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Written By ,
Reviewed By Praneetha Akunuri , M.Pharmacy

Indoiv Injection is used to close patent ductus arteriosus (PDA) in premature babies. It works by inhibiting prostaglandin production, which keeps the ductus arteriosus open. As a result, the ductus arteriosus contracts and closes, improving blood flow to the lungs and reducing the risk of complications such as pulmonary hypertension and heart failure. Indoiv Injection may cause side effects like bleeding problems, temporary decrease in urine production, and kidney function impairment.

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Composition :

INDOMETHACIN-1MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Indoiv Injection

Indoiv Injection is used to close patent ductus arteriosus (PDA) in premature babies. Patent ductus arteriosus is a congenital heart defect where the ductus arteriosus, a blood vessel connecting the aorta and pulmonary artery, fails to close after birth. This causes excessive blood flow to the lungs, increased pressure in the pulmonary arteries, and strain on the heart. Symptoms include shortness of breath, fatigue, poor feeding, and failure to thrive (fail to grow and develop normally).

Indoiv Injection contains Indomethacin. It works by inhibiting prostaglandin production, specifically prostaglandin E2 (PGE2), which keeps the ductus arteriosus open. By blocking PGE2, the ductus arteriosus contracts and closes, allowing blood to flow normally to the lungs, effectively reducing the risk of complications and improving lung function.

The dose and duration of treatment with Indoiv Injection will be determined by your doctor based on your child’s medical condition. Your child may experience some common side effects like bleeding problems, temporary decrease in urine production, and kidney function impairment, which will be closely monitored by your child's doctor.

Before giving Indoiv Injection to your baby, it's essential to inform your pediatrician about any medication or food allergies, pre-existing medical conditions such as kidney or liver disease, heart disease, or high blood pressure, and any current infections. This is crucial, as Indoiv Injection may mask infection symptoms, potentially leading to delayed diagnosis or underestimation of severity, ensuring your pediatrician can provide the best possible care for your baby.

Uses of Indoiv Injection

Indoiv Injection is used to close the patent ductus arteriosus (PDA) in premature babies. The detailed use of Indoiv Injection is as follows:<br/>• Treating Patent Ductus Arteriosus (PDA) in Premature Infants: Indoiv Injection is used to close a patent ductus arteriosus (PDA) in premature infants weighing 500-1750g when standard medical treatment is ineffective, helping to alleviate respiratory distress and improve cardiac function.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Indoiv Injection is administered by the doctor or nurse in a healthcare setting.• Do not self-administer.

Medicinal Benefits

Indoiv Injection provides several medicinal benefits, including the effective closure of Patent Ductus Arteriosus (PDA) in premature babies, reduction of prostaglandin production, and improved lung function. Additionally, it provides pain relief, anti-inflammatory effects, and fever reduction. By treating PDA, Indoiv Injection helps prevent complications such as respiratory distress, making it a crucial medication in neonatal care.

How Indoiv Injection Works

Indoiv Injection works by inhibiting prostaglandin production, specifically prostaglandin E2 (PGE2), which keeps the ductus arteriosus open. By blocking PGE2, the ductus arteriosus contracts and closes, allowing blood to flow normally to the lungs, effectively reducing the risk of complications and improving lung function.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Indoiv Injection out of the sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Indoiv Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Limit processed foods and eat more vegetables and fruits.
  • Exercise at least 30 minutes every day.
  • Maintain a healthy weight.
  • Quit smoking as it can worsen kidney damage.
  • Control your blood pressure and blood glucose.
  • Limit salt intake and alcohol consumption.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Eat fiber-rich foods like fruits, whole grains, and vegetables as a part of your diet.
  • Minimize fasting, intense physical exercises, smoking and better to avoid drinking alcohol to reduce symptoms.
  • Maintain a normal routine by having three meals a day and staying hydrated.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

What if I have taken an overdose of Indoiv Injection

Since the doctor or nurse will administer the medication, the risk of overdose is minimal. However, in the case of any accidental overdose, it is essential to contact the doctor immediately for prompt care and ensure the patient is closely monitored.

