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Diof Suspension is used to treat various infections caused by bacteria and parasites. It is also effective in treating diarrhoea due to mixed infections and dysentery caused by amoebas. It contains Ofloxacin and Metronidazole, which work by killing the bacteria and parasites responsible for the infections. In some cases, you may experience side effects such as nausea, vomiting, stomach upset, loss of appetite, dry mouth, and a metallic taste. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and any pre-existing medical conditions.

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Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Zuventus Healthcare Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Diof Suspension

Diof Suspension is an oral prescription combination used for certain bacterial and parasitic infections, including some infections affecting the digestive tract. It may be prescribed for conditions such as bacterial diarrhea or dysentery when your doctor considers this combination appropriate. Because diarrhea can have many causes, including viruses, this medicine should be used only when prescribed for a suspected or confirmed infection that can respond to these medicines.

For the best results, take Diof Suspension exactly as prescribed and at evenly spaced times. It may be taken with food if it causes stomach upset, unless your doctor or product instructions say otherwise. Drink adequate fluids, particularly if you have diarrhea, to help prevent dehydration. Follow your healthcare professional's advice about food and other medicines during treatment.

Some people may experience mild side effects such as nausea, stomach discomfort, headache, dizziness, or a metallic taste. These effects are often temporary. However, contact your doctor promptly if you develop severe or persistent diarrhea, unusual numbness or tingling, tendon pain or swelling, yellowing of the skin or eyes, or other concerning symptoms. Seek emergency medical help if you develop severe difficulty breathing or swelling of the face, lips, tongue, or throat.

Before starting this medicine, tell your doctor if you have liver disease, epilepsy or seizures, nerve problems, heart-rhythm problems, or a history of tendon disorders. Also tell your doctor if you have previously experienced a serious reaction to ofloxacin, metronidazole, other fluoroquinolone antibiotics, or nitroimidazole medicines. Your doctor will decide whether this combination is appropriate for you.

Diof Suspension can interact with several medicines and substances. Tell your doctor or pharmacist about all prescription medicines, over-the-counter products, supplements, and antacids you use. Avoid alcohol during treatment with metronidazole and for at least 48–72 hours after the final dose, unless your doctor gives different advice. If you are pregnant, breastfeeding, or an older adult, discuss the benefits and possible risks with your doctor before using this medicine.

Uses of Diof Suspension

Diof Suspension is used in the treatment of various bacterial and parasitic infections. Its detailed uses are as follows:

  • Gastrointestinal infections: It may be prescribed for certain bacterial or mixed infections of the stomach and intestines when both components are considered appropriate.
  • Bacterial diarrhea and dysentery: It may help treat selected bacterial causes of diarrhea or dysentery by eliminating susceptible bacteria. It should not be used routinely for every episode of diarrhea.
  • Gynecological infections: In some situations, the combination may be prescribed for specific mixed bacterial infections of the female reproductive tract when the causative organisms are susceptible.
  • Dental infections: It may be used in selected dental or gum infections involving susceptible bacteria, particularly when anaerobic bacteria are suspected.

Key Benefits

Diof Suspension combines two antibiotics with different mechanisms of action. When prescribed for an infection caused by susceptible organisms, the combination can help eliminate the bacteria and certain parasites responsible for the illness, allowing infection-related symptoms to improve.

For appropriate gastrointestinal infections, successful treatment may help reduce symptoms such as frequent stools, abdominal discomfort, and infection-related weakness. However, antibiotics do not treat viral diarrhea, and fluid and electrolyte replacement remain important when diarrhea causes significant fluid loss.

Side effects of Diof Suspension 60 ml
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
  • Eat a balanced diet rich in fruits, vegetables, and whole grains to support overall health.
  • Include foods high in omega-3 fatty acids, like salmon and walnuts, to support eye health.
  • Stay hydrated by drinking plenty of water.
  • Engage in regular physical activity, like walking or yoga, to improve mobility and balance.
  • Practice stress-reducing techniques, like meditation or deep breathing, to manage emotional challenges.
  • Establish a daily routine to maintain independence and organization.
  • Consider learning Braille or using assistive technologies to enhance daily life.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • To the affected part, apply warm compresses to get a temporary relief.
  • Rinse your eye carefully with clean water and try to blow any dust particle that could have entered.
  • Take over the counter medication to lubricate your eye or if there is pain due to allergy to soothe the eye.
  • If there is persistent pain in your eye, consult your doctor and follow the medication immediately.

