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  3. Dafi-S Tablet 10's

Dafi-S Tablet 10's, Pack of 10
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Dafi-S Tablet 10's is used in the reduction of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. It contains Diclofenac and Serratiopeptidase, which works by inhibiting the production od substnaces that cause pain and swelling at the injured or damaged tissue.Also, it helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue. It may cause common side effects like stomach pain, diarrhoea, nausea, and indigestion. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

DICLOFENAC-50MG + SERRATIOPEPTIDASE-10MG

Manufacturer/Marketer :

Sag Health Science Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Dafi-S Tablet 10's

Dafi-S Tablet 10's belongs to the class of drugs known as 'non-steroidal anti-inflammatory drug' (NSAID). It is a fixed-dose combination composed of diclofenac and serratiopeptidase. Pain can be temporary (acute) or lifelong (chronic) in nature. Acute pain is for short time caused by damage to the tissues of the muscle, bone, or organs. While, chronic pain lasts for life long caused due to nerve damage, osteoarthritis, and dental pain due to damage of the tooth nerve, infection, decay, extraction, or injury.

Dafi-S Tablet 10's is used in the reduction of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX) which causes pain and swelling at the injured or damaged tissue. Serratiopeptidase is a proteolytic enzyme which helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue.

You can take Dafi-S Tablet 10's with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on how often you take Dafi-S Tablet 10's based on your medical condition. Dafi-S Tablet 10's may have common side effects like stomach ache, diarrhoea, nausea (feeling sick), and indigestion. Most of these side effects of Dafi-S Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Do not take Dafi-S Tablet 10's if you are allergic to painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children. Dafi-S Tablet 10's may be associated with a small increased risk of heart attack ‘myocardial infarction. It is advisable not to exceed the recommended dose or duration of treatment.

Uses of Dafi-S Tablet 10's

Treatment of Post-traumatic pain, Low back pain, Cervical pain, Spondylitis, Osteoarthritis, Rheumatoid arthritis.

Directions for Use

• Dafi-S Tablet 10's can be taken with or without food. However, taking it with food may help reduce stomach upset.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Dafi-S Tablet 10's as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Dafi-S Tablet 10's plays a vital role in reducing pain and inflammation by blocking the release of chemical messengers which cause pain and fever. Dafi-S Tablet 10's relieves pain and inflammation in arthritic conditions with the benefit of increased antibiotic penetration and micro-circulation at the injury site. Serratiopeptidase present in Dafi-S Tablet 10's is a proteolytic enzyme which helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue.

How Dafi-S Tablet 10's Works

Dafi-S Tablet 10's is used in the reduction of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX) which causes pain and swelling at the injured or damaged tissue. Serratiopeptidase is a proteolytic enzyme which helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue.

Storage

Keep out of the sight and reach of children.
Side effects of Dafi-S Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Dafi-S Tablet 10's

Do not take more than the prescribed dose of Dafi-S Tablet 10's as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Consumption of alcohol should be avoided during the treatment with Dafi-S Tablet 10's as it may lead to an increase in the risk of liver damage. Patients with a stomach ulcer, gastric bleeding, severe heart failure, stroke, and hypertension (high blood pressure), should not take Dafi-S Tablet 10's. Besides this, it should be avoided during the last trimester of pregnancy, unless there are compelling reasons for doing so. If you have a severe allergy to pain killers and, complications like asthma, rhinitis, angioedema (swelling under the skin) or skin rashes, immediately stop taking Dafi-S Tablet 10's. Do not drive or operate heavy machinery as intake of Dafi-S Tablet 10's may cause dizziness. Patients who had recently undergone heart bypass surgery should take Dafi-S Tablet 10's with caution and only under medical supervision. Use of Dafi-S Tablet 10's is contraindicated in kidney failure patients or who are undergoing dialysis.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
DiclofenacTenofovir disoproxil
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Dafi-S Tablet:
Co-administration of Dafi-S Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Dafi-S Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
DiclofenacTenofovir disoproxil
Severe
How does the drug interact with Dafi-S Tablet:
Co-administration of Dafi-S Tablet with tenofovir disoproxil may increase the risk of developing kidney problems.

