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compositionComposition:HUMAN NORMAL IMMUNOGLOBULIN-16.5%W/V
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Prescription Medicine
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Bharglob 16.5% Injection is used to treat immunoglobulin (antibody) deficiency and certain inflammatory disorders. It contains Human normal immunoglobulin which helps the body fight against infections and works the same way as natural immunoglobulins. In some cases, this medicine may cause side effects such as injection site reactions, headache, fever, flu-like symptoms, and throat tightness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

HUMAN NORMAL IMMUNOGLOBULIN-16.5%W/V

Manufacturer/Marketer :

Bharat Serums and Vaccines Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Bharglob 16.5% Injection

Bharglob 16.5% Injection is an injection used to protect the body against infections and to treat certain inflammatory conditions. It is prescribed for people whose immune systems do not make enough of their own protective antibodies. It is also used to treat specific autoimmune disorders where the body mistakenly attacks its own healthy tissues.

This medicine is given regularly, with the frequency depending on your specific condition and how your body responds to treatment. Because it is given as an injection or infusion, its absorption is not affected by food, though drinking plenty of fluids before your treatment is highly recommended. Incorporating simple habits like practising good hand hygiene and avoiding close contact with sick individuals can further support your immune health.

While taking Bharglob 16.5% Injection, some people may experience mild side effects like headaches, chills, or redness at the injection site. It is important to watch for more serious symptoms, such as severe back pain, a sudden decrease in urination, or chest discomfort, and consult your doctor immediately if these occur.

Before you begin treatment, talk to your doctor if you have pre-existing kidney disease, diabetes, high blood pressure, or a history of blood clots. Do not take this medicine if you have had a severe allergic reaction to immunoglobulin therapies in the past, or if you have selective IgA deficiency with anti-IgA antibodies.

This medicine can interfere with live virus vaccines, making them less effective. Avoid drinking alcohol or smoking during treatment, as they can worsen side effects like dehydration and headaches. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss the risks and benefits before starting this therapy.

Uses of Bharglob 16.5% Injection

Bharglob 16.5% Injection is used in the treatment of Immunoglobulin deficiency and inflammatory disorders. The detailed use of Bharglob 16.5% Injection is as follows:

  • Primary Immunodeficiency Diseases (PIDD): Bharglob 16.5% Injection provides necessary antibodies to protect individuals whose bodies cannot produce enough of their own to fight off bacteria and viruses.
  • Idiopathic Thrombocytopenic Purpura (ITP): It helps raise low platelet counts in the blood, reducing the risk of severe bruising or dangerous bleeding episodes.
  • Guillain-Barré Syndrome: Bharglob 16.5% Injection helps reduce nerve inflammation, which helps speed up recovery and restores muscle strength.
  • Kawasaki Disease: It is used to lower severe blood vessel inflammation, helping prevent long-term damage to the heart's blood vessels.
  • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): It protects the protective covering of nerves from being damaged by the immune system, preserving muscle strength and coordination.

Key Benefits

Bharglob 16.5% Injection helps strengthen the body's immune defences and manage certain autoimmune and nerve conditions.

The following are the benefits of Bharglob 16.5% Injection:

  • Helps reduce the frequency of serious infections.
  • Supports a stronger immune system in people with immune deficiencies.
  • Improves muscle strength and physical mobility in certain nerve disorders.
  • Reduces symptoms caused by an overactive immune response.
  • Promotes faster recovery and better day-to-day functioning.
  • Provides long-term support for immune and neurological health.

Directions for Use

  • This medicine is given as an injection under the skin (subcutaneously) or infused directly into a vein (intravenously).
  • Most often, a healthcare professional will inject or infuse this medicine in a hospital, clinic, or doctor's office.
  • In some cases, you or a caregiver may be trained to inject the medicine at home. Always follow the step-by-step training provided by your medical team.
  • Before injecting, look at the liquid in the vial. It should be clear or slightly yellow. Do not use it if it looks cloudy, is discoloured, or contains visible floating particles.
  • If you are injecting under the skin, choose a different injection spot each time to help prevent skin irritation or pain.
  • Always follow your doctor's exact instructions regarding your schedule and the rate at which the medicine is injected.

