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compositionComposition:ENTECAVIR-0.5MG
prescription
Prescription Medicine
info
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Entimate 0.5 Tablet is used to treat chronic hepatitis B virus (HBV) infection. It helps reduce the amount of virus in the body, prevents further liver damage, and supports long-term liver health. With regular use, it lowers the risk of complications such as cirrhosis and liver failure, helping to slow the progression of liver disease.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ENTECAVIR-0.5MG

Manufacturer/Marketer :

RSL Bioscience Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Entimate 0.5 Tablet

Entimate 0.5 Tablet is an oral antiviral prescription medication used to treat chronic hepatitis B virus infection in adults and children. It works by lowering the amount of the virus in your body, which helps prevent the infection from causing severe damage to your liver. It is important to know that while this medication helps manage the virus, it is not a cure for hepatitis B.

For Entimate 0.5 Tablet to work effectively, you must take it consistently at the same time every day. Taking your dose on an empty stomach is highly important, meaning you should take it at least 2 hours after a meal and at least 2 hours before your next meal. Making healthy lifestyle choices, such as eating a balanced diet and avoiding alcohol, can also support your liver health while using this treatment.

While taking Entimate 0.5 Tablet , some people may experience mild side effects like headaches, fatigue, dizziness, or nausea. However, you must contact your doctor immediately if you experience signs of rare but serious conditions, such as lactic acid buildup in your blood or worsening liver symptoms. Your healthcare team is always your best resource if you notice any unusual physical changes.

Do not take this medicine if you are allergic to any of its ingredients. Before starting Entimate 0.5 Tablet , tell your doctor if you have kidney disease, as your dose may need to be adjusted. It is also vital to be tested for HIV before starting this medication; taking Entimate 0.5 Tablet if you have untreated HIV can make the HIV virus much harder to treat in the future.

Certain medications can interact with Entimate 0.5 Tablet , especially those that affect how your kidneys filter waste. Additionally, you should consult your doctor or pharmacist if you are pregnant, planning to become pregnant, breastfeeding, or if you are caring for an elderly patient, to ensure this medication is safe for your specific situation.

Uses of Entimate 0.5 Tablet

Entimate 0.5 Tablet is used in the treatment of chronic (long-term) hepatitis B virus (HBV) infection. The detailed uses of Entimate 0.5 Tablet are as follows:

  • Chronic HBV Infection: Entimate 0.5 Tablet is prescribed to manage long-term hepatitis B infections. It helps by slowing down the multiplication of the virus, which protects the liver from progressive damage and scarring.

Key Benefits

Entimate 0.5 Tablet helps treat chronic hepatitis B infection by reducing the amount of virus in the body and protecting your liver from ongoing damage. Although it is not a cure for hepatitis B, it can help keep the infection under control, improve liver health, and lower the risk of serious liver-related complications.

Benefits may include:

  • Helps reduce the amount of hepatitis B virus in the body.
  • Supports healthy liver function by limiting ongoing liver damage.
  • Reduces the risk of complications such as cirrhosis and liver failure.
  • Helps lower the risk of disease progression associated with chronic hepatitis B.
  • Provides effective long-term control of chronic hepatitis B infection when taken as prescribed.
Side effects of Entimate 0.5 Tablet
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Directions for Use

  • Take Entimate 0.5 Tablet on an empty stomach. This means taking your dose at least 2 hours after eating a meal and at least 2 hours before your next meal.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
  • Take your dose at the same time every day to keep a steady level of the medicine in your body.
  • Always follow your doctor's exact instructions regarding your treatment. Never stop taking this medicine without speaking to your doctor first, as stopping can cause your hepatitis infection to suddenly flare up and worsen.

How Entimate 0.5 Tablet Works

Entimate 0.5 Tablet contains Entecavir, a nucleoside analogue. It works by blocking a specific enzyme in your body that the hepatitis B virus needs to replicate its DNA and make copies of itself. By interfering with this copying process, the medicine stops the virus from multiplying. This lowers the amount of virus in your body, allowing your immune system to better manage the infection and reducing active inflammation in your liver.
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Alcohol

Consult your doctor

The interaction of alcohol with Entimate 0.5 Tablet is unknown. Please consult a doctor before consuming alcohol while using Entimate 0.5 Tablet .

