Rilutor (containing Riluzole) is the standard, globally approved drug for Motor Neuron Disease (MND). While it is not a cure, it is highly recommended because it slows the progression of the disease and can prolong survival. It works by reducing the levels of glutamate, a chemical messenger that can damage motor neurons when present in excess. It is generally well-tolerated, but because it can affect liver enzymes, your mother will need regular blood tests to monitor her liver function, especially during the first few months. Please ensure she takes it exactly as prescribed by her neurologist.

Yes, Motor Neuron Disease (MND) affecting all four limbs since 2006 is considered a permanent disability. You are highly eligible for a physical disability certificate; please consult a government-authorized neurologist or medical board for an official assessment. Regarding treatment, MND is managed symptomatically. Riluzole is commonly prescribed to slow progression. Other medications can manage muscle stiffness, cramps, and drooling. Physical, occupational, and speech therapy, along with assistive devices, are vital to maintain your quality of life. Please consult your healthcare team for a personalized treatment plan.

Currently, there are a few FDA-approved medications that can help manage ALS. Riluzole is an oral medication that helps extend survival. Edaravone (Radicava) is an infusion or oral drug that slows the decline in daily physical functioning. Tofersen (Qalsody) is a newer gene therapy specifically for patients with the genetic SOD1 mutation. Regarding upcoming treatments, several promising therapies targeting nerve protection and neuroinflammation are currently in clinical trials. I highly recommend discussing these standard treatments and potential clinical trial enrollment with his neurologist to find the best plan for him.