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  3. Diltra 50 mg/300 mg/300 mg Tablet 30's

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Diltra 50 mg/300 mg/300 mg Tablet 30's, Pack of 1
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Diltra 50 mg/300 mg/300 mg Tablet 30's is used to treat HIV-1 infection. It works by increasing the immune cells that help fight infections in the body and interfering with the working of certain enzymes which are necessary for the reproduction of the virus; thereby decreasing the amount of HIV in the blood. In some cases, this medicine may cause side effects such as fatigue, diarrhoea, headache, pain, fever, cough, and insomnia. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions. Practise safe sex and other necessary precautions as this medicine does not prevent the spread of HIV infection.
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Composition :

DOLUTEGRAVIR-50MG + LAMIVUDINE-300MG + TENOFOVIR DISOPROXIL FUMARATE-300MG

Manufacturer/Marketer :

Aurobindo Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Diltra 50 mg/300 mg/300 mg Tablet 30's

Diltra 50 mg/300 mg/300 mg Tablet 30's belongs to a group of antiretroviral medicines indicated for the treatment of HIV-1 infection in adults and children weighing at least 35kgs. HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help in fighting infection, making the individual susceptible to other infections or illnesses.
 
Diltra 50 mg/300 mg/300 mg Tablet 30's contains Dolutegravir (integrase inhibitor), Lamivudine (nucleoside reverse transcriptase inhibitor), and Tenofovir disoproxil fumarate (nucleotide reverse transcriptase inhibitor). Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50 mg/300 mg/300 mg Tablet 30's helps in treating HIV infection.
 
You are advised to take Diltra 50 mg/300 mg/300 mg Tablet 30's for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as fatigue, diarrhoea, headache, pain, rash, depression, fever, cough, and insomnia. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Practise safe sex and other necessary precautions as Diltra 50 mg/300 mg/300 mg Tablet 30's does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Diltra 50 mg/300 mg/300 mg Tablet 30's. Diltra 50 mg/300 mg/300 mg Tablet 30's may cause dizziness, so drive with caution. Diltra 50 mg/300 mg/300 mg Tablet 30's is not recommended for children weighing below 35 kg. Keep your doctor informed about your health condition and the medicines you are taking to prevent any side effects/interactions.

Uses of Diltra 50 mg/300 mg/300 mg Tablet 30's

Treatment of HIV infection

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Directions for Use

• Diltra 50 mg/300 mg/300 mg Tablet 30's can be taken with or without food.• It is recommended to take Diltra 50 mg/300 mg/300 mg Tablet 30's once daily, or as advised by your doctor.• Swallow Diltra 50 mg/300 mg/300 mg Tablet 30's as a whole with a glass of water.• Do not break, chew, or crush it.

Medicinal Benefits

Diltra 50 mg/300 mg/300 mg Tablet 30's is a combination of three drugs, namely: Dolutegravir, Lamivudine and Tenofovir disoproxil fumarate. Diltra 50 mg/300 mg/300 mg Tablet 30's belongs to a group of antiretroviral medicines indicated for the treatment of HIV-1 infection in adults and children weighing at least 35kgs. Dolutegravir is an integrase inhibitor that increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine is a nucleoside reverse transcriptase inhibitor, and Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor. They work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50 mg/300 mg/300 mg Tablet 30's helps in treating HIV infection.

How Diltra 50 mg/300 mg/300 mg Tablet 30's Works

Diltra 50 mg/300 mg/300 mg Tablet 30's contains Dolutegravir (integrase inhibitor), Lamivudine (nucleoside reverse transcriptase inhibitor), and Tenofovir disoproxil fumarate (nucleotide reverse transcriptase inhibitor). Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50 mg/300 mg/300 mg Tablet 30's helps in treating HIV infection.

Storage

Keep Diltra 50 mg/300 mg/300 mg Tablet 30's out of reach and sight of children.
Side effects of Diltra 50 mg/300 mg/300 mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Diltra 50 mg/300 mg/300 mg Tablet 30's

Take Diltra 50 mg/300 mg/300 mg Tablet 30's only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Diltra 50 mg/300 mg/300 mg Tablet 30's if you are allergic to any of its components. Inform your doctor if you have a history of hepatitis B or C infection, bone problems, pancreas disorder, kidney/liver problems, or if you are taking dofetilide (anti-arrhythmic agent). Practise safe sex and other necessary precautions as Diltra 50 mg/300 mg/300 mg Tablet 30's does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Diltra 50 mg/300 mg/300 mg Tablet 30's. Diltra 50 mg/300 mg/300 mg Tablet 30's may cause dizziness, so drive with caution. Diltra 50 mg/300 mg/300 mg Tablet 30's is not recommended for children weighing below 35 kg. Talk to your doctor immediately if you notice any signs or symptoms of infection or inflammation.

