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  3. Serapep-D Tablet 10's

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Serapep-D Tablet 10's, Pack of 10 TabletS
Serapep-D Tablet 10's, Pack of 10 TabletS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Serapep-D Tablet is used in the reduction of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. It contains Diclofenac and Serratiopeptidase, which works by inhibiting the production od substnaces that cause pain and swelling at the injured or damaged tissue.Also, it helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue. It may cause common side effects like stomach pain, diarrhoea, nausea, and indigestion. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

DICLOFENAC-50MG + SERRATIOPEPTIDASE-10MG

Manufacturer/Marketer :

Isis Healthcare India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Serapep-D Tablet

Serapep-D Tablet belongs to the class of drugs known as 'non-steroidal anti-inflammatory drug' (NSAID). It is a fixed-dose combination composed of diclofenac and serratiopeptidase. Pain can be temporary (acute) or lifelong (chronic) in nature. Acute pain is for short time caused by damage to the tissues of the muscle, bone, or organs. While, chronic pain lasts for life long caused due to nerve damage, osteoarthritis, and dental pain due to damage of the tooth nerve, infection, decay, extraction, or injury.

Serapep-D Tablet is used in the reduction of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX) which causes pain and swelling at the injured or damaged tissue. Serratiopeptidase is a proteolytic enzyme which helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue.

You can take Serapep-D Tablet with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on how often you take Serapep-D Tablet based on your medical condition. Serapep-D Tablet may have common side effects like stomach ache, diarrhoea, nausea (feeling sick), and indigestion. Most of these side effects of Serapep-D Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Do not take Serapep-D Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children. Serapep-D Tablet may be associated with a small increased risk of heart attack ‘myocardial infarction. It is advisable not to exceed the recommended dose or duration of treatment.

Uses of Serapep-D Tablet

Treatment of Post-traumatic pain, Low back pain, Cervical pain, Spondylitis, Osteoarthritis, Rheumatoid arthritis.

Have a query?

Directions for Use

• Serapep-D Tablet can be taken with or without food. However, taking it with food may help reduce stomach upset.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Serapep-D Tablet as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Serapep-D Tablet plays a vital role in reducing pain and inflammation by blocking the release of chemical messengers which cause pain and fever. Serapep-D Tablet relieves pain and inflammation in arthritic conditions with the benefit of increased antibiotic penetration and micro-circulation at the injury site. Serratiopeptidase present in Serapep-D Tablet is a proteolytic enzyme which helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue.

How Serapep-D Tablet Works

Serapep-D Tablet is used in the reduction of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX) which causes pain and swelling at the injured or damaged tissue. Serratiopeptidase is a proteolytic enzyme which helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue.

Storage

Keep out of the sight and reach of children.
Side effects of Serapep-D Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Serapep-D Tablet

Do not take more than the prescribed dose of Serapep-D Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Consumption of alcohol should be avoided during the treatment with Serapep-D Tablet as it may lead to an increase in the risk of liver damage. Patients with a stomach ulcer, gastric bleeding, severe heart failure, stroke, and hypertension (high blood pressure), should not take Serapep-D Tablet . Besides this, it should be avoided during the last trimester of pregnancy, unless there are compelling reasons for doing so. If you have a severe allergy to pain killers and, complications like asthma, rhinitis, angioedema (swelling under the skin) or skin rashes, immediately stop taking Serapep-D Tablet . Do not drive or operate heavy machinery as intake of Serapep-D Tablet may cause dizziness. Patients who had recently undergone heart bypass surgery should take Serapep-D Tablet with caution and only under medical supervision. Use of Serapep-D Tablet is contraindicated in kidney failure patients or who are undergoing dialysis.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
DiclofenacFurosemide
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Serapep-D Tablet:
Co-administration of Serapep-D Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Serapep-D Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
DiclofenacFurosemide
Severe
How does the drug interact with Serapep-D Tablet:
Concomitant administration of Serapep-D Tablet and furosemide may decrease the therapeutic efficacy of furosemide and adversely affect renal function.