Drug Warnings

Inform your pediatrician about any medication or food allergies, pre-existing medical conditions such as kidney or liver disease, heart disease, or high blood pressure, and any current infections. Inform your child had bleeding disorders such as active intracranial hemorrhage or gastrointestinal bleeding, thrombocytopenia, coagulation defects, suspected or confirmed necrotizing enterocolitis, severe renal impairment, and congenital heart disease.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Indoiv Injection:
Co-administration of Indomethacin with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Indoiv Injection with Cidofovir is not recommended as it can lead to an interaction, it can be used if prescribed by a doctor. However, if you experience nausea, vomiting, decreased hunger, increased or decreased urination, weight gain or loss that occurs suddenly, fluid retention, swelling, shortness of breath, cramping in the muscles, weakness, confusion, and irregular heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Indoiv Injection:
Co-administration of Ketorolac together with Indomethacin may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, and ulcers.

How to manage the interaction:
Taking Indoiv Injection with Ketorolac is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Indoiv Injection:
The combined use of Indoiv Injection and Ibuprofen can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Indoiv Injection and Ibuprofen together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Indoiv Injection:
Taking Indomethacin with Prasugrel can increase the risk of bleeding.

How to manage the interaction:
Taking Indoiv Injection with Prasugrel together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Indoiv Injection:
Co-administration of Indomethacin with Tenofovir alafenamide may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Indoiv Injection with Tenofovir alafenamide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, lack of appetite, increased or decreased urination, weight gain or loss that occurs suddenly, fluid retention, swelling, breathing difficulty, cramping in the muscles, disorientation, confusion, and irregular heartbeat, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Indoiv Injection:
Coadministration of Indomethacin with Celecoxib can increase the risk of gastrointestinal bleeding and ulcers.

How to manage the interaction:
Although there is a interaction between Indoiv Injection and Celecoxib, but it can be taken if your doctor has advised it. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Indoiv Injection:
Co-administration of Methotrexate with Indomethacin can increase the levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between Methotrexate and Indomethacin, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms like mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, breathing difficulty, a dry cough, dizziness or fainting, unusual bruising or bleeding, seizures(fits), infection, as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Indoiv Injection:
Use of Indoiv Injection with Piroxicam can increase the risk of side effects such as inflammation(swelling with redness and pain), bleeding, ulceration.

How to manage the interaction:
Taking Indoiv Injection with Piroxicam together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Indoiv Injection:
Using Indomethacin with Enoxaparin can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Taking Indoiv Injection with Enoxaparin together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Indoiv Injection:
The combined use of Indoiv Injection and ketoprofen can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Indoiv Injection with Ketoprofen together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

NON-STEROIDAL DRUG
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Alcohol

Not applicable

-

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Pregnancy

Not applicable

-

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Breast Feeding

Not applicable

-

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Driving

Not applicable

-

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Liver

Caution

Before administering Indoiv Injection, please inform your pediatrician if your child has a history of liver impairments or problems.

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Kidney

Caution

Before administering Indoiv Injection, please inform your pediatrician if your child has a history of kidney impairments or problems.

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Children

Safe if prescribed

Indoiv Injection is generally safe when prescribed by a doctor, particularly in premature babies. Please consult your doctor for further information.

Have a query?

FAQs

Indoiv Injection is specifically used to treat premature infants weighing between 500 and 1750 grams who have a hemodynamically significant patent ductus arteriosus (PDA). Its primary purpose is to close the PDA, a congenital heart defect that can cause significant health issues in premature babies.

Indoiv Injection works by inhibiting prostaglandin production, specifically prostaglandin E2 (PGE2), which keeps the ductus arteriosus open. By blocking PGE2, the ductus arteriosus contracts and closes, allowing blood to flow normally to the lungs, effectively reducing the risk of complications and improving lung function.

Indoiv Injection is contraindicated in neonates with certain medical conditions, including untreated infections, bleeding disorders such as active intracranial hemorrhage or gastrointestinal bleeding, thrombocytopenia, coagulation defects, suspected or confirmed necrotizing enterocolitis, severe renal impairment, and congenital heart disease requiring patency of the ductus arteriosus for pulmonary or systemic blood flow.

Your child may experience some common side effects like bleeding problems, temporary decrease in urine production, and kidney function impairment, which will be closely monitored by your child's doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - IND0219

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