Because you have had your spleen removed, your body is at a much higher risk for severe bacterial infections. Taking daily penicillin is a highly effective, lifelong shield to keep you safe. You should not reduce your dosage to one tablet daily without consulting your hematologist, as a lower dose may not provide enough protection. If you are looking for alternatives due to convenience or side effects, your doctor can discuss other generic penicillin options or alternative antibiotics like erythromycin. Please consult your specialist before making any changes to ensure you remain fully protected.