It is completely understandable to feel frustrated. You are currently taking a highly potent combination of multiple antibiotics (rifampicin, roxithromycin, and sulfamethoxazole-trimethoprim), antifungals (fluconazole), and anti-inflammatory enzymes. Since you have seen no improvement after three months on this heavy regimen, I highly recommend seeking a second opinion from another board-certified dermatologist. A fresh perspective is important to re-evaluate your diagnosis, as persistent acne can sometimes mimic other conditions like hormonal imbalances or fungal folliculitis, and to safely transition you to a simpler, more targeted treatment plan. Do not stop your current medications abruptly without professional medical supervision.