How to manage the interaction:
There may be a possible interaction between Dafi-S Tablet and Tenofovir disoproxil but they can be taken together if your doctor has prescribed them. However consult your doctor immediately if you experience symptoms such as such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
DiclofenacDasatinib
Severe
How does the drug interact with Dafi-S Tablet:
Taking Dasatinib together with Dafi-S Tablet may increase the risk of bleeding.

How to manage the interaction:
There may be a possible interaction between Dafi-S Tablet and Dasatinib but they can be taken together if a doctor has prescribed them. However, consult a doctor immediately if you experience dizziness, red or black, tarry stools, or severe headaches. Do not discontinue any medications without consulting a doctor.
DiclofenacLomitapide
Severe
How does the drug interact with Dafi-S Tablet:
Taking Dafi-S Tablet with Lomitapide will have an additive effect and may cause liver problems.

How to manage the interaction:
There may be a possible interaction between Dafi-S Tablet and Lomitapide, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
DiclofenacSirolimus
Severe
How does the drug interact with Dafi-S Tablet:
Co-administration of Dafi-S Tablet with Sirolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
Co-administration of Dafi-S Tablet and Sirolimus can lead to an interaction, but it can be taken if advised by a doctor. However, consult a doctor if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
DiclofenacIbuprofen
Severe
How does the drug interact with Dafi-S Tablet:
Taking Dafi-S Tablet and ibuprofen can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Dafi-S Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacOmacetaxine mepesuccinate
Severe
How does the drug interact with Dafi-S Tablet:
Taking Dafi-S Tablet with Omacetaxine mepesuccinate can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Dafi-S Tablet and Omacetaxine mepesuccinate but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding like dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headaches. Do not discontinue any medications without consulting your doctor.
DiclofenacOxaprozin
Severe
How does the drug interact with Dafi-S Tablet:
Taking Dafi-S Tablet and oxaprozin can increase the risk of side effects.

How to manage the interaction:
Co-administration of Dafi-S Tablet and oxaprozin can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacDabigatran etexilate
Severe
How does the drug interact with Dafi-S Tablet:
Concomitant use of Dafi-S Tablet with dabigatran may increase the risk of stomach bleeding.

How to manage the interaction:
Taking Dafi-S Tablet with dabigatran together possibly results in an interaction, it can be taken if your doctor has advised it. You should consult a doctor immediately if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness, light headedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness. Do not stop using any medications without first talking to your doctor.
DiclofenacBromfenac
Severe
How does the drug interact with Dafi-S Tablet:
Taking Dafi-S Tablet with bromfenac will have an additive effect and may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
There may be possible interaction between Dafi-S Tablet and bromfenac but you can take it if prescribed by a doctor. Consult your doctor if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulphate, Vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.

  • Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead you can do stretching, low impact aerobic exercise like walking on treadmill, bike riding and swimming. You can also strengthen your muscle strength by lifting light weights.

  • In chronic condition of arthritis or joint pain try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize level of chemical called cytokines, which ramp up inflammation.

  • Your sitting posture is important especially when have pain and inflammation conditions. Try to sit little as possible, and only for short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a foot rest if required.

Habit Forming

No

Therapeutic Class

ANALGESICS

Dafi-S Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

You are recommended not to consume alcohol along with Dafi-S Tablet 10's to avoid unpleasant side-effects.

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Pregnancy

Caution

Please inform your doctor if you are pregnant or planning to become pregnant before taking Dafi-S Tablet 10's.

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Breast Feeding

Caution

Dafi-S Tablet 10's may pass into the breast milk. Consult your doctor for more information on this if you are a breastfeeding mother.

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Driving

Caution

Dafi-S Tablet 10's may affect driving as it causes dizziness. Drive or operate machinery only when you are alert.

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Liver

Caution

Dafi-S Tablet 10's to be taken with caution, especially if you have a history of liver diseases/conditions. Dose may have to be adjusted by your doctor.

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Kidney

Caution

Dafi-S Tablet 10's to be taken with caution if you have a history of kidney diseases/conditions. Dose may have to be adjusted by your doctor.

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Children

Caution

Dafi-S Tablet 10's is not recommended for children under 10 years of age. For them dose has to be adjusted and recommended by a child specialist only.

Have a query?

FAQs

Dafi-S Tablet 10's is used in the treatment of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain.

