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compositionComposition:BIVALIRUDIN-250MG
prescription
Prescription Medicine
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Bivacard 250mg Injection is used to prevent the formation of blood clots. It works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack) or stroke, especially in people who have had heart surgery, known as angioplasty.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BIVALIRUDIN-250MG

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Bivacard 250mg Injection

Because this medicine is injected directly into a vein during a medical procedure, it is typically given as a single, continuous dose for the duration of your procedure. You do not need to worry about daily scheduling or taking it with food, as a healthcare professional will handle the entire process. Following any heart-healthy lifestyle recommendations from your doctor, such as eating a low-salt diet and avoiding sudden physical strain, will support your recovery.

While receiving this medicine, you may experience mild side effects like minor bleeding, bruising, or nausea. It is vital to tell your healthcare team immediately if you notice serious signs such as severe, uncontrollable bleeding, blood in your urine or stool, or sudden weakness.

Before your procedure, tell your doctor if you have kidney disease, a history of bleeding disorders, or if you have recently had surgery. Before your procedure, tell your doctor if you have kidney disease, a history of bleeding disorders, have recently had surgery, or have recently had brain or spinal surgery, as these conditions may increase your risk of bleeding. Do not receive this medicine if you have active, severe bleeding or a known severe allergy to Bivacard 250mg Injection.

This medicine can interact with other blood thinners, certain pain relief medicines, and some herbal supplements, which can increase your risk of bleeding. If you are pregnant, breastfeeding, or over the age of 65, talk to your doctor about the risks and benefits of receiving this medication during your procedure.

Uses of Bivacard 250mg Injection

Your doctor may prescribe Bivacard 250mg Injection to help manage the following conditions:

  • Blood clots during coronary procedures: Bivacard 250mg Injection helps prevent dangerous blood clots from forming in the heart's blood vessels during angioplasty or other procedures to open blocked arteries.
    Unstable angina: It is used to reduce the risk of clot formation in patients experiencing severe chest pain who are undergoing heart procedures.
  • Heparin-induced thrombocytopenia (HIT) support: It serves as a safe alternative blood thinner for patients undergoing heart procedures who have a history of a specific severe immune reaction to heparin.
  • Heart attack (STEMI) during emergency angioplasty: Bivacard 250mg Injection is also used in people having an emergency procedure (primary PCI) to open a blocked heart artery during a serious heart attack (STEMI). It helps reduce the risk of blood clots while the procedure is being performed. 

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Heart Protection During Procedures: This medicine helps protect your heart during delicate medical procedures by keeping your blood thin and flowing. By preventing blood clots, it reduces the risk of serious complications like heart attacks or strokes while your doctor is working on your blood vessels.
  • Fast and Predictable Action: Another significant benefit of Bivacard 250mg Injection is its predictable action and quick clearance from the body. Once the injection is stopped, its blood-thinning effects wear off relatively quickly, which helps your body return to its normal clotting ability sooner after your procedure is complete.
Side effects of Bivacard 250mg Injection

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Bivacard 250mg Injection will be administered by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How Bivacard 250mg Injection Works

Bivacard 250mg Injection contains bivalirudin, which is a direct thrombin inhibitor. Thrombin is a key protein in your blood that acts like a chemical switch to trigger clot formation during injury. While clot formation is normally helpful, it can be dangerous during heart procedures. By binding directly to thrombin, this medicine temporarily blocks its action. This prevents platelets from sticking together and stops the chain reaction that builds blood clots. Because it works directly on this specific protein, it provides reliable, immediate protection against clotting during your procedure.
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption while receiving Bivacard 250mg Injection to prevent unpleasant side effects.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Bivacard 250mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data are available on the effect of Bivacard 250mg Injection on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Bivacard 250mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Bivacard 250mg Injection does not affect your ability to drive.

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Liver

Caution

Bivacard 250mg Injection should be used with caution in patients with liver impairment. Please inform your doctor if you have liver disease or any concerns regarding this.

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Kidney

Caution

Bivacard 250mg Injection should be used with caution in patients with kidney impairment. Please inform your doctor if you have kidney disease or any concerns regarding this.

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Children

Unsafe

Bivacard 250mg Injection is not recommended for use in children, as efficacy and safety have not been established.

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Heart

Caution

Bivacard 250mg Injection should be avoided in heart patients unless specifically prescribed. It affects blood clotting and demands strict medical supervision during cardiac procedures.

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Geriatrics

Caution

Bivacard 250mg Injection should be avoided in geriatric patients unless specifically prescribed. Older adults may have reduced kidney function and higher bleeding risk, requiring strict medical supervision.

What if I have taken an overdose of Bivacard 250mg Injection

Since this medication is carefully measured and injected by healthcare professionals in a controlled clinical environment, an overdose is extremely rare. However, if an overdose occurs, your medical team is equipped to manage it immediately by stopping the injection and monitoring you closely for any signs of bleeding.

