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  3. Indease 400mg Capsule

Indease 400mg Capsule, Pack of 1 Capsule
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Indease 400mg Capsule is used for the treatment of HIV infection. It contains Indinavir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 (T) cells, a type of white blood cell that helps the body fight infection. Common side effects of this medication may include nausea, headache, loss of appetite, and weakness. Inform the doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding whilst on treatment with this medication.

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Composition :

INDINAVIR-400MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Indease 400mg Capsule

Indease 400mg Capsule belongs to a group of antiretroviral medicines indicated for the treatment of HIV infection. Indease 400mg Capsule does not cure HIV infection. It reduces the viral load in the body and keeps it at a low level. Taking Indease 400mg Capsule decreases the chance of developing AIDS (acquired immunodeficiency syndrome) and HIV-related illnesses such as cancer or serious infections.

Indease 400mg Capsule contains Indinavir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 (T) cells, a type of white blood cell that helps the body fight infection.

In some cases, Indease 400mg Capsule may cause side effects such as nausea, headache, loss of appetite, and weakness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.

Consult the doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding whilst on treatment with Indease 400mg Capsule. Tell the doctor about your new or worsening symptoms during treatment with Indease 400mg Capsule. Keep your doctor informed about your health condition and medications to prevent any side effects/interactions.

Uses of Indease 400mg Capsule

Indease 400mg Capsule is used in the treatment of HIV (human immunodeficiency virus) infection. The detailed uses of Indease 400mg Capsule are as follows:<br/>• Treatment of HIV infection: Indease 400mg Capsule is used in combination with other antiretroviral medications to reduce the amount of HIV in the body, improve immune function, and slow the progression of the disease.<br/>

Directions for Use

• Indease 400mg Capsule can be taken 1 hour before or 2 hours after a meal, with water, juice, milk, coffee, or tea.• It is usually taken every 8 hours; however, follow your doctor's advice regarding the dosage and duration.• Swallow the capsule as a whole with a glass of water.• Do not crush, open or break Indease 400mg Capsule.

Medicinal Benefits

Indease 400mg Capsule belongs to a group of antiretroviral medicines called protease inhibitors used to treat HIV infection. Indease 400mg Capsule contains Indinavir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 (T) cells, a type of white blood cell that helps the body fight infection. Indease 400mg Capsule reduces the viral load in the body and keeps it at a low level. Taking Indease 400mg Capsule decreases the chance of developing AIDS (acquired immunodeficiency syndrome) and HIV-related illnesses such as cancer or serious infections. Indease 400mg Capsule may also be used in combination with other medicines to treat people exposed to HIV infection after accidental contact with HIV-contaminated blood, body fluids, or tissues.

How Indease 400mg Capsule Works

Indease 400mg Capsule contains Indinavir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 (T) cells, a type of white blood cell that helps the body fight infection.

Storage

• Store in a cool and dry place away from sunlight.• Keep Indease 400mg Capsule out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Indease 400mg Capsule
  • Stay hydrated by drinking at least 8 glasses of water daily.
  • Limit sodium intake by reducing salty foods.
  • Moderate animal protein by limiting red meat, poultry, and fish.
  • Incorporate calcium-rich plant-based foods like leafy greens and fortified foods.
  • Limit oxalate-rich foods like spinach, rhubarb, beets, chocolate, nuts, and certain berries.
  • Eat citrus fruits like lemons and oranges for citric acid benefits.
  • Exercise regularly with moderate physical activity.
  • Maintain a healthy weight to reduce stone risk.
  • Monitor urine output by tracking volume and color.
  • Keep a food diary to track kidney stone-friendly diet.
  • Consult a healthcare professional to discuss kidney stone type and management plan.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
  • Stay hydrated by drinking at least 8 glasses of water daily.
  • Limit sodium intake by reducing salty foods.
  • Moderate animal protein by limiting red meat, poultry, and fish.
  • Incorporate calcium-rich plant-based foods like leafy greens and fortified foods.
  • Limit oxalate-rich foods like spinach, rhubarb, beets, chocolate, nuts, and certain berries.
  • Eat citrus fruits like lemons and oranges for citric acid benefits.
  • Exercise regularly with moderate physical activity.
  • Maintain a healthy weight to reduce stone risk.
  • Monitor urine output by tracking volume and color.
  • Keep a food diary to track kidney stone-friendly diet.
  • Consult a healthcare professional to discuss kidney stone type and management plan.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

What if I have taken an overdose of Indease 400mg Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Indease 400mg Capsule may include pain in the side of your body, blood in urine, nausea, vomiting, and diarrhea. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Indease 400mg Capsule if you are allergic to any of its components. Inform your doctor if you have liver problems, especially if you have mild/moderate liver disease caused by cirrhosis, kidney problems, diabetes, haemophilia (a disorder in which the blood does not clot properly), high cholesterol and if you are taking cholesterol-lowering medicines known as statins. Let the doctor know if you are taking prescription/non-prescription medicines, including herbal products or dietary supplements.

Drug-Drug Interactions

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IndinavirMidazolam
Critical
IndinavirTicagrelor
Critical

Drug-Drug Interactions

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IndinavirMidazolam
Critical
How does the drug interact with Indease 400mg Capsule:
Indease 400mg Capsule and Midazolam co-administration may considerably enhance Midazolam blood levels and effects.

