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  3. Desleaf ER 100 Tablet 10's

Desleaf ER 100 Tablet 10's, Pack of 10
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Desleaf ER 100 Tablet 10's is used to treat a major depressive disorder (depression). It contains Desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression. In some cases, you may experience certain common side effects such as nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

DESVENLAFAXINE-100MG

Manufacturer/Marketer :

Adivis Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Desleaf ER 100 Tablet 10's

Desleaf ER 100 Tablet 10's is used to treat a major depressive disorder (depression). Major depressive disorder, also known as clinical depression, is a mental health disorder characterised by a persistent and intense feeling of sadness for an extended duration of time. Symptoms include sadness, loss of interest, appetite changes, sleep problems, restlessness, lack of energy, feeling worthless or guilty, thoughts of harming oneself, difficulty concentrating, making decisions, and thinking.
 
Desleaf ER 100 Tablet 10's contains desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression. 
 
You are advised to take Desleaf ER 100 Tablet 10's for as long as your doctor has prescribed it for you, depending on your medical condition and response to the treatment. In some cases, you may experience certain common side effects such as nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders. Talk to your doctor if you experience these side effects persistently.
 
Please do not stop taking Desleaf ER 100 Tablet 10's suddenly, as it might cause withdrawal symptoms. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. Avoid driving as Desleaf ER 100 Tablet 10's may cause sleepiness and dizziness. Desleaf ER 100 Tablet 10's should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Desleaf ER 100 Tablet 10's as it could lead to increased sleepiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Desleaf ER 100 Tablet 10's

Treatment of Depression

Directions for Use

• Desleaf ER 100 Tablet 10's can be taken with or without food as advised by your doctor.• It is usually taken once a day or as directed by the doctor.• Swallow Desleaf ER 100 Tablet 10's as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Desleaf ER 100 Tablet 10's belongs to a group of antidepressant medicines indicated for the treatment of a major depressive disorder. Desleaf ER 100 Tablet 10's works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps in regulating mood, and treats depression. 

How Desleaf ER 100 Tablet 10's Works

Desleaf ER 100 Tablet 10's contains desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression.

Storage

Keep Desleaf ER 100 Tablet 10's out of reach and sight of children.
Side effects of Desleaf ER 100 Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.

What if I have taken an overdose of Desleaf ER 100 Tablet 10's

Do not take more than the prescribed dose of Desleaf ER 100 Tablet 10's as it may cause overdose. The symptoms of overdose include drowsiness, coma, seizures, vomiting, agitation, hallucinations, fever, sweating, severe muscle stiffness or twitching, confusion, fast heartbeat, shivering, loss of coordination, fast/slow/irregular heartbeat, nausea, vomiting, or diarrhea. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Desleaf ER 100 Tablet 10's if you are allergic to any of its contents; if you are taking linezolid, intravenous methylene blue, other serotonergic agents, monoamine oxidase inhibitors (MAOI) or have taken them in the last 14 days. Inform your doctor before taking Desleaf ER 100 Tablet 10's if you have heart problems, hypotension, bipolar disorder, glaucoma, epilepsy, lung or breathing problems, bleeding problems, or low sodium levels in the blood. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. Desleaf ER 100 Tablet 10's should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Desleaf ER 100 Tablet 10's as it could lead to increased sleepiness and dizziness. 

Drug-Drug Interactions

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DesvenlafaxineRasagiline
Critical
DesvenlafaxineTranylcypromine
Critical

Drug-Drug Interactions

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DesvenlafaxineRasagiline
Critical
How does the drug interact with Desleaf ER 100 Tablet:
Taking rasagiline with Desleaf ER 100 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Desleaf ER 100 Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineTranylcypromine
Critical
How does the drug interact with Desleaf ER 100 Tablet:
Taking tranylcypromine with Desleaf ER 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and Desleaf ER 100 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with Desleaf ER 100 Tablet:
Combining Isocarboxazid and Desleaf ER 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and Desleaf ER 100 Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineProcarbazine
Critical
How does the drug interact with Desleaf ER 100 Tablet:
Combining Procarbazine and Desleaf ER 100 Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and Desleaf ER 100 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with Desleaf ER 100 Tablet and do not discontinue any medications without first consulting your doctor.
DesvenlafaxineSafinamide
Critical
How does the drug interact with Desleaf ER 100 Tablet:
Taking Safinamide with Desleaf ER 100 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Desleaf ER 100 Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineErgotamine
Severe
How does the drug interact with Desleaf ER 100 Tablet:
Co-administration of Ergotamine and Desleaf ER 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Ergotamine and Desleaf ER 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, in co-ordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineDesipramine
Severe
How does the drug interact with Desleaf ER 100 Tablet:
Co-administration of Desipramine and Desleaf ER 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Desipramine and Desleaf ER 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxinePhenelzine
Severe
How does the drug interact with Desleaf ER 100 Tablet:
Co-administration of Phenelzine and Desleaf ER 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Phenelzine and Desleaf ER 100 Tablet can lead to interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineDihydroergotamine
Severe
How does the drug interact with Desleaf ER 100 Tablet:
Co-administration of Dihydroergotamine and Desleaf ER 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Desleaf ER 100 Tablet and Dihydroergotamine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineTapentadol
Severe
How does the drug interact with Desleaf ER 100 Tablet:
Co-administration of tapentadol and Desleaf ER 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of tapentadol and Desleaf ER 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

  • Regularly attend therapy sessions.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Include foods rich in omega-fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.

  • Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters. 

  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.

  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improves mood, boosts self-esteem, and provides restful sleep.

  • Avoid smoking and alcohol consumption.

  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

Desleaf ER 100 Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Desleaf ER 100 Tablet 10's as it may cause increased sleepiness and dizziness.

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Pregnancy

Caution

Desleaf ER 100 Tablet 10's belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning for pregnancy, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Desleaf ER 100 Tablet 10's may pass into breastmilk. Consult your doctor before taking Desleaf ER 100 Tablet 10's your doctor will decide whether Desleaf ER 100 Tablet 10's can be taken by breastfeeding mothers or not.

bannner image

Driving

Unsafe

Desleaf ER 100 Tablet 10's causes sleepiness and dizziness. Do not drive or operate machinery.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Desleaf ER 100 Tablet 10's should not be given to children as safety and effectiveness have not been established.

Have a query?

FAQs

Desleaf ER 100 Tablet 10's is used to treat a major depressive disorder (depression).

Desleaf ER 100 Tablet 10's works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain, which maintain mental balance, thereby regulating mood that treats depression.

Do not discontinue Desleaf ER 100 Tablet 10's without consulting your doctor, as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking Desleaf ER 100 Tablet 10's for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Desleaf ER 100 Tablet 10's.

Desleaf ER 100 Tablet 10's may cause decreased sex drive (libido) and problems with ejaculation and orgasm. Consult your doctor if you have any concerns regarding this.

Hypertension should be controlled before starting treatment with Desleaf ER 100 Tablet 10's. Therefore, consult your doctor if you have high blood pressure. Regular monitoring of blood pressure levels is advised while taking Desleaf ER 100 Tablet 10's.

Desleaf ER 100 Tablet 10's may increase the chances of bleeding and bruising. The risk increases when Desleaf ER 100 Tablet 10's is taken along with painkillers and blood thinners. Consult your doctor if you notice unusual bleeding or bruising.

When taken along with other medicines, Desleaf ER 100 Tablet 10's may cause a rare but potentially life-threatening condition called serotonin syndrome. This condition causes changes in how the brain, blood vessels, muscles and digestive system work. Avoid taking Desleaf ER 100 Tablet 10's along with MAOIs (used to treat depression), linezolid, intravenous methylene blue and other serotonergic agents.

Desleaf ER 100 Tablet 10's may dilate your pupils (widen the dark centres of your eyes). This can trigger a glaucoma attack. Before taking Desleaf ER 100 Tablet 10's, consult your doctor if you have glaucoma.

Desleaf ER 100 Tablet 10's may cause seizures. If you’ve ever had a seizure, tell your doctor before taking Desleaf ER 100 Tablet 10's.

Many people have sexual side effects when using antidepressants. Working together with your doctor will help you find a solution that addresses both your mental and sexual wellness.

You may have to take Desleaf ER 100 Tablet 10's for several weeks before you begin to feel better.

Desleaf ER 100 Tablet 10's can begin lowering anxiety symptoms in as little as one week, according to one clinical study. Generally, you'll start to feel the full effects after taking it for eight weeks.

Although Desleaf ER 100 Tablet 10's is only officially allowed to treat depression, doctors frequently prescribe it to treat anxiety as well.

Take Desleaf ER 100 Tablet 10's exactly as prescribed by your healthcare practitioner. Take Desleaf ER 100 Tablet 10's once a day, about the same time every day. Desleaf ER 100 Tablet 10's can be taken with or without food. Swallow Desleaf ER 100 Tablet 10's pills whole and with drink.

It should be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.

Desleaf ER 100 Tablet 10's works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance. Thus, it helps to treat depression.

Desleaf ER 100 Tablet 10's doesn't typically cause weight gain for most people. In very rare case, people taking it experience weight changes (gain or loss) of less than 2 kgs.

Desleaf ER 100 Tablet 10's may cause sexual dysfunction; however, men are more affected than women. If it happens to you, please seek medical attention from your doctor.

Common side effects of Desleaf ER 100 Tablet 10's may include nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders.

Country of origin

India

Manufacturer/Marketer address

P NO-19-WZ-5-A-1,Vishnu Garden, West Delhi, Delhi,India-110018
Other Info - DES0277

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:41 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204150s005lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a608022.html#:~:text=Desvenlafaxine%20is%20used%20to%20treat,that%20help%20maintain%20mental%20balance
  3. https://www.drugs.com/mtm/desvenlafaxine.html

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