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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Diltra 50mg/300mg/300mg Tablet is used to treat HIV-1 infection. It works by increasing the immune cells that help fight infections in the body and interfering with the working of certain enzymes which are necessary for the reproduction of the virus; thereby decreasing the amount of HIV in the blood. In some cases, this medicine may cause side effects such as fatigue, diarrhoea, headache, pain, fever, cough, and insomnia. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions. Practise safe sex and other necessary precautions as this medicine does not prevent the spread of HIV infection.
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About Diltra 50mg/300mg/300mg Tablet

Diltra 50mg/300mg/300mg Tablet belongs to a group of antiretroviral medicines indicated for the treatment of HIV-1 infection in adults and children weighing at least 35kgs. HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help in fighting infection, making the individual susceptible to other infections or illnesses.
 
Diltra 50mg/300mg/300mg Tablet contains Dolutegravir (integrase inhibitor), Lamivudine (nucleoside reverse transcriptase inhibitor), and Tenofovir disoproxil fumarate (nucleotide reverse transcriptase inhibitor). Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50mg/300mg/300mg Tablet helps in treating HIV infection.
 
You are advised to take Diltra 50mg/300mg/300mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as fatigue, diarrhoea, headache, pain, rash, depression, fever, cough, and insomnia. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Practise safe sex and other necessary precautions as Diltra 50mg/300mg/300mg Tablet does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Diltra 50mg/300mg/300mg Tablet. Diltra 50mg/300mg/300mg Tablet may cause dizziness, so drive with caution. Diltra 50mg/300mg/300mg Tablet is not recommended for children weighing below 35 kg. Keep your doctor informed about your health condition and the medicines you are taking to prevent any side effects/interactions.

Uses of Diltra 50mg/300mg/300mg Tablet

Treatment of HIV infection

Directions for Use

• Diltra 50mg/300mg/300mg Tablet can be taken with or without food.• It is recommended to take Diltra 50mg/300mg/300mg Tablet once daily, or as advised by your doctor.• Swallow Diltra 50mg/300mg/300mg Tablet as a whole with a glass of water.• Do not break, chew, or crush it.

Medicinal Benefits

Diltra 50mg/300mg/300mg Tablet is a combination of three drugs, namely: Dolutegravir, Lamivudine and Tenofovir disoproxil fumarate. Diltra 50mg/300mg/300mg Tablet belongs to a group of antiretroviral medicines indicated for the treatment of HIV-1 infection in adults and children weighing at least 35kgs. Dolutegravir is an integrase inhibitor that increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine is a nucleoside reverse transcriptase inhibitor, and Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor. They work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50mg/300mg/300mg Tablet helps in treating HIV infection.

How Diltra 50mg/300mg/300mg Tablet Works

Diltra 50mg/300mg/300mg Tablet contains Dolutegravir (integrase inhibitor), Lamivudine (nucleoside reverse transcriptase inhibitor), and Tenofovir disoproxil fumarate (nucleotide reverse transcriptase inhibitor). Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50mg/300mg/300mg Tablet helps in treating HIV infection.

Storage

Keep Diltra 50mg/300mg/300mg Tablet out of reach and sight of children.

What if I have taken an overdose of Diltra 50mg/300mg/300mg Tablet

Take Diltra 50mg/300mg/300mg Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Diltra 50mg/300mg/300mg Tablet if you are allergic to any of its components. Inform your doctor if you have a history of hepatitis B or C infection, bone problems, pancreas disorder, kidney/liver problems, or if you are taking dofetilide (anti-arrhythmic agent). Practise safe sex and other necessary precautions as Diltra 50mg/300mg/300mg Tablet does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Diltra 50mg/300mg/300mg Tablet. Diltra 50mg/300mg/300mg Tablet may cause dizziness, so drive with caution. Diltra 50mg/300mg/300mg Tablet is not recommended for children weighing below 35 kg. Talk to your doctor immediately if you notice any signs or symptoms of infection or inflammation.

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
LamivudineEmtricitabine
Critical

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Taking Diltra 50mg/300mg/300mg Tablet with dofetilide may possibly reduce the blood levels and effects of Diltra 50mg/300mg/300mg Tablet. This can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Diltra 50mg/300mg/300mg Tablet with Dofetilide is not recommended, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LamivudineEmtricitabine
Critical
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Combining these two medications may reduce overall effectiveness due to potential antagonistic effects (opposite actions).

How to manage the interaction:
Taking Emtricitabine with Diltra 50mg/300mg/300mg Tablet is not recommended, but it can be taken if your doctor prescribes it. Contact your doctor if your symptoms do not improve. Do not stop taking any medication without consulting your doctor.
Critical
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Coadministration of Didanosine with Diltra 50mg/300mg/300mg Tablet can increase the levels and risk of Didanosine side effects.

How to manage the interaction:
Taking Didanosine with Diltra 50mg/300mg/300mg Tablet is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. However, if you experience severe headaches, confusion, weakness, trouble walking, muscle pain, or high fever, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Combining Diltra 50mg/300mg/300mg Tablet and Streptozocin can increase the risk of kidney problems.

How to manage the interaction:
Taking Diltra 50mg/300mg/300mg Tablet with Streptozocin is not recommended, as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Taking Diltra 50mg/300mg/300mg Tablet with magnesium sulfate can reduce the effects of Diltra 50mg/300mg/300mg Tablet.

