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Drug-Drug Interactions
Critical
Severe
Drug-Drug Interactions
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Critical
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Taking AFF 10mg/160mg/5mg Tablet with Posaconazole can increase the blood levels of AFF 10mg/160mg/5mg Tablet. This can increase the risk of side effects.
How to manage the interaction:
Although there is an interaction between posaconazole with AFF 10mg/160mg/5mg Tablet, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
Taking AFF 10mg/160mg/5mg Tablet with Posaconazole can increase the blood levels of AFF 10mg/160mg/5mg Tablet. This can increase the risk of side effects.
How to manage the interaction:
Although there is an interaction between posaconazole with AFF 10mg/160mg/5mg Tablet, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Sulfadiazine may decrease the blood levels and effects of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Sulfadiazine, you can take these medicines together if prescribed by your doctor.
Sulfadiazine may decrease the blood levels and effects of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Sulfadiazine, you can take these medicines together if prescribed by your doctor.
Severe
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Coadministration of AFF 10mg/160mg/5mg Tablet and Fluorouracil may increase the effects of Fluorouracil and increase the risk of serious side effects such as bleeding problems, anaemia (lack of blood), infections, and nerve damage.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Fluorouracil, you can take these medicines together if prescribed by your doctor. However, if you experience diarrhoea, paleness of skin, severe nausea and vomiting, over-tiredness, dizziness, fainting, blood in the stools, unusual bleeding or bruising, fever, chills, body pains, flu-like symptoms, skin reactions, mouth ulcers or sores, and/or numbness, burning or tingling in your hands and feet, contact your doctor.
Coadministration of AFF 10mg/160mg/5mg Tablet and Fluorouracil may increase the effects of Fluorouracil and increase the risk of serious side effects such as bleeding problems, anaemia (lack of blood), infections, and nerve damage.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Fluorouracil, you can take these medicines together if prescribed by your doctor. However, if you experience diarrhoea, paleness of skin, severe nausea and vomiting, over-tiredness, dizziness, fainting, blood in the stools, unusual bleeding or bruising, fever, chills, body pains, flu-like symptoms, skin reactions, mouth ulcers or sores, and/or numbness, burning or tingling in your hands and feet, contact your doctor.
Severe
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Co-administration of AFF 10mg/160mg/5mg Tablet with Capecitabine may increase the risk of serious side effects such as bleeding problems, anemia, infections, and nerve damage.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Capecitabine, you can use these medicines together if prescribed by the doctor. However, if you experience paleness of skin, diarrhea, severe nausea and vomiting, over-tiredness, dizziness, fainting, blood in the stools, unusual bleeding or bruising, fever, chills, body aches, flu-like symptoms, skin reactions, mouth ulcers or sores, and/or numbness, burning or tingling sensation in the hands and feet, contact a doctor. Do not discontinue the medication without consulting a doctor. Do not discontinue the medication without consulting a doctor.
Co-administration of AFF 10mg/160mg/5mg Tablet with Capecitabine may increase the risk of serious side effects such as bleeding problems, anemia, infections, and nerve damage.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Capecitabine, you can use these medicines together if prescribed by the doctor. However, if you experience paleness of skin, diarrhea, severe nausea and vomiting, over-tiredness, dizziness, fainting, blood in the stools, unusual bleeding or bruising, fever, chills, body aches, flu-like symptoms, skin reactions, mouth ulcers or sores, and/or numbness, burning or tingling sensation in the hands and feet, contact a doctor. Do not discontinue the medication without consulting a doctor. Do not discontinue the medication without consulting a doctor.
Severe
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Coadministration of AFF 10mg/160mg/5mg Tablet and Carbamazepine may reduce the blood levels of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Carbamazepine, you can take these medicines together if prescribed by your doctor. However, if your condition changes or you experience loss of seizure control, contact your doctor.
Coadministration of AFF 10mg/160mg/5mg Tablet and Carbamazepine may reduce the blood levels of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Carbamazepine, you can take these medicines together if prescribed by your doctor. However, if your condition changes or you experience loss of seizure control, contact your doctor.
