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compositionComposition:GRANISETRON-1MG
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Grandem Syrup is used to prevent nausea and vomiting caused by chemotherapy or radiation therapy in children. It contains Granisetron, which works by blocking a natural substance (serotonin) in the body that causes nausea and vomiting. This medicine may sometimes cause side effects such as diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, and drowsiness. Inform your doctor if your child is allergic to Grandem Syrup. Also, let your doctor know your child's complete medication history and medical history before taking Grandem Syrup. This medicine is not recommended for use in pregnant and breastfeeding mothers.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Grandem Syrup

Grandem Syrup is a prescription oral syrup used to prevent and manage nausea and vomiting in children undergoing medical treatments like chemotherapy or radiation therapy. This medicine is specifically formulated as a liquid to make it easy for pediatric patients to swallow and absorb. It works by targeting the chemical pathways in the body that trigger the reflex to throw up.

For the best results, this medicine must be given consistently at the exact times prescribed by your doctor, typically shortly before a therapy session begins. It can be given with or without food, depending on what is easiest on your child's stomach. Keeping your child in a quiet, well-ventilated room and offering small, frequent sips of cool water can also help support the medicine's effectiveness.

Most children tolerate this medicine well, though some may experience mild temporary side effects like headaches or constipation. If you notice any signs of a serious reaction, such as an irregular heartbeat, sudden dizziness, or a severe skin rash, you must contact your doctor immediately.

Do not give this medicine to your child if they have a known allergy to similar anti-nausea medications. Before starting treatment, talk to your doctor if your child has a history of heart rhythm problems, severe liver issues, or a blockage in their digestive tract.

Grandem Syrup can interact with other medicines that alter heart rhythm or brain chemistry, which may lead to serious complications. While alcohol and smoking are not typical concerns for pediatric patients, older adolescents must avoid these substances as they can worsen stomach irritation. Always consult your pediatrician if the patient is a pregnant or breastfeeding teenager, or if they are taking any other medications.

Uses of Grandem Syrup

Grandem Syrup is an antiemetic medication used primarily to prevent and treat nausea and vomiting, especially those caused by chemotherapy, radiation therapy, or surgery. The detailed uses of Grandem Syrup are as follows:

  • Chemotherapy-induced nausea and vomiting: Grandem Syrup helps prevent the severe urge to vomit and the feeling of sickness that commonly occurs in children receiving cancer chemotherapy drugs.
  • Radiation-induced nausea and vomiting: This medicine is used to protect the child's stomach and brain from the nausea triggers caused by radiation therapy treatments.
  • Postoperative nausea and vomiting: In some cases, doctors prescribe this syrup to prevent or treat sickness that children might experience after undergoing surgery.

Key Benefits

  • Helps prevent nausea and vomiting before they start.
  • Reduces stomach upset during chemotherapy, radiation therapy, or after surgery.
  • children more comfortable during medical treatment.
  • Helps reduce discomfort and anxiety caused by repeated vomiting.
  • Makes it easier for children to keep down food, fluids, and other medicines.
  • Helps prevent dehydration by reducing vomiting.
  • Supports faster recovery by maintaining hydration and nutrition.
  • The syrup formulation is easy for children to take.

Directions for Use

  • Grandem Syrup can be given with or without food, or as the doctor advises.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Measure the prescribed dose using a measuring cup to get an accurate dose and administer it orally.
  • Avoid using regular household spoons, as they may not measure the dose correctly. Shake well before use.

How Grandem Syrup Works

Grandem Syrup works by preventing the signals that cause nausea and vomiting. During chemotherapy, radiation therapy, or after surgery, the body releases a natural chemical called serotonin, which sends signals to the brain that make you feel sick or cause vomiting. Grandem Syrup blocks these signals before they reach the brain. As a result, it helps prevent nausea and vomiting, making treatment and recovery more comfortable.
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Alcohol

Not applicable

Grandem Syrup is for paediatric use.

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Pregnancy

Not applicable

Grandem Syrup is not recommended for use in pregnant women.

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Breast Feeding

Not applicable

Grandem Syrup is intended for use in paediatrics.

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Driving

Not applicable

Grandem Syrup is for paediatric use.

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Liver

Caution

Grandem Syrup should be cautiously used by patients with liver diseases. Please consult your paediatrician if you have a history of liver impairment before starting Grandem Syrup.

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Kidney

Caution

Grandem Syrup should be cautiously used by patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Safe if prescribed

Grandem Syrup is safe for use in children as prescribed by your doctor. The paediatrician will decide the dose based on the age and body weight of the child.

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Heart

Caution

Please inform your child’s doctor before giving Grandem Syrup if your child has heart problems, as it may cause changes in heartbeat, dizziness, palpitations, or fainting, which can be more serious in children with pre-existing cardiovascular conditions.

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Geriatrics

Not applicable

Grandem Syrup is specifically for children use and is not meant for geriatric patients.

What if I have taken an overdose of Grandem Syrup

If your child accidentally takes more than the prescribed dose of Grandem Syrup, seek immediate medical attention or contact a poison control center right away. Watch for signs such as a rapid heartbeat, severe headache, or confusion.

