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  3. Deferataj 500mg Tablet DT

Deferataj 500mg Tablet DT, Pack of 1 Tablet
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Deferataj 500mg Tablet DT is used to treat iron overload due to transfusional hemosiderosis (the accumulation of iron in the body due to frequent blood transfusions) or non-transfusion-dependent thalassemia (patients who do not require lifelong regular transfusions for survival). It works by binding to the extra iron and facilitates its removal from the body through faeces. In some cases, this medicine may cause side effects like diarrhoea, vomiting, nausea, abdominal pain, and skin rashes.

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Composition :

DEFERASIROX-500MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Deferataj 500mg Tablet DT

Deferataj 500mg Tablet DT is used for treating chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients two years older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

The active ingredient in Deferataj 500mg Tablet DT is deferasirox, which binds the excess iron and eliminates it through faeces. The danger of organ damage is reduced as a result.

In some cases, you may experience common side effects such as diarrhoea, vomiting, nausea, abdominal pain, and skin rashes. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Avoid taking Deferataj 500mg Tablet DT if you are allergic to it. Do not use Deferataj 500mg Tablet DT without a doctor's advice if you have a skin reaction or irritation to any medicine. Consult your doctor before using the Deferataj 500mg Tablet DT if you are pregnant or breastfeeding. Do not use Deferataj 500mg Tablet DT in more than prescribed doses or for a longer duration as it may cause adverse effects. Keep your doctor informed about your health condition and all the medicines you take before taking Deferataj 500mg Tablet DT to rule out any side effects.

Uses of Deferataj 500mg Tablet DT

Deferataj 500mg Tablet DT is used for treating chronic iron overload that occurs due to blood transfusions. The detailed uses of Deferataj 500mg Tablet DT are as follows:

  • Transfusional hemosiderosis: Used for treating chronic iron overload that occurs due to blood transfusions in patients two years of age and older.
  • Non-transfusion-dependent thalassemia (NTDT): Deferataj 500mg Tablet DT can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia.

Directions for Use

  • Deferataj 500mg Tablet DT should be taken on an empty stomach, at least 30 minutes before a meal.
  • Follow your doctor's instructions on the dosage and timing of this medication. However, it is suggested to take Deferataj 500mg Tablet DT at the same time each day to maintain a consistent level of medicine in your body.
  • Swallow the whole Deferataj 500mg Tablet DT with a glass of water.
  • Do not break, chew, or crush it.

Medicinal Benefits

  • Deferasirox is the active component in Deferataj 500mg Tablet DT.
  • It's a chelating agent that selectively binds to trivalent iron.
  • It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

How Deferataj 500mg Tablet DT Works

The active ingredient in Deferataj 500mg Tablet DT is deferasirox. It is a trivalent iron-selective chelating agent. It binds the excess iron and eliminates it through faeces. The danger of organ damage is reduced as a result.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Deferataj 500mg Tablet DT
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

What if I have taken an overdose of Deferataj 500mg Tablet DT

Do not exceed the recommended dose, as it might cause an overdose. Overdose symptoms may include nausea, abdominal pain, vomiting, diarrhoea, and kidney/liver problems that might be serious. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Deferataj 500mg Tablet DT if you are allergic to Deferataj 500mg Tablet DT or its ingredients.
  • Deferataj 500mg Tablet DT is not usually recommended if you are a pregnant or lactating woman; there is not enough information to say whether it's safe.
  • It is unknown whether Deferataj 500mg Tablet DT alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.
  • Seek medical attention if the symptoms persist longer.
  • Avoid consuming alcohol along with Deferataj 500mg Tablet DT as it could lead to unpleasant side effects.
  • Should monitor elderly and paediatric patients closely for toxicity.

Drug-Drug Interactions

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DeferasiroxTicagrelor
Severe
DeferasiroxTenofovir alafenamide
Severe

Drug-Drug Interactions

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DeferasiroxTicagrelor
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Taking Deferataj 500mg Tablet DT together with ticagrelor may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Although taking ticagrelor and Deferataj 500mg Tablet DT together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as abdominal pain, bloating, dizziness, lightheadedness, loss of hunger, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools. Do not stop using any medications without consulting doctor.
DeferasiroxTenofovir alafenamide
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Tenofovir may cause kidney problems and combining it with Deferataj 500mg Tablet DT may increase that risk.

How to manage the interaction:
Although taking tenofovir and Deferataj 500mg Tablet DT together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
DeferasiroxSulfasalazine
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Coadministration of Deferataj 500mg Tablet DT and Sulfasalazine may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking sulfasalazine and Deferataj 500mg Tablet DT together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
DeferasiroxClozapine
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Taking Deferataj 500mg Tablet DT with Clozapine may increase the risk of infections.

