Dexrabeprazole+levosulpiride
About Dexrabeprazole+levosulpiride
Dexrabeprazole+levosulpiride is used to treat gastroesophageal reflux disease (GERD), acidity, heartburn, Zollinger-Ellison syndrome, Helicobacter pylori infection, irritable bowel syndrome, indigestion, and duodenal and gastric ulcers. The stomach is usually protected from acid by a mucous layer. In some cases, excess acid production erodes the mucous layer, which leads to acidity.
Dexrabeprazole+levosulpiride combines two drugs: dexrabeprazole (proton pump inhibitor) and levosulpiride (prokinetic agent). Dexrabeprazole works by blocking the action of an enzyme called the gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Dexrabeprazole+levosulpiride helps prevent acid reflux, thereby relieving acidity and heartburn.
Depending on your medical condition, you are advised to take Dexrabeprazole+levosulpiride for as long as your doctor has prescribed it for you. Sometimes, you may experience common side effects, such as headache, nausea, vomiting, gas, abdominal pain, dizziness, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Let your doctor know if you have a history of intestinal blockage or gastrointestinal bleeding. Long-term usage of Dexrabeprazole+levosulpiride may result in hypomagnesemia and osteoporosis. If you are pregnant or nursing, see a doctor. Drive only if you are aware since Dexrabeprazole+levosulpiride may make you drowsy and dizzy. Dexrabeprazole+levosulpiride is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with Dexrabeprazole+levosulpiride as it could lead to increased drowsiness and elevate stomach acid production.
Uses of Dexrabeprazole+levosulpiride
Medicinal Benefits
Dexrabeprazole+levosulpiride is a combination of two drugs: dexabeprazole and Levosulpiride. Dexrabeprazole+levosulpiride belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD), acidity, heartburn, Zollinger-Ellison syndrome, Helicobacter pylori infection, irritable bowel syndrome, indigestion, duodenal and gastric ulcers. Dexrabeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride is a prokinetic agent that increases the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Dexrabeprazole+levosulpiride helps in preventing acid reflux, thereby providing relief from acidity and heartburn.
Directions for Use
- Take Dexrabeprazole+levosulpiride with food or as advised by your doctor.
- Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
- Swallow Dexrabeprazole+levosulpiride as a whole with a glass of water.
- Do not break, crush or chew it.
Storage
Side Effects of Dexrabeprazole+levosulpiride
- Nausea
- Vomiting
- Abdominal pain
- Dizziness
- Diarrhoea
- Headache
- Flatulence
Drug Warnings
Do not take Dexrabeprazole+levosulpiride if you are allergic to any of its components. Inform your doctor if you have a history of pheochromocytoma (tumour of the adrenal gland), epilepsy, mania, gastrointestinal bleeding, intestinal obstruction, or severe kidney or liver impairment. Dexrabeprazole+levosulpiride may cause osteoporosis (weak and brittle bones) and hypomagnesemia (low magnesium levels) on long-term treatment. Consult a doctor if you are pregnant or breastfeeding. Dexrabeprazole+levosulpiride may cause dizziness and drowsiness, so drive only if you are alert. Dexrabeprazole+levosulpiride is not recommended for children as safety and effectiveness have not been established. Avoid alcohol intake while using Dexrabeprazole+levosulpiride since it can increase acid production in the stomach.
Drug Interactions
Drug-Drug Interactions: Dexrabeprazole+levosulpiride may interact with a blood thinner (warfarin), anti-cancer (methotrexate), cardiac glycoside (digoxin), immunosuppressant (mycophenolate mofetil, tacrolimus), and antibiotic (amoxicillin, clarithromycin).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have gastrointestinal bleeding, intestinal obstruction, epilepsy, mania, hyperprolactinemia (high levels of prolactin), bone fractures, or hypomagnesemia (low levels of magnesium).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Dexrabeprazole+levosulpiride. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Pregnancy
consult your doctorConsult your doctor if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
consult your doctorConsult your doctor if you are breastfeeding; your doctor may prescribe this medicine if the benefits outweigh the risks.