Severe
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Trimethoprim may decrease the blood levels and effects of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Trimethoprim, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without consulting your doctor.
Trimethoprim may decrease the blood levels and effects of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although there is a possible interaction between AFF 10mg/160mg/5mg Tablet and Trimethoprim, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without consulting your doctor.
Severe
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Coadministration of AFF 10mg/160mg/5mg Tablet and Cholestyramine may interfere with the absorption of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although taking Cholestyramine and AFF 10mg/160mg/5mg Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience Constipation, Diarrhea, Stomach pain, Nausea, or Loss of appetite, consult a doctor. Do not stop using any medications without consulting a doctor.
Coadministration of AFF 10mg/160mg/5mg Tablet and Cholestyramine may interfere with the absorption of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although taking Cholestyramine and AFF 10mg/160mg/5mg Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience Constipation, Diarrhea, Stomach pain, Nausea, or Loss of appetite, consult a doctor. Do not stop using any medications without consulting a doctor.
AtorvastatinConivaptan
Severe
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Using conivaptan together with AFF 10mg/160mg/5mg Tablet may significantly increase the blood levels of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Taking AFF 10mg/160mg/5mg Tablet with Conivaptan together can result in an interaction, but it can be taken if a doctor has advised it. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
Using conivaptan together with AFF 10mg/160mg/5mg Tablet may significantly increase the blood levels of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Taking AFF 10mg/160mg/5mg Tablet with Conivaptan together can result in an interaction, but it can be taken if a doctor has advised it. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
AtorvastatinNelfinavir
Severe
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Taking AFF 10mg/160mg/5mg Tablet with nelfinavir may considerably raise AFF 10mg/160mg/5mg Tablet levels in the blood. This can raise the chance of side effects (liver injury and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).
How to manage the interaction:
Although taking AFF 10mg/160mg/5mg Tablet and cyclosporine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
Taking AFF 10mg/160mg/5mg Tablet with nelfinavir may considerably raise AFF 10mg/160mg/5mg Tablet levels in the blood. This can raise the chance of side effects (liver injury and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).
How to manage the interaction:
Although taking AFF 10mg/160mg/5mg Tablet and cyclosporine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinSimeprevir
Severe
How does the drug interact with AFF 10mg/160mg/5mg Tablet:
Using AFF 10mg/160mg/5mg Tablet together with simeprevir may significantly increase the blood levels of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although taking AFF 10mg/160mg/5mg Tablet and Simeprevir together can cause an interaction, it can be taken if a doctor has suggested it. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
Using AFF 10mg/160mg/5mg Tablet together with simeprevir may significantly increase the blood levels of AFF 10mg/160mg/5mg Tablet.
How to manage the interaction:
Although taking AFF 10mg/160mg/5mg Tablet and Simeprevir together can cause an interaction, it can be taken if a doctor has suggested it. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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AFF 10mg/160mg/5mg Tablet Substitute
Product Substitutes
Alcohol
Caution
Avoid drinking alcohol while taking AFF 10mg/160mg/5mg Tablet. It can raise triglyceride levels and may increase your risk of liver damage.
Pregnancy
Caution
Please consult your doctor. There are no well-controlled studies on the effects of AFF 10mg/160mg/5mg Tablet in pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Breast Feeding
Caution
There is no substantial research yet on the use of AFF 10mg/160mg/5mg Tablet in breastfeeding/nursing mothers. Tell your doctor if you are a nursing mother before taking AFF 10mg/160mg/5mg Tablet; your doctor will decide whether AFF 10mg/160mg/5mg Tablet can be taken by breastfeeding mothers.
Driving
Not applicable
AFF 10mg/160mg/5mg Tablet usually does not affect your ability to drive or operate machinery. However, do not drive or operate machinery if you feel sleepy or dizzy after taking your medicine.
Liver
Safe if prescribed
Inform your doctor before taking AFF 10mg/160mg/5mg Tablet if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
Safe if prescribed
Inform your doctor before taking AFF 10mg/160mg/5mg Tablet if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.
Children
Safe if prescribed
There was limited information about the usage of AFF 10mg/160mg/5mg Tablet in paediatric patients. Please seek medical advice.
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