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Pregnancy

Caution

Entimate 0.5 Tablet is a category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Entimate 0.5 Tablet is excreted in human milk. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Caution

Entimate 0.5 Tablet may cause dizziness, drowsiness or tiredness in some people. Therefore, avoid driving or operating heavy machinery if you feel dizzy, drowsy or tired after taking Entimate 0.5 Tablet .

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Liver

Caution

Take Entimate 0.5 Tablet with caution, especially if you have a history of liver disease. The dose may be adjusted by your doctor as required. Please consult a doctor.

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Kidney

Caution

Take Entimate 0.5 Tablet with caution, especially if you have a history of kidney disease. The dose may be adjusted by your doctor as required. Please consult a doctor.

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Children

Caution

Entimate 0.5 Tablet is not recommended for children below 2 years or weighing less than 10 kg. However, in children above 2 years, Entimate 0.5 Tablet should be used with caution and doses prescribed by a doctor.

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Heart

Safe if prescribed

Entimate 0.5 Tablet is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Entimate 0.5 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Entimate 0.5 Tablet .

What if I have taken an overdose of Entimate 0.5 Tablet

If you suspect an overdose or if someone has accidentally taken too much of this medication, seek immediate emergency medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Alcohol causes extra strain on your liver and can speed up liver damage, making it harder for your treatment to work safely.
  • Eat a liver-friendly diet: Focus on whole foods, including fresh fruits, vegetables, lean proteins, and whole grains. Limit foods high in saturated fats, sugar, and processed ingredients.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys efficiently process and clear the medication from your body.
  • Avoid self-medicating with supplements: Do not take any herbal remedies, vitamins, or liver detox supplements without asking your pharmacist or doctor first, as some can cause direct liver toxicity.
  • Practice safe habits: Remember that hepatitis B can spread through contact with infected blood or bodily fluids. Avoid sharing personal items like razors or toothbrushes, and use barrier protection during sexual activity to protect others.
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Have a query?

How Soon It Starts Working

  • The time required for Entimate 0.5 Tablet to start to work: The time required for Entimate 0.5 Tablet to show its action is unknown.
  • The time for which the effects of Entimate 0.5 Tablet last: The duration of action for Entimate 0.5 Tablet is unknown.

What if you forget to take Entimate 0.5 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular routine. Do not take two doses at the same time to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Never stop taking this medicine abruptly: Stopping your treatment suddenly can cause a severe, life-threatening flare-up of your hepatitis B infection.
  • Get regular blood tests: You must visit your doctor for regular blood tests to check your liver function and monitor how well the medicine is working.
  • Get tested for HIV: Ensure you are tested for HIV before starting Entimate 0.5 Tablet . If you have untreated HIV, taking this drug can cause the HIV virus to become resistant to standard HIV treatments.
  • Watch your kidney health: Tell your doctor if you have kidney problems, as you may need a lower dose or a modified dosing schedule.
  • Set a daily reminder: Because this medicine must be taken on an empty stomach, setting a daily phone alarm can help you maintain a safe, consistent routine.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction:

  • Medicines That May Reduce Kidney Function (e.g., cyclosporine, tacrolimus, gentamicin, amikacin, vancomycin): Taking these medicines alongside Entimate 0.5 Tablet may slow the removal of Entimate 0.5 Tablet from the body and increase the risk of side effects.

Drug-Food Interaction:

  • Food: Consuming food while taking Entimate 0.5 Tablet may reduce the amount of medicine absorbed, making it less effective. Take Entimate 0.5 Tablet on an empty stomach, at least 2 hours before or 2 hours after a meal.

Drug-Disease Interaction:

  • Kidney Disease: Because this medicine is cleared by the kidneys, decreased kidney function can cause the drug to build up to unsafe levels in the blood. Your doctor may need to adjust your dose.
  • HIV Infection: If you have undiagnosed or untreated HIV, taking Entimate 0.5 Tablet can lead to the HIV virus developing resistance to similar antiviral medications, making future HIV treatment much more difficult.
EntecavirCiprofloxacin
Severe
EntecavirAllopurinol
Severe

Drug-Drug Interactions

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EntecavirCiprofloxacin
Severe
How does the drug interact with Entimate 0.5 Tablet:
Combining Entimate 0.5 Tablet with ciprofloxacin may result in higher blood levels of one or both the medications.

