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  3. Azimbra 40 mg Injection 0.4 ml

Azimbra 40 mg Injection 0.4 ml, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Santoshini Reddy G , M Pharmacy

Azimbra 40 mg Injection 0.4 ml is used to help reduce signs and symptoms of autoimmune disorders such as Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, Plaque psoriasis, Crohn's disease, Uveitis and Ulcerative colitis. It consists of Adalimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

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Composition :

ADALIMUMAB-40MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Azimbra 40 mg Injection 0.4 ml

Azimbra 40 mg Injection 0.4 ml belongs to the class of monoclonal TNF (Tumor necrosis factor) inhibitors that help reduce signs and symptoms of autoimmune disorders. It is primarily used in the treatment of rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, plaque psoriasis, and psoriatic arthritis. This medicine is also used in the treatment of Crohn’s disease, ulcerative colitis, hidradenitis suppurativa, and uveitis.

Azimbra 40 mg Injection 0.4 ml consists of Adalimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Azimbra 40 mg Injection 0.4 ml may cause certain side effects such as nausea, headache, back pain, upper respiratory tract infections, vision problems, dizziness, pale skin, numbness, chest pain, rash, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor on priority. Azimbra 40 mg Injection 0.4 ml is a parenteral medicine. It will be administered by a trained healthcare doctor. Hence, do not self-administer. Your physician will decide the dose and duration of the medicine based on the type and severity of the condition.

Azimbra 40 mg Injection 0.4 ml should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, tuberculosis, optimistic infections, cancer, alcoholic hepatitis, hepatitis B virus infection, heart failure, liver, heart, or kidney diseases, or a weak immune system, as it can worsen your health condition. Azimbra 40 mg Injection 0.4 ml may cause dizziness, so drive only if you are alert and focused. Azimbra 40 mg Injection 0.4 ml should not be given to children under two years of age as safety has not been established. Consult the doctor if you are pregnant or breastfeeding.

Uses of Azimbra 40 mg Injection 0.4 ml

Azimbra 40 mg Injection 0.4 ml is used in the treatment of autoimmune inflammatory diseases. The detailed uses of Azimbra 40 mg Injection 0.4 ml are as follows:<br/>• Treatment of Rheumatoid arthritis (RA): Azimbra 40 mg Injection 0.4 ml reduces inflammation, joint pain, and stiffness in adults with moderate to severe RA, improving mobility and quality of life.<br/>• Treatment of Juvenile idiopathic arthritis (JIA): Azimbra 40 mg Injection 0.4 ml is used in children to control inflammation, relieve joint symptoms, and support normal growth and development.<br/>• Treatment of Crohn’s disease: Azimbra 40 mg Injection 0.4 ml treats moderate to severe Crohn’s disease in adults and children by reducing intestinal inflammation when other treatments fail.<br/>• Treatment of Ulcerative colitis: Azimbra 40 mg Injection 0.4 ml is indicated for adults and children with moderate to severe ulcerative colitis who are unresponsive to conventional therapy.<br/>• Treatment of Ankylosing spondylitis: Azimbra 40 mg Injection 0.4 ml helps manage chronic back pain and stiffness by reducing spinal inflammation in adults.<br/>• Treatment of Psoriatic arthritis: Azimbra 40 mg Injection 0.4 ml improves joint and skin symptoms in adults by decreasing swelling, pain, and the formation of psoriatic skin lesions.<br/>• Treatment of Hidradenitis suppurativa: Azimbra 40 mg Injection 0.4 ml is used in adults and adolescents to reduce painful lumps and inflammation in areas like the armpits and groin.<br/>• Treatment of Uveitis: Azimbra 40 mg Injection 0.4 ml treats non-infectious uveitis in adults and children by lowering eye inflammation and helping preserve vision.<br/>• Treatment of Chronic plaque psoriasis: Azimbra 40 mg Injection 0.4 ml is used in adults with moderate to severe plaque psoriasis to reduce red, scaly patches and improve skin appearance.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Azimbra 40 mg Injection 0.4 ml will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Azimbra 40 mg Injection 0.4 ml consists of Adalimumab, which belongs to the class of monoclonal TNF (Tumor necrosis factor) inhibitors. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain, redness, and inflammation (swelling) caused by various autoimmune diseases.

How Azimbra 40 mg Injection 0.4 ml Works

Azimbra 40 mg Injection 0.4 ml consists of Adalimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Azimbra 40 mg Injection 0.4 ml out of the sight and reach of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Azimbra 40 mg Injection 0.4 ml
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

What if I have taken an overdose of Azimbra 40 mg Injection 0.4 ml

Since Azimbra 40 mg Injection 0.4 ml is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Azimbra 40 mg Injection 0.4 ml should be avoided if allergic to it or any other components present. Inform your doctor if you have any history of serious infections, tuberculosis, optimistic infections, cancer, alcoholic hepatitis, hepatitis B virus infection, heart failure, liver, heart or kidney diseases, weak immune system, multiple sclerosis (nerve and muscle disease), or diabetes as it can worsen your health condition. Do not take live vaccines while being treated with Azimbra 40 mg Injection 0.4 ml to prevent any serious consequences. Azimbra 40 mg Injection 0.4 ml is not recommended for use in children below two years of age as safety and efficacy are not established. This medicine is not recommended for patients suffering from sepsis as it can worsen the condition.

Drug-Drug Interactions

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AdalimumabFludrocortisone
Severe
AdalimumabThalidomide
Severe

Drug-Drug Interactions

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AdalimumabFludrocortisone
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
Co-administration of Azimbra 40 mg Injection 0.4 ml with fludrocortisone can increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between Fludrocortisone and Azimbra 40 mg Injection 0.4 ml, it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating contact a doctor right away. Do not stop using any medications without talking to a doctor.
AdalimumabThalidomide
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
Taking Thalidomide with Azimbra 40 mg Injection 0.4 ml may increase the risk of infection.

