoversol
Critical
MetforminIopamidol
Critical

Drug-Drug Interactions

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MetforminIoversol
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Ioversol with Linapil-M 2.5 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIopamidol
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Iopamidol with Linapil-M 2.5 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopydol
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Iopydol with Linapil-M 2.5 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Iopydol is not recommended, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Iopentol with Linapil-M 2.5 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIoglicic acid
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Ioglicic acid with Linapil-M 2.5 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Ioglicic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIobitridol
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Linapil-M 2.5 mg/1000 mg Tablet and Iobitridol can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Iobitridol is generally avoided as it can result in an interaction. Please consult your doctor before taking it.
MetforminIocetamic acid
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Linapil-M 2.5 mg/1000 mg Tablet and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIodamide
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Linapil-M 2.5 mg/1000 mg Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIoxitalamic acid
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Linapil-M 2.5 mg/1000 mg Tablet and Ioxitalamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Ioxitalamic acid is not recommended, please consult your doctor before taking it.
MetforminIotroxic acid
Critical
How does the drug interact with Linapil-M 2.5 mg/1000 mg Tablet:
Co-administration of Iotroxic acid with Linapil-M 2.5 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Linapil-M 2.5 mg/1000 mg Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
  • Eat at regular intervals. Do not take a long gap between a meal or snack.
  • Monitor your blood sugar level regularly, especially when there are lots of fluctuations.
  • Invest at least 150 minutes of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise weekly.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrates containing whole-grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
  • Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Keep your blood pressure as normal (140/90) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Linapil-M 2.5/1000Mg Tab Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

It is best to avoid alcohol while taking Linapil-M 2.5/1000Mg Tab .

bannner image

Pregnancy

Consult your doctor

Please consult your doctor for advice before using Linapil-M 2.5/1000Mg Tab .

bannner image

Breast Feeding

Consult your doctor

Please consult your doctor for advice before using Linapil-M 2.5/1000Mg Tab .

bannner image

Driving

Caution

Drive only if you are physically stable and mentally focussed; if you experience drowsiness after taking these medications, you should not drive or operate any machinery or vehicles.

bannner image

Liver

Consult your doctor

If u have or had a history of any liver-related diseases, please consult the doctor before taking medicine.

bannner image

Kidney

Caution

If u have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

bannner image

Children

Caution

It is advisable to consult a doctor before using it.

Have a query?

FAQs

Linapil-M 2.5/1000Mg Tab is used in the treatment of Type 2 Diabetes Mellitus.

Type 2 diabetes is a common form of diabetes in which the blood sugar-lowering hormone called insulin, produced by the body, does not function properly. Thus, the blood glucose level increases, and symptoms such as frequent urination, increased thirst, and increased hunger start. Diabetes, if left untreated or not treated properly, can cause long-term complications such as nerve damage, kidney damage, eye damage, foot problems, and poses a high risk of developing heart diseases.

Lactic acidosis is a rare but life-threatening condition when there is too much lactic acid built up in the bloodstream. Long term intake of Linapil-M 2.5/1000Mg Tab may lead to lactic acidosis when cells get deprived of oxygen levels. Lactic acidosis symptoms include a burning sensation of muscle, muscle ache, fast breathing, nausea, and stomach pain. Immediately contact the doctor about this complication.

Do not take excessive alcohol while taking Linapil-M 2.5/1000Mg Tab , as this may increase the risk of a life-threatening condition called lactic acidosis (too much lactic acid in the body).

No, Linapil-M 2.5/1000Mg Tab is only prescribed to treat type 2 diabetes, also called 'non-insulin-dependent diabetes.

Linapil-M 2.5/1000Mg Tab should be given with caution in older adults as they are at an increased risk of hypoglycemia. Consult your doctor; dose adjustment may be required, and take Linapil-M 2.5/1000Mg Tab in dose as prescribed by your doctor.

If you feel that your blood sugar level is decreasing and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.

Linapil-M 2.5/1000Mg Tab contains Linagliptin (DPP4 inhibitors) and Metformin (Biguanide). Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that blocks the action of DPP-4, an enzyme that destroys the hormone incretin that helps the body produce more insulin only when required. It also reduces the amount of sugar produced by the liver when not needed. Metformin functions by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.

Linapil-M 2.5/1000Mg Tab may cause lactic acidosis. Consult the doctor if you experience symptoms of lactic acidosis, such as discomfort, muscle aches, nausea, and stomach pain.

Possible side effects of Linapil-M 2.5/1000Mg Tab are low blood sugar, taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms. Consult the doctor if the side effects persist or worsen.

Linapil-M 2.5/1000Mg Tab should not be taken if you are allergic to any of its components, have metabolic acidosis, diabetic ketoacidosis, or severe renal impairment.

Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as lactic acidosis. So, avoid intake of alcoholic beverages with Linapil-M 2.5/1000Mg Tab .

Store Linapil-M 2.5/1000Mg Tab at room temperature, in a dry place. Keep out of sight and reach of children.

Yes, Linapil-M 2.5/1000Mg Tab may cause hypoglycaemia (low blood sugar) characterised by dizziness, sweating, palpitations, hunger pangs, and dry mouth/skin. Carry sugary food such as candy or juice and consume it if you experience these symptoms.

Yes, Linapil-M 2.5/1000Mg Tab may lead to vitamin B12 deficiency, particularly on long-term use. Consult the doctor if you experience symptoms of vitamin B12 deficiency, such as headache, loss of appetite, fatigue, mental impairment, numbness or tingling, and pale skin.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - LIN0348

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 8, 2025 | 12:28 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.mayoclinic.org/drugs-supplements/linagliptin-and-metformin-oral-route/before-using/drg-20075407
  2. https://www.healthline.com/health/linagliptin-metformin-oral-tablet
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284079/
  4. https://www.nhs.uk/medicines/metformin/
  5. https://www.nhs.uk/medicines/linagliptin/

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