Two days is a short time; your prescribed antibiotic and anti-inflammatory medications typically need 3 to 4 days to show visible improvement. Because there is pus accumulation, medications alone may struggle to completely cure the sinus, as trapped fluid physically needs to escape. You can support your healing with warm sitz baths to encourage natural drainage and relieve pain. If there is no improvement in 24 hours, please consult your doctor. Often, a minor, quick in-office procedure to drain the pus is needed for immediate relief. This is a simple, routine step and much less invasive than major surgery.