Dafi-S Tablet 10's when taken by patients who are allergic to pain-killers can be harmful. It should also be avoided in person with history of heart failure, kidney or liver disease, stomach ulcers and high blood pressure.

You should only take Dafi-S Tablet 10's if doctor has prescribed you. The maximum recommended dose of Dafi-S Tablet 10's is twice daily. Dafi-S Tablet 10's can be one in the morning and one in the evening.

Rheutamoid arthritis is an autoimmune disease that causes chronic inflammation and pain of the joints.

Ankylosing spondylitis is a arthritis of the spine which can lead to the fusion of the vertebrae, lead to pain and inflammation in the spine.

Yes, Dafi-S Tablet 10's can cause stomach upset. So, it should be preferably taken with food to avoid it.

Dafi-S Tablet 10's should be stored in a cool and dry place, away from direct sunlight. Keep the medicine out of reach of children.

Dafi-S Tablet 10's is generally safe when used as directed by your doctor for short-term pain and inflammation relief. However, you should not use Dafi-S Tablet 10's if you have a stomach ulcer, gastric bleeding, severe heart failure, stroke, hypertension (high blood pressure), kidney failure, or if you are undergoing dialysis.

Yes, you can stop taking Dafi-S Tablet 10's once your pain is relieved, but only after consulting your doctor. It is recommended to follow your doctor's advice on the duration and dosage of Dafi-S Tablet 10's, as stopping the medication too early could affect your recovery.

Yes, the use of Dafi-S Tablet 10's can cause nausea and vomiting as side effects. Taking it with food may help prevent nausea. If you experience vomiting, try drinking small sips of water or other fluids frequently. If these symptoms persist, please consult your doctor.

Yes, the use of Dafi-S Tablet 10's may cause dizziness as a side effect in some individuals. Avoid driving or operating machinery if you experience dizziness. If dizziness persists, please consult your doctor.

Yes, Dafi-S Tablet 10's is contraindicated in patients who are allergic to any of its components, those with kidney failure, or those undergoing dialysis. It should not be taken by patients with a stomach ulcer, gastric bleeding, severe heart failure, stroke, or hypertension (high blood pressure). Also, it should be avoided during the last trimester of pregnancy. Please consult your doctor if you have any concerns while using Dafi-S Tablet 10's.

No, Dafi-S Tablet 10's is not generally recommended for stomach pain. In fact, it may cause stomach upset, ulcers, or bleeding. If you have stomach pain, please consult your doctor for a proper diagnosis and treatment.

Yes, long-term or high-dose use of Dafi-S Tablet 10's, a nonsteroidal anti-inflammatory drug (NSAID), can potentially damage the kidneys. Regular monitoring and caution are advised when using Dafi-S Tablet 10's, especially in individuals with existing kidney disease. Please consult your doctor before using Dafi-S Tablet 10's.

Yes, Dafi-S Tablet 10's can be taken on an empty stomach, but it is generally advisable to take Dafi-S Tablet 10's with food to reduce the risk of side effects. Always follow your doctor's instructions when taking Dafi-S Tablet 10's.

Dafi-S Tablet 10's is generally not recommended for children under 10 years of age unless prescribed by a doctor. Always consult a paediatrician before giving Dafi-S Tablet 10's to a child, as the dosage may need to be adjusted for them.

Dafi-S Tablet 10's is intended for short-term use only, as it may potentially cause side effects such as gastrointestinal or cardiovascular issues. Always follow your doctor's advice regarding the duration and dosage.

No, it is generally not recommended to consume alcohol while taking Dafi-S Tablet 10's as it may increase the risk of side effects, such as stomach irritation, ulcers, and bleeding. Your doctor may advise you to limit or avoid alcohol consumption while taking Dafi-S Tablet 10's.

Country of origin

India

Manufacturer/Marketer address

487/35, National Market, Peeragarhi, New Delhi-110087, Delhi, India
Other Info - DAF0070

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:33 AM IST

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Reference

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149131/
  2. https://www.medicines.org.uk/emc/files/pil.2660.pdf
  3. https://www.sciencedirect.com/science/article/pii/S181808761630160X
  4. https://vibcare.co.in/diclofenac-serratiopeptidase/

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