Tadalafil+dapoxetine
About Tadalafil+dapoxetine
Tadalafil+dapoxetine is used to treat erectile dysfunction and premature ejaculation in men. Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Premature ejaculation is a problem in which a man ejaculates sooner than his partner during sexual intercourse.
Tadalafil+dapoxetine contains Tadalafil and Dapoxetine. Tadalafil works by inhibiting the phosphodiesterase enzyme, which breaks down cGMP and causes smooth muscle relaxation and vasodilation (widening) of blood vessels in the penis. Dapoxetine works by increasing the serotonin level in nerves, which improves control over ejaculation and hence increases the time taken to ejaculate.
In some cases, you may experience nausea, dizziness, vomiting, dryness in the mouth, indigestion, nosebleeds, headache, and flushing. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.
Do not take Tadalafil+dapoxetine if you take nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension), or alpha-blockers if you have heart problems or stroke, low or uncontrolled high blood pressure. Tadalafil+dapoxetine is not intended for use in women. Tadalafil+dapoxetine may cause dizziness, so drive with caution.
Uses of Tadalafil+dapoxetine
• Management of Erectile Dysfunction: Tadalafil+dapoxetine is commonly prescribed to help men with erectile dysfunction achieve and maintain an erection during sexual activity.
• Improvement of Sexual Performance: Tadalafil+dapoxetine can increase blood flow to the penis, allowing for improved sexual response.
• Support for Psychological Factors: Tadalafil+dapoxetine can help address psychological causes of erectile dysfunction, such as anxiety or stress, by enabling better physical responses.
• Treatment of Premature Ejaculation: Tadalafil+dapoxetine may be used to help manage issues related to premature ejaculation, contributing to a more satisfying sexual experience.
• Facilitation of Reproductive Health: By addressing erectile dysfunction, Tadalafil+dapoxetine can play a role in supporting overall reproductive health in men, potentially improving fertility outcomes.
Medicinal Benefits
- Tadalafil+dapoxetine is a combination drug containing 'impotent agents', primarily used to treat erectile dysfunction (impotence) and premature ejaculation in men.
- Tadalafil+dapoxetine contains Tadalafil and Dapoxetine.
- Tadalafil works by inhibiting the phosphodiesterase enzyme, which leads to the breakdown of cGMP and causes relaxation of smooth muscles and vasodilation (widening) of blood vessels in the penis.
- Tadalafil+dapoxetine helps to treat erectile dysfunction and symptoms of an enlarged prostate.
- Dapoxetine works by increasing the serotonin level in nerves, which improves control over ejaculation and increases the time taken to ejaculate.
Directions for Use
- Take Tadalafil+dapoxetine with or without food, or as advised by a doctor.
- Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
- Swallow the medicine as a whole with a glass of water.
- Do not crush, break, or chew it.
Storage
Side Effects of Tadalafil+dapoxetine
- Nausea
- Dizziness
- Vomiting
- Dryness in the mouth
- Indigestion
- Nosebleeds
- Headache
- Flushing (sense of warmth in the face, ears, neck, and trunk)
Drug Warnings
- Do not take Tadalafil+dapoxetine if you are allergic to any of its contents.
- Also, avoid taking Tadalafil+dapoxetine if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension), or alpha-blockers; if you have heart problems or stroke, low blood pressure, or uncontrolled high blood pressure, or if you have ever had a loss of vision.
- Inform your doctor before taking Tadalafil+dapoxetine if you have sickle cell anemia (abnormal red blood cells), multiple myeloma (cancer of bone marrow), leukemia (blood cell cancer), deformation in the penis, or severe kidney or liver problems.
- Consult your doctor immediately if you experience loss of vision or hearing while taking Tadalafil+dapoxetine.
- Tadalafil+dapoxetine is not intended for use in women.
- Tadalafil+dapoxetine may cause dizziness, so drive with caution.
- Avoid consuming alcohol as it might cause increased dizziness.
- Tadalafil+dapoxetine should not be given to children as safety and effectiveness have not been established.
- Do not take Tadalafil+dapoxetine if you have taken an MAO inhibitor (anti-depressant medication like Isocarboxazid, Phenelzine, Selegiline, and Tranylcypromine) in the last 14 days.
Drug Interactions
Drug-Drug Interactions: Tadalafil+dapoxetine may have interaction with anti-hypertensive (amlodipine, lisinopril, losartan, metoprolol, riociguat), alpha-blockers (tamsulosin), anti-anginal (nitroglycerin), anti-fungal (ketoconazole, itraconazole), antibiotics (erythromycin, clarithromycin), anti-TB (rifampicin), anticonvulsants (phenobarbital, phenytoin, carbamazepine), anti-HIV (ritonavir, saquinavir, nelfinavir), pain-killers (tramadol), anti-depressants (lithium, nefazodone), MAO inhibitor (Isocarboxazid, Phenelzine, Selegiline, and Tranylcypromine).
Drug-Food Interactions: Avoid consumption of alcohol as it may temporarily impair your ability to get an erection. Also, do not take St John's wort plant (a natural remedy to treat depression).
