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compositionComposition:DESVENLAFAXINE-100MG
prescription
Prescription Medicine
info
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Denlafax 100mg Tablet is used in the treatment of major depressive disorder (depression). It helps improve mood, restore emotional balance, and reduce symptoms such as persistent sadness, loss of interest in daily activities, fatigue, and anxiety. This medicine supports mental well-being by enhancing energy levels, concentration, and overall motivation, thereby improving daily functioning and quality of life.

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Written By Dr. Priyanka Desai , BDS, MDS
Reviewed By Dr. Chandrakanth Jena , Pharm.D
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More about the Product

Composition :

DESVENLAFAXINE-100MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Denlafax 100mg Tablet

Denlafax 100mg Tablet is an oral prescription medication used to treat depression, specifically major depressive disorder in adults. It belongs to a group of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs), which help balance certain natural chemicals in the brain. By restoring this balance, it helps improve mood, sleep, appetite, and energy levels.

Take Denlafax 100mg Tablet once daily, at the same time each day, to maintain a consistent level of the medicine in your body. You can take this tablet with or without food, but swallowing it whole is essential. Combining this treatment with regular physical activity, balanced meals, and proper sleep hygiene can significantly support your overall progress.

While taking Denlafax 100mg Tablet , you may experience mild side effects like nausea, dry mouth, or excessive sweating, which often improve over time. However, you must contact your doctor immediately if you experience severe symptoms such as high blood pressure, unusual bleeding, or sudden changes in vision.

Do not take this if you are allergic to any of its ingredients or if you are currently taking monoamine oxidase inhibitors (MAOIs). Before starting, talk to your doctor if you have a history of high blood pressure, heart problems, kidney disease, liver damage, or seizures.

Denlafax 100mg Tablet can interact with other medicines, especially blood thinners and other antidepressants, which can increase your risk of bleeding or a rare condition called serotonin syndrome. It is highly recommended to avoid alcohol while taking this medicine, as it can worsen drowsiness. If you are pregnant, breastfeeding, or an elderly patient, consult your healthcare provider to discuss the risks and benefits.

Uses of Denlafax 100mg Tablet

Denlafax 100mg Tablet is used to treat depression, specifically major depressive disorder in adults. The detailed uses of Denlafax 100mg Tablet are as follows:

  • Major Depressive Disorder (MDD): Denlafax 100mg Tablet helps relieve persistent feelings of sadness, loss of interest in daily activities, and emotional exhaustion by regulating chemical messengers in the brain.
     

Key Benefits

Denlafax 100mg Tablet helps manage depression by restoring the balance of chemical messengers in the brain. By improving mood and reducing depressive symptoms, it supports emotional wellbeing, daily functioning, and overall quality of life.

  • Helps Improve Mood and Emotional Wellbeing: By balancing brain chemicals involved in mood regulation, Denlafax 100mg Tablet helps reduce symptoms of depression, such as persistent sadness, loss of interest, and emotional distress.
  • Supports Better Energy and Sleep: As depressive symptoms improve, Denlafax 100mg Tablet may help restore energy levels and promote healthier sleep patterns, allowing you to feel more refreshed and alert during the day.
  • Enhances Daily Functioning: By reducing the emotional and physical effects of depression, Denlafax 100mg Tablet helps you manage daily responsibilities, participate in social activities, and maintain a more stable and productive routine.
     
Side effects of Denlafax 100 mg Tablet
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Drink plenty of water to stay hydrated.
  • Eat smaller meals more frequently to help manage your condition.
  • Limit large carbohydrate-rich meals to avoid exacerbating your symptoms.
  • Before adding more salt to your diet, it's best to talk to your doctor to see if it's a good idea for you.
  • Rise slowly from a sitting or lying position to avoid feeling dizzy or lightheaded.
  • Avoid standing for long periods without moving around to reduce your risk of fainting.
  • Perform leg muscle exercises like ankle circles when standing for extended periods to improve blood flow.
  • Wear compression stockings to help improve blood flow in your legs and reduce swelling.
  • Engage in regular moderate exercise, avoiding strenuous activities in hot weather to prevent dehydration and worsening of symptoms.
  • Limit alcohol consumption and be mindful of caffeine intake as they can worsen symptoms and exacerbate your condition.
  • If you experience frequent or severe symptoms of dizziness, lightheadedness, or fainting upon standing, seek medical attention.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Denlafax 100mg Tablet can be taken with or without food as advised by your doctor.
  • It is usually taken once a day or as directed by the doctor.
  • Swallow Denlafax 100mg Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Denlafax 100mg Tablet Works

Denlafax 100mg Tablet contains desvenlafaxine. It works as a serotonin-norepinephrine reuptake inhibitor (SNRI). In the brain, nerve cells release natural chemical messengers called serotonin and norepinephrine to transmit signals. After sending the signal, the cells normally reabsorb these chemicals. Denlafax 100mg Tablet works by blocking this reabsorption process, which keeps more serotonin and norepinephrine active in the spaces between brain cells. This increased activity enhances communication between nerve pathways, helping to elevate and stabilise mood.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Denlafax 100mg Tablet as it may cause increased sleepiness and dizziness.

