Leg swelling with pain, along with high uric acid, mildly raised creatinine, weakness, and prostate enlargement, may happen because of Hyperuricemia, kidney strain, reduced kidney filtering ability, side effects of medicines, poor circulation, or fluid retention. A creatinine level of 1.46 may indicate reduced kidney function in some people, especially if blood pressure, diabetes, dehydration, or long-term medicine use are also present. Prostate enlargement can sometimes affect urine flow and place additional stress on the urinary system. Febumac 40 helps reduce uric acid levels, but weakness, swelling or persistent pain may still require further evaluation. Kidney function tests, urine tests, ultrasound, electrolyte levels and blood pressure monitoring are important because both high uric acid and uncontrolled blood pressure can affect the kidneys gradually. Proper hydration, reduced salt intake, avoiding alcohol, limiting red meat and high purine foods, and regular follow-up may help improve uric acid and kidney health. Some blood pressure medications and painkillers may additionally influence kidney function or uric acid levels. Consulting a doctor may be helpful, especially if swelling, weakness, creatinine levels, or urine-related symptoms continue increasing. Seek urgent medical care if urine output decreases, breathing becomes difficult, chest pain occurs, or swelling rapidly worsens.