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compositionComposition:CETUXIMAB-100MG
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Prescription Medicine
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Erbitux 100 Injection 20 ml is used with or without radiation therapy to treat various cancer conditions, such as metastatic cancer of the large intestine and squamous cell cancer (a specific type of head and neck cancer). It contains Cetuximab, which works by slowing or stopping the growth of cancer cells. As a result, it prevents the cancer from spreading. The most common side effects are inflammation of the lining of the intestine, mouth, and nose, nose bleeding, headache, tiredness, irritation and redness of the eye, diarrhoea, feeling sick, vomiting, loss of appetite, and weight loss.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CETUXIMAB-100MG

Manufacturer/Marketer :

Merck Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Erbitux 100 Injection 20 ml

Erbitux 100 Injection 20 ml is a targeted prescription medicine used to treat advanced colorectal cancer and head and neck cancer. Eligibility criteria differ depending on the cancer type: before starting treatment for bowel cancer, your doctor will perform a RAS gene mutation test to confirm suitability, whereas for head and neck cancer, tumour EGFR protein expression or specific clinical staging is assessed. It is designed to slow or stop the growth of cancer cells by targeting specific proteins on their surface.

This medicine is given as an injection directly into a vein, typically once a week or every two weeks, depending on your treatment plan. To get the best results, it is important to keep all your scheduled appointments and maintain a balanced diet while drinking plenty of fluids. Protecting your skin from the sun is also highly recommended during your treatment.

While taking Erbitux 100 Injection 20 ml, you may experience common side effects like an acne-like rash, dry skin, or tiredness. However, if you experience serious side effects such as breathing difficulties, sudden chest pain, or a severe skin reaction, you must consult your doctor immediately.

Talk to your doctor before starting this medicine if you have a history of lung disease, heart rhythm issues, or abnormal salt levels in your blood. You must not receive this medicine if you have had a severe allergic reaction to Erbitux 100 Injection 20 ml, or if you have a RAS-mutant colorectal cancer, as the medicine is ineffective for this specific tumor type.

It is important to tell your healthcare provider about other treatments you are receiving, as combining this medicine with radiation can increase skin sensitivity, and you should avoid alcohol if it interacts with your overall treatment plan. Pregnant or breastfeeding individuals should not use this medicine, and elderly patients should consult their doctor for personalised monitoring.

Uses of Erbitux 100 Injection 20 ml

Erbitux 100 Injection 20 ml is used to treat certain types of advanced cancers. The detailed uses of Erbitux 100 Injection 20 ml are as follows:

  • Colorectal cancer: Erbitux 100 Injection 20 ml helps by targeting and blocking specific proteins that cause advanced or spreading bowel cancer cells to grow and multiply, often given alone or in combination with standard bowel cancer chemotherapy regimens (such as FOLFIRI or FOLFOX).
  • Head and neck cancer: Erbitux 100 Injection 20 ml helps by shrinking tumours or stopping them from spreading when used alone or alongside radiation therapy or platinum-based chemotherapy (such as cisplatin) for squamous cell cancers of the head and neck.

Key Benefits

Erbitux 100 Injection 20 ml provides targeted treatment to help slow the growth of certain cancers and improve treatment outcomes. The key benefits of Erbitux 100 Injection 20 ml are as follows:

  • Targeted tumour control: By directly blocking growth signals in cancer cells, Erbitux 100 Injection 20 ml helps limit tumour growth, which can reduce cancer-related pain and physical discomfort.
  • Enhanced treatment success: When used with radiation or other chemotherapy, this medicine helps make those treatments more effective, leading to better control of the disease.
  • Preservation of healthy tissue: Because it targets specific cancer cell proteins, it behaves differently from standard chemotherapy, aiming to spare more of your healthy cells.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Erbitux 100 Injection 20 ml will be given in a hospital setting under the supervision of a physician trained and experienced in administering cancer chemotherapeutic drugs.
  • Do not self-administer.

How Erbitux 100 Injection 20 ml Works

Erbitux 100 Injection 20 ml contains cetuximab, which is a type of targeted therapy known as a monoclonal antibody. It works by finding and locking onto a specific protein called the Epidermal Growth Factor Receptor (EGFR) on the surface of certain cancer cells. Under normal conditions, this protein acts like an 'on' switch that tells cells to grow and divide. In many cancers, this switch is permanently stuck in the active position, causing rapid tumour growth. By binding to this receptor, Erbitux 100 Injection 20 ml blocks the growth signals, essentially turning the switch off. This action slows down or stops the cancer cells from multiplying and spreading to other parts of the body.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Erbitux 100 Injection 20 ml as it may cause serious side effects.

