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compositionComposition:ENTACAPONE-200MG
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Prescription Medicine
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Entacom Tablet is used to treat Parkinson's disease. It contains Entacapone which works by inhibiting a chemical messenger that supports increasing the amount of dopamine in the body; thereby, it helps the brain to control body movements. In some cases, this medicine may cause side effects such as nausea, fatigue, vomiting, confusion, constipation, diarrhoea, and abdominal pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ENTACAPONE-200MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Entacom Tablet

Entacom Tablet is a prescription medication used to treat patients with Parkinson's disease who are experiencing 'wearing-off' symptoms. It is prescribed alongside standard Parkinson's therapies to help prolong the effectiveness of those treatments and maintain steadier muscle control. This medication serves to reduce the sudden return of motor symptoms, such as muscle stiffness, tremors, and slow movement, between your regularly scheduled doses.

To achieve the best results, you must take Entacom Tablet consistently with each of your primary Parkinson's medication doses throughout the day. You can take this tablet with or without food, though maintaining a consistent routine is highly recommended. Incorporating regular, gentle physical therapy and keeping a structured daily routine can significantly support your physical mobility and overall treatment outcomes.

While taking Entacom Tablet , some people may experience mild side effects like a harmless change in urine colour or slight nausea. However, you must contact your doctor immediately if you experience severe or persistent diarrhoea, confusion, or unusual, severe muscle pain. These serious symptoms require prompt medical evaluation to ensure your safety throughout therapy.

Before starting Entacom Tablet , talk to your doctor if you have a history of liver damage, severe muscle disorders, or skin conditions. Do not take this if you have had a severe allergic reaction to this medication in the past, or if you have a history of neuroleptic malignant syndrome (a rare but serious reaction to certain medicines) or non-traumatic muscle breakdown. Your doctor will carefully review your medical history to ensure this is the right option for you.

This medication can interact with other substances, such as iron supplements and certain types of antidepressants, which can reduce its effectiveness or cause unwanted side effects. Avoid alcohol while taking Entacom Tablet , as it can significantly increase dizziness and drowsiness. If you are pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to discuss your specific risks and benefits.

Uses of Entacom Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • Parkinson's disease 'wearing-off' symptoms: Entacom Tablet is used in combination with other primary Parkinson's medications to prevent the treatment from wearing off prematurely. It helps provide more consistent control over muscle movements, reducing the time spent experiencing stiffness, shaking, and slow movement.

Key Benefits

Entacom Tablet helps improve movement control in people with Parkinson's disease by maintaining more consistent levels of therapy throughout the day. Key benefits include:

  • Increases 'On' Time: By helping maintain stable treatment effects, Entacom Tablet increases the amount of time during the day when movement is better controlled, reducing periods of symptom recurrence.
  • Provides Smoother Motor Control: By reducing fluctuations in movement, Entacom Tablet helps minimise episodes of stiffness, slowness, and impaired mobility, supporting more consistent physical function.
  • Supports Daily Activities: By improving motor control, Entacom Tablet helps make everyday tasks such as walking, eating, writing, and other routine activities easier, promoting greater independence and quality of life.
Side effects of Entacom Tablet
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Talk to your doctor about identifying the cause of the discoloration, adjusting your dose, or switching to a different medication.
  • Keep an eye on your urine colour and let your doctor know if you notice any unusual changes.
  • Increase your intake of water or other liquids to dilute your urine and restore its normal colour.
  • Avoid foods that can change your urine colour, such as beets, rhubarb, and berries.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.

Directions for Use

  • Entacom Tablet can be taken with food or as directed by your doctor.
  • It is best advised to take Entacom Tablet at the same time each day to get effective results.
  • Swallow the tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

How Entacom Tablet Works

In people with Parkinson's disease, the brain lacks a chemical messenger called dopamine. Primary medications like levodopa are converted into dopamine in the brain to help control movement. However, certain enzymes in the body naturally break down levodopa before it can ever reach the brain, reducing its effectiveness over time. Entacom Tablet contains entacapone, which works by blocking one of these key enzymes, known as COMT. By temporarily turning off this enzyme, Entacom Tablet allows more of your primary Parkinson's medication to enter the brain where it is needed. This ensures a steadier, longer-lasting supply of dopamine, which keeps your movements smoother and prevents sudden, frustrating 'off' episodes.
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Alcohol

Unsafe

Taking the drug along with alcohol may increase the side effects such as confusion, drowsiness and trouble in concentration.

