To relieve a sore throat, several over-the-counter options can help. For pain and inflammation, oral pain relievers like ibuprofen or acetaminophen are highly effective. For direct, temporary relief, you can use numbing throat lozenges or sprays containing active ingredients like benzocaine, pectin, or phenol. If your sore throat is caused by allergies or post-nasal drip, an antihistamine may also assist. Remember to stay hydrated and rest your throat. If your sore throat lasts more than a few days, is severe, or is accompanied by a high fever or difficulty swallowing, please consult a doctor for a proper evaluation.