Diet & Lifestyle Advise

  • Activity Precautions: Avoid sudden, rough physical activities or contact sports for a few days after your procedure to prevent bruising or bleeding.
  • Bleeding Precautions: Use a soft-bristled toothbrush and an electric razor to minimise the risk of minor cuts and bleeding while the medicine is still clearing from your system.
  • Dietary Advice: There are no specific food restrictions while receiving Bivacard 250mg Injection. Eat a balanced diet and follow any dietary instructions provided by your healthcare team after your procedure.
  • Hydration Advice: Stay hydrated as directed by your doctor to help your kidneys naturally clear the medicine from your body after your procedure.
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How Soon It Starts Working

The time required for Bivacard 250mg Injection to start to work: Bivacard 250mg Injection ideally shows its action within 15 to 20 minutes after administration. The time for which the effects of Bivacard 250mg Injection last: The effect of Bivacard 250mg Injection lasts for 1 hour.

What if you forget to take Bivacard 250mg Injection

Because this medicine is injected by a healthcare professional in a hospital setting during a specific medical procedure, it is highly unlikely that you will miss a dose. If your procedure is delayed or rescheduled, your medical team will adjust your treatment plan accordingly.

Storage

•Medical History: Ensure your medical team knows if you have a history of heparin-induced thrombocytopenia before they inject this medicine.

Drug Warnings

  • Medical History: Ensure your medical team knows if you have a history of heparin-induced thrombocytopenia before they inject this medicine.
  • Injection Site Care: Keep the injection site clean and dry after your procedure, and monitor it closely for any swelling, warmth, or active bleeding.
  • Medical Procedures: Do not receive any dental work or other minor surgical procedures immediately after receiving this medicine without consulting your doctor.
  • Inform Healthcare Provider: Inform any healthcare professional treating you in an emergency that you have recently received Bivacard 250mg Injection, as this affects how they manage any bleeding risks.
  • Injection Safety: Verify that the injection solution is clear and free of visible particles before it is injected by your healthcare team.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood Thinner Interaction: Combining this medicine with other blood thinners (like warfarin, heparin, or clopidogrel) can significantly increase your risk of bleeding.
  • NSAID Bleeding Risk: Taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, or high-dose aspirin can increase the risk of stomach ulcers and bleeding.
  • Herbal Supplement Warning: Certain herbal supplements, such as ginkgo biloba, garlic, or ginger, may enhance the blood-thinning effect and should be avoided close to your procedure.
BivalirudinMifepristone
Critical
BivalirudinEstradiol
Critical

Drug-Drug Interactions

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BivalirudinMifepristone
Critical
How does the drug interact with Bivacard 250mg Injection:
Co-administration of Mifepristone with Bivacard 250mg Injection can increase the risk of negative side effects.

How to manage the interaction:
Taking Bivacard 250mg Injection with Mifepristone together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
BivalirudinEstradiol
Critical
How does the drug interact with Bivacard 250mg Injection:
When Etodolac is taken with Bivacard 250mg Injection, the risk or severity of bleeding and haemorrhage increases.

How to manage the interaction:
Taking Bivacard 250mg Injection with Estradiol can cause an interaction, consult a doctor before taking it. Do not discontinue any medications without a doctor's advice.
BivalirudinIbrutinib
Severe
How does the drug interact with Bivacard 250mg Injection:
Co-administration of Ibrutinib with Bivacard 250mg Injection can increase the risk of bleeding.

How to manage the interaction:
Taking Ibrutinib with Bivacard 250mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
BivalirudinDeferasirox
Severe
How does the drug interact with Bivacard 250mg Injection:
Using Deferasirox together with Bivacard 250mg Injection may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Co-administration of Bivacard 250mg Injection with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
BivalirudinPrasugrel
Severe
How does the drug interact with Bivacard 250mg Injection:
Co-administration of Prasugrel with Bivacard 250mg Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Prasugrel and Bivacard 250mg Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
BivalirudinWarfarin
Severe
How does the drug interact with Bivacard 250mg Injection:
Coadministration of Warfarin with Bivacard 250mg Injection can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Bivacard 250mg Injection and warfarin, you can take these medicines together if prescribed by a doctor. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
BivalirudinRivaroxaban
Severe
How does the drug interact with Bivacard 250mg Injection:
Co-administration of Bivacard 250mg Injection and Rivaroxaban can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Bivacard 250mg Injection and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
BivalirudinCefdinir
Severe
How does the drug interact with Bivacard 250mg Injection:
Taking cefdinir with Bivacard 250mg Injection may increase the effects of Bivacard 250mg Injection.

How to manage the interaction:
Although taking Cefdinir and Argatroban together can evidently cause an interaction, but it can be taken if prescribed by a doctor. In case you experience any side effects like chest tightness, shortness of breath, swelling of legs, or palpitations, consult a doctor. Do not stop using any medications without first talking to your doctor.
BivalirudinDasatinib
Severe
How does the drug interact with Bivacard 250mg Injection:
Using Dasatinib together with Bivacard 250mg Injection may increase the risk of bleeding.