Diet & Lifestyle Advise

  • Offer small, frequent meals: Instead of three large meals, give your child small portions of bland foods throughout the day to keep their stomach settled.
  • Choose gentle foods: Opt for easy-to-digest foods like dry toast, crackers, plain rice, bananas, or applesauce. Avoid greasy, fried, sweet, or highly spiced foods.
  • Focus on hydration: Encourage your child to sip clear fluids, such as water, clear broths, or oral rehydration solutions, slowly between meals rather than during meals.
  • Minimize food odors: Serve foods cold or at room temperature, as warm foods often have stronger smells that can trigger nausea. Keep the dining and resting areas well-ventilated.
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How Soon It Starts Working

The time required for Grandem Syrup to start to work: The time required for Grandem Syrup to show its action is clinically not established. The time for which the effects of Grandem Syrup last: The duration of action for Grandem Syrup has not been clinically established.

What if you forget to take Grandem Syrup

If you miss giving a dose at the scheduled time, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular schedule. Never give a double dose to make up for a missed one. If you are unsure, talk to your doctor or pharmacist.

Storage

• Store Grandem Syrup syrup at room temperature, between 15°C and 30°C.

Drug Warnings

  • Inspect the liquid: Before giving each dose, check the appearance of the syrup. It should look clear and free of any floating particles. Do not use it if it appears cloudy or discolored.
  • Use the correct device: Never guess the dosage or use a regular teaspoon. Only use the clean, marked measuring syringe or cup that came with the packaging.
  • Watch for bowel changes: Because this medicine can cause constipation, monitor your child's bowel movements closely. Speak to your doctor if your child goes multiple days without a bowel movement.
  • Report heart concerns: Inform your doctor immediately if your child has a personal or family history of heart rhythm irregularities before starting this syrup.

Drug-Drug Interactions

verifiedApollotooltip
  • Heart rhythm medicines: Combining Grandem Syrup with other medications that affect the heart's electrical activity can increase the risk of irregular heartbeats.
  • Serotonergic medicines: Taking this medicine alongside certain antidepressants or other serotonin-boosting drugs may increase the risk of a rare, serious condition called serotonin syndrome.

Drug-Drug Interactions

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How does the drug interact with Grandem Syrup 30 ml:
Taking Grandem Syrup 30 ml with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 30 ml with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Grandem Syrup 30 ml:
Taking Grandem Syrup 30 ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 30 ml with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronMesoridazine
Critical
How does the drug interact with Grandem Syrup 30 ml:
Taking Grandem Syrup 30 ml with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Grandem Syrup 30 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem Syrup 30 ml:
Taking Grandem Syrup 30 ml with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 30 ml with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem Syrup 30 ml:
Taking Grandem Syrup 30 ml with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 30 ml with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Grandem Syrup 30 ml:
Taking Grandem Syrup 30 ml with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 30 ml with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem Syrup 30 ml:
Taking Grandem Syrup 30 ml with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 30 ml with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSaquinavir
Critical
How does the drug interact with Grandem Syrup 30 ml:
When Grandem Syrup 30 ml is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 30 ml with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem Syrup 30 ml:
Coadministration of Grandem Syrup 30 ml with Nilotinib can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
There may be a possibility of interaction between Grandem Syrup 30 ml and Nilotinib, but it can be taken if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Grandem Syrup 30 ml:
Taking amisulpride with Grandem Syrup 30 ml increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Grandem Syrup 30 ml along with amisulpride can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Grandem Syrup when used as directed.     
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Grandem Syrup is used to treat nausea and vomiting caused by medical treatments.
Grandem Syrup contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Grandem Syrup relieves symptoms of post-operative nausea and vomiting.
You are advised to complete the course prescribed by your doctor. Please do not stop giving this medicine unless advised by your doctor, since it may lead to recurrent episodes of nausea and vomiting.
Take Grandem Syrup as soon as possible. However, if it's time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.
Grandem Syrup may cause constipation as a side effect. You can avoid it by including high-fibre foods in your diet, which improves your digestion. Limit the intake of alcohol to manage your constipation.
Grandem Syrup syrup typically starts working within 1 hour after it is swallowed. It is designed to be given before cancer treatment begins to prevent nausea from developing. Talk to your doctor if your child continues to feel sick after taking it.
Yes, you can give Grandem Syrup syrup with or without food. If your child has an upset stomach, giving it with a small amount of bland food may make it easier to tolerate. Talk to your doctor for personalized advice.
Do not give another dose right away without guidance. If your child throws up shortly after swallowing the medicine, contact your healthcare provider to ask whether you should repeat the dose or wait. Talk to your doctor or pharmacist.
Yes, some children may feel slightly sleepy or fatigued after taking Grandem Syrup syrup. This is a common and usually temporary side effect. If the drowsiness is severe or does not improve, talk to your doctor.
Grandem Syrup syrup is usually prescribed on specific days—such as the days of chemotherapy or radiation treatments—rather than as a continuous daily medicine. Always follow the specific schedule prescribed for your child. Talk to your doctor.
No, you should never use a regular household spoon because they are not accurate and can lead to giving too much or too little medicine. Always use the measuring device provided with the bottle. Talk to your pharmacist if you need help measuring.

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Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai ? 400 001, India.
Other Info - GRA0041
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