Apollo
logo

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
Select Delivery Location
compositionComposition:CAPECITABINE-400MG+CYCLOPHOSPHAMIDE-20MG
prescription
Prescription Medicine
info
image icons
image icons
image icons
Best Price

₹583 with coupons & bank offers*

View

Comcapsy 400 mg/20 mg Tablet is an antineoplastic (anticancer) medication used to treat metastatic breast cancer. It contains Capecitabine and Cyclophosphamide, which work by damaging the genetic material of cancer cells and stopping their growth and multiplication. It may sometimes cause common side effects, such as nausea, vomiting, loss of appetite, diarrhoea, stomach pain, skin rash, weakness, tiredness, fever, mouth sores, and hair loss. Before taking this medication, inform your doctor if you are allergic to any of its ingredients or other cancer medicines, are pregnant or breastfeeding, or have any pre-existing medical conditions.

Read more
Written By ,
Reviewed By Praneetha Akunuri , M.Pharmacy
OffersOffers & Discounts

Get Free delivery (₹99) with circle icon

Join Circle
coupon
Get Extra 18% Off with Coupons
coupon
Extra 10% Off with Bank Offers
bank offer
bank offer
bank offer

More about the Product

Composition :

CAPECITABINE-400MG+CYCLOPHOSPHAMIDE-20MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Comcapsy 400 mg/20 mg Tablet

Comcapsy 400 mg/20 mg Tablet is a prescription medication used to treat certain types of cancer, most commonly advanced or metastatic breast cancer. It combines two active anticancer medicines to help slow down or stop the growth of cancer cells in your body. This medicine is typically prescribed when other standard treatments may not have worked or as part of a specific combination plan.

You will typically take Comcapsy 400 mg/20 mg Tablet in repeating treatment cycles, which involve taking the medicine daily for a set period followed by a rest period. It is important to take this medicine consistently at the same times each day, usually within 30 minutes after finishing a meal, to ensure proper absorption and reduce stomach upset. Drinking plenty of fluids and maintaining a balanced, easy-to-digest diet are key lifestyle adjustments that help your body manage this treatment.

While taking Comcapsy 400 mg/20 mg Tablet, you may experience common side effects such as nausea, tiredness, diarrhoea, or temporary skin changes on your hands and feet. If you notice more severe symptoms, such as severe watery diarrhoea, a high fever, severe skin peeling, or unusual bruising, you must contact your doctor immediately.

Before starting Comcapsy 400 mg/20 mg Tablet, tell your doctor if you have a history of kidney disease, liver damage, heart problems, or a specific enzyme deficiency (DPD deficiency). Do not take this if you are pregnant, planning to become pregnant, or have had severe allergic reactions to either of the active components in this medicine.

This medicine can interact with blood thinners, certain antacids, and alcohol, which can increase your risk of severe bleeding, stomach irritation, or liver strain. Pregnant or breastfeeding women must not take Comcapsy 400 mg/20 mg Tablet because it can harm an unborn baby or nursing infant, while elderly patients may require closer monitoring due to a higher risk of side effects like dehydration.

Uses of Comcapsy 400 mg/20 mg Tablet

Uses of Comcapsy 400 mg/20 mg Tablet may include:

  • Advanced or metastatic breast cancer: Comcapsy 400 mg/20 mg Tablet helps by shrinking tumours or slowing their growth when the cancer has spread to other parts of the body.
  • Other advanced cancers: In some clinical cases, doctors may prescribe Comcapsy 400 mg/20 mg Tablet to manage specific solid tumours that have not responded to other chemotherapy options.

Key Benefits

Comcapsy 400 mg/20 mg Tablet is a combination chemotherapy used to treat certain cancers. Capecitabine is converted in the body to 5-fluorouracil, while cyclophosphamide interferes with the growth and multiplication of cancer cells.