How to manage the interaction:
Although taking thalidomide and Azimbra 40 mg Injection 0.4 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
AdalimumabAbemaciclib
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
Using Azimbra 40 mg Injection 0.4 ml together with abemaciclib may increase the risk of serious infections.

How to manage the interaction:
Taking Abemaciclib with Azimbra 40 mg Injection 0.4 ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AdalimumabIdarubicin
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
Combining Idarubicin and Azimbra 40 mg Injection 0.4 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Azimbra 40 mg Injection 0.4 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
AdalimumabImatinib
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
When Imatinib is taken with Azimbra 40 mg Injection 0.4 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Imatinib and Azimbra 40 mg Injection 0.4 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
AdalimumabAzacitidine
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
Taking Azimbra 40 mg Injection 0.4 ml with Azacitidine may raise the risk of severe infections.

How to manage the interaction:
Taking Azacitidine with Azimbra 40 mg Injection 0.4 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AdalimumabEverolimus
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
When Everolimus is used with Azimbra 40 mg Injection 0.4 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Everolimus with Azimbra 40 mg Injection 0.4 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AdalimumabTacrolimus
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
Taking Tacrolimus with Azimbra 40 mg Injection 0.4 ml may increase the risk of serious infections.

How to manage the interaction:
Although taking tacrolimus and Azimbra 40 mg Injection 0.4 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
AdalimumabCapecitabine
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
Co-administration of Capecitabine is taken with Azimbra 40 mg Injection 0.4 ml, which may increase the risk or severity of infections.

How to manage the interaction:
There may be a possibility of interaction between Capecitabine and Azimbra 40 mg Injection 0.4 ml, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include an enlarged spleen or liver, stomach pain, ongoing fever, excessive sweating at night, unexplained weight loss, complications, infection, fever, chills, diarrhea, a sore throat, muscle aches, difficulty breathing, or pain or discomfort while urinating. Do not stop using any medications without a doctor's advice.
AdalimumabHydroxycarbamide
Severe
How does the drug interact with Azimbra 40 mg Injection 0.4 ml:
Hydroxycarbamide when used with Azimbra 40 mg Injection 0.4 ml may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between hydroxycarbamide with Azimbra 40 mg Injection 0.4 ml, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well and get plenty of sleep.
  • Stay hydrated; drink plenty of water.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Azimbra 40 mg Injection 0.4 ml Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is not known if alcohol interacts with Azimbra 40 mg Injection 0.4 ml. Please consult the doctor.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Azimbra 40 mg Injection 0.4 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Azimbra 40 mg Injection 0.4 ml.

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Driving

Caution

Azimbra 40 mg Injection 0.4 ml will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

Azimbra 40 mg Injection 0.4 ml should be used with caution if you have liver disease. Dose adjustment may be needed in patients with liver impairment.

bannner image

Kidney

Caution

Azimbra 40 mg Injection 0.4 ml should be used with caution if you have kidney disease. Dose adjustment may be needed in patients with liver impairment.

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Children

Caution

Azimbra 40 mg Injection 0.4 ml is not recommended in children below two years of age as safety and efficacy are not established. In children above two years of age, it will be administered by the pediatrician. Azimbra 40 mg Injection 0.4 ml is used in children only for the treatment of juvenile idiopathic arthritis, paediatric Crohn’s disease, and uveitis.

Have a query?

FAQs

Azimbra 40 mg Injection 0.4 ml is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, Plaque psoriasis, Crohn’s disease, Uveitis and Ulcerative colitis.

Azimbra 40 mg Injection 0.4 ml contains Adalimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive.

Azimbra 40 mg Injection 0.4 ml affects your immune system and makes you more susceptible to infections. Hence, it is not recommended in people with active infections like tuberculosis or abnormal liver enzymes. Azimbra 40 mg Injection 0.4 ml can also increase the risk of developing cancers; hence, informing your doctor if you have a history of any cancer is essential.

Azimbra 40 mg Injection 0.4 ml is an antirheumatic medicine that belongs to the TNF (tumor necrosis factor) inhibitor class. It contains the active ingredient Adalimumab.

Treatment with Azimbra 40 mg Injection 0.4 ml can help reduce inflammation, pain, redness, and swelling associated with various autoimmune disorders.

Azimbra 40 mg Injection 0.4 ml which contains Adalimumab, can weaken your immune system. Since it affects the immune system, it may increase your risk of developing infections. It is important to follow your doctor's advice and inform them if you have any existing infections or health concerns before starting treatment.

Azimbra 40 mg Injection 0.4 ml can be used alongside other arthritis medicines such as methotrexate, prednisolone, naproxen, ibuprofen, and paracetamol. However, Azimbra 40 mg Injection 0.4 ml should not be used with other biological disease-modifying antirheumatic drugs (bDMARDs).

Azimbra 40 mg Injection 0.4 ml should be stopped before surgery. It can be resumed after the operation, once the wound has healed and there is no infection, as determined by your surgeon and rheumatologist.

Azimbra 40 mg Injection 0.4 ml causes side effects such as rash, headache, sinusitis, upper respiratory infections, fever, and application site reactions. Therefore, please contact a doctor if these do not reduce and persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot C, Block, Bandra-Kurla Complex, Bandra (East), Mumbai 400 051, India
Other Info - AZI1134

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Author Details

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/125057s410lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a603010.html
  3. https://go.drugbank.com/drugs/DB00051
  4. https://reference.medscape.com/drug/amjevita-humira-adalimumab-343187
  5. https://www.nhs.uk/medicines/adalimumab/
  6. https://www.humira.com/
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