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
LamivudineEmtricitabine
Critical

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Taking Diltra 50 mg/300 mg/300 mg Tablet with dofetilide may possibly reduce the blood levels and effects of Diltra 50 mg/300 mg/300 mg Tablet. This can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Diltra 50 mg/300 mg/300 mg Tablet with Dofetilide is not recommended, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LamivudineEmtricitabine
Critical
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Combining these two medications may reduce overall effectiveness due to potential antagonistic effects (opposite actions).

How to manage the interaction:
Taking Emtricitabine with Diltra 50 mg/300 mg/300 mg Tablet is not recommended, but it can be taken if your doctor prescribes it. Contact your doctor if your symptoms do not improve. Do not stop taking any medication without consulting your doctor.
Tenofovir disoproxilDidanosine
Critical
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Coadministration of Didanosine with Diltra 50 mg/300 mg/300 mg Tablet can increase the levels and risk of Didanosine side effects.

How to manage the interaction:
Taking Didanosine with Diltra 50 mg/300 mg/300 mg Tablet is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. However, if you experience severe headaches, confusion, weakness, trouble walking, muscle pain, or high fever, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Tenofovir disoproxilStreptozocin
Critical
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Combining Diltra 50 mg/300 mg/300 mg Tablet and Streptozocin can increase the risk of kidney problems.

How to manage the interaction:
Taking Diltra 50 mg/300 mg/300 mg Tablet with Streptozocin is not recommended, as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
DolutegravirZinc sulfate
Severe
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Coadministration of Diltra 50 mg/300 mg/300 mg Tablet with zinc sulfate can reduce the efficacy of Diltra 50 mg/300 mg/300 mg Tablet.

How to manage the interaction:
Although taking Diltra 50 mg/300 mg/300 mg Tablet and Zinc sulfate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Diltra 50 mg/300 mg/300 mg Tablet either two hours before or six hours after taking a dose of Zinc sulfate. Do not discontinue using any medications without consulting a doctor.
DolutegravirPhenytoin
Severe
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Taking Diltra 50 mg/300 mg/300 mg Tablet with phenytoin may significantly reduce the blood levels of Diltra 50 mg/300 mg/300 mg Tablet, which may make the medication less effective in treating infections.

How to manage the interaction:
Although taking Diltra 50 mg/300 mg/300 mg Tablet and Phenytoin together can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue using any medications without consulting a doctor.
DolutegravirFerrous fumarate
Severe
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Taking Diltra 50 mg/300 mg/300 mg Tablet with ferric fumarate can reduce the effectiveness of Diltra 50 mg/300 mg/300 mg Tablet.

How to manage the interaction:
Taking Ferrous Fumarate and Diltra 50 mg/300 mg/300 mg Tablet together may result in an interaction, but they can be taken together as directed by your doctor. It is advised to take Diltra 50 mg/300 mg/300 mg Tablet 2 hours before or 6 hours after taking Ferrous fumarate. Do not discontinue using any medications without consulting a doctor.
DolutegravirZinc acetate
Severe
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Taking Diltra 50 mg/300 mg/300 mg Tablet with zinc acetate can reduce the effectiveness of Diltra 50 mg/300 mg/300 mg Tablet.

How to manage the interaction:
Although taking Diltra 50 mg/300 mg/300 mg Tablet and Zinc acetate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Diltra 50 mg/300 mg/300 mg Tablet either two hours before or six hours after taking a dose of Zinc acetate. Do not discontinue using any medications without consulting a doctor.
DolutegravirSodium bicarbonate
Severe
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Co-administration of Sodium bicarbonate and Diltra 50 mg/300 mg/300 mg Tablet reduces the levels of Diltra 50 mg/300 mg/300 mg Tablet, resulting in reduced effectiveness.

How to manage the interaction:
Although taking Diltra 50 mg/300 mg/300 mg Tablet and Sodium bicarbonate together can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DolutegravirCalcium acetate
Severe
How does the drug interact with Diltra 50 mg/300 mg/300 mg Tablet:
Co-administration of Diltra 50 mg/300 mg/300 mg Tablet with calcium acetate can reduce the effectiveness of Diltra 50 mg/300 mg/300 mg Tablet.

