For severe, persistent nighttime heartburn, standard antacids often fall short. You may benefit from longer-acting generic medications: Proton Pump Inhibitors (PPIs), such as omeprazole, pantoprazole, or esomeprazole. Taken once daily before breakfast, they reduce acid production for 24 hours. H2 Blockers, like famotidine, which can be taken before dinner or at bedtime to target nighttime acid spikes. These medications are highly effective and safe. I recommend consulting a doctor to determine the best choice and dosage for you. Meanwhile, avoid eating within three hours of bedtime and elevate your head slightly while sleeping.