How to manage the interaction:
There may be a possible interaction between Serapep-D Tablet and furosemide, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms like nausea, dizziness, irregular heartbeats, altered blood pressure, tingling. Do not stop using any medications without first talking to your doctor.
DiclofenacRamucirumab
Severe
How does the drug interact with Serapep-D Tablet:
Co-administration of Serapep-D Tablet and Ramucirumab can cause bleeding and ulcers.

How to manage the interaction:
Co-administration of Serapep-D Tablet and Ramucirumab can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacTenofovir alafenamide
Severe
How does the drug interact with Serapep-D Tablet:
Co-administration of Serapep-D Tablet and tenofovir alafenamide may cause kidney problems.

How to manage the interaction:
There may be a possible interaction between Serapep-D Tablet and Tenofovir alafenamide but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms such as such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
DiclofenacTolmetin
Severe
How does the drug interact with Serapep-D Tablet:
Taking Serapep-D Tablet with Tolmetin may increase the risk of side effects.

How to manage the interaction:
There may be a possible interaction between Serapep-D Tablet and Tolmetin but can be taken if prescribed by doctor. However, consult your doctor immediately if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medications without consulting a doctor.
DiclofenacSirolimus
Severe
How does the drug interact with Serapep-D Tablet:
Co-administration of Serapep-D Tablet with Sirolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
Co-administration of Serapep-D Tablet and Sirolimus can lead to an interaction, but it can be taken if advised by a doctor. However, consult a doctor if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
DiclofenacIbuprofen
Severe
How does the drug interact with Serapep-D Tablet:
Taking Serapep-D Tablet and ibuprofen can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Serapep-D Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacPonatinib
Severe
How does the drug interact with Serapep-D Tablet:
Taking Serapep-D Tablet with Ponatinib can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Serapep-D Tablet and Ponatinib, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headaches. Do not discontinue any medications without consulting your doctor.
DiclofenacIndometacin
Severe
How does the drug interact with Serapep-D Tablet:
The combined use of Serapep-D Tablet and Indomethacin can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Serapep-D Tablet and Indomethacin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacAmiloride
Severe
How does the drug interact with Serapep-D Tablet:
Taking amiloride with Serapep-D Tablet can increase the risk of kidney problems, hyperkalemia(high potassium levels in blood), and high blood pressure.

How to manage the interaction:
There could be a possible interaction between Serapep-D Tablet and amiloride, but they can be taken together if your doctor has prescribed them. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulphate, Vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.

  • Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead you can do stretching, low impact aerobic exercise like walking on treadmill, bike riding and swimming. You can also strengthen your muscle strength by lifting light weights.

  • In chronic condition of arthritis or joint pain try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize level of chemical called cytokines, which ramp up inflammation.

  • Your sitting posture is important especially when have pain and inflammation conditions. Try to sit little as possible, and only for short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a foot rest if required.

Habit Forming

No

Therapeutic Class

ANALGESICS

Serapep-D Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

You are recommended not to consume alcohol along with Serapep-D Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

Please inform your doctor if you are pregnant or planning to become pregnant before taking Serapep-D Tablet .

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Breast Feeding

Caution

Serapep-D Tablet may pass into the breast milk. Consult your doctor for more information on this if you are a breastfeeding mother.

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Driving

Caution

Serapep-D Tablet may affect driving as it causes dizziness. Drive or operate machinery only when you are alert.

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Liver

Caution

Serapep-D Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Dose may have to be adjusted by your doctor.

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Kidney

Caution

Serapep-D Tablet to be taken with caution if you have a history of kidney diseases/conditions. Dose may have to be adjusted by your doctor.

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Children

Caution

Serapep-D Tablet is not recommended for children under 10 years of age. For them dose has to be adjusted and recommended by a child specialist only.

FAQs

Serapep-D Tablet is used in the treatment of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain.

