Disodium Edta+polymyxin B Sulphate
About Disodium Edta+polymyxin B Sulphate
Disodium Edta+polymyxin B Sulphate is a specialized injection used to treat severe, complicated bacterial infections, particularly those that do not respond to other standard antibiotics. It is typically prescribed to treat serious infections in the bloodstream, the urinary tract, or the protective membranes surrounding the brain. Your doctor will determine if this medication is appropriate for your specific condition.
This medicine is given at regular intervals to ensure a steady level remains in your body to fight the bacteria effectively. It is critical to complete the full course of treatment exactly as prescribed, even if you start feeling better. Since it is given directly as an injection or drip, food does not interfere with how it works, but drinking plenty of water and maintaining a balanced diet will support your body during recovery.
While using Disodium Edta+polymyxin B Sulphate, you may experience mild side effects, such as pain or redness at the injection site, or minor dizziness. However, you must contact your doctor immediately if you notice serious symptoms like changes in how much you urinate, numbness, or tingling in your hands and feet.
Before starting your treatment, talk to your doctor if you have a history of kidney disease or nerve-muscle disorders. Do not take this if you have had a severe allergic reaction to this medication or any similar injections in the past.
This medication can interact with other drugs that place stress on your kidneys or nerves, so always share a complete list of your current medicines with your healthcare team. If you are pregnant, breastfeeding, or are an elderly individual, consult your doctor to ensure this treatment is safe for your specific situation.
Uses of Disodium Edta+polymyxin B Sulphate
Medicinal Benefits
- Helps clear serious bacterial infections when many standard antibiotics are no longer effective.
- Reduces the spread of infection to other parts of the body when used as prescribed.
- Supports recovery by controlling difficult-to-treat infections under close medical supervision.
- May improve treatment outcomes when combined with appropriate supportive care and regular monitoring.
Directions for Use
- Follow your doctor's instructions on the dosage and timing of this medication.
- Disodium Edta+polymyxin B Sulphate will be administered by a healthcare professional in a medical setting.
- Do not self-administer it.
Storage
Side Effects of Disodium Edta+polymyxin B Sulphate
Common Side Effects (Usually mild):
- Pain, redness, or swelling where the injection was given
- Mild dizziness or feeling lightheaded
- Temporary fever or chills
Serious Side Effects (Call a doctor right away):
- Signs of kidney issues, such as producing less urine, lower back pain, or swelling in your legs and feet
- Numbness, tingling, or a pins and needles sensation in your skin
- Unusual muscle weakness or difficulty breathing
- Severe allergic reactions, including a sudden rash, itching, or swelling of the face, tongue, and throat
- Difficulty breathing, severe muscle weakness, or trouble swallowing: This is a medical emergency. Stop receiving the medicine (if possible), seek immediate emergency medical care, or call your local emergency services right away.
Drug Warnings
- Inspect the vial: Always look at the liquid before it is injected; do not use it if you notice cloudiness, discoloration, or floating particles.
- Monitor your breathing: Alert your medical provider immediately if you experience shortness of breath or sudden muscle weakness after receiving a dose.
- Complete the course: Do not stop treatment early, even if you feel completely better, to prevent the infection from returning.
- Rotate injection sites: If you receive this medicine as an injection into the muscle, ensure the injection site is changed each time to prevent tissue soreness.
- Do not use this medicine: if you have had a severe allergic reaction to polymyxin antibiotics or any ingredient in this injection.
- Use with extra caution: if you have severe kidney disease or a neuromuscular disorder such as myasthenia gravis. Your doctor will decide whether the benefits outweigh the risks.
- Use antibiotics responsibly: This medicine is usually reserved for serious infections caused by bacteria that are resistant to many other antibiotics. Always complete the prescribed course and never share or reuse leftover antibiotics, as this can contribute to antibiotic resistance.
- Do not use this medicine: if you have previously had a severe allergic reaction to polymyxin antibiotics or to sulfite-containing products (if present in your formulation). Check the product label or ask your pharmacist if you are unsure.
Drug Interactions
- Medicines that can affect the kidneys (nephrotoxic medicines): Taking this medicine together with certain antibiotics such as aminoglycosides (a type of antibiotic like gentamicin), antifungal medicine like amphotericin B (an antifungal medicine), or other medicines that affect the kidneys may increase the risk of kidney damage.
- Medicines that relax muscles during surgery (neuromuscular blockers): This medicine can increase the effects of these medicines, which may raise the risk of severe muscle weakness or breathing problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is unknown if alcohol interacts with Disodium Edta+polymyxin B Sulphate. Please consult your doctor if you have concerns regarding this.
Pregnancy
cautionIf you are pregnant or planning to become pregnant, inform your doctor before receiving Disodium Edta+polymyxin B Sulphate. Your doctor will prescribe Disodium Edta+polymyxin B Sulphate if only the benefits outweigh the risks.
Breast Feeding
cautionIf you are breastfeeding, inform your doctor before receiving Disodium Edta+polymyxin B Sulphate. Your doctor will prescribe Disodium Edta+polymyxin B Sulphate if only the benefits outweigh the risks.
Driving
consult your doctorIt is unknown if Disodium Edta+polymyxin B Sulphate affects your ability to drive. Drive only if you are mentally alert.
Liver
consult your doctorIf you have a history of liver problems, consult your doctor before receiving Disodium Edta+polymyxin B Sulphate.
Kidney
cautionIf you have a history of kidney problems, inform your doctor before receiving Disodium Edta+polymyxin B Sulphate.
Children
safe if prescribedDisodium Edta+polymyxin B Sulphate may be safe for use in children if prescribed by the doctor.
Habit Forming
Diet & Lifestyle Advise
- Drink plenty of fluids: Stay highly hydrated by drinking water throughout the day to help your kidneys flush the medication safely from your body.
