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compositionComposition:CLOBAZAM-5MG
prescription
Prescription Medicine
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Clobium Suspension is used to treat epilepsy (fits) in children aged 2 years and above. It stabilises the electrical activity of nerve cells in the brain and prevents fits. Some children may experience side effects such as restlessness, irritability, drowsiness, constipation, tiredness, appetite changes or breathing problems.

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Written By ,
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

CLOBAZAM-5MG

Manufacturer/Marketer :

Icon Life Sciences

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Clobium Suspension

Clobium Suspension is a suspension prescribed to help control seizures, particularly in children with specific types of epilepsy. It works by calming overactive electrical signals in the brain to reduce the frequency and severity of fits. This medicine is typically used alongside other seizure treatments to improve daily seizure control.

To work effectively, Clobium Suspension must be taken consistently at the same times every day as directed by your doctor. It can be taken with or without food, but keeping a consistent routine helps maintain stable medicine levels in the child's body. Helping your child maintain regular sleep patterns and avoiding known seizure triggers can also support their treatment progress.

Some children may experience mild side effects, such as sleepiness, drooling, or feeling unsteady on their feet. While these are often temporary as the body adjusts, you should consult your doctor immediately if you notice signs of severe breathing difficulties, extreme mood changes, or an allergic reaction.

Before starting this medicine, tell your doctor if your child has a history of breathing problems, muscle weakness, or kidney or liver damage. Do not take this if your child has severe breathing difficulties, untreated sleep apnea, or a known allergy to any of the ingredients in this medicine.

This medicine can interact with other treatments that cause sleepiness, such as certain allergy or cough medicines, making your child excessively drowsy. It is also important to talk to your doctor if this medicine is being prescribed for adolescents who may be pregnant or breastfeeding, as it can affect the developing baby.

Uses of Clobium Suspension

Your doctor may prescribe Clobium Suspension to help manage the following seizure disorders:

  • Severe epilepsy (such as Lennox-Gastaut syndrome): Clobium Suspension is used as an add-on treatment to help control and reduce the frequency of different types of seizures in children.
  • Difficult-to-control seizures: It helps manage sudden, intense electrical activity in the brain when other standard treatments are not fully effective on their own.

Key Benefits

Using Clobium Suspension as prescribed helps improve seizure control and support your child's daily life. Here are the key benefits you can expect:

  • Fewer seizure disruptions: By reducing the number of daily or weekly seizures, Clobium Suspension allows children to participate more fully and safely in school, play, and family activities.
  • Brings peace of mind: Helping to stabilize brain activity reduces the constant worry of unpredictable seizure episodes for parents and caregivers.
  • Supports better sleep and rest: Improved seizure control can help prevent nocturnal seizures, leading to more restful, uninterrupted sleep for the child.
Side effects of Clobium Suspension 60ml
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Stay hydrated by drinking plenty of water to make swallowing easier.
  • Maintaining dental health and minimizing irritation that could cause drooling can be achieved with regular brushing and flossing.
  • Eat smaller, more frequent meals to reduce saliva production and manage drooling.
  • Good posture can help you stop drooling. Hold your head up straight and raise your chin a little.
  • Avoid spicy foods like chili peppers, wasabi, and horseradish, as they can increase saliva production and worsen drooling.
  • Try natural products like papaya juice, dark grape juice, or sage tea.
  • Contact your doctor for alternative options if these strategies and exercises don't improve saliva management.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Try to practice deep breathing exercises or repeat calming words or phrases.
  • Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
  • You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.

Directions for Use

  • Clobium Suspension can be given with or without food.
  • Follow your doctor's instructions regarding the dosage and duration of the medication.
  • Shake well before use. Administer the advised dose to the child using the measuring cup/measuring spoon/dropper.
  • Avoid using regular household spoons, as they may not measure the dose correctly.

How Clobium Suspension Works

Clobium Suspension contains clobazam, a medicine that belongs to the benzodiazepine class of anticonvulsants. Clobium Suspension works by enhancing the activity of gamma-aminobutyric acid (GABA), a natural calming chemical in the brain. GABA helps reduce excessive electrical activity between nerve cells. By increasing the effect of GABA, Clobium Suspension helps calm overactive nerve signals that can trigger seizures. This reduces the frequency and severity of seizures and helps improve seizure control in children with epilepsy, including difficult-to-control seizure disorders such as Lennox-Gastaut syndrome.
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Alcohol

Not applicable

-

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Pregnancy

Not applicable

-

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Breast Feeding

Not applicable

-

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Driving

Not applicable

-

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Liver

Caution

Give Clobium Suspension with caution, especially if your child has a history of liver diseases/conditions.

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Kidney

Caution

Give Clobium Suspension with caution, especially if your child has a history of kidney diseases/conditions.

