For acute ulcerative colitis (inflammation and ulcers in the lining of the large intestine), any additional medications, such as steroids or immunosuppressants, must be carefully prescribed by your doctor or gastroenterologist according to your current symptoms. It is important to continue taking Coolgut (Mesalazine) exactly as directed, even when your symptoms are under control, to prevent flare-ups and maintain gut health. Always consult your doctor before starting new medicines, and attend regular follow-ups to adjust treatment if needed.