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Pregnancy

Caution

Entacom Tablet is generally not recommended for use in pregnancy. If you are pregnant, please consult your doctor before taking this medicine. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

No clinical use of Entacom Tablet during breastfeeding has been reported. The drug might reduce serum prolactin and may affect milk production. If you are breastfeeding, consult your doctor before taking Entacom Tablet .

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Driving

Caution

Entacom Tablet may cause low blood pressure that further cause drowsiness and dizziness. So, it is not recommended to drive or operate heavy machinery after taking Entacom Tablet .

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Liver

Caution

Entacom Tablet should be used with caution in patients with liver disease. If you have liver problems, your doctor may adjust the dose of Entacom Tablet or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Entacom Tablet should be used with caution in patients with kidney disease. If you have kidney problems, your doctor may adjust the dose of Entacom Tablet or prescribe a suitable alternative based on your condition.

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Children

Caution

Entacom Tablet is not recommended for use in children under 18 years as the safety and effectiveness were not established. Consult a child specialist for further information.

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Heart

Safe if prescribed

Entacom Tablet is safe for use in heart patients if prescribed by the physician.

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Geriatrics

Safe if prescribed

Entacom Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Entacom Tablet

In case of an accidental overdose, seek immediate emergency medical attention or contact your local poison control centre right away.

Diet & Lifestyle Advise

  • Protein timing: Large amounts of dietary protein can compete with your companion Parkinson's medications for absorption. Talk to your doctor or a dietitian about how to space out high-protein foods throughout the day.
  • Stay hydrated: Drink plenty of water throughout the day to help manage common issues like dry mouth and to support healthy bowel movements.
  • Avoid alcohol: Consuming alcohol while taking this medicine can worsen dizziness and make you feel extremely drowsy, increasing the risk of falls.
  • Space iron supplements: If you take iron pills, make sure to take them at least 2 to 3 hours before or after taking Entacom Tablet , as iron can bind to the medication and stop your body from absorbing it properly.
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Have a query?

How Soon It Starts Working

The time required for Entacom Tablet to start to work: The time required for Entacom Tablet to show its action is unknown. The time for which the effects of Entacom Tablet last: The duration of action for Entacom Tablet is unknown.

What if you forget to take Entacom Tablet

If you miss a dose, take it as soon as you remember, provided you are also taking your companion Parkinson's medication. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

• Store Entacom Tablet tablets at controlled room temperature, specifically between 20°C and 25°C (68°F and 77°F• Keep the medication in its original container, tightly closed, to protect it from moisture and direct light.

Drug Warnings

  • Expect urine colour changes: Do not be alarmed if your urine turns reddish-brown or orange while taking Entacom Tablet . This is a harmless and expected effect of the medicine.
  • Stand up slowly: Rise gradually from a sitting or lying position, as this medicine may cause a sudden drop in blood pressure, leading to dizziness, light-headedness, or falls.
  • Do not stop treatment suddenly: Never discontinue Entacom Tablet without consulting your doctor. Stopping the medicine abruptly may cause a serious reaction with high fever, severe muscle stiffness, confusion, and changes in consciousness.
  • Use caution with activities requiring alertness: This medicine may cause severe drowsiness or sudden episodes of falling asleep. Avoid driving, operating machinery, or performing hazardous tasks until you know how it affects you.
  • Report severe diarrhoea promptly: If you develop persistent or severe diarrhoea, stop taking the medicine and contact your healthcare provider immediately, as prolonged diarrhoea can lead to dehydration and electrolyte imbalance.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Non-selective MAO inhibitors: Combining this medicine with certain antidepressants (such as phenelzine or tranylcypromine) can cause dangerously high blood pressure.
  • Iron supplements: Taking iron pills or multivitamins containing iron at the same time can greatly reduce the absorption and effectiveness of Entacom Tablet .
  • COMT-metabolized drugs: It may increase the effects of medications like epinephrine, norepinephrine, or dobutamine, which can affect your heart rate and blood pressure.
EntacaponeIsocarboxazid
Critical
EntacaponeTranylcypromine
Critical

