Treating a diabetic foot wound depends on the infection's severity. For mild to moderate infections, doctors commonly prescribe oral antibiotics such as amoxicillin-clavulanate, cephalexin, clindamycin, or trimethoprim-sulfamethoxazole. If the infection is more severe, intravenous (IV) antibiotics like piperacillin-tazobactam or vancomycin may be used in a hospital setting to ensure rapid healing. Because these wounds require precise care, your doctor will select the best option, sometimes using a wound culture to target the specific bacteria. Please ensure you take the full course exactly as prescribed and keep your medical team updated on your healing progress.