Yes, it can be safe to continue these hormonal supports if specifically prescribed by your obstetrician. Hucog-5000 Injection, Proluton Depot Injection, and Duphaston tablets are often used in combination to support high-risk pregnancies and prevent preterm birth. However, the requirement for hCG support typically decreases by the second trimester (19 weeks) as the placenta takes over hormone production. Please do not discontinue any medication on your own. It is best to consult your doctor to review your current regimen and confirm if all three therapies are still necessary for your ongoing pregnancy.