How to manage the interaction:
Although taking Indease 400mg Capsule and Midazolam together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
IndinavirTicagrelor
Critical
How does the drug interact with Indease 400mg Capsule:
Using ticagrelor together with Indease 400mg Capsule can cause risk of bleeding.

How to manage the interaction:
Taking Ticagrelor with Indease 400mg Capsule is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.
IndinavirTolvaptan
Critical
How does the drug interact with Indease 400mg Capsule:
When Tolvaptan and Indease 400mg Capsule are taken together, may significantly increase the blood levels and effects of Tolvaptan.

How to manage the interaction:
There may be a possibility of interaction between Tolvaptan and Indease 400mg Capsule, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
IndinavirSilodosin
Critical
How does the drug interact with Indease 400mg Capsule:
Coadministration of Silodosin with Indease 400mg Capsule may significantly increase the blood levels and effects of Silodosin, this may cause blood pressure to fall excessively and heart rate to increase, especially when you rise from a sitting or lying position.

How to manage the interaction:
Taking Silodosin with Indease 400mg Capsule together is not recommended s it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
IndinavirAmiodarone
Critical
How does the drug interact with Indease 400mg Capsule:
The combination of Amiodarone and Indease 400mg Capsule may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Despite the fact that Amiodarone and Indease 400mg Capsule interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor.
IndinavirAlprazolam
Critical
How does the drug interact with Indease 400mg Capsule:
The combination of Alprazolam and Indease 400mg Capsule may considerably increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Alprazolam and Indease 400mg Capsule, it can be used if prescribed by a doctor. Consult a doctor if you have drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
IndinavirRifampicin
Critical
How does the drug interact with Indease 400mg Capsule:
When Indease 400mg Capsule is taken with Rifampicin, it can reduce the blood levels and effects of Indease 400mg Capsule.

How to manage the interaction:
Although there is an interaction between Indease 400mg Capsule and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
IndinavirSimvastatin
Critical
How does the drug interact with Indease 400mg Capsule:
Combining Indease 400mg Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Indease 400mg Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
IndinavirSildenafil
Critical
How does the drug interact with Indease 400mg Capsule:
Coadministration of Indease 400mg Capsule and Sildenafil can increase the blood levels and side effects of sildenafil.

How to manage the interaction:
Taking Indease 400mg Capsule and Sildenafil together is avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
IndinavirLurasidone
Critical
How does the drug interact with Indease 400mg Capsule:
Using Lurasidone together with Indease 400mg Capsule may result in significantly higher Lurasidone blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurasidone and Indease 400mg Capsule may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items that can have body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injections or drug equipment.
  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or doing whatever makes you happy.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS

Indease 400mg Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is not known whether Indease 400mg Capsule interacts with alcohol. Please consult your doctor for more information.

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Pregnancy

Caution

Indease 400mg Capsule belongs to pregnancy category C. It should be used during pregnancy only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Indease 400mg Capsule. HIV-positive women must not breastfeed as HIV infection can be passed to the baby in breast milk.

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Driving

Consult your doctor

It is not known if Indease 400mg Capsule affects your ability to drive. Drive or operate machinery only if you are feeling well.

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Liver

Caution

Please consult your doctor if you have liver problems, particularly if you have mild or moderate liver disease caused by cirrhosis.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Consult your doctor

Please consult the doctor. Your doctor may prescribe a suitable dose based on your child's age and condition.

Have a query?

FAQs

Indease 400mg Capsule is used to treat HIV infection.

Indease 400mg Capsule works by decreasing the amount of HIV in the blood. Thereby, Indease 400mg Capsule helps treat HIV infection.

Taking Indease 400mg Capsule with cholesterol-lowering medicines called statins may cause severe muscle pain and weakness. Consult the doctor if you experience severe muscle pain or weakness.

Indease 400mg Capsule may cause kidney stones. Therefore, drink plenty of fluids while on treatment with Indease 400mg Capsule as it helps reduce the chances of forming a kidney stone. Consult the doctor if you develop kidney pain (middle to the lower stomach or back pain) or blood in the urine.

Indease 400mg Capsule does not reduce the risk of passing HIV to others through blood contamination or sexual contact. Therefore, practice safe sex to prevent the risk of transmission.

Consult the doctor before taking sildenafil, tadalafil, or vardenafil with Indease 400mg Capsule as taking them together might increase the risk of side effects like low blood pressure, penile erection lasting more than 4 hours, or visual changes associated with sildenafil, tadalafil, and vardenafil. Seek immediate medical assistance if you have an erection lasting longer than 4 hours.

Didanosine can be taken with Indease 400mg Capsule if prescribed by the doctor. However, maintain a gap of 1 hour between didanosine and Indease 400mg Capsule.

Indease 400mg Capsule may cause hyperglycaemia (high blood sugar) even though you do not have diabetes. Consult the doctor immediately if you notice symptoms of high blood sugar, like frequent urination, extreme thirst, blurred vision, extreme hunger, or weakness. High blood sugar can lead to a serious condition called ketoacidosis if not treated. Symptoms of ketoacidosis include nausea, vomiting, dry mouth, shortness of breath, and decreased consciousness.

Manufacturer/Marketer address

1251, SECTOR-8, FARIDABAD, HARYANA
Other Info - IN63254

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:20 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020685s073lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a696028.html
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