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Faricimab

About Faricimab

Faricimab is a prescription injection used to treat serious eye conditions that can lead to vision loss, including wet age-related macular degeneration (nAMD) and diabetic macular oedema (DME). It works by targeting specific proteins inside the eye that cause abnormal blood vessel leakage and swelling. By reducing this leakage, the medicine helps protect your vision and may help maintain or improve your eyesight.

Faricimab is injected directly into the eye by a trained eye specialist, usually every few weeks or months depending on how well your eye responds to treatment. Keeping all scheduled appointments is important because delaying or missing injections may reduce the effectiveness of treatment. Eating a balanced diet rich in leafy green vegetables and protecting your eyes from ultraviolet (UV) light may also help support long-term eye health.

Some people experience mild side effects such as temporary eye discomfort, small floating spots in their vision (floaters), or a brief increase in pressure inside the eye after the injection. These effects usually improve with time. However, seek immediate medical attention if you develop severe eye pain, worsening redness, sudden vision changes, or increasing sensitivity to light, as these may be signs of a serious eye problem.

Before starting treatment, tell your eye specialist if you have an active infection in or around your eye or inflammation inside your eye. Do not receive this medicine if you are allergic to this medicine or any of the ingredients in the injection.

Because this medicine works mainly inside the eye, interactions with oral medicines or alcohol are unlikely. However, smoking may worsen age-related macular degeneration and reduce the benefits of treatment. If you are pregnant, breastfeeding, or planning a pregnancy, discuss the potential benefits and risks with your doctor before starting treatment.

Uses of Faricimab

Faricimab is used to improve and maintain vision in neovascular (wet) age-related macular degeneration (nAMD), diabetic macular edema (DME), or macular edema following retinal vein occlusion (RVO). The detailed uses of Faricimab are as follows: • nAMD Treatment: Faricimab treats neovascular age-related macular degeneration (nAMD), an ongoing disease causing central vision loss and impacting daily activities, by targeting VEGF and Ang-2 to slow vision loss and preserve vision. • Diabetic macular edema (DME): Faricimab treats Diabetic Macular Edema (DME), an eye disease caused by diabetes that can lead to vision loss, by dual-action targeting of VEGF and Ang-2, reducing edema and preserving vision. • Macular edema followed by retinal vein occlusion: Faricimab is also used for treating macular edema secondary to retinal vein occlusion (RVO), aiming to reduce edema and improve vision.

Medicinal Benefits

When used as prescribed, Faricimab may provide the following benefits:

  • Helps preserve vision: By reducing fluid leakage and swelling in the retina, it helps slow further vision loss and may improve vision in some people.
  • May reduce the number of injections: Many people can gradually extend the time between injections compared with some older treatments, resulting in fewer clinic visits.
  • Reduces retinal swelling: Helps decrease swelling in the retina, reducing stress on the delicate tissues responsible for vision.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Faricimab is administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Faricimab

Common Side Effects (Usually mild)

  • Temporary eye pain or discomfort
  • Seeing small dark spots or floaters
  • Blood on the white of the eye (conjunctival haemorrhage)
  • Temporary increase in pressure inside the eye
     

Serious Side Effects (Consult your doctor right away)

  • Severe eye pain, worsening redness, or extreme sensitivity to light, which may be signs of an eye infection
  • Sudden changes in vision, flashes of light, or a shadow or curtain across your vision, which may indicate retinal detachment
  • Signs of a severe allergic reaction, such as swelling of the face, lips, tongue, or throat, or difficulty breathing

Drug Warnings

  • Monitor your vision: Pay close attention to any changes in your eyesight during the days after each injection.
  • Avoid driving immediately after treatment: Your pupils may be dilated and your vision may be temporarily blurred following the procedure.
  • Watch for signs of infection: Contact your eye specialist immediately if you develop worsening eye pain, redness, increasing sensitivity to light, or worsening vision.
  • Avoid rubbing your eye: Try not to rub or press on the treated eye for a few days after the injection to reduce the risk of injury or infection.
  • Keep all follow-up appointments: Missing scheduled injections may allow your eye condition to worsen and could lead to permanent vision loss.

Drug Interactions

  • Other medicines injected into the eye (i.e. ranibizumab, aflibercept, brolucizumab): Using multiple medicines injected into the same eye should only be done under the guidance of an eye specialist, as treatment schedules and safety need careful monitoring.
  • Medicines that affect blood clotting (i.e. warfarin, apixaban, rivaroxaban, aspirin, clopidogrel): These medicines are not known to interact directly with faricimab. However, they may slightly increase the chance of a small bleed on the white part of the eye after the injection. Do not stop these medicines unless your doctor advises you to.

