Yes, nausea and vomiting are common side effects of cefpodoxime, especially when taking a higher dose of 400 mg (two 200 mg tablets) at once. Please do not panic, as this is a manageable stomach reaction. To help prevent this, try taking your medication with a meal, which reduces stomach irritation and actually helps this medicine absorb better. Make sure to sip water throughout the day to stay hydrated. Please contact your prescribing doctor before your next dose; they may suggest splitting the dosage to one tablet twice a day, or prescribe a mild anti-nausea medication to help you comfortably complete your treatment.