Driving
unsafeDexrabeprazole+levosulpiride may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Let your doctor know if you have any history of liver disease. Your doctor will weigh the benefits and potential risks before prescribing Dexrabeprazole+levosulpiride.
Kidney
cautionDose adjustment may be needed. Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Dexrabeprazole+levosulpiride.
Children
unsafeDexrabeprazole+levosulpiride should not be given to children below 18 years of age as the safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Maintain a healthy weight through regular exercise.
- Avoid lying down after eating to prevent acid reflux.
- Avoid tight-fitting clothes as they might increase the pressure on the abdomen, leading to acid reflux.
- Practice relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat foods, spicy foods, chocolate, citrus fruits, pineapple, tomatoes, onions, garlic, tea, and soda.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Avoid sitting for long periods, as it may trigger acidity. Take a 5-minute break every hour by going for a brisk walk or stretching.
Special Advise
- Dexrabeprazole+levosulpiride might cause false-positive results for secretin stimulation test, prolactin test, and tests for tetrahydrocannabinol (THC). Inform the person doing the tests that you are taking Dexrabeprazole+levosulpiride.
- Regular blood tests to monitor magnesium levels and bone density tests are recommended if you are on long-term treatment with Dexrabeprazole+levosulpiride.
Patients Concern
Disease/Condition Glossary
Gastrointestinal diseases: The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like acidity, GERD, heartburn, stomach ulcer, and Zollinger-Ellison syndrome.
Gastroesophageal reflux disease (GERD) is a condition in which stomach acid frequently flows back into the oesophagus. This backflow (acid reflux) irritates the food pipe and causes heartburn.
Zollinger-Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production, leading to peptic ulcers.
Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of the protective stomach lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, peptic ulcers and Zollinger-Ellison syndrome.
FAQs
Dexrabeprazole+levosulpiride is used in the treatment of Gastro-oesophageal reflux disease, acidity, indigestion, heartburn, and peptic ulcers. It is used to reduce excessive stomach acid production conditions.
Dexrabeprazole+levosulpiride is a combination of dexrabeprazole (proton pump inhibitor) and levosulpiride (prokinetic agent). Dexrabeprazole works by blocking the action of an enzyme called the gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Dexrabeprazole+levosulpiride helps prevent acid reflux, thereby relieving acidity and heartburn.
Talk to your doctor if you do not feel better even after taking Dexrabeprazole+levosulpiride for 14 days. Do not take Dexrabeprazole+levosulpiride for longer durations unless prescribed by the doctor. If Dexrabeprazole+levosulpiride is prescribed for longer periods, regular check-ups are advised.
Dexrabeprazole+levosulpiride contains dexrabeprazole which might increase the risk of osteoporosis (weak and brittle bones). This mainly occurs in people taking higher doses of Dexrabeprazole+levosulpiride for longer durations. Inform your doctor if you are at risk of osteoporosis. Your doctor may prescribe calcium and vitamin D supplements.
Dry mouth could be a side-effect of Dexrabeprazole+levosulpiride. Limiting caffeine intake, avoiding smoking and mouthwashes that contain alcohol, drinking water regularly, and chewing sugar-free gum or candy may help stimulate saliva and prevent mouth dryness.
Dexrabeprazole+levosulpiride starts working within 60 minutes of taking it and takes about 2-4 hours to fully take effect. Although it may take up to 4 weeks to relieve your symptoms considerably, you should begin to feel better within 2 to 3 days. If you have concerns, discuss with your doctor.
The best time to take Dexrabeprazole+levosulpiride depends on your doctor's specific instructions. However, a common recommendation is to take it before breakfast. This helps the medication effectively reduce stomach acid production throughout the day.
Dexrabeprazole+levosulpiride is more often used to treat gastrointestinal disorders. However, its use may be contraindicated in individuals with allergies to either the drug or its excipients, pregnant or breastfeeding women, those with gastrointestinal bleeding or obstruction, severe kidney or liver impairment, and individuals with certain medical conditions. Before using Dexrabeprazole+levosulpiride, it's essential to consult with a healthcare professional to assess your individual situation and determine if it's safe for you.