Serapep-D Tablet when taken by patients who are allergic to pain-killers can be harmful. It should also be avoided in person with history of heart failure, kidney or liver disease, stomach ulcers and high blood pressure.

You should only take Serapep-D Tablet if doctor has prescribed you. The maximum recommended dose of Serapep-D Tablet is twice daily. Serapep-D Tablet can be one in the morning and one in the evening.

Rheutamoid arthritis is an autoimmune disease that causes chronic inflammation and pain of the joints.

Ankylosing spondylitis is a arthritis of the spine which can lead to the fusion of the vertebrae, lead to pain and inflammation in the spine.

Yes, Serapep-D Tablet can cause stomach upset. So, it should be preferably taken with food to avoid it.

Serapep-D Tablet should be stored in a cool and dry place, away from direct sunlight. Keep the medicine out of reach of children.

Serapep-D Tablet is generally safe when used as directed by your doctor for short-term pain and inflammation relief. However, you should not use Serapep-D Tablet if you have a stomach ulcer, gastric bleeding, severe heart failure, stroke, hypertension (high blood pressure), kidney failure, or if you are undergoing dialysis.

Yes, you can stop taking Serapep-D Tablet once your pain is relieved, but only after consulting your doctor. It is recommended to follow your doctor's advice on the duration and dosage of Serapep-D Tablet , as stopping the medication too early could affect your recovery.

Yes, the use of Serapep-D Tablet can cause nausea and vomiting as side effects. Taking it with food may help prevent nausea. If you experience vomiting, try drinking small sips of water or other fluids frequently. If these symptoms persist, please consult your doctor.

Yes, the use of Serapep-D Tablet may cause dizziness as a side effect in some individuals. Avoid driving or operating machinery if you experience dizziness. If dizziness persists, please consult your doctor.

Yes, Serapep-D Tablet is contraindicated in patients who are allergic to any of its components, those with kidney failure, or those undergoing dialysis. It should not be taken by patients with a stomach ulcer, gastric bleeding, severe heart failure, stroke, or hypertension (high blood pressure). Also, it should be avoided during the last trimester of pregnancy. Please consult your doctor if you have any concerns while using Serapep-D Tablet .

No, Serapep-D Tablet is not generally recommended for stomach pain. In fact, it may cause stomach upset, ulcers, or bleeding. If you have stomach pain, please consult your doctor for a proper diagnosis and treatment.

Yes, long-term or high-dose use of Serapep-D Tablet , a nonsteroidal anti-inflammatory drug (NSAID), can potentially damage the kidneys. Regular monitoring and caution are advised when using Serapep-D Tablet , especially in individuals with existing kidney disease. Please consult your doctor before using Serapep-D Tablet .

Yes, Serapep-D Tablet can be taken on an empty stomach, but it is generally advisable to take Serapep-D Tablet with food to reduce the risk of side effects. Always follow your doctor's instructions when taking Serapep-D Tablet .

Serapep-D Tablet is generally not recommended for children under 10 years of age unless prescribed by a doctor. Always consult a paediatrician before giving Serapep-D Tablet to a child, as the dosage may need to be adjusted for them.

Serapep-D Tablet is intended for short-term use only, as it may potentially cause side effects such as gastrointestinal or cardiovascular issues. Always follow your doctor's advice regarding the duration and dosage.

No, it is generally not recommended to consume alcohol while taking Serapep-D Tablet as it may increase the risk of side effects, such as stomach irritation, ulcers, and bleeding. Your doctor may advise you to limit or avoid alcohol consumption while taking Serapep-D Tablet .

Country of origin

India

Manufacturer/Marketer address

No 49, 50L, Whites Rd, Express Estate, Royapettah, Chennai, Tamil Nadu 600002
Other Info - SER0103

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:33 AM IST

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Reference

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149131/
  2. https://www.medicines.org.uk/emc/files/pil.2660.pdf
  3. https://www.sciencedirect.com/science/article/pii/S181808761630160X
  4. https://vibcare.co.in/diclofenac-serratiopeptidase/

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