Trinbelimab
About Trinbelimab
Trinbelimab is used to prevent Rh sensitization in Rh-negative individuals, especially during pregnancy and after certain medical procedures. Rh sensitization occurs when an Rh-negative individual is exposed to Rh-positive red blood cells, leading their immune system to produce antibodies against the Rh factor. This can happen during pregnancy if an Rh-negative mother carries an Rh-positive baby, or through blood transfusions with Rh-positive blood.
Trinbelimab contains Trinbelimad, which belongs to the class of drugs called immunoglobulins. It works by eliminating or neutralizing any Rh D-positive fetal red blood cells that may enter the Rh D-negative mother's bloodstream during childbirth, abortion, or any pregnancy-related complications that could cause bleeding across the placenta.
The dose and duration of treatment with Trinbelimab may vary depending on your medical condition. Trinbelimab usually does not have any known side effect. However, in some cases, it may cause some side effects, including local pain, fever, flushing, headache, and chills, which may occur after administration. Most of these side effects are temporary and resolve on their own. It is essential to consult your doctor if they persist or worsen over time.
Inform your doctor if you are allergic to Trinbelimab. Also inform your doctor about all the medicines you are taking and about your pre-existing health conditions. Trinbelimab is for intramuscular use only, do not inject intravenously. It is for maternal administration. Do not inject the new-born infant. Trinbelimab is contraindicated in pregnant woman with positive ICT (Indirect Coombs' test) and Rh-D positive.
Uses of Trinbelimab
Medicinal Benefits
Trinbelimab is used to prevent Rh sensitization in individuals with Rh-negative blood. It is typically given to Rh-negative pregnant women within 72 hours after delivery if the baby is Rh-positive. This helps prevent the mother's immune system from reacting to Rh-positive red blood cells. Additionally, it is used in Rh-negative individuals who receive Rh-positive blood transfusions to prevent an immune reaction.
Directions for Use
- Follow your doctor’s instructions on the dosage and timing of this medication.
- Trinbelimab is administered by the doctor or nurse in a healthcare setting.
- Do not self-administer.
Storage
Side Effects of Trinbelimab
- Local pain
- Fever
- Flushing
- Headache
- Chills
Drug Warnings
Trinbelimab is for intramuscular use only, do not inject intravenously. It is for maternal administration. Do not inject the new-born infant. Trinbelimab is contraindicated in pregnant woman with positive ICT (Indirect Coombs' test) and Rh-D positive. Inform your doctor if you are allergic to Trinbelimab. Also inform your doctor about all the medicines you are taking and about your pre-existing health conditions.
Drug Interactions
Drug-Drug Interactions: No interactions were found/established.
Drug-Food Interactions: No interactions were found/established.
Dug-Disease Interactions: No interactions were found/established.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is unknown whether Trinbelimab interacts with alcohol. Consult your doctor for more information.
Pregnancy
cautionTrinbelimab is contraindicated in pregnant woman with positive ICT (Indirect Coombs' test) and who is Rh-D positive. Trinbelimab does not harm the fetus or affect future pregnancies or the reproduction capacity of the maternal recipient. Trinbelimab is intended for use in other sensitizing events during pregnancy.
Breast Feeding
consult your doctorPlease inform your doctor if you are breastfeeding, before receiving Trinbelimab.
Driving
consult your doctorThere is limited information available on the use of Trinbelimab during driving. Please consult your doctor.
Liver
consult your doctorPlease inform your doctor if you have liver impairment/liver disease before receiving Trinbelimab.
Kidney
consult your doctorPlease inform your doctor if you have kidney disease before receiving Trinbelimab.
Children
unsafeTrinbelimab is not recommended for children.
Habit Forming
Diet & Lifestyle Advise
- Consume a range of entire grains, lean meats, fruits, veggies, and healthy fats.
- Ensure you get enough rest and sleep.
- Avoid alcohol and tobacco, as they can harm your baby.
- Practice stress-reducing activities like meditation or deep breathing exercises.
- Drink plenty of water to stay hydrated.
- Engage in moderate exercise, such as walking or prenatal yoga, unless contraindicated.
Patients Concern
Disease/Condition Glossary
Rh sensitization: Rh sensitization occurs when an individual with Rh-negative blood is exposed to Rh-positive blood, triggering the production of antibodies against the Rh factor. This can happen during pregnancy, blood transfusions, or injuries that mix the two blood types. Initially, there are no noticeable symptoms. However, if sensitization occurs during pregnancy, it can lead to severe complications in future pregnancies. These complications can include jaundice, anemia, hydrops fetalis, and even stillbirth.
FAQs
Trinbelimab is used to prevent Rh sensitization in Rh-negative individuals, especially during pregnancy and after certain medical procedures.
Trinbelimab contains Trinbelimad, which belongs to the class anti-Rh D immunoglobulin. It works by eliminating or neutralizing any Rh D-positive fetal red blood cells that may enter the Rh D-negative mother's bloodstream during childbirth, abortion, or any pregnancy-related complications that could cause bleeding across the placenta.
Trinbelimab is contraindicated in pregnant woman with positive ICT (Indirect Coombs' test), Rh-D positive and should not be given to an infant. Inform your doctor if you are allergic to Trinbelimab. Also inform about all the medicines you are taking and about your pre-existing health conditions.
There are no known side effects to Trinbelimab. However, it may cause local pain, flushing, fever, chills and headache, after administration. Most of these side effects gradually resolve on their own over time. However, please consult your doctor if these symptoms persist or worsen.
