Vericiguat
About Vericiguat
Vericiguat is a prescription medication in tablet form used to treat chronic heart failure in adults who have recently experienced worsening symptoms, such as being hospitalised or needing intravenous medications. It is specifically prescribed to help reduce the risk of cardiovascular death and the need for repeat hospital visits due to heart failure.
You should take Vericiguat once daily. It is highly recommended to take this medicine with food, as this significantly improves how well your body absorbs it. Consistency is key; taking your dose at the same time every day helps maintain a steady level of the medication in your system. Along with taking this medicine, incorporating heart-healthy lifestyle choices, such as reducing your salt intake, can help improve your overall treatment results.
While taking Vericiguat, you may experience some side effects. The most common issues include low blood pressure, which can make you feel dizzy, and a reduction in red blood cells. If you notice severe dizziness, fainting, or signs of extreme fatigue, contact your doctor right away.
Talk to your doctor before starting Vericiguat if you have liver damage, severe kidney disease, or if you are pregnant. Do not take this medicine if you are pregnant, as it can cause serious harm to an unborn baby. Women who can become pregnant must use reliable birth control during treatment.
This medicine can interact with other treatments, particularly those used for erectile dysfunction or high blood pressure in the lungs, which can cause a dangerous drop in blood pressure. If you are pregnant, breastfeeding, or are an elderly individual, consult your doctor or pharmacist to discuss whether this medication is safe for you.
Uses of Vericiguat
Medicinal Benefits
Vericiguat helps manage chronic heart failure by improving the heart's ability to pump blood efficiently. With regular use as prescribed, it helps reduce symptoms, lower the risk of hospitalisation, and improve overall quality of life.
- Reduces the Risk of Hospitalisation: By improving heart function and helping keep heart failure stable, this medicine lowers the likelihood of sudden worsening of symptoms that may require hospital admission.
- Relieves Heart Failure Symptoms: Improved blood flow helps reduce shortness of breath, fatigue, and exercise intolerance, allowing you to perform daily activities with greater comfort.
- Supports Better Heart Health: Regular treatment helps reduce the workload on the heart, improve cardiovascular function, and support long-term management of chronic heart failure, contributing to a better quality of life.
Directions for Use
- Take Vericiguat with food or as advised by your doctor.
- It is recommended to take Vericiguat once daily; however, follow your doctor’s advice regarding the dosage and duration.
- Swallow the tablet as a whole with water. Tablets may be crushed and mixed with water for patients who have difficulty swallowing.
- Do not chew Vericiguat.
Storage
Side Effects of Vericiguat
Common Side Effects (Usually mild):
- Dizziness or lightheadedness, especially when standing up quickly
- Low red blood cell levels (anaemia), which may cause you to feel unusually tired or pale
- Upset stomach or mild indigestion
Serious Side Effects (Consult a doctor right away):
- Severe dizziness or feeling like you might pass out (fainting)
- Extreme, unexplained weakness or shortness of breath
- Signs of a severe allergic reaction, such as a skin rash, itching, swelling of your face, lips, tongue, or throat, and difficulty breathing
Medicines Containing this Salt
View AllDrug Warnings
- Avoid pregnancy: This medicine can cause severe birth defects. If you can become pregnant, you must use effective birth control while taking Vericiguat and for one month after your last dose.
- Stand up slowly: To prevent dizziness or fainting, take your time when moving from a sitting or lying position to a standing one.
- Monitor your blood pressure: Check your blood pressure regularly at home as advised by your doctor, and keep a log of your readings to share at your next appointment.
- Check your medicines: Always let your doctor or pharmacist know about all other prescription drugs, over-the-counter medicines, and supplements you are taking before starting Vericiguat.
Drug Interactions
- Other soluble guanylate cyclase (sGC) stimulators: Do not take Vericiguat with other medicines in this same class, as combining them significantly increases the risk of severe, dangerous low blood pressure.
- Erectile dysfunction medicines (PDE5 inhibitors): Taking these medications alongside Vericiguat is not recommended because the combination can cause your blood pressure to drop too low.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeIntake of alcohol should be avoided with Vericiguat.
Pregnancy
unsafeVericiguat should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking Vericiguat.
Breast Feeding
unsafeYou should not breastfeed while taking this medication.
Driving
unsafeVericiguat may cause dizziness. So, driving vehicles and operating machinery which requires concentration should be avoided.
Liver
cautionCaution is advised. Vericiguat has not been studied in patients with severe hepatic impairment. Inform your doctor before using Vericiguat if you have liver problems or a history of liver conditions.
Kidney
cautionCaution is advised. Inform your doctor before using Vericiguat if you have kidney problems or a history of kidney conditions.
Children
unsafeThe safety and effectiveness of Vericiguat in children have not been established.
Habit Forming
Diet & Lifestyle Advise
- Keep a daily weight log: Weigh yourself every morning after using the bathroom but before eating. A sudden weight gain of 2 to 3 pounds in a day, or 5 pounds in a week, can indicate fluid buildup and should be reported to your doctor immediately.
- Reduce sodium intake: Avoid high-salt foods, as excess sodium causes your body to hold onto extra water, placing unnecessary strain on your heart.
- Monitor your fluids: If your doctor has recommended a daily fluid limit, stay strictly within those boundaries to prevent fluid overload.
- Engage in gentle exercise: With your doctor's approval, participate in moderate physical activities like daily walking to support your cardiovascular strength.