How to manage the interaction:
Although taking Diltra 50mg/300mg/300mg Tablet and Magnesium sulfate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if your condition gets worse or if you develop new infections while taking these medications, it is important to contact a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DolutegravirCalcium glubionate
Severe
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Co-administration of Diltra 50mg/300mg/300mg Tablet with Calcium glubionate can reduce the effectiveness of Diltra 50mg/300mg/300mg Tablet.

How to manage the interaction:
Taking Diltra 50mg/300mg/300mg Tablet with Calcium glubionate together can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, take Diltra 50mg/300mg/300mg Tablet at least two hours before or six hours after calcium citrate. Do not discontinue the medication without consulting a doctor.
DolutegravirMagnesium gluconate
Severe
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Taking Diltra 50mg/300mg/300mg Tablet with magnesium aspartate can reduce the effectiveness of Diltra 50mg/300mg/300mg Tablet.

How to manage the interaction:
Although taking Diltra 50mg/300mg/300mg Tablet and Magnesium gluconate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Diltra 50mg/300mg/300mg Tablet either two hours before or six hours after taking a dose of Magnesium gluconate. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Coadministration of Diltra 50mg/300mg/300mg Tablet with zinc sulfate can reduce the efficacy of Diltra 50mg/300mg/300mg Tablet.

How to manage the interaction:
Although taking Diltra 50mg/300mg/300mg Tablet and Zinc sulfate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Diltra 50mg/300mg/300mg Tablet either two hours before or six hours after taking a dose of Zinc sulfate. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Taking carbamazepine and Diltra 50mg/300mg/300mg Tablet may possibly reduce the blood levels and effects of Diltra 50mg/300mg/300mg Tablet.

How to manage the interaction:
Although taking carbamazepine and Diltra 50mg/300mg/300mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Diltra 50mg/300mg/300mg Tablet:
Taking Diltra 50mg/300mg/300mg Tablet with ferric citrate can reduce the effectiveness of Diltra 50mg/300mg/300mg Tablet.

How to manage the interaction:
Although taking Diltra 50mg/300mg/300mg Tablet and Ferric citrate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Diltra 50mg/300mg/300mg Tablet either two hours before or six hours after taking a dose of Ferric citrate. Do not discontinue using any medications without consulting a doctor.

Drug-Food Interactions

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DOLUTEGRAVIR-50MG+LAMIVUDINE-300MG+TENOFOVIR DISOPROXIL FUMARATE-300MGHerbal products/medicines
Moderate

Drug-Food Interactions

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DOLUTEGRAVIR-50MG+LAMIVUDINE-300MG+TENOFOVIR DISOPROXIL FUMARATE-300MGHerbal products/medicines
Moderate
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
Consuming St.John's Wort with Diltra 50mg/300mg/300mg Tablet can increase the risk of side effects. Avoid consuming St.John's Wort with Diltra 50mg/300mg/300mg Tablet.

Diet & Lifestyle Advise

  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injections or drug equipment.
  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruits as it helps to boost the immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or by doing whatever makes you happy.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS
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Alcohol

Caution

It is not known whether Diltra 50mg/300mg/300mg Tablet interacts with alcohol. Please consult your doctor.

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Pregnancy

Unsafe

Diltra 50mg/300mg/300mg Tablet might cause embryo-fetal toxicity when taken at the time of conception and during early pregnancy. Please consult your doctor if you have any concerns regarding this.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Diltra 50mg/300mg/300mg Tablet. Consult your doctor if you have any concerns regarding this.

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Driving

Caution

Diltra 50mg/300mg/300mg Tablet may cause dizziness. So, drive or operating machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Diltra 50mg/300mg/300mg Tablet is not recommended for children weighing below 35kgs. Consult your doctor if you have any concerns.

Have a query?

FAQs

Diltra 50mg/300mg/300mg Tablet is used to treat HIV infection.

Diltra 50mg/300mg/300mg Tablet contains Dolutegravir, Lamivudine, and Tenofovir disoproxil fumarate. Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50mg/300mg/300mg Tablet helps in treating HIV infection.

Do not stop taking Diltra 50mg/300mg/300mg Tablet without consulting your doctor as it may reduce the effectiveness of anti-HIV therapy. Continue taking Diltra 50mg/300mg/300mg Tablet for as long as your doctor has prescribed it to you to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Diltra 50mg/300mg/300mg Tablet.

Diltra 50mg/300mg/300mg Tablet might cause lactic acidosis (excess of lactic acid in the blood), a rare but severe side effect. Consult a doctor immediately if you experience stomach pain, vomiting, nausea, drowsiness, and deep rapid breathing, as these could be the signs of lactic acidosis.

Diltra 50mg/300mg/300mg Tablet may cause bone problems such as bone pain, softening or thinning of bone which might lead to bone fractures. A regular bone density test is advised while taking Diltra 50mg/300mg/300mg Tablet.

Antacids, laxatives, or other medicines containing magnesium, aluminium or buffered medicines (medicines used to neutralise stomach acids) should be taken 2 hours before and 6 hours after taking Diltra 50mg/300mg/300mg Tablet. Consult your doctor if you have any concerns.

You can take iron or calcium supplements with Diltra 50mg/300mg/300mg Tablet if you have taken Diltra 50mg/300mg/300mg Tablet with food. If you haven’t taken Diltra 50mg/300mg/300mg Tablet with food, take Diltra 50mg/300mg/300mg Tablet 2 hours before or 6 hours after taking iron or calcium supplements. Consult your doctor if you have any concerns.

Manufacturer/Marketer address

Aurobindo Pharma Limited, Plot No. 2, Maitrivihar, Ameerpet, Hyderabad - 500038 , Telangana, India.
Other Info - DILT232

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