No, these are not normal side effects. Swelling, itching, and watering strongly suggest an allergic reaction or medication toxicity, which can be triggered by using Mycin drops as frequently as every 10 minutes. Do not stop your medications abruptly on your own, as this could cause the underlying infection to worsen. Instead, contact your eye specialist immediately. They need to examine your eye and will likely change your prescription to a safer alternative or adjust the dosage. Seek emergency care if you experience severe pain or vision changes.