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Pregnancy

Caution

Denlafax 100mg Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning a pregnancy; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Denlafax 100mg Tablet may pass into breastmilk. Consult your doctor before taking Denlafax 100mg Tablet your doctor will decide whether Denlafax 100mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Denlafax 100mg Tablet causes sleepiness and dizziness. Do not drive or operate machinery.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Denlafax 100mg Tablet should not be given to children as safety and effectiveness have not been established.

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Heart

Caution

Denlafax 100mg Tablet is used with caution in cardiac patients and regular monitoring is required.

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Geriatrics

Caution

Denlafax 100mg Tablet should be administered with caution in elderly patients. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Denlafax 100mg Tablet

In case of an accidental overdose, seek immediate emergency medical attention or contact your local hospital right away.

Diet & Lifestyle Advise

  • Avoid drinking alcohol while taking this medicine, as it can worsen drowsiness, impair coordination, and decrease the effectiveness of your treatment.
  • Stay well-hydrated throughout the day, especially if you experience dry mouth or increased sweating as side effects.
  • Maintain a consistent daily routine that includes gentle physical exercise, such as walking, and a regular sleep schedule to complement the therapeutic effects of Denlafax 100mg Tablet .
  • Monitor your blood pressure regularly at home, as this class of medication can occasionally cause mild increases in blood pressure.

 

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How Soon It Starts Working

The time required for Denlafax 100mg Tablet to start to work: The time required for Denlafax 100mg Tablet to show its action is unknown.

The time for which the effects of Denlafax 100mg Tablet last: The effect of Denlafax 100mg Tablet lasts for 20 to 25 days.

What if you forget to take Denlafax 100mg Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and return to your regular dosing schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Denlafax 100mg Tablet at controlled room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Always inspect your tablet packaging before use to ensure the blister strip or bottle seal is completely intact.
  • You may occasionally notice the empty shell of the tablet in your stool; this is normal for extended-release tablets and does not mean the medicine did not work.
  • Avoid driving, riding a bicycle, or operating machinery until you know how Denlafax 100mg Tablet affects you, as it may cause initial dizziness or drowsiness.
  • Do not stop taking Denlafax 100mg Tablet abruptly. If you need to discontinue the medicine, your doctor will provide instructions on gradually decreasing your dose to prevent withdrawal symptoms.
  • Inform laboratory technicians and doctors that you take Denlafax 100mg Tablet before any urine screenings, as it can sometimes cause false-positive results on certain drug tests.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine Oxidase Inhibitors (MAOIs): Do not take Denlafax 100mg Tablet if you are taking an MAOI or have stopped taking one within the last 14 days. This combination can cause high blood pressure, tremors, and severe mental changes.
  • Serotonergic Medicines: Taking this drug with other antidepressants, triptans or tramadol can increase the risk of a rare, serious condition called serotonin syndrome.
  • Blood Thinners and NSAIDs: Combining this medicine with aspirin, warfarin, ibuprofen, or other nonsteroidal anti-inflammatory drugs can increase your risk of bruising and bleeding.
     
DesvenlafaxineRasagiline
Critical
DesvenlafaxineIsocarboxazid
Critical

Drug-Drug Interactions

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DesvenlafaxineRasagiline
Critical
How does the drug interact with Denlafax 100 mg Tablet:
Taking rasagiline with Denlafax 100 mg Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Denlafax 100 mg Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with Denlafax 100 mg Tablet:
Combining Isocarboxazid and Denlafax 100 mg Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and Denlafax 100 mg Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineSafinamide
Critical
How does the drug interact with Denlafax 100 mg Tablet:
Taking Safinamide with Denlafax 100 mg Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Denlafax 100 mg Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineProcarbazine
Critical
How does the drug interact with Denlafax 100 mg Tablet:
Combining Procarbazine and Denlafax 100 mg Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and Denlafax 100 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with Denlafax 100 mg Tablet and do not discontinue any medications without first consulting your doctor.
DesvenlafaxineTranylcypromine
Critical
How does the drug interact with Denlafax 100 mg Tablet:
Taking tranylcypromine with Denlafax 100 mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and Denlafax 100 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineTapentadol
Severe
How does the drug interact with Denlafax 100 mg Tablet:
Co-administration of tapentadol and Denlafax 100 mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of tapentadol and Denlafax 100 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxinePhenelzine
Severe
How does the drug interact with Denlafax 100 mg Tablet:
Co-administration of Phenelzine and Denlafax 100 mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Phenelzine and Denlafax 100 mg Tablet can lead to interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineCitalopram
Severe
How does the drug interact with Denlafax 100 mg Tablet:
Co-administration of citalopram and Denlafax 100 mg Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of citalopram and Denlafax 100 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineVilazodone
Severe
How does the drug interact with Denlafax 100 mg Tablet:
Co-administration of vilazodone and Denlafax 100 mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of vilazodone and Denlafax 100 mg Tablet can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineClomipramine
Severe
How does the drug interact with Denlafax 100 mg Tablet:
Coadministration of Denlafax 100 mg Tablet with clomipramine might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although taking clomipramine and Denlafax 100 mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhoea, consult the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: May increase drowsiness, impair mental alertness, and worsen the underlying symptoms of depression.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[PSYCHOTHERAPEUTICS]