How to manage the interaction:
Taking Diltra 50 mg/300 mg/300 mg Tablet with calcium acetate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take Diltra 50 mg/300 mg/300 mg Tablet at least two hours before or six hours after the calcium acetate dose. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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DOLUTEGRAVIR-50MG+LAMIVUDINE-300MG+TENOFOVIR DISOPROXIL FUMARATE-300MGHerbal products/medicines
Moderate

Drug-Food Interactions

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DOLUTEGRAVIR-50MG+LAMIVUDINE-300MG+TENOFOVIR DISOPROXIL FUMARATE-300MGHerbal products/medicines
Moderate
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
Consuming St.John's Wort with Diltra 50 mg/300 mg/300 mg Tablet can increase the risk of side effects. Avoid consuming St.John's Wort with Diltra 50 mg/300 mg/300 mg Tablet.

Diet & Lifestyle Advise

  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injections or drug equipment.
  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruits as it helps to boost the immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or by doing whatever makes you happy.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS

Diltra 50 mg/300 mg/300 mg Tablet 30's Substitute

Substitutes safety advice
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Alcohol

Caution

It is not known whether Diltra 50 mg/300 mg/300 mg Tablet 30's interacts with alcohol. Please consult your doctor.

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Pregnancy

Unsafe

Diltra 50 mg/300 mg/300 mg Tablet 30's might cause embryo-fetal toxicity when taken at the time of conception and during early pregnancy. Please consult your doctor if you have any concerns regarding this.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Diltra 50 mg/300 mg/300 mg Tablet 30's. Consult your doctor if you have any concerns regarding this.

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Driving

Caution

Diltra 50 mg/300 mg/300 mg Tablet 30's may cause dizziness. So, drive or operating machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

Diltra 50 mg/300 mg/300 mg Tablet 30's is not recommended for children weighing below 35kgs. Consult your doctor if you have any concerns.

FAQs

Diltra 50 mg/300 mg/300 mg Tablet 30's is used to treat HIV infection.

Diltra 50 mg/300 mg/300 mg Tablet 30's contains Dolutegravir, Lamivudine, and Tenofovir disoproxil fumarate. Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Diltra 50 mg/300 mg/300 mg Tablet 30's helps in treating HIV infection.

Do not stop taking Diltra 50 mg/300 mg/300 mg Tablet 30's without consulting your doctor as it may reduce the effectiveness of anti-HIV therapy. Continue taking Diltra 50 mg/300 mg/300 mg Tablet 30's for as long as your doctor has prescribed it to you to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Diltra 50 mg/300 mg/300 mg Tablet 30's.

Diltra 50 mg/300 mg/300 mg Tablet 30's might cause lactic acidosis (excess of lactic acid in the blood), a rare but severe side effect. Consult a doctor immediately if you experience stomach pain, vomiting, nausea, drowsiness, and deep rapid breathing, as these could be the signs of lactic acidosis.

Diltra 50 mg/300 mg/300 mg Tablet 30's may cause bone problems such as bone pain, softening or thinning of bone which might lead to bone fractures. A regular bone density test is advised while taking Diltra 50 mg/300 mg/300 mg Tablet 30's.

Antacids, laxatives, or other medicines containing magnesium, aluminium or buffered medicines (medicines used to neutralise stomach acids) should be taken 2 hours before and 6 hours after taking Diltra 50 mg/300 mg/300 mg Tablet 30's. Consult your doctor if you have any concerns.

You can take iron or calcium supplements with Diltra 50 mg/300 mg/300 mg Tablet 30's if you have taken Diltra 50 mg/300 mg/300 mg Tablet 30's with food. If you haven’t taken Diltra 50 mg/300 mg/300 mg Tablet 30's with food, take Diltra 50 mg/300 mg/300 mg Tablet 30's 2 hours before or 6 hours after taking iron or calcium supplements. Consult your doctor if you have any concerns.

Country of origin

India

Manufacturer/Marketer address

Plot No. 2, Maitrivihar, Ameerpet, Hyderabad - 500038 , Telangana, India.
Other Info - DIL0264

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:53 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/210787PI.pdf
  2. https://clinicaltrials.gov/ct2/show/NCT03991013
  3. https://www.ncbi.nlm.nih.gov/books/NBK541968/

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