Directions for Use

  • Diof Suspension may be taken with or without food (excluding dairy), but taking it with food may lessen stomach discomfort.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions. Shake the bottle well before each use.
  • Take the prescribed dose orally using the measuring cup provided with the package.
  • Avoid using regular household spoons, as they may not accurately measure the dose correctly.

How Diof Suspension Works

Diof Suspension contains two active germ-fighting ingredients that work together to clear infections. OFLOXACIN works by blocking bacterial enzymes called DNA gyrase and topoisomerase IV. These enzymes are needed for bacteria to copy and repair their genetic material. Blocking these enzymes prevents susceptible bacteria from multiplying and leads to their death. METRONIDAZOLE works mainly against susceptible anaerobic bacteria and certain parasites. Inside these organisms, it is converted into active compounds that damage their DNA. This prevents the organisms from surviving and multiplying. Together, the two medicines can provide coverage against susceptible aerobic and anaerobic organisms when this combination is appropriate for the infection.
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Alcohol

Unsafe

Alcohol should not be consumed while taking Diof Suspension, as it may increase the risk of side effects like dizziness and drowsiness.

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Pregnancy

Unsafe

Diof Suspension should not be taken during pregnancy, especially during the first trimester, as it may cause harm to the fetus. If you become pregnant while taking Diof Suspension, stop taking the medication, and contact your doctor immediately.

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Breast Feeding

Unsafe

Diof Suspension may pass into the breast milk, so avoid taking Diof Suspension while breastfeeding.

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Driving

Unsafe

Diof Suspension can cause dizziness, confusion, and drowsiness. Therefore, avoid driving or operating machinery unless you are mentally alert and competent.

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Liver

Consult your doctor

Diof Suspension to be taken with caution, especially if you have a history of liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Consult your doctor

Diof Suspension to be taken with caution, especially if you have a history of kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

Diof Suspension should be given to the children only if prescribed by a doctor.

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Heart

Consult your doctor

Inform your doctor if you have heart disease before using Diof Suspension. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Your doctor will adjust the use of Diof Suspension for the elderly based on their condition and medical requirements.

What if I have taken an overdose of Diof Suspension

In case of an accidental overdose, seek immediate medical attention or contact a local poison control center. Symptoms of an overdose may include severe dizziness, nausea, vomiting, or numbness. Prompt medical care is essential to prevent complications.

Diet & Lifestyle Advise

  • Stay hydrated: Drink enough water and consider oral rehydration solution if you have significant diarrhea or fluid loss. This helps replace fluids and electrolytes lost through frequent stools.
  • Choose easily tolerated foods: During digestive illness, simple foods such as rice, bananas, toast, or other foods that you tolerate well may be easier to digest. Return gradually to your normal balanced diet as you recover.
  • Separate calcium-containing products from ofloxacin: Calcium can reduce absorption of the ofloxacin component. Avoid taking ofloxacin at the same time as milk, yogurt, calcium-fortified drinks, or calcium supplements. Follow the specific spacing instructions provided with your product or by your pharmacist.
  • Avoid alcohol: Do not drink alcohol while taking metronidazole and for at least 48–72 hours after the final dose, unless your doctor advises otherwise. Combining alcohol with metronidazole may cause nausea, vomiting, abdominal discomfort, flushing, or headache.
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How Soon It Starts Working

The time required for Diof Suspension to start to work: Diof Suspension ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Diof Suspension last: The effect of Diof Suspension lasts for 12 hours.

What if you forget to take Diof Suspension

If you miss a dose of Diof Suspension, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Diof Suspension at room temperature, ideally below 30°C (86°F), in a cool, dry place.