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Pregnancy

Unsafe

Erbitux 100 Injection 20 ml is not recommended for use during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while on treatment with Erbitux 100 Injection 20 ml.

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Breast Feeding

Unsafe

Do not breastfeed your baby when you are being treated with Erbitux 100 Injection 20 ml and for two months after the last dose.

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Driving

Caution

Drive only if alert, as the Erbitux 100 Injection 20 ml may cause feeling sick or tiredness.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Erbitux 100 Injection 20 ml. Your doctor will weigh the benefits and potential risks before prescribing this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Erbitux 100 Injection 20 ml. Your doctor may titrate the dose if required based on your condition.

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Children

Safe if prescribed

Erbitux 100 Injection 20 ml can be used to treat certain cancers in children. Please consult your doctor for more information.

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Heart

Caution

If you have a pre-existing or a history of heart disease, inform your doctor before receiving Erbitux 100 Injection 20 ml. Your doctor will weigh the benefits and potential risks before prescribing this medicine.

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Geriatrics

Safe if prescribed

Erbitux 100 Injection 20 ml is generally safe for elderly patients. However, please consult your doctor if you have any concerns.

What if I have taken an overdose of Erbitux 100 Injection 20 ml

Since this medicine is given to you by a medical professional in a clinical setting, an overdose is highly unlikely. However, if you suspect there has been an error or if you experience unusual symptoms after your treatment, tell your healthcare provider or seek emergency medical attention right away.

Diet & Lifestyle Advise

  • Protect your skin from the sun: This medicine makes your skin highly sensitive to ultraviolet (UV) light. Wear protective clothing, wide-brimmed hats, and apply broad-spectrum sunscreen (SPF 30 or higher) daily, even on cloudy days.
  • Moisturise gently and follow preventive skin care: Use thick, alcohol-free moisturisers and mild, fragrance-free soaps. Avoid harsh over-the-counter acne products. Your oncology team may also prescribe preventive treatments from the start of therapy to reduce rash severity. These may include certain prescription oral antibiotics (such as doxycycline) or mild steroid creams (topical corticosteroids).
  • Stay hydrated and monitor minerals: Drink plenty of water throughout the day. Because this medicine can cause low blood magnesium levels (hypomagnesaemia), your doctor will check your electrolyte levels before each infusion and periodically after treatment ends. If your levels drop below healthy clinical thresholds, oral supplements or intravenous (IV, given through a drip) magnesium replacement will be administered.
  • Practice gentle nail care: Keep your fingernails and toenails clean and trimmed straight across to prevent painful nail bed infections. Wear protective gloves when washing dishes or doing yard work.
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Have a query?

How Soon It Starts Working

The time required for Erbitux 100 Injection 20 ml to start to work: The exact onset time of Erbitux 100 Injection 20 ml has not been clinically established. The time for which the effects of Erbitux 100 Injection 20 ml last: The duration of Erbitux 100 Injection 20 ml’s effect is clinically not established.

What if you forget to take Erbitux 100 Injection 20 ml

If you miss an appointment for your injection, contact your clinic or healthcare provider immediately to reschedule. Keeping a consistent schedule is very important for the success of your treatment. Do not attempt to double the dose or change your schedule without consulting your doctor.

Storage

• This medicine is stored under strict clinical conditions in a hospital or clinic. • It must be kept in a refrigerator between 2°C and 8°C.

Drug Warnings

  • Inspect the solution: Before your injection, your healthcare team will check that the solution is clear to slightly colored and free of visible particles. You have the right to ask them to confirm this check.
  • Expect routine monitoring: You should expect regular blood tests before each infusion to track your magnesium, electrolyte, and blood count levels, as well as routine skin assessments by your care team.
  • Know when to seek urgent medical care: Seek emergency attention if you experience red-flag symptoms such as sudden difficulty breathing, chest pain, irregular heartbeat, severe infusion-related fever or chills, or severe, painful skin blistering and cracking.
  • Watch for infusion reactions: Stay alert during and immediately after your injection. Tell your nurse right away if you feel sudden chills, fever, shortness of breath, or dizziness.
  • Avoid pregnancy and use effective contraception: Both female and male patients should use highly effective birth control during treatment and for at least two months after the final dose, as this medicine can cause harm to an unborn baby.
  • Limit alcohol intake: Avoid drinking alcohol during your treatment, as it can worsen dehydration and skin dryness associated with this medicine.

verifiedApollotooltip

Platinum-Based Chemotherapy: Combining this medicine with other cancer treatments (such as platinum-based chemotherapy) may increase the risk of severe skin reactions or cause a sudden drop in white blood cell counts.
 

