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  3. Desfine Sr 100Mg Tablet 10'S

Desfine Sr 100Mg Tablet 10'S, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Desfine Sr 100Mg Tablet is used to treat a major depressive disorder (depression). It contains Desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression. In some cases, you may experience certain common side effects such as nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

DESVENLAFAXINE-100MG

Manufacturer/Marketer :

Vrddhi Life Sciences

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Desfine Sr 100Mg Tablet

Desfine Sr 100Mg Tablet is used to treat a major depressive disorder (depression). Major depressive disorder, also known as clinical depression, is a mental health disorder characterised by a persistent and intense feeling of sadness for an extended duration of time. Symptoms include sadness, loss of interest, appetite changes, sleep problems, restlessness, lack of energy, feeling worthless or guilty, thoughts of harming oneself, difficulty concentrating, making decisions, and thinking.
 
Desfine Sr 100Mg Tablet contains desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression. 
 
You are advised to take Desfine Sr 100Mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition and response to the treatment. In some cases, you may experience certain common side effects such as nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders. Talk to your doctor if you experience these side effects persistently.
 
Please do not stop taking Desfine Sr 100Mg Tablet suddenly, as it might cause withdrawal symptoms. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. Avoid driving as Desfine Sr 100Mg Tablet may cause sleepiness and dizziness. Desfine Sr 100Mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Desfine Sr 100Mg Tablet as it could lead to increased sleepiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Desfine Sr 100Mg Tablet

Treatment of Depression

Directions for Use

• Desfine Sr 100Mg Tablet can be taken with or without food as advised by your doctor.• It is usually taken once a day or as directed by the doctor.• Swallow Desfine Sr 100Mg Tablet as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Desfine Sr 100Mg Tablet belongs to a group of antidepressant medicines indicated for the treatment of a major depressive disorder. Desfine Sr 100Mg Tablet works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps in regulating mood, and treats depression. 

How Desfine Sr 100Mg Tablet Works

Desfine Sr 100Mg Tablet contains desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression.

Storage

Keep Desfine Sr 100Mg Tablet out of reach and sight of children.
Side effects of Desfine Sr 100Mg Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
  • Include omega-3 rich foods like fatty fish, ground flax, flaxseed oil, and walnuts.
  • Consume calcium-rich dairy products for bone health.
  • Eat green and leafy vegetables for essential nutrients.
  • Include lean protein sources like eggs and whole grains.
  • Use herbs and spices for added flavor and nutrition.
  • Choose fortified foods for extra nutritional benefits.
  • Get plenty of sleep for overall health and well-being.

What if I have taken an overdose of Desfine Sr 100Mg Tablet

Do not take more than the prescribed dose of Desfine Sr 100Mg Tablet as it may cause overdose. The symptoms of overdose include drowsiness, coma, seizures, vomiting, agitation, hallucinations, fever, sweating, severe muscle stiffness or twitching, confusion, fast heartbeat, shivering, loss of coordination, fast/slow/irregular heartbeat, nausea, vomiting, or diarrhea. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Desfine Sr 100Mg Tablet if you are allergic to any of its contents; if you are taking linezolid, intravenous methylene blue, other serotonergic agents, monoamine oxidase inhibitors (MAOI) or have taken them in the last 14 days. Inform your doctor before taking Desfine Sr 100Mg Tablet if you have heart problems, hypotension, bipolar disorder, glaucoma, epilepsy, lung or breathing problems, bleeding problems, or low sodium levels in the blood. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. Desfine Sr 100Mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Desfine Sr 100Mg Tablet as it could lead to increased sleepiness and dizziness. 

Drug-Drug Interactions

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DesvenlafaxineSafinamide
Critical
DesvenlafaxineIsocarboxazid
Critical

Drug-Drug Interactions

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DesvenlafaxineSafinamide
Critical
How does the drug interact with Desfine Sr 100Mg Tablet:
Taking Safinamide with Desfine Sr 100Mg Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Desfine Sr 100Mg Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with Desfine Sr 100Mg Tablet:
Combining Isocarboxazid and Desfine Sr 100Mg Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and Desfine Sr 100Mg Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineTranylcypromine
Critical
How does the drug interact with Desfine Sr 100Mg Tablet:
Taking tranylcypromine with Desfine Sr 100Mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and Desfine Sr 100Mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineProcarbazine
Critical
How does the drug interact with Desfine Sr 100Mg Tablet:
Combining Procarbazine and Desfine Sr 100Mg Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and Desfine Sr 100Mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with Desfine Sr 100Mg Tablet and do not discontinue any medications without first consulting your doctor.
DesvenlafaxineRasagiline
Critical
How does the drug interact with Desfine Sr 100Mg Tablet:
Taking rasagiline with Desfine Sr 100Mg Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Desfine Sr 100Mg Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineLithium succinate
Severe
How does the drug interact with Desfine Sr 100Mg Tablet:
Coadministration of Lithium with Desfine Sr 100Mg Tablet may increase the levels and side effects of Desfine Sr 100Mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Desfine Sr 100Mg Tablet and Lithium succinate, you can take these medicines together if prescribed by your doctor. However, if you experience Headache, nausea, vomiting, diarrhea, constipation, dry mouth, increased sweating, decreased appetite, tremor, feeling nervous, restless, fatigue, or having trouble sleeping (insomnia), contact your doctor immediately. Do not discontinue any medications without first consulting your doctor. Do not stop using any medications without first talking to your doctor.
DesvenlafaxineBuspirone
Severe
How does the drug interact with Desfine Sr 100Mg Tablet:
When buspirone, is combined with Desfine Sr 100Mg Tablet it increases the risk of serotonin syndrome, (too much serotonin causes signs and symptoms that can range from mild (shivering and diarrhea) to severe (muscle rigidity, fever and seizures).