How Bharglob 16.5% Injection Works

Bharglob 16.5% Injection contains Human normal immunoglobulin, which works by supplying your body with healthy antibodies obtained from donor blood. Antibodies are crucial proteins that the immune system normally uses to recognise and destroy foreign invaders like bacteria and viruses. If your body does not make enough antibodies, this medicine acts as a direct replacement to help fight off infections. In autoimmune or inflammatory conditions, your immune system mistakenly attacks healthy cells. In these cases, the healthy antibodies in Bharglob 16.5% Injection help block or neutralise the harmful antibodies causing the attack, lowering inflammation and preventing further tissue damage.
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Alcohol

Safe if prescribed

Bharglob 16.5% Injection may not interact with alcohol. However, limit or avoid consumption of alcohol to avoid possible side effects.

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Pregnancy

Safe if prescribed

Inform your doctor if you are pregnant or planning pregnancy before receiving Bharglob 16.5% Injection. Your doctor will assess the benefits and the risks before prescribing.

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Breast Feeding

Safe if prescribed

Inform your doctor if you are breastfeeding before receiving Bharglob 16.5% Injection. Your doctor will assess the benefits and the risks before prescribing.

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Driving

Caution

Bharglob 16.5% Injection may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy after receiving this medicine.

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Liver

Caution

Bharglob 16.5% Injection should be used with caution in patients with liver diseases. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Caution

Bharglob 16.5% Injection should be used with caution in patients with kidney diseases. Your doctor may adjust the dose if necessary based on your condition.

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Children

Safe if prescribed

Bharglob 16.5% Injection can be safely used in children when prescribed.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Bharglob 16.5% Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Bharglob 16.5% Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Bharglob 16.5% Injection

Because this medicine is typically managed by healthcare professionals, an overdose is highly unlikely. However, if you self-inject and suspect you have used too much, seek emergency medical care or call your doctor right away.

Diet & Lifestyle Advise

  • Prioritise Hydration: Drink plenty of water or clear fluids before, during, and after your infusion. Proper hydration helps protect your kidneys from damage and can significantly lower your risk of getting a severe headache.
  • Practice Infection Prevention: Since this therapy is used for immune support, continue to wash your hands regularly, avoid close contact with people who are sick, and stay up to date on non-live vaccines recommended by your doctor.
  • Maintain a Balanced Diet: Eat a nutrient-rich diet with plenty of fruits, vegetables, and lean proteins to support your body's healing processes and overall strength.
  • Track Your Symptoms: Keep a health journal to record the dates of your injections, the site used, and any symptoms or side effects you notice. Share this log with your medical team.
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How Soon It Starts Working

  • The time required for Bharglob 16.5% Injection to start to work: Bharglob 16.5% Injection ideally shows its action within 30 to 60 minutes after administration.
  • The time for which the effects of Bharglob 16.5% Injection last: The effect of Bharglob 16.5% Injection lasts for 3 to 4 weeks.

What if you forget to take Bharglob 16.5% Injection

If you miss an appointment for your infusion or forget to inject your scheduled dose at home, contact your doctor or healthcare provider immediately to reschedule. Do not inject a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep this medicine out of the sight and reach of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Check the Medicine: Always inspect the liquid before injecting. It should be clear or pale yellow. If it is cloudy or contains particles, do not inject it.
  • Do Not Shake: Avoid shaking the vial, as this can cause foaming and ruin the active proteins. Gently swirl the vial if needed.
  • Infuse Slowly: Ensure the infusion speed is kept slow, especially during the first half-hour of your session, to minimise side effects like headache or chills.
  • Rotate Injection Sites: If you are self-injecting under the skin, change your injection site every time to protect your skin tissues.
  • Delay Live Vaccines: Talk to your doctor before getting any vaccinations. This medicine can make live virus vaccines (like MMR or chickenpox) ineffective for several months after your last dose.
  • Watch Your Kidneys: Have your kidney function monitored regularly by your doctor, as this medicine can occasionally put strain on the kidneys.