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verifiedApollotooltip

No clinically significant food interactions are known with Erbitux 100 Injection 20 ml when used as directed.

 

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Erbitux 100 Injection 20 ml is used to treat Cancer.
Erbitux 100 Injection 20 ml contains Cetuximab, which works by slowing or stopping the growth of cancer cells. Thereby, it prevents the cancer from spreading.
Attend all your doctor's appointments while taking Erbitux 100 Injection 20 ml to ensure the therapy is effective. Regular blood tests and weight checks must be performed. While taking the Erbitux 100 Injection 20 ml, both men and women should use an effective means of contraception. Do not use any other medications unless prescribed by the doctor. If you have low levels of Magnesium and Calcium in your blood, inform your doctor before treating you with this medicine.
Do not stop taking Erbitux 100 Injection 20 ml on your own. Take Erbitux 100 Injection 20 ml for as long as your doctor prescribes it, depending on your medical condition. Do not miss any scheduled dose. Speak with your doctor if you experience difficulty using Erbitux 100 Injection 20 ml.
Some dietary changes can help you manage side effects; for example, in case of diarrhoea-Choose foods or drinks with sodium (sports drinks or broth) and potassium (bananas and all-natural fruit juices).
Yes, Erbitux 100 Injection 20 ml is a chemotherapy drug, but it is specifically classified as a monoclonal antibody. It works by targeting and blocking the epidermal growth factor receptor (EGFR) on cancer cells, which helps slow or stop tumour growth. It is used primarily for the treatment of certain types of cancers, such as colorectal cancer and head and neck cancers.
Erbitux 100 Injection 20 ml is a monoclonal antibody used to treat cancer. It is neither a cytotoxic agent nor a vesicant, but it acts as a radio sensitizer by enhancing the effects of radiation therapy on cancer cells.
Erbitux 100 Injection 20 ml is administered through intravenous infusion by the doctor or nurse. The infusion is typically given over a period of time, with the rate depending on the patient's tolerance and the treatment plan. Do not self-administer.
Yes, Erbitux 100 Injection 20 ml may cause hair loss as a common side effect. If you experience this symptom, manage stress, use gentle hair care practices, and eat nutritious food. However, if hair loss persists consult the doctor for further guidance.
Erbitux 100 Injection 20 ml may cause a rash as a side effect because it targets and blocks the epidermal growth factor receptor (EGFR), which plays a key role in skin cell growth and repair. Inhibiting EGFR can lead to skin inflammation and reactions, resulting in the rash. However, consult the doctor if this symptom persists or worsens.
The duration of a rash depends on its cause. Some rashes may last for only a few days, while others can persist for weeks or even months. If the rash persists or worsens, consult the doctor for proper diagnosis and treatment.
The side effects of Erbitux 100 Injection 20 ml include headache, inflammation of the lining of the intestine, mouth, and nose, nose bleeding, tiredness, irritation and redness of the eye, diarrhoea, feeling sick, vomiting, loss of appetite, and weight loss. Consult the doctor if any of these symptoms persist or worsen.
You should avoid direct sun exposure as much as possible, as this medicine makes your skin extremely sensitive to UV light. Always wear sunscreen, protective clothing, and a hat when outdoors. Talk to your doctor about safe skin care routines.
Contact your doctor or the clinic immediately to reschedule your appointment. Keeping your treatment schedule consistent is crucial for the medicine to work effectively. Talk to your doctor to plan any rescheduled visits.
You should consult your healthcare team before getting any vaccinations. Some vaccines, especially live vaccines, may not be recommended while you are undergoing cancer treatment. Talk to your doctor or pharmacist before scheduling a vaccine.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

L-2, J.R. Complex, Gate No. 4, Village Mandoli, Delhi-110 093, India
Other Info - ERB0057
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