Patients Concern
Disease/Condition Glossary
Heart failure: Heart failure is a condition in which the heart is unable to pump blood as effectively as it should. Conditions such as coronary artery disease, arrhythmia, congenital heart defect, diabetes, overactive/underactive thyroid, or high blood pressure make the heart too weak to pump blood efficiently. Symptoms of heart failure include shortness of breath, rapid heartbeat, swollen legs, and fatigue. People with disease conditions such as diabetes, thyroid problems, anaemia, emphysema, and behavioural conditions like smoking and being overweight are at an increased risk of developing heart failure.
FAQs
Vericiguat is used to reduce the risk of death and the need for hospitalization in adults with heart failure.
Vericiguat contains Vericiguat, which works by relaxing the blood vessels and allowing blood to flow easily. As a result, the heart can pump more efficiently and does not have to work as hard. As a result, it helps to lower the risk of death and hospitalization in people with heart failure.
No, you should not combine Vericiguat with an erectile dysfunction medicine such as sildenafil or tadalafil since it may interfere with the blood pressure-lowering action of Vericiguat.
Yes, dizziness or light-headedness is the most common side effect encountered while using Vericiguat. Please take sufficient rest. If the problem persists, consult your doctor.
Vericiguat may not be recommended for patients with hypotension (low blood pressure); inform your doctor before using Vericiguat if you have a history of hypotension.
Vericiguat may not be recommended for patients with severe anaemia (does not have enough healthy red blood cells); inform your doctor before using Vericiguat if you have ever had anaemia.
Entresto and Vericiguat are both medications used to manage heart failure, but they work in different ways and have distinct uses. Entresto contains sacubitril/valsartan, while Vericiguat contains Vericiguat. Both medications have shown effectiveness in managing heart failure and reducing hospitalizations. The choice between them may depend on individual patient factors, such as medical history, current symptoms, and overall health. Ultimately, the decision between Entresto and Vericiguat should be made in consultation with your doctor, who can consider your medical history and needs.
Vericiguat should be taken once daily with food. The specific time of day is not as important as taking it consistently at the same time each day to maintain an even level in your blood. If you have any concerns or specific instructions from your healthcare provider, it is best to follow their guidance.
Vericiguat is primarily used to reduce the risk of cardiovascular death and heart failure hospitalization in patients with symptomatic chronic heart failure with reduced ejection fraction (HFrEF). While Vericiguat helps improve heart function by enhancing the production of cyclic guanosine monophosphate (cGMP), which relaxes blood vessels and reduces the workload on the heart, it does not directly improve ejection fraction.
Your doctor will determine the dosing of Vericiguat and prescribe the appropriate dose based on various factors, such as your medical condition, response to treatment, and ability to tolerate the medication.
No, Vericiguat should not be taken during pregnancy. It may cause fetal harm when administered to a pregnant woman. It is important to exclude pregnancy before starting treatment with Vericiguat and to use effective contraception during treatment and for at least one month after stopping the medication.
Vericiguat can lower blood pressure, and hypotension (low blood pressure) is a common side effect of this medication. If you experience symptoms such as dizziness or lightheadedness, taking precautions to avoid falls or injuries is essential. To cope with these symptoms, sit or lie down immediately if you feel dizzy, stay hydrated by drinking plenty of water, avoid standing for long periods, rise slowly from sitting or lying down positions, and avoid heavy lifting or bending. However, consult your healthcare provider for guidance if symptoms persist or worsen.
Heart failure can present a variety of symptoms, some of which may be subtle and easily overlooked. Here are some common symptoms to watch out for: shortness of breath with activity or when lying down, fatigue and weakness, swelling in the legs, ankles and feet, rapid or irregular heartbeat, wheezing, very fast weight gain from fluid buildup, nausea and lack of appetite, difficulty concentrating or decreased alertness, chest pain if a heart attack causes heart failure. If you or someone you know is experiencing these symptoms, it is essential to seek medical attention for proper evaluation and management.
Making positive lifestyle changes can significantly impact heart failure management and overall health. Some key lifestyle modifications that can make a difference are maintaining a healthy diet, regular exercise, weight management, managing stress, quitting smoking, limiting alcohol, and following medical advice.
A heart-healthy diet is designed to support cardiovascular health and reduce the risk of heart disease. Some key components of a heart-healthy diet are fruits and vegetables, limited added sugars, moderate alcohol intake, whole grains, lean proteins, and hydration. Following these guidelines can help protect your heart and improve your overall well-being.
No, you should always take Vericiguat with a meal. Food helps your body absorb the medicine properly so that it can work effectively to protect your heart. Talk to your doctor or pharmacist if you struggle to take it with meals.
Yes, if you cannot swallow the tablet whole, you can crush it and mix it with a small amount of water right before taking your dose. Be sure to drink the entire mixture immediately. Talk to your doctor or pharmacist for further guidance.
It is highly recommended to limit or avoid alcohol while taking this medicine. Alcohol can widen your blood vessels further, which increases the risk of severe dizziness, lightheadedness, and fainting. Talk to your doctor to understand what is safe for you.
Vericiguat is a long-term treatment designed to manage chronic heart failure and prevent serious complications. You should continue taking it even if you feel better. Do not stop taking this medication without consulting your doctor first.
If you miss a dose, take it with food as soon as you remember on that same day. If it is already the next day, skip the missed dose and take your next regularly scheduled dose. Never take two doses at once. Talk to your doctor or pharmacist if you miss multiple doses.
Yes, Vericiguat is typically prescribed alongside other standard medicines for heart failure. However, some combinations, especially with certain blood pressure medications, can cause interactions. Talk to your doctor or pharmacist to make sure all your current medications are safe to use together.

