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compositionComposition:SODIUM VALPROATE-200MG
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Prescription Medicine
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Encorate Syrup is used to treat epilepsy and helps control different types of seizures or fits. It reduces the frequency and severity of seizure episodes and supports long-term seizure management, improving overall quality of life. Additionally, Encorate Syrup is used in the treatment of bipolar disorder, where it helps stabilise mood, reduce episodes of mania, and control mood swings.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SODIUM VALPROATE-200MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Encorate Syrup

Encorate Syrup is an oral liquid medicine prescribed primarily to control and prevent various types of seizures in children. It helps stabilise the electrical activity in the brain, reducing the frequency and severity of fits. This syrup is a key part of long-term management for paediatric epilepsy.

For the medicine to work effectively, your child must take it consistently at the same times every day as directed by their doctor. It can be taken with or after food to help prevent an upset stomach, which is a common initial side effect. Maintaining a regular sleep schedule and avoiding known seizure triggers can significantly support the benefits of this treatment.

While many children tolerate this medicine well, some may experience temporary side effects like sleepiness, mild nausea, or changes in appetite. If you notice any serious signs such as unusual bruising, yellowing of the skin or eyes, or severe stomach pain with vomiting, you must contact your child's doctor immediately.

Before starting this treatment, tell your doctor if your child has a history of liver problems, kidney disease, or a family history of metabolic disorders. This medicine should not be given to children who have active liver disease or certain rare genetic conditions affecting liver function.

It can interact with other medicines, such as certain antibiotics or other anti-seizure drugs, which may change how well it works or increase the risk of side effects. Although this is a pediatric formulation, it is important to know that this medicine can cause harm during pregnancy, so teenage patients or caregivers of childbearing age should discuss appropriate precautions with their doctor.

Uses of Encorate Syrup

Encorate Syrup is used to control and prevent various types of seizures in children. The detailed uses of Encorate Syrup are as follows:

  • Epilepsy and seizures: Encorate Syrup helps control various types of seizures, including absence seizures, generalised tonic-clonic seizures, and partial seizures, by calming overactive nerve signals in the brain.
  • Manic episodes: In older children or teenagers, it may be used under specialist supervision to manage phases of extreme excitement or overactivity associated with bipolar disorder.

Key Benefits

Encorate Syrup helps control seizures in children by stabilising abnormal electrical activity in the brain. With regular use as prescribed, it helps reduce the frequency of seizures, supports healthy growth and development, and provides an easy-to-administer treatment option for young children.

  • Reduces Seizure Frequency: By helping stabilise brain activity, this medicine helps reduce the number of seizures, allowing your child to participate more comfortably in daily activities.
  • Supports Healthy Growth and Development: Better seizure control helps minimise disruptions to learning, sleep, play, and social interactions, supporting your child's physical, cognitive, and emotional development.
  • Easy for Children to Take: The syrup formulation is suitable for infants and young children who cannot swallow tablets, ensuring accurate dosing and making treatment more convenient for caregivers.
Side effects of Encorate Syrup 100 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Brush and floss regularly twice a day with fluoride toothpaste and once a day with floss.
  • Use a soft or extra-soft toothbrush.
  • Avoid tobacco products, as smoking can worsen gum problems.
  • Use an antimicrobial mouthwash to reduce bacteria and prevent bleeding.
  • Drink green tea rich in catechin to reduce inflammation from oral bacteria.
  • Eat a balanced diet high in nutrients and low in sugar.
  • Reduce stress to minimize inflammation and gum bleeding.
  • Consult your dentist if gums bleed consistently.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

Directions for Use

  • Encorate Syrup can be administered with or without food as directed by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Administer the prescribed dose to the child using the measuring cup/dosing syringe.
  • Shake well before use.

How Encorate Syrup Works

Encorate Syrup contains sodium valproate, which works by regulating natural chemicals in the brain that carry signals between nerve cells. When a seizure occurs, there is a sudden, abnormal burst of electrical activity. This medicine helps increase the levels of a calming chemical messenger called GABA (gamma-aminobutyric acid). By boosting GABA, the medicine dampens excessive and rapid nerve signalling. This stabilises the electrical pathways in the brain, making it much harder for a seizure to start or spread.
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Alcohol

Not applicable

It is intended for Children.