Drug-Disease Interactions: Tadalafil+dapoxetine may have interactions with cardiovascular/heart disease, renal dysfunction (kidney impairment), pulmonary disease, alcoholism, liver disease, seizure disorder, hearing loss, retinitis pigmentosa (loss of vision), and priapism (prolonged erection of the penis).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionYou are advised not to consume alcohol while taking Tadalafil+dapoxetine as it may cause increases dizziness.
Pregnancy
unsafeTadalafil+dapoxetine contains Tadalafil, which belongs to pregnancy category B. Tadalafil+dapoxetine is not intended for use in women.
Breast Feeding
unsafeTadalafil+dapoxetine is not intended for use in women.
Driving
cautionTadalafil+dapoxetine may cause dizziness. Therefore, you are advised to drive and operate machinery only if you are alert.
Liver
consult your doctorDose adjustment may be needed. Please consult your doctor before taking Tadalafil+dapoxetine if you have liver impairment/liver disease or any concerns regarding this.
Kidney
consult your doctorDose adjustment may be needed. Please consult your doctor before taking Tadalafil+dapoxetine if you have kidney impairment/kidney disease or any concerns regarding this.
Children
unsafeTadalafil+dapoxetine should not be given to children as safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Maintaining a healthy weight, eating a balanced diet, and regularly exercising may help you manage erectile dysfunction.
- Avoid alcohol consumption to treat your condition effectively, as consuming an excessive amount of alcohol may temporarily impair your ability to get an erection.
- Avoid the use of tobacco.
- Share intimate time with your partner.
- Stay sexually active to prevent further problems with erectile dysfunction.
Special Advise
- Take Tadalafil+dapoxetine 30minutes to 4 hours before sexual intercourse. However, it is best to take it an hour before sexual activity.
- Do not take Tadalafil+dapoxetine more than once in a day. Take Tadalafil+dapoxetine as prescribed by the doctor.
- Talk to your doctor if the erection persists for greater than four hours.
Patients Concern
Disease/Condition Glossary
Erectile dysfunction: It is the inability to keep a hard and erect penis suitable for sexual intercourse. It could signify physical or psychological conditions such as fear of sexual failure, anxiety, depression, low self-esteem, or stress. Certain health-related factors, such as smoking, drinking, being overweight, being physically inactive, and having high blood pressure, also contribute to erectile dysfunction. Symptoms of erectile dysfunction include difficulty in getting an erection, difficulty in maintaining an erection during intercourse, and decreased sexual desire.
Premature ejaculation: It is a problem in which a man ejaculates sooner than his partner during sexual intercourse. It is a very common sexual complaint and generally occurs one in every three men. If it occurs infrequently, it is not a concern. Still, if you are unable to delay ejaculation and ejaculate within one minute of penetration, then it is a problem. It can be due to both biological and psychological factors.
FAQs
Tadalafil+dapoxetine is used to treat erectile dysfunction (impotence) and premature ejaculation in men.
Tadalafil+dapoxetine works by relaxing the blood vessels in the penis, thereby allowing the blood flow into the penis when the person is sexually excited.
Yes, using Tadalafil+dapoxetine can cause dry mouth. If you experience dry mouth or feel excessively thirsty, drink plenty of water and increase fluid intake. You may also keep a lip balm with you if your lips are also dry.
No, do not take Tadalafil+dapoxetine with nitrates. Taking Tadalafil+dapoxetine with medicines used to treat angina/chest pain, such as nitrates/nitroglycerin, may cause severe lowering of blood pressure. You are advised not to take Tadalafil+dapoxetine if you are taking nitrates or have a history of heart attack/stroke.
No, Tadalafil+dapoxetine should not be taken along with blood-pressure-lowering medicines. Tadalafil+dapoxetine relaxes and widens blood vessels, lowering blood pressure. Therefore, if Tadalafil+dapoxetine is taken with blood pressure-lowering medicines, it could lead to a severe blood pressure decrease.
It usually takes 30-60 minutes for Tadalafil+dapoxetine to show its effect. You should be able to get an erection at any time between 30 minutes to 36 hours after taking Tadalafil+dapoxetine. However, you need to be sexually excited for Tadalafil+dapoxetine to work.
No, it is recommended not to take Tadalafil+dapoxetine along with MAO inhibitor (a medicine for depression) as Tadalafil+dapoxetine contains Dapoxetine, which is known to contraindicate if taken along with MAO inhibitor. So, concurrent use of Tadalafil+dapoxetine and MAO inhibitor should be avoided, and a gap of 14 days should be maintained between the last dose of MAO inhibitor and the first dose Tadalafil+dapoxetine.
Tadalafil+dapoxetine may cause side effects such as nausea, dizziness, vomiting, dry mouth, indigestion, nosebleeds, headache, and flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Tadalafil+dapoxetine may cause dizziness. Therefore you are advised to drive and operate machinery only if you are alert.
Store Tadalafil+dapoxetine at room temperature, in a dry place. Keep out of sight and reach of children.
Inform your doctor before taking Tadalafil+dapoxetine if you have sickle cell anemia (abnormal red blood cells), multiple myeloma (cancer of bone marrow), leukemia (blood cell cancer), deformation in penis, severe kidney or liver problems.
