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  3. GLZ Total Tablet 10's

GLZ Total Tablet 10's, Pack of 10 TABLETS
GLZ Total Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
GLZ Total Tablet is used to treat Type 2 diabetes. It works by increasing the insulin released by the pancreas, lowers glucose production in the liver, delays glucose absorption from the intestines and increases the body's response to insulin. It may cause side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and respiratory infection. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

GLICLAZIDE-60MG + METFORMIN-500MG + PIOGLITAZONE-15MG

Manufacturer/Marketer :

Alembic Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About GLZ Total Tablet

GLZ Total Tablet is used to treat Type 2 diabetes. Type 2 diabetes is a chronic or lifelong condition affecting how your body processes glucose. People with type 2 diabetes either do not produce enough insulin or if at all the insulin is produced, it is unable to perform its function in the body (insulin resistance). Due to this, the blood glucose level increases and symptoms such as frequent urination increased thirst and increased hunger start. 

GLZ Total Tablet contains Gliclazide, metformin and pioglitazone. Gliclazide works by increasing the insulin released by the pancreas. Metformin acts by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects.

In some cases, GLZ Total Tablet may cause side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and a respiratory infection. Most of these side effects may not require medical attention and resolve gradually overtime. However, talk to the doctor if the side effects persist or worsen.

Do not take GLZ Total Tablet if you are allergic to any of its components, have diabetic ketoacidosis (excess acids in your blood), type 1 diabetes mellitus or severe kidney/liver disease. Please inform the doctor if you have heart disease, are pregnant, are planning to get pregnant or are breastfeeding. GLZ Total Tablet may cause lactic acidosis (accumulation of lactic acid in the blood), which requires immediate medical attention. Do not consume alcohol (risk of lactic acidosis) or fast for prolonged periods (risk of hypoglycemia).

Uses of GLZ Total Tablet

Treatment of Type 2 Diabetes Mellitus.

Directions for Use

• Take GLZ Total Tablet with food to avoid stomach upset or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

GLZ Total Tablet contains Gliclazide, Metformin, and Pioglitazone. Gliclazide increases the production of insulin by acting on the pancreas. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects. Together, GLZ Total Tablet decreases the elevated blood sugar level after the meal, along with the recommended diet and exercise. GLZ Total Tablet also helps to prevent serious complications of diabetes such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), loss of sensation in your hands and feet (diabetic neuropathy) or even loss of the foot.

How GLZ Total Tablet Works

GLZ Total Tablet contains Gliclazide, metformin and pioglitazone. Gliclazide works by increasing the insulin released by the pancreas. Metformin acts by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects.

Storage

stored at room temperature below 30°C
Side effects of GLZ Total Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.

What if I have taken an overdose of GLZ Total Tablet

Do not take more than the prescribed dose of GLZ Total Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

GLZ Total Tablet may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. It is a life-threatening condition that requires immediate medical attention. Inform your doctor if you have any severe liver or kidney problems, as their normal functioning is required to eliminate excess lactic acid from the body.  Do not consume excess alcohol, as it increases the risk of lactic acidosis. It should be used with caution in patients with heart disease as it increases the risk of heart failure.

Drug-Drug Interactions

verifiedApollotooltip
MetforminIodamide
Critical
MetforminIoglycamic acid
Critical

Drug-Drug Interactions

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MetforminIodamide
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of GLZ Total Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking GLZ Total Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIoglycamic acid
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of Ioglycamic acid with GLZ Total Tablet can increase the risk of side effects.

How to manage the interaction:
Taking GLZ Total Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIodixanol
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of Iodixanol with GLZ Total Tablet can increase the risk of side effects.

How to manage the interaction:
Taking GLZ Total Tablet with Iodixanol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIotroxic acid
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of Iotroxic acid with GLZ Total Tablet can increase the risk of side effects.

How to manage the interaction:
Taking GLZ Total Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.
MetforminIopanoic acid
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of Iopanoic acid with GLZ Total Tablet can increase the risk of side effects.

How to manage the interaction:
Taking GLZ Total Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIoxitalamic acid
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of GLZ Total Tablet and Ioxitalamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking GLZ Total Tablet with Ioxitalamic acid is not recommended, please consult your doctor before taking it.
MetforminIofendylate
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of Iofendylate with GLZ Total Tablet can increase the risk of side effects.

How to manage the interaction:
Taking GLZ Total Tablet with Iofendylate is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIocetamic acid
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of GLZ Total Tablet and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking GLZ Total Tablet with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopromide
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of Iopromide with GLZ Total Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with GLZ Total Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIoglicic acid
Critical
How does the drug interact with GLZ Total Tablet:
Co-administration of Ioglicic acid with GLZ Total Tablet can increase the risk of side effects.

How to manage the interaction:
Taking GLZ Total Tablet with Ioglicic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat at regular intervals. Do not take the long gap between a meal or snack.
  • Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
  • Invest in at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise weekly.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrate-containing foods with whole grain foods and increase intake of fruits and veggies and other fibre-enriched foods.
  • Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Keep your blood pressure as normal (120/80) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS AND ANTIHYPERGLYCEMICS

GLZ Total Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Alcohol may increase the risk of side effects and worsen the condition.

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Pregnancy

Caution

If you are pregnant, consult your doctor before taking GLZ Total Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, consult your doctor before taking GLZ Total Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

GLZ Total Tablet may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using GLZ Total Tablet .

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Liver

Caution

GLZ Total Tablet should be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose if required based on your condition.

bannner image

Kidney

Caution

GLZ Total Tablet should be taken with caution in patients with kidney diseases. Your doctor may adjust the dose if required based on your condition.

bannner image

Children

Unsafe

GLZ Total Tablet is not recommended for use in children below 18 years.

Have a query?

FAQs

GLZ Total Tablet is used to treat type II diabetes, a chronic or lifelong condition affecting how your body processes glucose.

GLZ Total Tablet works by increasing the production of insulin by acting on the pancreas, decreasing liver glucose production and intestinal glucose uptake. It also decreases the amount of glucose released by the liver.

Some patients may experience a decline in blood sugar levels lower than normal (hypoglycemia), resulting in sweating, dizziness, headache, confusion, feeling hungry, temporary changes in vision, uneasiness, irritability, and weakness. In such cases, seek medical attention immediately.

GLZ Total Tablet may cause side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and a respiratory infection. Most of these side effects may not require medical attention and resolve gradually overtime. However, talk to the doctor if the side effects persist or worsen.

Symptoms of hypoglycaemia (low blood sugar) are feeling hungry, dizziness, irritability, sweating, tiredness, and palpitations. If you experience these symptoms consume glucose biscuits, sugar candy or fruit juice.

Include healthy food in your diet, exercise regularly, manage stress with relaxation techniques, and avoid smoking & alcohol consumption.

Country of origin

India

Manufacturer/Marketer address

Alembic Road, Vadodara - 390 003, Gujarat,INDIA
Other Info - GLZ0010

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:44 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicineindia.org/pharmacology-for-generic/3154/gliclazide-metformin-pioglitazone
  2. https://www.medicines.org.uk/emc/files/pil.4731.pdf
  3. https://mri.cts-mrp.eu/human/downloads/NL_H_1544_002_FinalPL_2of3.pdf

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