Drug-Drug Interactions Checker List:

Safety Advice

  • Safety Warning

    Alcohol

    consult your doctor

    It is not known whether Faricimab interacts with alcohol. Please consult your doctor.

  • Safety Warning

    Pregnancy

    consult your doctor

    If you are pregnant or planning to become pregnant, inform your doctor before receiving Faricimab. Your doctor may recommend Faricimab if the potential benefits outweigh the possible risks.

  • Safety Warning

    Breast Feeding

    consult your doctor

    It is unknown whether Faricimab passes into breast milk. If you are breastfeeding or plan to breastfeed, please consult your doctor before receiving it.

  • Safety Warning

    Driving

    caution

    Faricimab may cause blurred vision. Therefore, avoid driving or operating machinery until your vision is clear.

  • Safety Warning

    Liver

    consult your doctor

    Please inform your doctor if you have liver impairment/liver disease before receiving Faricimab.

  • Safety Warning

    Kidney

    consult your doctor

    Please inform your doctor if you have kidney impairment/kidney disease before receiving Faricimab.

  • Safety Warning

    Children

    consult your doctor

    The safety and effectiveness of Faricimab in children have not been established. Please consult your doctor if you have any concerns regarding use of Faricimab for children.

Habit Forming

No

Diet & Lifestyle Advise

  • Eat eye-healthy foods: Include leafy green vegetables, oily fish rich in omega-3 fatty acids, and citrus fruits as part of a balanced diet.
  • Stop smoking: Smoking increases the risk of worsening age-related macular degeneration and may reduce the benefits of treatment.
  • Wear UV-protective sunglasses: Choose sunglasses that provide 100% UVA and UVB protection whenever you are outdoors.
  • Monitor your vision: Use an Amsler grid at home if your eye specialist has recommended one, and report any new changes promptly.
  • Control diabetes and blood pressure: Keeping your blood sugar and blood pressure within the target range helps protect the blood vessels in your eyes.

Patients Concern

Disease/Condition Glossary

Neovascular (wet) age-related macular degeneration (nAMD): Wet age-related macular degeneration (nAMD) is a chronic eye condition where abnormal blood vessels grow under the retina, causing fluid leaks, swelling, and vision loss. Age, genetics, and smoking contribute to its development. Symptoms include blurred vision, distorted lines, and dark spots. 

Diabetic macular edema (DME): Diabetes macular edema (DME) is swelling in the macula, or central, part of the retina of eye. It occurs when high blood sugar levels affect the blood vessels in eyes causing fluid leakage into the macula. This leads to symptoms such as blurred or distorted vision, dark spots, and difficulty distinguishing colors.

Macular edema following retinal vein occlusion (RVO): Retinal vein occlusion (RVO) is a partial or total blockage in a vein that drains blood from retina, certain health conditions, such as high blood pressure, diabetes, or heart problems, can cause vision problems. Symptoms may include dark spots, blurry or distorted vision, and gradual vision loss.

FAQs

Faricimab is given as an injection directly into the eye by a trained eye specialist in a clinic or hospital. Local anaesthetic eye drops are used to help make the procedure as comfortable as possible.

Most people experience only mild discomfort because the eye is numbed before the injection. If you are anxious about the procedure, discuss your concerns with your eye specialist before treatment.

The interval between injections depends on your eye condition and how well you respond to treatment. Some people require injections every 4 weeks, while others may gradually extend to every 16 weeks. Your eye specialist will decide the most suitable schedule.

No. Your vision may be temporarily blurred and your pupils may remain dilated after the procedure. Arrange for someone to drive you home or use alternative transport if needed.

Contact your eye clinic as soon as possible to arrange another appointment. Keeping to your treatment schedule is important to help protect your eyesight.

No. These conditions cannot usually be cured, but Faricimab helps manage them by reducing retinal swelling, slowing disease progression, and helping preserve vision.

Avoid rubbing your eye, swimming, or getting water directly into the treated eye for a few days after the injection to reduce the risk of infection. Your eye specialist will advise you when you can safely resume your usual activities.

The safety of this medicine during pregnancy and breastfeeding has not been fully established. Your doctor will carefully weigh the potential benefits and risks before recommending treatment.

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