Drug-Drug Interactions

verifiedApollotooltip
  • Live Vaccines (e.g., measles, mumps, rubella, varicella): May decrease the effectiveness of live vaccines if given within several months of this therapy.
  • Other Medicines(e.g., ibuprofen, gentamicin, furosemide): Taking this medicine alongside other drugs that can cause kidney strain may increase your risk of kidney damage.
Human immunoglobulinValdecoxib
Severe
Human immunoglobulinPiroxicam
Severe

Drug-Drug Interactions

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Human immunoglobulinValdecoxib
Severe
How does the drug interact with Bharglob 16.5% Injection:
Taking Bharglob 16.5% Injection with valdecoxib, may raise the risk of kidney problems.

How to manage the interaction:
Taking Bharglob 16.5% Injection with Valdecoxib together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinPiroxicam
Severe
How does the drug interact with Bharglob 16.5% Injection:
Taking Bharglob 16.5% Injection with piroxicam, may raise the risk of kidney problems.

How to manage the interaction:
Co-administration of Bharglob 16.5% Injection with Piroxicam can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, breathing difficulty, muscle cramps, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinCelecoxib
Severe
How does the drug interact with Bharglob 16.5% Injection:
Taking celecoxib with Bharglob 16.5% Injection may increase risk of kidney problems.

How to manage the interaction:
Although taking celecoxib and Bharglob 16.5% Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinDiclofenac
Severe
How does the drug interact with Bharglob 16.5% Injection:
Taking diclofenac with Bharglob 16.5% Injection may increase the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between Bharglob 16.5% Injection and Diclofenac, you can take these medicines together if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinPamidronic acid
Severe
How does the drug interact with Bharglob 16.5% Injection:
Taking Bharglob 16.5% Injection with pamidronic acid, may raise the risk of kidney problems.

How to manage the interaction:
Co-administration of Bharglob 16.5% Injection with Pamidronic acid can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinVancomycin
Severe
How does the drug interact with Bharglob 16.5% Injection:
Coadministration of Vancomycin with Bharglob 16.5% Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Bharglob 16.5% Injection can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinPentamidine isethionate
Severe
How does the drug interact with Bharglob 16.5% Injection:
Taking Bharglob 16.5% Injection with Pentamidine isethionate, may raise the risk of kidney problems.

How to manage the interaction:
Co-administration of Bharglob 16.5% Injection with Pentamidine isethionate can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinTenofovir alafenamide
Severe
How does the drug interact with Bharglob 16.5% Injection:
Taking Bharglob 16.5% Injection with tenofovir alafenamide, may raise the risk of kidney problems.

How to manage the interaction:
Taking Bharglob 16.5% Injection with Tenofovir alafenamide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinKetoprofen
Severe
How does the drug interact with Bharglob 16.5% Injection:
Taking Bharglob 16.5% Injection with ketoprofen, may raise the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Bharglob 16.5% Injection and Ketoprofen, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinIbuprofen
Severe
How does the drug interact with Bharglob 16.5% Injection:
Taking Bharglob 16.5% Injection with Ibuprofen may raise the risk of kidney problems.

How to manage the interaction:
Co-administration of Bharglob 16.5% Injection with Ibuprofen can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food or drink interactions are commonly recognized with this medicine.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[IMMUNIZING AGENTS]

