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Histocalamine Lotion is used in the treatment of allergic skin conditions. It is also used to treat itching, insect/sting bites, eczema, and other minor skin conditions. It works by imparting a cooling sensation on the skin to relieve minor skin irritation and also relieves the symptoms of skin allergy. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Somatico Laboratories Pvt Ltd

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Histocalamine Lotion

Histocalamine Lotion belongs to the class of  'anti-allergens'. Histocalamine Lotion is used in the treatment of allergic skin conditions. It is also used to treat itching, insect/sting bites, eczema, and other minor skin conditions.

Histocalamine Lotion is a combination of three medicines namely: calamine, diphenhydramine, and camphor. Calamine and camphor are two astringents whereas diphenhydramine is anti-allergic. The astringents work by imparting a cooling sensation on the skin to relieve minor skin irritation and the antiallergic works by blocking the effects of a chemical messenger (histamine), thereby relieving symptoms of skin allergy.

Use  Histocalamine Lotion exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Before you apply Histocalamine Lotion topical, wash the skin with soap and water. Allow the skin to dry completely. Apply Histocalamine Lotion  directly to the skin and rub it gently, allowing it to dry on your skin. You may also use a cotton ball to smooth the medicine onto your skin. Usually, Histocalamine Lotion does not cause any side-effects, sometimes may have side effects like hives, rash, redness, and difficulty in breathing, in that case, contact your doctor immediately.

Let your doctor know if you are using a prescription, non-prescription drugs, and herbal products before starting Histocalamine Lotion . If you are known to be allergic to Histocalamine Lotion or its inactive components, please inform your doctor. Store at room temperature away from moisture and heat. Do not freeze or refrigerate. Wash your hands with soap and water after applying for the medicine. Do not use the Histocalamine Lotion for internal use, it is only for external use. Discontinue if rash or burning sensation occurs by informing your doctor.

Description

The Histocalamine Lotion is a remarkable product that brings relief to red and itchy skin. This lotion is particularly useful in managing various skin conditions including diaper rashes, prickly heat, pregnancy-related itching, post-chickenpox and measles rashes in children, insect bites, viral fever rashes, and pre and post-plaster itch. The effectiveness of this Histo Calamine Lotion lies in its key active ingredients, i.e. calamine, and camphor.

Camphor carries antibacterial and antifungal properties which help heal skin inflammation while also providing a cooling sensation upon application. Calamine, on the other hand, aids in alleviating itching, pain, and other skin irritations. So if you're looking for a soothing solution for your skin problems, Histocalamine Lotion might be worth considering.



Features

  • Infused with 1% Diphenhydramine HCl - an antihistamine
  • Fortified with Glycerin for added skin benefits
  • Created for external use on inflamed skin areas
  • Incorporates 0.1% Camphor for its cooling properties
  • Comes with a pleasant Sandalwood fragrance

Uses of Histocalamine Lotion

Histocalamine Lotion is used in the treatment of allergic skin conditions. Its detailed uses are as follows:

  • Relieves Symptoms of Skin Allergies: Histocalamine Lotion contains diphenhydramine (an antiallergic), which helps relieve symptoms such as skin rashes, redness, itching, and swelling caused by allergic skin conditions like contact dermatitis, eczema (atopic dermatitis), or urticaria (hives)
  • Soothes Skin Irritation: Camphor in Histocalamine Lotion produces a cooling sensation on the skin and helps relieve minor skin irritation caused by insect bites, sunburns, poison ivy, or other allergic skin reactions.
  • Treats Oozing and Weeping Skin Lesions: Calamine acts as an astringent and drying agent, helping to dry out and heal oozing or weeping skin lesions caused by eczema, poison ivy, or poison oak.

Key Benefits

Histocalamine Lotion is used to treat allergic skin conditions which contains calamine, diphenhydramine, and camphor. Calamine and camphor are two astringents whereas diphenhydramine is anti-allergic. The astringents work by imparting a cooling sensation on the skin to relieve minor skin irritation and the antiallergic works by blocking the effects of a chemical messenger (histamine), thereby relieving symptoms of skin allergy.Histocalamine Lotion can also be used in treating itching, sting/insect bites, rashes, eczema.

Directions for Use

  • Recommended to apply Histocalamine Lotion 2 to 4 times daily, or as advised by your doctor.
  • Apply a thin layer of the lotion using your fingers or a cotton pad. Let it dry completely before putting on any clothing over the area.
  • Shake the bottle well before use.
  • Clean and thoroughly dry the affected area of the skin.
  • Avoid applying it near the eyes, mouth, nose, or other mucous membranes.

How Histocalamine Lotion Works

Histocalamine Lotion is a combination of three medicines namely: calamine, diphenhydramine, and camphor. Calamine and camphor are two astringents whereas diphenhydramine is anti-allergic. The astringents work by imparting a cooling sensation on the skin to relieve minor skin irritation and the antiallergic works by blocking the effects of a chemical messenger (histamine), thereby relieving symptoms of skin allergy.
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Alcohol

Caution

Histocalamine Lotion should not be taken with alcohol, because it may aggravate the symptoms of skin allergy.