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Children

Safe if prescribed

Clobium Suspension should be used for children only as per the dose and duration prescribed by the doctor.

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Heart

Consult your doctor

If your child has any heart disease, please consult a doctor before giving Clobium Suspension.

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Geriatrics

Not applicable

Clobium Suspension is for paediatric patients only.

What if I have taken an overdose of Clobium Suspension

If you suspect your child has taken too much of this medicine, seek emergency medical care immediately. Signs of an overdose can include extreme sleepiness, confusion, limp muscles, or difficulty breathing.

Diet & Lifestyle Advise

  • Ensure consistent sleep: Lack of sleep is a well-known seizure trigger. Help your child maintain a regular sleep schedule, even on weekends.
  • Maintain a seizure diary: Keep a detailed log of when seizures occur, what they looked like, and any potential triggers (like fever, stress, or missed meals) to help your doctor optimize treatment.
  • Stay hydrated: Ensure your child drinks plenty of water throughout the day, as dehydration can sometimes make seizures more likely.
  • Discuss dietary therapies: Ask your doctor if specific dietary options, such as a supervised ketogenic diet, are appropriate as supportive therapies for your child's condition.
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How Soon It Starts Working

The time required for Clobium Suspension to start to work: The peak effect of Clobium Suspension can be observed within 4 hours of administration. The time for which the effects of Clobium Suspension last: Clobium Suspension effect lasts for 3-4 days.

What if you forget to take Clobium Suspension

If you forget to give a dose, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with your regular schedule. Do not give a double dose to make up for a missed one.

Storage

• Store Clobium Suspension oral suspension at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Check the suspension: Always inspect the liquid before giving it to your child. It should look uniform after shaking; do not use it if you notice unusual clumps or discolouration that does not go away.
  • Gradual withdrawal is critical: Never stop giving this medicine suddenly. Doing so can cause severe, continuous seizures. Your doctor will provide instructions for gradually increasing dose or safely tapering off.
  • Monitor breathing and alertness: Watch your child closely, especially when starting the medicine or after a dose change, for signs of excessive sleepiness or slowed breathing.
  • Avoid other sedatives: Do not give your child other over-the-counter medicines that cause drowsiness, such as allergy or cold medicines containing antihistamines, without checking with your pharmacist first.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that slow brain activity: Taking Clobium Suspension with opioid pain relievers, sleeping medicines, muscle relaxants, or other medicines that cause drowsiness may increase the risk of excessive sleepiness, dizziness, and serious breathing problems.
  • Other anti-seizure medicines: Some anticonvulsants may increase or decrease the amount of Clobium Suspension in the body, which may affect its effectiveness or increase the risk of side effects. Your doctor may adjust the dose and monitor your child closely.
ClobazamThioridazine
Critical
ClobazamSodium oxybate
Critical

Drug-Drug Interactions

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ClobazamThioridazine
Critical
How does the drug interact with Clobium Suspension 60ml:
When Thioridazine is taken with Clobium Suspension 60ml, may increase the blood levels of thioridazine and cause an irregular heart rhythm.

How to manage the interaction:
Co-administration of Clobium Suspension 60ml and Thioridazine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClobazamSodium oxybate
Critical
How does the drug interact with Clobium Suspension 60ml:
Co-administration of Clobium Suspension 60ml can enhance the sedative effects of Sodium oxybate on the central nervous system.

How to manage the interaction:
Co-administration of Clarithromycin and Terfenadine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like respiratory depression, low blood pressure, fainting, coma, and even death, a doctor immediately. Do not stop using any medications without a doctor's advice.
ClobazamPentazocine
Severe
How does the drug interact with Clobium Suspension 60ml:
Co-administration of Clobium Suspension 60ml with Pentazocine can increase the risk of breathing problems.

How to manage the interaction:
Although there is a possible interaction between Clobium Suspension 60ml and Pentazocine, you can take these medicines together if prescribed by your doctor. If you are experiencing symptoms like dizziness, drowsiness, or difficulty concentrating, it is important to contact a doctor right away. They may be able to suggest alternative medications that do not interact with each other. Do not discontinue any medications without consulting a doctor.
ClobazamOxycodone
Severe
How does the drug interact with Clobium Suspension 60ml:
Co-administration of Clobium Suspension 60ml with Oxycodone may cause serious side effects like respiratory depression.

How to manage the interaction:
Consult the doctor if you are taking Clobium Suspension 60ml with Oxycodone. Avoid driving or operating hazardous machinery as these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination. Do not exceed the doses and duration prescribed by your doctor.
ClobazamAlfentanil
Severe
How does the drug interact with Clobium Suspension 60ml:
Co-administration of Clobium Suspension 60ml can enhance the sedative effects of Alfentanil on the central nervous system.