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Pregnancy

Not applicable

It is intended for Children.

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Breast Feeding

Not applicable

It is intended for Children.

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Driving

Not applicable

It is intended for Children.

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Liver

Consult your doctor

Inform your doctor if your child has liver problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor if your child has kidney problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Encorate Syrup can be given safely to children. Give this medicine to your child in the doses as prescribed by the doctor.

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Heart

Caution

Encorate Syrup is generally safe for children, but caution is needed if they have heart problems. Always consult a paediatrician before use to ensure it’s appropriate for your child’s condition and medications.

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Geriatrics

Not applicable

Encorate Syrup is specifically for children's use and is not meant for geriatric patients.

What if I have taken an overdose of Encorate Syrup

If your child takes more than their prescribed dose, seek emergency medical care immediately. Look out for signs like extreme sleepiness, shallow breathing, or confusion.

Diet & Lifestyle Advise

  • Maintain a strict sleep schedule: Sleep deprivation is a common trigger for seizures. Ensure your child gets a consistent, age-appropriate amount of sleep every night.
  • Offer meals with the medicine: Giving the syrup with healthy, non-acidic foods or milk can ease digestive side effects like nausea or stomach ache.
  • Keep a seizure diary: Track when seizures occur, what your child was doing beforehand, and when they took their medicine. This helps the doctor monitor how well the treatment is working.
  • Avoid sudden dietary shifts: Do not start specialised diets (like a ketogenic diet) unless specifically recommended and monitored by your child's medical team.

Health Queries

My baby has been taking Encorate syrup for 6 months. The pediatrician has now prescribed Calday P syrup. Is it safe to give both together?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

It is generally safe to give Encorate syrup and Calday P syrup together if they have been prescribed by your paediatrician, as calcium supplements do not usually interfere with sodium valproate; in fact, calcium and vitamin D may be beneficial because long-term use of anti-seizure medicines like Encorate can sometimes affect bone health. Make sure you give both medicines in the correct dose and at the advised times, and continue regular follow-up with your doctor to monitor your baby's growth and response to treatment. If you notice any unusual symptoms such as excessive sleepiness, vomiting, poor feeding, or irritability, inform your doctor promptly.
health query

Have a query?

How Soon It Starts Working

  • The time required for Encorate Syrup to start to work: Encorate Syrup ideally shows its action within 1 hour after administration.
  • The time for which the effects of Encorate Syrup last: The effect of Encorate Syrup lasts for 8 to 12 hours.

What if you forget to take Encorate Syrup

If you forget to give a dose, give it as soon as you remember. However, if it is nearly time for the next scheduled dose, skip the missed one and continue with the regular schedule. Do not give a double dose to make up for a missed one.

Storage

•Store Encorate Syrup syrup at controlled room temperature, ideally between 15°C and 25°C.•Keep the bottle tightly closed in its original packaging to protect the liquid from direct sunlight and moisture.

Drug Warnings

  • Inspect the liquid before use: Ensure the syrup is clear and free of unusual particles or cloudiness before giving it to your child.
  • Use the correct measuring device: Always use the syringe or cup that comes with the package to ensure precise dosing; a normal teaspoon is not accurate.
  • Never stop treatment abruptly: Suddenly stopping this medicine can trigger severe, continuous seizures that can be dangerous.
  • Watch for early warning signs: Monitor your child closely for severe abdominal pain, persistent vomiting, or extreme lethargy, especially during the first six months of starting the treatment.
  • Schedule regular blood tests: Your doctor will need to perform periodic blood tests to check your child's liver function and monitor medicine levels in the body.