FAQs

Bharglob 16.5% Injection is used to treat immunoglobulin (antibody) deficiency and certain inflammatory disorders.
The Bharglob 16.5% Injection contains Human normal immunoglobulin, which helps restore the deficient immunoglobulins or antibodies in the body. Antibodies are an essential part of the immune system that help to reduce infection and inflammation. They act by identifying, attacking, and thereby destroying the antigen or foreign body that has entered or is present in the body.
Bharglob 16.5% Injection may alter some blood test results for a certain time, so inform your doctor that you have Bharglob 16.5% Injection before undergoing blood tests. Taking any vaccines (especially live vaccines) at least three months after taking Bharglob 16.5% Injection is not recommended as this medicine may make the vaccines less effective.
Bharglob 16.5% Injection should be used with caution in patients with diabetes if this medicine is given as an infusion, as it may alter blood sugar levels. Bharglob 16.5% Injection doesn't contain sugar; however, it can be diluted in a special sugar solution before giving the infusion.
Bharglob 16.5% Injection is usually well-tolerated. However, some patients may experience side effects such as swelling or hardening at the injection site and headache, pain in the face, back, arms, legs, joints, or neck, fever, flu-like illness (runny nose and sore throat), blisters in the mouth, and throat, and throat tightness. If any side effects persist or get worse, inform your doctor immediately.
It is a condition in which there is a decrease in antibody levels in the body due to decreased ability or inability to produce enough antibodies. It can be present from birth (primary) or acquired during the later stages of life (secondary).
Certain vaccinations, such as those for chickenpox, measles, mumps, and rubella, may become less effective when administered with Bharglob 16.5% Injection. Therefore, before receiving any vaccinations, inform your doctor if you are allergic to Bharglob 16.5% Injection. Let your doctor know that you are taking Bharglob 16.5% Injection. And also inform your doctor if you are breastfeeding, pregnancy or planning pregnancy.
No, you should not discontinue using Bharglob 16.5% Injection without consulting your doctor, even if you feel fine. Stopping the usage of Bharglob 16.5% Injection early can increase the risk of infections. Always follow your doctor's instructions and complete the prescribed course of treatment to ensure the best outcome.
The effects of Bharglob 16.5% Injection can vary depending on the individual and the condition being treated. Generally, it may take up to 4 weeks of regular therapy to notice a steady improvement in your symptoms. Therefore, complete the full course of treatment as prescribed by your doctor.
Yes, Bharglob 16.5% Injection can cause kidney damage but not in everyone. Patients having a pre-existing kidney problem, hypovolemia (a decrease in the volume of circulating blood) and diabetes are at risk of developing kidney failure. Additionally, patients who are overweight, above 65 years of age and who are taking medicines that can cause kidney damage are also at risk of developing kidney failure. Therefore, please inform your doctor if you have any pre-existing kidney problems.
No, hair loss is not a commonly reported side effect of Bharglob 16.5% Injection. If you experience hair loss, it might be due to some other underlying problem. Please consult your doctor if bothers you.
Bharglob 16.5% Injection benefits people with weakened immune systems, such as those who have undergone bone marrow transplants or have severely reduced antibody-forming capacity. It can also treat or prevent infections who are suffering with measles, hepatitis, and mumps. It is used for patients with primary immunodeficiency syndromes (PID) and acquired or secondary immunodeficiency (SID). Please consult your doctor if you have any concerns.
If you are pregnant, take your doctor’s advice before using Bharglob 16.5% Injection. Your doctor will assess the benefits and risks of Bharglob 16.5% Injection before prescribing.
Store Bharglob 16.5% Injection in a refrigerator (2 - 8°C). Do not freeze. Protect it from light. Keep out of reach of children.
Bharglob 16.5% Injection is given parenterally, meaning it is injected under the skin (subcutaneously) or infused directly into a vein (intravenously). It is usually given by a trained healthcare professional, though some patients may be taught how to inject it at home. Talk to your doctor about the safest way to receive your treatment.
You should avoid receiving live vaccines, such as the measles, mumps, rubella (MMR), or chickenpox vaccine, while receiving Bharglob 16.5% Injection, as the medicine can make these vaccines less effective. Non-live vaccines are generally safe but may not work as well. Always talk to your doctor or pharmacist before scheduling any vaccinations.
Headaches are a very common side effect of Bharglob 16.5% Injection infusions. They are often caused by the speed of the infusion or mild dehydration. Drinking plenty of water before and during your treatment can help prevent this. If your headache is severe, lasts a long time, or is accompanied by a stiff neck and fever, talk to your doctor immediately.
If you miss a scheduled dose or infusion, contact your healthcare provider as soon as possible to reschedule your appointment. Maintaining a regular schedule is important for keeping your antibody levels stable. Do not try to double your next dose. Talk to your doctor if you have questions about your schedule.

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Country of origin

INDIA

Manufacturer/Marketer address

17th Floor, Hoechst House, Nariman Point, Mumbai ? 400 021, Maharashtra, India.
Other Info - BHA0002

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