FAQs

Denlafax 100mg Tablet is used to treat a major depressive disorder (depression).
Denlafax 100mg Tablet works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain, which help maintain mental balance and regulate mood, thereby treating depression.
Do not discontinue Denlafax 100mg Tablet without consulting your doctor, as it could lead to withdrawal symptoms. To treat your condition effectively, continue taking Denlafax 100mg Tablet for as long as prescribed. Do not hesitate to consult your doctor if you experience any difficulties while taking Denlafax 100mg Tablet .
Hypertension should be controlled before starting treatment with Denlafax 100mg Tablet . Therefore, consult your doctor if you have high blood pressure. Regular monitoring of blood pressure levels is advised while taking Denlafax 100mg Tablet .
Denlafax 100mg Tablet may increase the chances of bleeding and bruising. The risk increases when Denlafax 100mg Tablet is taken along with painkillers and blood thinners. Consult your doctor if you notice unusual bleeding or bruising.
When taken along with other medicines, Denlafax 100mg Tablet may cause a rare but potentially life-threatening condition called serotonin syndrome. This condition causes changes in how the brain, blood vessels, muscles and digestive system work. Avoid taking Denlafax 100mg Tablet along with MAOIs (used to treat depression), linezolid, intravenous methylene blue and other serotonergic agents.
Denlafax 100mg Tablet may dilate your pupils (widen the dark centres of your eyes). This can trigger a glaucoma attack. Before taking Denlafax 100mg Tablet , consult your doctor if you have glaucoma.
Denlafax 100mg Tablet may cause seizures. If you have ever had a seizure, tell your doctor before taking Denlafax 100mg Tablet .
Yes. Denlafax 100mg Tablet may cause sexual side effects such as reduced sex drive (libido), difficulty achieving orgasm, delayed ejaculation, or erectile dysfunction in some people. Do not stop taking the medicine on your own if you experience these effects. Talk to your doctor, who may recommend ways to manage these symptoms while continuing treatment for your depression.
Take Denlafax 100mg Tablet exactly as prescribed by your healthcare practitioner. Take Denlafax 100mg Tablet once a day, about the same time every day. Denlafax 100mg Tablet can be taken with or without food. Swallow the medicine as a whole with water.
It should be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.
Denlafax 100mg Tablet typically does not cause weight gain for most people. In very rare cases, people taking it experience weight changes (gain or loss) of less than 2 kgs.
Common side effects of Denlafax 100mg Tablet may include nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders.
Clinical studies indicate that weight changes with Denlafax 100mg Tablet are typically minimal; some patients may experience a slight loss of appetite and weight, while others may notice minor weight gain. Talk to your doctor or pharmacist if you have concerns about weight changes.
Taking this class of medicine during the third trimester may cause temporary breathing or feeding difficulties in newborns. However, untreated depression also carries health risks, so talk to your doctor to weigh the benefits and risks.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can increase drowsiness, reduce the effectiveness of the drug, and worsen depression symptoms. Talk to your doctor if you have questions about alcohol use.
Take the missed dose as soon as you remember. If it is close to your next scheduled dose, skip it and continue with your normal daily routine. Do not double the dose. Talk to your doctor or pharmacist if you frequently miss doses.
Yes, Denlafax 100mg Tablet can raise blood pressure in some patients, so your doctor will likely monitor your blood pressure regularly while you are taking it. Talk to your doctor if you notice consistently high readings.
Certain pain relievers like ibuprofen, naproxen, or aspirin can increase your risk of bleeding when taken with this medicine. Acetaminophen is usually a safer alternative, but you should talk to your doctor or pharmacist before taking any new over-the-counter product.

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Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - DEN0064

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