Drug-Drug Interactions

verifiedApollotooltip
  • Other Epilepsy Medicines: Medicines used to treat seizures, such as phenobarbital, phenytoin, or carbamazepine, may interact with Encorate Syrup , increasing the risk of drowsiness or altering how well either medicine works. Your doctor may monitor your child's treatment and adjust the dose if necessary.
  • Certain Antibiotics: Antibiotics such as erythromycin may affect how your child's body processes Encorate Syrup , increasing the risk of side effects. Inform your doctor if your child is taking any antibiotics.
  • Blood Thinners: Encorate Syrup may interact with blood-thinning medicines, affecting how they work and potentially increasing the risk of bleeding. Your doctor may recommend closer monitoring if these medicines are used together.
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateVorinostat
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Encorate Syrup 100 ml:
Combining Sodium phenylbutyrate and Encorate Syrup 100 ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Encorate Syrup 100 ml is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Encorate Syrup 100 ml:
Co-administration of Vorinostat with Encorate Syrup 100 ml can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Encorate Syrup 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Encorate Syrup 100 ml:
Co-administration of Encorate Syrup 100 ml with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Encorate Syrup 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Encorate Syrup 100 ml:
Co-administration of Meropenam and Encorate Syrup 100 ml together can reduce the effect of Encorate Syrup 100 ml.

How to manage the interaction:
Co-administration of Meropenam and Encorate Syrup 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Encorate Syrup 100 ml:
Using buprenorphine together with Encorate Syrup 100 ml may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Encorate Syrup 100 ml can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Encorate Syrup 100 ml:
Co-administration of Leflunomide and Encorate Syrup 100 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Encorate Syrup 100 ml can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Encorate Syrup 100 ml:
Co-administration of Lithium with Encorate Syrup 100 ml can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Encorate Syrup 100 ml can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Encorate Syrup 100 ml:
Co-administration of Ketamine and Encorate Syrup 100 ml can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Encorate Syrup 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Encorate Syrup 100 ml:
Co-administration of Teriflunomide and Encorate Syrup 100 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Encorate Syrup 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Encorate Syrup 100 ml:
The combined use of Ertapenem and Encorate Syrup 100 ml can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Encorate Syrup 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food: There are no major food interactions with Encorate Syrup . However, giving the syrup with food may help reduce stomach irritation and improve your child's comfort during treatment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Encorate Syrup is used to treat epilepsy/seizures/fits and bipolar disorder.
Encorate Syrup decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizure episodes.
Encorate Syrup helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.
Do not discontinue Encorate Syrup without consulting your doctor. To treat your child's condition effectively, continue using Encorate Syrup for as long as prescribed. Do not be reluctant to speak with your doctor if your child experiences difficulty while taking Encorate Syrup ; your doctor will gradually reduce the dose to avoid worsening seizures.
Encorate Syrup may change the results of liver enzymes, urine, and blood tests. Inform the person doing the tests that your child is using Encorate Syrup .
Yes, you can mix the syrup with a small amount of water, milk, or fruit juice if your child dislikes the taste, but ensure they drink the entire mixture immediately. Talk to your doctor or pharmacist for specific advice.
If your child vomits within 15 minutes of taking the medicine, talk to your doctor or pharmacist to ask if you should give another dose. Do not give a second dose without professional advice.
Yes, mild sleepiness or drowsiness is a common side effect, especially when starting the medicine or after gradually increasing the dose. Talk to your doctor if the sleepiness is severe or does not improve.
Generally, paracetamol is safe to use for occasional pain or fever, but you should avoid aspirin as it can interact with this medicine. Always talk to your doctor or pharmacist before introducing any new over-the-counter medicines.
Some children may experience mild mood shifts, hyperactivity, or irritability. However, if you notice severe mood changes, depression, or unusual behaviours, talk to your doctor immediately.
Give the missed dose as soon as you remember, unless it is close to the next scheduled dose. Never double the dose to make up for a missed one, and talk to your doctor or pharmacist if you miss multiple doses.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.1500 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Sodium Valproate - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Epilim Syrup 200Mg 5Ml Leaflet Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Valproic acid [Package Leaflet]. 2023. [Accessed on 06 Apr. 2024]Check here
  5. Valproate sodium [Prescribing Information]. 2013. [Accessed on 18 Sep. 2024]Check here
  6. Rahman M, Awosika AO, Nguyen H Valproic Acid. [Updated 2024 Mar 19]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024Check here
  7. Valproic Acid: MedlinePlus Drug InformationMedlinePlus. Sulfasalazine [Internet]. U.S. National Library of Medicine; 2025 [Accessed on 10 Mar 2025]Check here

Country of origin

India

Manufacturer/Marketer address

SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - ENC0013

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