Drug Warnings

  • Protect your skin: Ofloxacin may increase sensitivity to sunlight in some people. Limit unnecessary sun exposure and use protective clothing or sunscreen when outdoors.
  • Watch for tendon problems: Stop the medicine and contact your doctor promptly if you develop new tendon pain, swelling, or stiffness. Avoid strenuous exercise involving the affected area until you receive medical advice.
  • Be careful with driving: Ofloxacin and metronidazole may cause dizziness or other nervous-system effects in some people. Do not drive or operate machinery if you feel dizzy, confused, unusually sleepy, or less alert.
  • Monitor for nerve symptoms: Tell your doctor promptly if you develop persistent numbness, tingling, burning, or weakness in your hands or feet.
  • Complete the prescribed course: Take the medicine for the duration prescribed by your doctor. Do not stop early simply because you feel better, unless your doctor advises you to do so.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners: Ofloxacin or metronidazole may affect the action of certain anticoagulants, such as warfarin, and may increase bleeding risk. Your doctor may recommend closer monitoring.
  • Antacids and mineral supplements: Products containing magnesium, aluminum, calcium, iron, or other minerals can reduce absorption of the ofloxacin component. Separate these products from ofloxacin according to your doctor's or pharmacist's instructions.
  • Medicines affecting heart rhythm: Ofloxacin may increase the risk of abnormal heart rhythms in susceptible people when combined with other medicines that prolong the QT interval.
  • Lithium: Ofloxacin may alter lithium levels in some patients. If you take lithium, your doctor may need to monitor your lithium concentration and kidney function.
Critical

Drug-Drug Interactions

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How does the drug interact with Diof Suspension 60 ml:
Coadministration of Ofloxacin and Metronidazole with Cisapride can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Ofloxacin Metronidazole with Cisapride together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, chest pain, rapid heartbeat contact a doctor immediately. Do not discontinue any medications without consulting a doctor. Note: Cisapride is no longer available on the market.
Critical
How does the drug interact with Diof Suspension 60 ml:
Using halofantrine together with ofloxacin and Metronidazole can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Ofloxacin and Metronidazole with Halofantrine can cause an interaction, please consult a doctor before taking it. You should seek immediate medical attention if you develop dizziness, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
Critical
How does the drug interact with Diof Suspension 60 ml:
Co-administration of Amprenavir with Ofloxacin and Metronidazole can increase the risk or severity of side effects.

How to manage the interaction:
Taking Ofloxacin and Metronidazole with Amprenavir is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience throbbing in the head and neck, difficulty breathing, vomiting, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Diof Suspension 60 ml:
Taking Amiodarone with Ofloxacin and Metronidazole may significantly increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Amiodarone with Ofloxacin and Metronidazole interact, it can be taken if prescribed by a doctor. If you get dizziness, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without consulting a doctor.
Severe
How does the drug interact with Diof Suspension 60 ml:
Co-administration of Ofloxacin and Metronidazole with Acetohexamide can affect blood glucose levels.

How to manage the interaction:
Although combining Ofloxacin and Metronidazole with Acetohexamide can lead to an interaction, they can be taken on a doctor's advice. If you experience headache, rapid heartbeat, increased thirst, and urination, notify a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Diof Suspension 60 ml:
Taking Dexamethasone with Ofloxacin and Metronidazole can cause tendinitis (inflammation of the thick fibrous cords that connect muscle to bone) and tendon rupture (injuries to the soft tissues that connect muscles and joints).