How to manage the interaction:
Although taking Deferataj 500mg Tablet DT and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor. They may be able to recommend other options for you that won't cause any problems. Do not stop using any medications without a doctor's advice.
DeferasiroxFlurbiprofen
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Taking Flurbiprofen with Deferataj 500mg Tablet DT can increase the risk of gastrointestinal bleeding and peptic ulcer.

How to manage the interaction:
Co-administration of Flurbiprofen with Deferataj 500mg Tablet DT can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxPrednisolone
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Co-administration of Deferataj 500mg Tablet DT with Prednisolone can increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Although taking Deferataj 500mg Tablet DT with Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience stomach pain, bloating, dizziness, lightheadedness, loss of appetite, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools, you should consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DeferasiroxFludrocortisone
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Using Deferataj 500mg Tablet DT together with fludrocortisone may increase the risk of stomach ulcers and bleeding.

How to manage the interaction:
Co-administration of Fludrocortisone with Deferataj 500mg Tablet DT can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts. If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxPiroxicam
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Using Deferataj 500mg Tablet DT together with Piroxicam may increase the risk of ulcers.

How to manage the interaction:
Co-administration of Piroxicam with Deferataj 500mg Tablet DT can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxBacitracin
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Deferataj 500mg Tablet DT may cause kidney problems and combining it with bacitracin may increase that risk.

How to manage the interaction:
Although taking Bacitracin and Deferataj 500mg Tablet DT together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
DeferasiroxCapreomycin
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Deferataj 500mg Tablet DT may cause kidney problems and combining it with capreomycin may increase that risk.

How to manage the interaction:
Although taking Capreomycin and Deferataj 500mg Tablet DT together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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DEFERASIROX-500MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEFERASIROX-500MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
The blood levels and effects of caffeine may be enhanced by Deferataj 500mg Tablet DT. Avoid consumption of caffeinated drinks during the treatment with Deferataj 500mg Tablet DT. If you experience any unusual symptoms call a doctor.

Diet & Lifestyle Advise

  • Choose foods high in nutrients, such as fruits, vegetables, and whole grains.
  • Replace fatty protein sources with lean alternatives and consume modest quantities of healthy fat sources for improved well-being.
  • Create a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
  • Instead of saturated and trans fats, choose monounsaturated and polyunsaturated fats (fish, nuts, and vegetable oils).
  • Select/prepare foods and beverages with fewer added sugars/caloric sweeteners.
  • Be mindful of salt; consume no more than 2,300 mg each day.
  • Limit or avoid alcohol and caffeine consumption.

Habit Forming

No

Therapeutic Class

CHELATING AGENTS

Deferataj 500mg Tablet DT Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Consuming alcohol along with Deferataj 500mg Tablet DT is not advisable, as it may cause unpleasant side effects, or you also may become more sensitive to the effects of alcohol.

bannner image

Pregnancy

Consult your doctor

Deferataj 500mg Tablet DT is not usually recommended if you are pregnant. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks. Please consult the doctor.

bannner image

Breast Feeding

Consult your doctor

Deferataj 500mg Tablet DT is not usually recommended if you are a lactating woman. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks.

bannner image

Driving

Caution

It is not known whether Deferataj 500mg Tablet DT alters the ability to drive, so do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react.

bannner image

Liver

Caution

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Kidney

Caution

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Caution

Deferataj 500mg Tablet DT should be used under the supervision of healthcare provider

Have a query?

FAQs

Deferataj 500mg Tablet DT is used to treat chronic iron overload due to blood transfusions (transfusional hemosiderosis).

Deferasirox is the active component in Deferataj 500mg Tablet DT. It is a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.

Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose. Do not take a double dose to make up for the dose that you missed.

Deferataj 500mg Tablet DT is safe if used in the dose and duration recommended by your doctor. Take it precisely as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.

The extra iron due to iron overload is stored in pancreas. This damages the pancreas and it does not produce insulin properly. Insulin is required by the body to utilise sugar/glucose efficiently. As insulin is not produced properly, it affects blood sugar levels.

Yes, iron overload is the same as haemochromatosis. Hemochromatosis, or iron overload, is a condition in which your body stores too much iron.

Yes, Deferataj 500mg Tablet DT can be used in children above 2 years if prescribed by the doctor. Talk to the doctor if you have any concerns regarding this.

Deferataj 500mg Tablet DT may cause side effects like diarrhoea, vomiting, nausea, abdominal pain, skin rashes, and increased serum creatinine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

India
Other Info - DE73408

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 11, 2025 | 11:46 AM IST

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Reference

  1. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=207968
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/207968s009lbl.pdf
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