Drug-Drug Interactions

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EntacaponeIsocarboxazid
Critical
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Isocarboxazid can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Entacom Tablet with Isocarboxazid is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, Contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeTranylcypromine
Critical
How does the drug interact with Entacom Tablet:
Coadministration of Entacom Tablet with Tranylcypromine can increase the risk of high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Entacom Tablet with Tranylcypromine can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
EntacaponeLinezolid
Critical
How does the drug interact with Entacom Tablet:
Coadministration of Entacom Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Entacom Tablet with Linezolid is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponePhenelzine
Critical
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Phenelzine can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Entacom Tablet with Phenelzine is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeProcarbazine
Severe
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Procarbazine can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Entacom Tablet and Procarbazine together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like confusion, hallucinations, seizures, fast heartbeat, fever, sweating, shivering, blurred vision, muscle spasms, stiffness, trouble moving, cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeFurazolidone
Severe
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Furazolidone can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although there is a possible interaction between Entacom Tablet and Furazolidone, you can take these medicines together if prescribed by your doctor. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling really unwell, confusion, seeing or hearing things that aren't there, having a seizure, a faster heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty moving, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeMethylene blue
Severe
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Methylene blue can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Entacom Tablet with Methylene blue together can result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling confused or hallucinating, having a seizure, a fast heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty coordinating movements, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
EntacaponeEsketamine
Severe
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Esketamine can increase the risk and severity of side effects (drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination).

How to manage the interaction:
Although taking Entacom Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like feeling sleepy, having trouble concentrating, or feeling confused, it's important to let a doctor know right away. Do not stop using any medications without talking to a doctor.
EntacaponeSodium oxybate
Severe
How does the drug interact with Entacom Tablet:
Taking Entacom Tablet with Sodium oxybate can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Entacom Tablet and Sodium oxybate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like fatigue, dizziness, lightheaded, drowsiness, confusion, shortness of breath, chest pain or tightness, make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • High-protein meals: Eating meals exceptionally high in protein at the same time you take your medication can interfere with how well your body absorbs your companion Parkinson's treatment, making it less effective.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPARKINSON AGENTS]

FAQs

This is a completely harmless side effect. The medication has a natural color that passes through your kidneys and is excreted in your urine. It does not mean there is blood in your urine, but it can stain clothing. Talk to your doctor if you have concerns.
Yes. Entacom Tablet , especially when taken together with levodopa, can cause significant daytime drowsiness and, in some people, sudden episodes of falling asleep during normal activities such as driving, eating, or talking. Do not drive or operate machinery until you know how this medicine affects you. Contact your doctor if you experience excessive sleepiness or sudden sleep episodes.
No, Entacom Tablet does not work on its own. It is designed specifically to assist other Parkinson's medications, like levodopa, by preventing them from breaking down too quickly in your body. It must always be taken together with your companion Parkinson's treatment. Talk to your doctor for more details.
You can take Entacom Tablet either with or without food. The most important thing is to be consistent with how you take it each day and to make sure you take it at the exact same time as your companion Parkinson's medication. Talk to your doctor or pharmacist if you need help planning your schedule.
Severe, persistent diarrhea is a recognized side effect that can occur even after weeks or months of taking this medicine. If you experience this, contact your doctor right away, as it can cause serious dehydration, and your doctor may advise you to stop taking the medication.
Iron can bind to Entacom Tablet in your stomach, which prevents your body from absorbing the medicine. If you must take iron supplements or multivitamins containing iron, take them at least 2 to 3 hours before or after you take your medication. Talk to your doctor or pharmacist to help schedule your doses safely.
Because Entacom Tablet is absorbed quickly, it begins working alongside your primary Parkinson's medication with your very first doses. You should notice a reduction in your "wearing-off" symptoms and more consistent movement control within a few days. Talk to your doctor if you do not notice any improvement.
No, you should never stop taking this medication suddenly. Doing so can cause a severe, dangerous reaction characterised by high fever, muscle rigidity, and rapid changes in blood pressure. If you need to stop or change your treatment, your doctor will guide you on how to do so safely. Talk to your doctor before making any changes.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ENT0005

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