How to manage the interaction:
Co- administration of buspirone along with Desfine Sr 100Mg Tablet can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineCyclobenzaprine
Severe
How does the drug interact with Desfine Sr 100Mg Tablet:
Co-administration of cyclobenzaprine and Desfine Sr 100Mg Tablet might raise serotonin hormone levels which can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Cyclobenzaprine and Desfine Sr 100Mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any fever, excessive sweating, shivering, muscle spasm, stomach cramp, or vomiting, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxinePhenelzine
Severe
How does the drug interact with Desfine Sr 100Mg Tablet:
Co-administration of Phenelzine and Desfine Sr 100Mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Phenelzine and Desfine Sr 100Mg Tablet can lead to interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineNaratriptan
Severe
How does the drug interact with Desfine Sr 100Mg Tablet:
Co-administration of Naratriptan and Desfine Sr 100Mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Naratriptan and Desfine Sr 100Mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

  • Regularly attend therapy sessions.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Include foods rich in omega-fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.

  • Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters. 

  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.

  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improves mood, boosts self-esteem, and provides restful sleep.

  • Avoid smoking and alcohol consumption.

  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Desfine Sr 100Mg Tablet as it may cause increased sleepiness and dizziness.

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Pregnancy

Caution

Desfine Sr 100Mg Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning for pregnancy, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Desfine Sr 100Mg Tablet may pass into breastmilk. Consult your doctor before taking Desfine Sr 100Mg Tablet your doctor will decide whether Desfine Sr 100Mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Desfine Sr 100Mg Tablet causes sleepiness and dizziness. Do not drive or operate machinery.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Desfine Sr 100Mg Tablet should not be given to children as safety and effectiveness have not been established.

Have a query?

FAQs

Desfine Sr 100Mg Tablet is used to treat a major depressive disorder (depression).

Desfine Sr 100Mg Tablet works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain, which maintain mental balance, thereby regulating mood that treats depression.

Do not discontinue Desfine Sr 100Mg Tablet without consulting your doctor, as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking Desfine Sr 100Mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Desfine Sr 100Mg Tablet .

Desfine Sr 100Mg Tablet may cause decreased sex drive (libido) and problems with ejaculation and orgasm. Consult your doctor if you have any concerns regarding this.

Hypertension should be controlled before starting treatment with Desfine Sr 100Mg Tablet . Therefore, consult your doctor if you have high blood pressure. Regular monitoring of blood pressure levels is advised while taking Desfine Sr 100Mg Tablet .

Desfine Sr 100Mg Tablet may increase the chances of bleeding and bruising. The risk increases when Desfine Sr 100Mg Tablet is taken along with painkillers and blood thinners. Consult your doctor if you notice unusual bleeding or bruising.

When taken along with other medicines, Desfine Sr 100Mg Tablet may cause a rare but potentially life-threatening condition called serotonin syndrome. This condition causes changes in how the brain, blood vessels, muscles and digestive system work. Avoid taking Desfine Sr 100Mg Tablet along with MAOIs (used to treat depression), linezolid, intravenous methylene blue and other serotonergic agents.

Desfine Sr 100Mg Tablet may dilate your pupils (widen the dark centres of your eyes). This can trigger a glaucoma attack. Before taking Desfine Sr 100Mg Tablet , consult your doctor if you have glaucoma.

Desfine Sr 100Mg Tablet may cause seizures. If you’ve ever had a seizure, tell your doctor before taking Desfine Sr 100Mg Tablet .

Many people have sexual side effects when using antidepressants. Working together with your doctor will help you find a solution that addresses both your mental and sexual wellness.

You may have to take Desfine Sr 100Mg Tablet for several weeks before you begin to feel better.

Desfine Sr 100Mg Tablet can begin lowering anxiety symptoms in as little as one week, according to one clinical study. Generally, you'll start to feel the full effects after taking it for eight weeks.

Although Desfine Sr 100Mg Tablet is only officially allowed to treat depression, doctors frequently prescribe it to treat anxiety as well.

Take Desfine Sr 100Mg Tablet exactly as prescribed by your healthcare practitioner. Take Desfine Sr 100Mg Tablet once a day, about the same time every day. Desfine Sr 100Mg Tablet can be taken with or without food. Swallow Desfine Sr 100Mg Tablet pills whole and with drink.

It should be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.

Desfine Sr 100Mg Tablet works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance. Thus, it helps to treat depression.

Desfine Sr 100Mg Tablet doesn't typically cause weight gain for most people. In very rare case, people taking it experience weight changes (gain or loss) of less than 2 kgs.

Desfine Sr 100Mg Tablet may cause sexual dysfunction; however, men are more affected than women. If it happens to you, please seek medical attention from your doctor.

Common side effects of Desfine Sr 100Mg Tablet may include nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders.

Country of origin

India

Manufacturer/Marketer address

#2828, B Type , 67th Street , MMDA Mathur , Chennai - 600 068
Other Info - DES0163

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:41 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204150s005lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a608022.html#:~:text=Desvenlafaxine%20is%20used%20to%20treat,that%20help%20maintain%20mental%20balance
  3. https://www.drugs.com/mtm/desvenlafaxine.html
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