You should store Adxate-OS 2 mg Oral Solution (Methotrexate) at room temperature in a cool, dry place away from direct sunlight and extreme heat rather than in the refrigerator. Even when the outside temperature is high, it is best kept in a cupboard that stays below 25 degrees Celsius, as refrigeration may sometimes compromise the liquid's stability. If your home becomes excessively hot, keep the bottle in the coolest room available to maintain its effectiveness. If you are unsure, it is best to confirm with your pharmacist or doctor for safe storage advice.