How to manage the interaction:
Although taking ciprofloxacin and Entimate 0.5 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. If your situation changes or you start to notice more side effects, consult your doctor.
EntecavirAllopurinol
Severe
How does the drug interact with Entimate 0.5 Tablet:
Coadministration of Allopurinol with Entimate 0.5 Tablet may increase the blood levels of one or both medicines and increase side effects.

How to manage the interaction:
If you are supposed to take Allopurinol and Entimate 0.5 Tablet together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience increased side effects, contact your doctor.
EntecavirMethotrexate
Severe
How does the drug interact with Entimate 0.5 Tablet:
The combined use of Entimate 0.5 Tablet with methotrexate may increase levels of Entimate 0.5 Tablet, and increase the risk or severity of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Entimate 0.5 Tablet and methotrexate, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Entimate 0.5 Tablet is used to treat chronic hepatitis B virus (HBV) infection.
Entimate 0.5 Tablet contains Entecavir, an antiviral drug that works by preventing viral DNA polymerase enzyme action in the liver cells, which is essential for the virus to multiply. Therefore, it prevents the virus from replicating and reduces the amount of hepatitis B virus in the body.
Yes, hepatitis B virus infection is highly contagious and spreads from one person to another. Therefore, it is recommended to avoid sharing personal items or needles containing an infected person's blood or body fluids.
Entimate 0.5 Tablet may cause lactic acidosis (excess of lactic acid in the blood), a rare but severe side effect, especially in women who are very obese. However, if you experience stomach pain, vomiting or nausea while taking Entimate 0.5 Tablet , please consult a doctor immediately.
You are not recommended to take Entimate 0.5 Tablet with celecoxib (painkiller), as it may increase the blood levels of Entimate 0.5 Tablet , leading to more adverse effects and may also affect kidney function. However, please consult your doctor before taking Entimate 0.5 Tablet with other medicines.
Entimate 0.5 Tablet does not cure hepatitis B virus infection. Entimate 0.5 Tablet reduces the amount of hepatitis B virus in the body and improves liver functioning by decreasing liver damage.
Entimate 0.5 Tablet is not recommended for hepatitis B patients with HIV infection unless they are taking medicines to treat HIV infection at the same time, as Entimate 0.5 Tablet may cause HIV infection to become resistant to certain HIV drugs and reduce their effectiveness. Therefore, it is advised to get tested for HIV infection before taking Entimate 0.5 Tablet .
You are not recommended to stop taking Entimate 0.5 Tablet without consulting your doctor, as it may worsen the infection or cause recurring symptoms. Therefore, take Entimate 0.5 Tablet for as long as your doctor has prescribed it. If you experience any difficulty while taking Entimate 0.5 Tablet , please consult your doctor.
Entimate 0.5 Tablet may cause side effects like dizziness, headache, nausea, vomiting, drowsiness, extreme tiredness, inability to sleep, diarrhoea, or indigestion. Most of these side effects do not require medical attention. However, if the side effects worsen, please consult your doctor.
Food significantly lowers the amount of medicine your body can absorb, making the treatment less effective. Taking it on an empty stomach ensures you receive the full therapeutic benefit. Talk to your doctor or pharmacist if you have trouble scheduling your doses.
Severe stomach pain, especially when accompanied by nausea, vomiting, or deep breathing, can be a sign of a serious condition called lactic acidosis or worsening liver issues. You should contact your doctor or seek emergency medical care immediately.
The safety of this medicine during pregnancy has not been fully established. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor to carefully weigh the risks and benefits for you and your baby.
No, taking this medicine does not prevent the spread of hepatitis B through sexual contact or blood exposure. You must continue to practice safe sex and avoid sharing personal items like needles or razors. Talk to your doctor about how to keep your loved ones safe.
Treatment for chronic hepatitis B is usually long-term and often lasts for several years or even indefinitely. Your doctor will monitor your blood tests regularly to determine how long you need to stay on the medication. Talk to your doctor if you have questions about the duration of your treatment.

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Country of origin

India

Manufacturer/Marketer address

B-57, First Floor, Amar Colony, Nangloi, New Delhi-110041.India
Other Info - ENT0198
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