How to manage the interaction:
Although taking Clobium Suspension 60ml and Alfentanil together can cause an interaction, it can be taken if a doctor has suggested it. If you are experiencing symptoms like dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination, it is important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
ClobazamMorphine
Severe
How does the drug interact with Clobium Suspension 60ml:
Using Morphine together with Clobium Suspension 60ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Morphine with Clobium Suspension 60ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
ClobazamMethadone
Severe
How does the drug interact with Clobium Suspension 60ml:
Co-administration of Clobium Suspension 60ml with Methadone may cause serious side effects like respiratory depression.

How to manage the interaction:
Consult the doctor if you are taking Clobium Suspension 60ml with methadone. Avoid driving or operating hazardous machinery as these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination. Do not exceed the doses and duration prescribed by your doctor.
ClobazamPethidine
Severe
How does the drug interact with Clobium Suspension 60ml:
Co-administration of Clobium Suspension 60ml with Meperidine can increase the risk of breathing problems.

How to manage the interaction:
Taking Pethidine with Clobium Suspension 60ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. This means that taking Clobium Suspension 60ml and opioids together can make it more likely to have trouble breathing. Talk to your doctor about other options that may not have this interaction. Do not stop using any medications without talking to a doctor.
ClobazamRemifentanil
Severe
How does the drug interact with Clobium Suspension 60ml:
Co-administration of Clobium Suspension 60ml with Remifentanil can increase the risk of breathing problems.

How to manage the interaction:
Taking Clobium Suspension 60ml with Remifentanil together can possibly result in an interaction, but it can be taken if your doctor has advised it. When used together, these effects can be worsened, increasing the risk of respiratory depression. If you experience symptoms such as difficulty breathing, dizziness, or drowsiness, it is important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
ClobazamHydromorphone
Severe
How does the drug interact with Clobium Suspension 60ml:
Co-administration of Clobium Suspension 60ml with Hydromorphone may cause serious side effects like respiratory depression or coma.

How to manage the interaction:
Consult the doctor if you are taking Clobium Suspension 60ml with Hydromorphone. Avoid driving or operating hazardous machinery as these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination. Do not exceed the doses and duration prescribed by your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit or grapefruit juice: Avoid giving grapefruit or grapefruit juice while your child is taking Clobium Suspension, as it may increase the amount of the medicine in the blood and raise the risk of side effects such as excessive drowsiness and dizziness.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANTICONVULSANT]

FAQs

Clobium Suspension is used to treat epilepsy (fits). It works by increasing the release of GABA (a chemical messenger that acts as a nerve-calming agent) in the brain and calming nerve cells.
No, you are not recommended to stop giving Clobium Suspension to your child without consulting your child’s doctor as it may cause confusion, difficulty in sleeping and loss of appetite. Therefore, give Clobium Suspension for as long as your child’s doctor has prescribed it, and if your child faces any difficulty while taking Clobium Suspension, please consult your child’s doctor.
Yes, Clobium Suspension may cause mental or physical dependence if used for a prolonged time. Therefore, give Clobium Suspension only in dose and duration as advised by the doctor.
No, Clobium Suspension does not cure epilepsy. Clobium Suspension only helps in controlling seizures (fits). There is no cure for epilepsy, but treatment at an early stage can make a huge difference, as prolonged or uncontrolled fits may result in brain damage.
Drowsiness and tiredness are common side effects, especially when first starting this medicine or when the dose is increased. In most cases, this sleepiness decreases over time as your child's body adjusts. If the drowsiness is severe or does not improve, talk to your doctor.
Some children may experience mood swings, restlessness, or irritability while taking this medicine. If you notice any unusual, severe, or worsening behavioural changes, or signs of sadness and depression, talk to your doctor immediately.
No, this oral suspension should be stored at room temperature, away from heat and direct light. Do not freeze the medicine. Talk to your pharmacist if you have questions about proper storage.
Yes, this medicine is frequently prescribed as an add-on treatment alongside other anti-seizure medications. However, because these medicines can interact, your doctor will carefully manage and monitor the combination. Always talk to your doctor before adding or changing any medications.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.7618 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 203993S005Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Clobazam Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Clobazam Clobazam. 2011. [Accessed on 19 Jun. 2019]Check here
  5. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 20 Feb. 2020]Check here
  6. Pubchem.ncbi.nlm.nih.gov. n.d. Clobazam. [online] Available at:Check here
  7. Jacquelyn Klehm, Sigride Thome-Souza, Et. Al., Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Paediatric Neurology. July 2014. [Accessed on 19th Aug 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Icon Life Sciences, Div. Of Mesmer Pharmaceuticals, No.202/6, Lane In.30, Phase-II, IDA, Cherlapally, Hyderabad, 500 051 AP
Other Info - CLO1155

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