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Pregnancy

Caution

Histocalamine Lotion may be used in pregnant. Because Histocalamine Lotion is a topical one, so it does not absorb into the systemic circulation and will not produce harmful effects to an unborn baby. Before using take advice of your doctor.

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Breast Feeding

Caution

Histocalamine Lotion may be used in breastfeeding mothers. because Histocalamine Lotion is a topical one, so it does not absorb into the systemic circulation and will not pass through the breastmilk.Before using Histocalamine Lotion take the advice of your doctor.

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Driving

Safe if prescribed

Histocalamine Lotion is used when you are driving.Histocalamine Lotion does not absorb through systemic circulation, because it is applied on the skin, so it does not cause any drowsiness.

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Liver

Caution

Histocalamine Lotion may be used in liver diseases. Because Histocalamine Lotion is a topical one, so it does not absorb into the systemic circulation.

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Kidney

Caution

Histocalamine Lotion may be used in kidney diseases. Because Histocalamine Lotion is a topical one, so it does not absorb into the systemic circulation.

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Children

Caution

Histocalamine Lotion should be given to the children below 12 years, but not to the infants (newborn child<4weeks). before using inform to your doctor.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Histocalamine Lotion in elderly patients. Please consult your doctor.

What if I have taken an overdose of Histocalamine Lotion

Do not apply Histocalamine Lotion in large amounts or use it for a long time than recommended, as it does not give quick or better results but increases the risk of side effects.

Diet & Lifestyle Advise

  • Quitting smoking
  • Limit alcohol
  • Take foods like blueberries, broccoli, guava, kiwi fruits, oranges, papaya, strawberries, and sweet potatoes.
  • Avoid oily content foods, white grains, chocolate.
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Have a query?

How Soon It Starts Working

The time required for Histocalamine Lotion to start to work: The time required for Histocalamine Lotion to show its action is unknown. The time for which the effects of Histocalamine Lotion last: The duration of action for Histocalamine Lotion is unknown.

What if you forget to take Histocalamine Lotion

If you miss a dose of Histocalamine Lotion , apply it as soon as you remember. If it is almost time for next dose, skip the missed dose and apply next dose at regular time. Do not apply a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not use on extensive areas of skin for longer than 7 days
  • Avoid contact with mucous membranes and eyes
  • Discontinue if rash or burning sensation occurs
  • Do not stop the Histocalamine Lotion suddenly after relieving the symptoms on your own, there may be a chance of reoccurrence of symptoms. So take the advise of your doctor before stopping the Histocalamine Lotion

Drug-Drug Interactions

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Drug-Drug Interaction: It is not likely that other drugs you take orally or inject will have an effect on topically applied Histocalamine Lotion . But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Drug-Food Interaction: No interaction found/established.

Drug-Disease Interaction: Use Histocalamine Lotion with medical advice as it is a topical application that does not cause any disease interaction.

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIALLERGIC]

FAQs

Yes, Histocalamine Lotion is effective in treating various skin conditions including diaper rashes. Always consult your doctor before using new products on an infant's delicate skin.
No, it is advised not to apply Histocalamine lotion on broken or damaged skin as it might cause irritation or an undesired reaction.
The time taken to show results may vary from person to person based on the severity and type of skin issue. However, relief from itchiness and discomfort should be noticeable within a short span of use.
Yes, Histocalamine lotion has been formulated to minimise allergic reactions. However, it's always best to perform a patch test before using any new skincare product widely.
Histocalamine Lotion is used in the treatment of allergic skin conditions. It is also used to treat itching, insect/sting bites, eczema, and other minor skin conditions.
Histocalamine Lotion is a combination of calamine, diphenhydramine, and camphor. Calamine and camphor both are astringents whereas diphenhydramine is an antiallergic, the astringents work by imparting a cooling sensation on the skin to relieve minor skin irritation. The antiallergic works by blocking the effects of a chemical messenger (histamine), thereby relieving symptoms of skin allergy.
Before you apply Histocalamine Lotion topical, wash the skin with soap and water. Allow the skin to dry completely.
Histocalamine Lotion cannot be stopped suddenly after relieving from symptoms without informing your doctor, as it may lead to the reoccurrence of symptoms.
Use Histocalamine Lotion as directed on the label or by your doctor. Before application, wash and dry the skin. Then apply the lotion gently and allow it to dry. Do not use more or less than recommended, or apply for longer than advised.
Histocalamine Lotion should be used as directed. Usually apply it 2 to 3 times a day to the affected areas. However, always apply Histocalamine Lotion as per dose and duration advised by your doctor.
Calamine is a topical treatment often used to relieve itching, irritation, and discomfort from skin issues like insect bites, and rashes
Usually, Histocalamine Lotion does not have side effects. In case you experience any side effects, please consult a doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Calamine Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Calamine + Diphenhydramine + Camphor Pharmacology & Usage Details. [Accessed on 02 Jun. 2026]Check here
  3. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Lycalamine Lotion
  4. Fox LP, Merk HF, Bickers DR Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1679-1706
  5. Robertson DB, Maibach HI Dermatologic Pharmacology. Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 1047-1065

Country of origin

India

Manufacturer/Marketer address

16Th Floor, Godrej Bkc, Plot C, G Block, Bandra-Kurla Complex, Bandra (East), Mumbai 400 051, India.
Other Info - HIS0086
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