How to manage the interaction:
Although taking Bivacard 250mg Injection and Dasatinib together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs: bruising, feeling dizzy or lightheaded, dark stools, headache, weakness, contact a doctor right away. Do not stop using any medications without a doctor's advice.
BivalirudinEnoxaparin
Severe
How does the drug interact with Bivacard 250mg Injection:
Coadministration of Bivacard 250mg Injection with Enoxaparin can increase the risk or severity of bleeding.

How to manage the interaction:
Co-administration of Bivacard 250mg Injection with Enoxaparin can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like bleeding, bruising, dizziness, black or red stools, severe headache, weakness, or vomiting call a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip

  • No clinically significant food interactions are known with Bivacard 250mg Injection when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANTS / ANTITHROMBOTICS. ANTICONVULSANTS]

FAQs

Bivacard 250mg Injection is an injectable blood thinner used to prevent blood clots, especially during heart procedures such as angioplasty. It works by preventing clot formation and helps keep blood flowing smoothly while the procedure is being performed. Your doctor will determine whether it is appropriate for your condition.
Bivacard 250mg Injection works by inhibiting the clumping of platelets, thereby reducing the chance of blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack).
Bivacard 250mg Injection may cause anaemia (low haemoglobin and low red blood cell count). So it would be best if you include iron-rich food in your diet to prevent anaemia.
Bivacard 250mg Injection does not affect the functioning of the liver. However, long-term use of Bivacard 250mg Injection may slightly increase the risk of mild liver damage, particularly in those with increased liver enzyme levels. Therefore, if you have any liver problem, please inform your doctor before starting Bivacard 250mg Injection.
It is best to avoid drinking alcohol while taking Bivacard 250mg Injection. Intake of alcohol might increase the risk of stomach or intestinal bleeding.
Store Bivacard 250mg Injection at controlled room temperature (15-25°C) in a cool and dry place. Do not freeze. Keep out of reach of children.
You might not feel any difference after taking Bivacard 250mg Injection, but you should continue taking it as prescribed by your doctor. Even though you don't notice any difference, you will still receive all benefits of Bivacard 250mg Injection.
Bivacard 250mg Injection should not be taken by individuals with allergies, bleeding issues, strokes, liver disease, or taking any blood thinners. It is important to inform your doctor if you develop thrombotic thrombocytopenic purpura while on treatment with Bivacard 250mg Injection. Pregnant or breastfeeding mothers should inform your doctor before receiving Bivacard 250mg Injection. Bivacard 250mg Injection is not recommended for children as efficacy and safety have not been established.
No, Bivacard 250mg Injection does not usually cause hair loss. However if you notice hair loss while on treatment with Bivacard 250mg Injection, please consult your doctor.
The common side effects of Bivacard 250mg Injection are nose bleeds, skin rash, bruising, bleeding in the bowels, blood in urine, low haemoglobin, and thrombocytopenia (low platelets). If any of these side effects persist or worsen, please consult your doctor.
This medicine is injected directly into a vein (intravenously) by a trained healthcare professional in a hospital or clinic setting. You will not need to inject this medicine yourself. Talk to your doctor about what to expect during the injection.
Yes, Bivacard 250mg Injection is often used as a safe alternative blood thinner for patients who have had a serious allergic or immune reaction to heparin (such as heparin-induced thrombocytopenia). Talk to your doctor to ensure this is the right alternative for you.
Both medicines help prevent blood clots during heart procedures. Your doctor may choose Bivacard 250mg Injection for some patients because it has a predictable effect, wears off relatively quickly after the procedure, and can be used in people with a history of heparin-induced thrombocytopenia (HIT). The best choice depends on your medical condition, bleeding risk, and the type of procedure you are having. Talk to your doctor about why this medicine was selected for you.
You should watch for unusual or severe bruising, blood in your urine or stool, frequent nosebleeds, or prolonged bleeding from the injection site. If you notice any of these signs, notify your medical team immediately. Talk to your doctor if you experience any unusual symptoms after your procedure.
There is limited research on the safety of using Bivacard 250mg Injection during pregnancy. It should only be used if the potential benefits outweigh the risks to the unborn baby. Talk to your doctor if you are pregnant or planning to become pregnant before undergoing your procedure.
No. You should avoid taking ibuprofen or other NSAIDs (such as naproxen) while receiving or shortly after receiving Bivacard 250mg Injection unless specifically advised by your doctor, as these medicines can significantly increase the risk of bleeding. Consult your doctor or pharmacist before taking any pain reliever or over-the-counter medicine.
If you experience minor bleeding or oozing at the injection site after going home, apply firm, continuous pressure to the area with a clean cloth. If the bleeding does not stop after several minutes, or if it is flowing heavily, seek emergency medical care immediately. Talk to your doctor about proper post-procedure wound care.

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Country of origin

India

Manufacturer/Marketer address

Plot No-17, Industrial Area (Himuda), Bhatolikalan, Baddi, Dist-Solan (H.P) 173205
Other Info - BI45966
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