  • Helps Control Cancer Growth: The combination works through different mechanisms to damage or inhibit rapidly dividing cancer cells, helping control tumour growth.
  • May Reduce Tumour Burden: By targeting cancer cells, treatment may help shrink tumours or slow their progression in cancers that are responsive to the combination.
  • Helps Manage Advanced Cancer: Effective treatment may help control disease progression and, depending on the cancer and treatment goal, may help relieve symptoms caused by tumour growth.
  • Offers Oral Treatment Convenience: Capecitabine is taken by mouth, which may reduce the need for some intravenous chemotherapy visits and allow part of the treatment to be managed at home as prescribed.
  • Provides Combination Therapy: Using medicines that act differently can provide a broader approach to cancer treatment and may improve tumour control in appropriate patients.
Side effects of Comcapsy 400 mg/20 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
  • Stay hydrated to support kidney and bladder health.
  • Rest on your back as advised by your doctor.
  • Limit physical strain for 1-2 weeks.
  • Avoid strenuous activities like running and contact sports.
  • Quit smoking to improve overall health.
  • Use pain medication responsibly.
  • Avoid foods that can irritate the urinary track, such as spicy or acidic foods.
  • Remember to consult your doctor for personalized advice and guidance on managing your symptoms and developing a treatment plan.

Directions for Use

  • Take Comcapsy 400 mg/20 mg Tablet within 30 minutes after meals or as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Swallow Comcapsy 400 mg/20 mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Comcapsy 400 mg/20 mg Tablet Works

Comcapsy 400 mg/20 mg Tablet contains capecitabine and cyclophosphamide. It combines two different anticancer strategies to target cancer cells and prevent them from multiplying. The first active component, capecitabine, is an antimetabolite. Once inside the body, it is converted into an active cancer-fighting substance, particularly within tumour tissue. It interferes with the production of DNA by mimicking natural building blocks needed by cells. This prevents cancer cells from copying their DNA properly, stopping them from dividing and eventually causing cell death. The second active component, cyclophosphamide, is an alkylating agent. It works by forming chemical links between DNA strands inside cancer cells. This damages the DNA and prevents the cells from replicating and repairing themselves, ultimately leading to their death. Together, these two active components target cancer cells through different mechanisms, helping slow tumour growth and prevent the cancer from spreading.
bannner image

Alcohol

Caution

It is unknown whether alcohol interacts with Comcapsy 400 mg/20 mg Tablet. However, it is advisable not to consume alcohol as a precautionary measure.

bannner image

Pregnancy

Unsafe

Comcapsy 400 mg/20 mg Tablet should not be used during pregnancy, as it may cause harmful effects on the baby. You are advised to avoid pregnancy by using birth control pills during treatment with Comcapsy 400 mg/20 mg Tablet and for 6 months after your last dose.

bannner image

Breast Feeding

Unsafe

Comcapsy 400 mg/20 mg Tablet should not be taken during breastfeeding, as it passes into the breast milk and may harm the baby. You are advised to stop breastfeeding during treatment with Comcapsy 400 mg/20 mg Tablet and for 2 weeks after your last dose.

bannner image

Driving

Caution

Comcapsy 400 mg/20 mg Tablet may cause dizziness and vision problems. Therefore, avoid driving and operating machines until you are fully alert.

bannner image

Liver

Caution

Comcapsy 400 mg/20 mg Tablet may sometimes cause harm to the liver or increase bilirubin levels in the blood. If you have a history of liver disease, please inform your doctor before taking Comcapsy 400 mg/20 mg Tablet. Your doctor may need to adjust the dose of Comcapsy 400 mg/20 mg Tablet.

bannner image

Kidney

Caution

Comcapsy 400 mg/20 mg Tablet may sometimes cause harm to the kidney. If you have a history of kidney disease, please inform your doctor before taking Comcapsy 400 mg/20 mg Tablet. Your doctor may need to adjust the dose of Comcapsy 400 mg/20 mg Tablet.

bannner image

Children

Unsafe

Comcapsy 400 mg/20 mg Tablet should not be used by children under 12 years, as its safety and effectiveness have not been established in this age group.

bannner image

Heart

Consult your doctor

Please inform your doctor if you have a heart problem before using Comcapsy 400 mg/20 mg Tablet.

bannner image

Geriatrics

Consult your doctor

Please consult your doctor before giving Comcapsy 400 mg/20 mg Tablet to elderly people. Your doctor will prescribe Comcapsy 400 mg/20 mg Tablet if the benefits outweigh the risk.