- Get adequate rest: Rest as much as possible to allow your immune system to focus its energy on fighting off the infection.
- Follow up with tests: Attend all scheduled blood and urine tests so your doctor can closely monitor your kidney health during treatment.
Special Advise
- Kidney function should be assessed before starting treatment with Disodium Edta+polymyxin B Sulphate. Both blood drug levels and kidney function should be regularly monitored during the treatment.
Patients Concern
Disease/Condition Glossary
Bacterial infection: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. These infectious or harmful bacteria produce toxins that can damage tissue and make you sick. They can target any body part and multiply very quickly. General symptoms of a bacterial infection include fever, chills, and fatigue. Anyone can become infected with a bacterial infection; however, people with a weakened immune system or those taking immunosuppressant medications are more prone to bacterial infections.
FAQs
Disodium Edta+polymyxin B Sulphate is an antimicrobial medication used to treat drug-resistant infections caused by Gram-negative bacteria. It is indicated for the treatment of urinary tract infections, meningitis (inflammation of the membranes covering the spinal cord and brain), and bacteraemia (bloodstream infections) caused by certain types of bacteria, such as Staphylococcus aureus and Pseudomonas aeruginosa.
Disodium Edta+polymyxin B Sulphate contains two ingredients: Polymyxin B Sulphate (an antibiotic) and Disodium EDTA (a chelating agent). Polymyxin B Sulphate works by destroying the bacterial cell membrane, a protective covering necessary for their survival, thereby killing the infection-causing bacteria. Disodium EDTA (ethylenediaminetetraacetic acid) works by reducing bacterial resistance and enhancing the effectiveness of the Polymyxin B Sulphate against the bacteria. Thus, Disodium Edta+polymyxin B Sulphate helps treat bacterial infections.
The common side effects of Disodium Edta+polymyxin B Sulphate may include diarrhoea, drowsiness, dizziness, facial flushing (redness or warmth of the face), fever, skin rash, pain, and swelling at the injection site. Most of these side effects of Disodium Edta+polymyxin B Sulphate do not require medical attention and will gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Diarrhoea may be a side effect of Disodium Edta+polymyxin B Sulphate. Symptoms can appear even two months after stopping Disodium Edta+polymyxin B Sulphate, so it is important to keep your doctor informed about your health condition. If diarrhoea persists or worsens, discontinue the treatment and consult your doctor. Drink enough fluids, take nutrient supplements, and avoid spicy food if you experience diarrhoea.
Disodium Edta+polymyxin B Sulphate may cause nerve problems. Consult your doctor if you experience weakness, irritability, change in balance, drowsiness, blurred vision, trouble breathing, or numbness or tingling sensation in the arms and legs.
Inform your doctor if you do not feel better even after finishing the full prescribed course of treatment. If symptoms worsen while using this medicine, consult your doctor right away.
Usually, Disodium Edta+polymyxin B Sulphate starts working soon after taking it. However, it may take a few days to kill all the harmful bacteria and make you feel better.
Please consult your doctor before receiving Disodium Edta+polymyxin B Sulphate if you are pregnant or planning to become pregnant. Your doctor will prescribe Disodium Edta+polymyxin B Sulphate if only the benefits outweigh the risks.
Receiving treatment for a serious bacterial infection can feel overwhelming, but your healthcare team will guide you through every step. This medicine is usually given by a trained healthcare professional in a hospital or clinic because it requires careful preparation and monitoring. Home administration should only be considered if your doctor decides it is appropriate and you or your caregiver have been properly trained.
Numbness, tingling, muscle weakness, or unusual sensations may be signs that the medicine is affecting your nerves. Contact your doctor or healthcare provider immediately if these symptoms occur. If you develop sudden muscle weakness, difficulty breathing, or trouble swallowing, seek emergency medical care immediately or call your local emergency services, as these symptoms require urgent treatment.
Yes, this medicine can affect kidney function in some people, particularly those with existing kidney disease or those receiving higher doses. Your doctor will usually monitor your kidney function with regular blood and urine tests during treatment to detect any problems early.
There is no well-established direct interaction between alcohol and this medicine. However, alcohol can contribute to dehydration, which may place additional strain on your kidneys while your body is recovering from a serious infection. Limiting or avoiding alcohol during treatment is generally recommended, especially if you have kidney problems or are feeling unwell.
This medicine is generally reserved for serious infections when the expected benefits outweigh the possible risks. If you are pregnant, planning to become pregnant, or think you may be pregnant, your doctor will carefully assess whether this treatment is the safest option for you.
Contact your doctor or healthcare facility as soon as possible to arrange another appointment. Missing doses can reduce the effectiveness of treatment, so it is important to stay as close to the prescribed schedule as possible.
This medicine is usually reserved for serious infections caused by bacteria that no longer respond to many commonly used antibiotics. Using it only when necessary helps slow the development of antibiotic resistance and preserves its effectiveness for patients who have very limited treatment options.
In rare cases of severe bacterial meningitis, specialists may give this medicine directly into the fluid surrounding the brain and spinal cord when other treatments are unlikely to be effective. Because this route carries a higher risk of nervous system side effects, it is used only in specialized hospitals with close medical monitoring.
The duration depends on the type and severity of your infection and how well you respond to treatment. Some infections require only several days of therapy, while others may need treatment for several weeks. Your doctor will decide the appropriate treatment duration based on your progress.
Most people gradually continue recovering after completing the full antibiotic course, although recovery time depends on the type and severity of the infection. Your doctor may arrange follow-up visits or laboratory tests to confirm the infection has cleared. Contact your doctor if your fever returns, your symptoms worsen, or you develop new signs of infection after treatment.