How to manage the interaction:
Taking Ofloxacin and Metronidazole with Dexamethasone together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience joint pains, Swelling, or skin discoloration, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Diof Suspension 60 ml:
Coadministration of Crizotinib together with ofloxacin and Metronidazole may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Ofloxacin and Metronidazole with Crizotinib interact, they can be used if prescribed by a doctor. Consult a doctor if you have dizziness, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Diof Suspension 60 ml:
Coadministration of Ribociclib together with ofloxacin and Metronidazole may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Ofloxacin and Metronidazole with Ribociclib interact, they can be used if prescribed by a doctor. Consult a doctor if you have dizziness, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Diof Suspension 60 ml:
Co-administration of Clozapine together with Ofloxacin and Metronidazole may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Ofloxacin and Metronidazole with Clozapine interact, they can be used if prescribed by a doctor. Consult a doctor if you have dizziness, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Diof Suspension 60 ml:
Coadministration of Panobinostat with ofloxacin and Metronidazole may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Ofloxacin and Metronidazole with Panobinostat interact, they can be used if prescribed by a doctor. Consult a doctor if you have dizziness, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Calcium-containing foods and drinks: Calcium can reduce absorption of ofloxacin when taken together. This interaction applies specifically to the ofloxacin component, not metronidazole.
  • Alcoholic beverages: Avoid alcohol during metronidazole treatment and for at least 48–72 hours after the last dose because it may cause unpleasant reactions such as nausea, vomiting, flushing, or headache.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Diof Suspension is a combination of antibacterial (ofloxacin) and anti-amoebic (metronidazole) medication used to treat various infections caused by bacteria. It is also effective in treating diarrhoea due to mixed infections and amoebic dysentery.
Diof Suspension is a combination of two antibiotics that include Ofloxacin and Metronidazole. Ofloxacin prevents the division of bacterial cells and inhibits their repair mechanism, leading to the death of the bacteria. Metronidazole kills parasites and anaerobic bacteria that cause infections. It works by damaging their DNA. Both antibiotics are bactericidal in nature and work together to treat the infection effectively.
The common side effects of Diof Suspension include nausea, vomiting, stomach upset, loss of appetite, dry mouth, a metallic taste, headache, dizziness, drowsiness, and confusion. Most of these side effects of Diof Suspension do not require medical attention and typically resolve on their own over time. However, if the side effects are persistent, reach out to your doctor.
It is not advised to take alcohol with Diof Suspension. Taking alcohol while taking Diof Suspension can cause serious side effects such as headaches, feeling or being sick, pain in the stomach, hot flushes, a fast or irregular heartbeat, dizziness, drowsiness, etc.
Diof Suspension can make your skin sensitive to sunlight, a condition known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In the event of an emergency, always wear sunscreen before going outdoors.
If you miss a dose of Diof Suspension, take it as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for the missed one.
No. Diof Suspension is an antibacterial medication that acts only against bacterial infections, not against viral infections. You should not take it without consulting your doctor. Self-medication is dangerous and can lower the efficacy of Diof Suspension, leading to antibiotic resistance.
Yes, intake of Diof Suspension may cause dry mouth, and you may feel thirsty frequently. Try to drink plenty of fluids (water with electrolytes) and probiotics. You may also experience dry lips, for which you can use lip balm.
Avoid intake of Diof Suspension if you have a history of liver diseases, low blood white cells (leukopenia), seizures (fits), gastrointestinal diseases (like Crohn's disease, Inflammatory bowel disease), and other neurological diseases.
This combination should be used during pregnancy only when your doctor considers it necessary and appropriate. If you are pregnant, planning pregnancy, or think you may be pregnant, tell your doctor before starting treatment.
A metallic or unusual taste can occur, particularly with metronidazole. It is usually temporary and generally improves after treatment is completed. Speak with your doctor if it becomes severe or persistent.
Do not stop the medicine on your own simply because your symptoms improve. Follow the duration prescribed by your doctor. If you develop significant side effects or feel you need to stop treatment, contact your doctor for advice.
Calcium-containing foods and drinks can reduce absorption of the ofloxacin component when taken at the same time. This does not significantly affect metronidazole. Follow the spacing instructions provided with your specific product or ask your pharmacist how to schedule dairy products, calcium supplements, and your medicine.
Contact your doctor promptly if you develop new tendon pain, swelling, or stiffness. Ofloxacin, a fluoroquinolone antibiotic, can rarely cause serious tendon problems. Avoid strenuous activity involving the painful area until you receive medical advice.
Antacids containing magnesium, aluminum, or calcium can reduce absorption of the ofloxacin component. Do not take them at the same time. Follow the spacing instructions on your medicine label or ask your pharmacist for advice.

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Country of origin

India

Manufacturer/Marketer address

Office No. 5119, 5th Floor, 'D' Wing, Oberoi Garden Estates, Chandivili, Andheri (E), Mumbai - 400 072.
Other Info - DIO0126
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