What if I have taken an overdose of Comcapsy 400 mg/20 mg Tablet

If you take more than your prescribed dose of Comcapsy 400 mg/20 mg Tablet, seek immediate medical attention or contact a poison control centre right away. An overdose can cause severe stomach issues, low blood counts, or other serious complications.

Diet & Lifestyle Advise

  • Stay well hydrated: Drink 8 to 10 glasses of water or clear fluids daily to protect your kidneys and prevent dehydration caused by diarrhoea or vomiting.
  • Protect your hands and feet: Avoid friction and extreme heat on your hands and feet. Use a gentle, alcohol-free moisturiser, wear loose-fitting shoes, and avoid hot showers to minimise the risk of hand-foot syndrome.
  • Practice strict food hygiene: Because this medicine can lower your white blood cell count, avoid raw or undercooked foods, unpasteurized dairy, and wash fruits and vegetables thoroughly to prevent infections.
  • Protect your skin from the sun: Comcapsy 400 mg/20 mg Tablet can make your skin more sensitive to sunlight. Wear protective clothing and apply a broad-spectrum sunscreen when outdoors.
health query

Have a query?

How Soon It Starts Working

The time required for Comcapsy 400 mg/20 mg Tablet to start to work: Comcapsy 400 mg/20 mg Tablet shows its action within a few hours to a few days of administration. The time for which the effects of Comcapsy 400 mg/20 mg Tablet last: The duration of Comcapsy 400 mg/20 mg Tablet effect is clinically unknown.

What if you forget to take Comcapsy 400 mg/20 mg Tablet

If you miss a dose of Comcapsy 400 mg/20 mg Tablet, skip the missed dose and take your next scheduled dose at your regular time. Do not take a double dose to make up for the missed one. Note the missed dose and let your healthcare team know at your next contact.

Storage

•Store Comcapsy 400 mg/20 mg Tablet tablets at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect your medicine: Check your tablets before every dose. Do not take any tablet that is broken, chipped, or showing signs of discolouration.
  • Use effective barrier birth control: Both men and women taking Comcapsy 400 mg/20 mg Tablet must use highly effective barrier contraception during treatment and for several months after the final dose to prevent pregnancy, as this medicine can cause severe birth defects.
  • Check your temperature daily: Keep a reliable thermometer at home. A fever is a medical emergency when your immune system is suppressed by this medication.
  • Keep up with regular blood tests: You must attend all scheduled appointments for blood work, as your doctor needs to monitor your kidney function, liver health, and blood cell counts regularly.
  • Avoid vaccines unless approved: Do not receive any live vaccines (such as the shingles or yellow fever vaccines) while taking this medicine without checking with your doctor first.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor about all medicines you are taking before starting Comcapsy 400 mg/20 mg Tablet:

  • Blood thinners (like warfarin): Taking Comcapsy 400 mg/20 mg Tablet alongside blood thinners can significantly increase your risk of severe bleeding. Your clotting times will need to be monitored very closely.
  • Phenytoin (seizure medicine): Comcapsy 400 mg/20 mg Tablet may increase the levels of phenytoin in your body, raising the risk of phenytoin toxicity.
  • Certain antacids (containing aluminium or magnesium): Taking these antacids at the same time as Comcapsy 400 mg/20 mg Tablet can alter how the medicine is absorbed, potentially increasing its side effects.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

Login/Sign Up

Drug-Food Interactions

verifiedApollotooltip

Inform your doctor about your usual diet and alcohol consumption before starting Comcapsy 400 mg/20 mg Tablet:

  • Alcohol: Avoid alcohol while taking Comcapsy 400 mg/20 mg Tablet as it can worsen stomach irritation, increase dehydration, and place extra stress on your liver.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Comcapsy 400 mg/20 mg Tablet is an anticancer medication primarily used to treat metastatic breast cancer. It is also used in combination with other medicines to treat various types of cancer, as advised by a doctor, including colorectal, colon, stomach, pancreatic, and ovarian cancer.
Comcapsy 400 mg/20 mg Tablet contains two anticancer medications: Capecitabine (an antimetabolite) and Cyclophosphamide (an alkylating agent). Both drugs exhibit potential synergistic effects; Cyclophosphamide boosts the activity of an enzyme (thymidine phosphorylase) that helps convert Capecitabine into its active form, 5-fluorouracil. They work by damaging the genetic material of cancer cells to stop their growth and multiplication. Thus, Comcapsy 400 mg/20 mg Tablet helps treat cancer by killing cancer cells.
Comcapsy 400 mg/20 mg Tablet may cause common side effects such as nausea, vomiting, loss of appetite, diarrhoea, stomach pain, skin rash, weakness, tiredness, mouth sores, hair loss, fever, low blood cell count, and hand-foot syndrome (swelling, redness, and peeling on palms and soles). If you experience any of these side effects, do not hesitate to report them clearly to your doctor. Your doctor may suggest lifestyle changes, medications, and supportive therapies to help reduce discomfort and improve your quality of life.
Do not stop taking Comcapsy 400 mg/20 mg Tablet on your own without consulting your doctor, as it can affect your treatment and recovery. You are advised to take Comcapsy 400 mg/20 mg Tablet for as long as your doctor has prescribed it, depending on your medical condition, for effective treatment of cancer.
Yes, Comcapsy 400 mg/20 mg Tablet may impair fertility by temporarily stopping sperm production in men and disrupting normal menstrual periods in women. Therefore, consult your doctor for advice before taking Comcapsy 400 mg/20 mg Tablet if you are planning to have a child. Also, it is important to use birth control pills while taking Comcapsy 400 mg/20 mg Tablet and for 6 months after your last dose to prevent pregnancy.
Comcapsy 400 mg/20 mg Tablet might cause myelosuppression (reduced bone marrow function) leading to a decrease in white blood cells. This could lead to an increased risk of infections. You are advised to get regular blood tests while taking Comcapsy 400 mg/20 mg Tablet.
Yes, Comcapsy 400 mg/20 mg Tablet contains two chemotherapy medicines: Capecitabine, which is an antimetabolite, and Cyclophosphamide, which is an alkylating agent. They work by destroying cancer cells.
Comcapsy 400 mg/20 mg Tablet may cause weight loss due to decreased appetite and may also be a result of the underlying cancer. Please consult your doctor if you experience significant weight loss while using Comcapsy 400 mg/20 mg Tablet.
No, you must not crush, chew, or split Comcapsy 400 mg/20 mg Tablet tablets. They must be swallowed whole to make sure you get the correct dose safely and to prevent exposure to chemotherapy dust. If you have trouble swallowing tablets, talk to your doctor or pharmacist.
Do not take another dose to replace the one you threw up. Simply wait and take your next scheduled dose at your regular time. Let your healthcare team know right away if you are struggling with nausea or vomiting. Talk to your doctor or pharmacist.
Taking Comcapsy 400 mg/20 mg Tablet after food helps your body absorb the medicine properly and reduces stomach irritation and nausea. Always try to take it after breakfast and dinner. Talk to your doctor or pharmacist.
It is highly recommended to avoid alcohol during your treatment. Alcohol can increase your risk of liver damage, cause dehydration, and worsen stomach side effects like nausea. Talk to your doctor or pharmacist.
Many patients can continue working, but it depends heavily on how you feel, your energy levels, and the type of work you do. Because this medicine can lower your immune system, you should avoid close contact with sick people. Talk to your doctor or pharmacist.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Center for Biotechnology Information (NCBI). Main Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Capecitabine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 020896S037Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Cyclophosphamide Oral And Injection Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  6. Mayo Clinic Staff. Syc 20352470 Inhalation and Dosage Monograph. Rochester, MN: Mayo Foundation for Medical Education; 2025. [Accessed on 02 Jun. 2026]Check here
  7. 1. Gupta S, Biswas G, Babu S, et al. Fixed dose combination of capecitabine and cyclophosphamide in metastatic breast cancer: Results from THE ENCLOSE phase 2/3 randomized multicenter study. The Breast. 2021;60:147-154Check here

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - COM0735
whatsapp Floating Button
Buy Now
Add to Cart