Since your symptoms include numbness relieved by standing, and muscle relaxants like Miofree 4 or OTC painkillers aren?t working, the issue is likely nerve compression (like a pinched nerve) rather than a muscle spasm. Standard painkillers do not target nerve-related symptoms. Alternative prescription medications specifically for nerve pain include neuropathic agents like Gabapentin or Pregabalin. However, you should not self-medicate. I strongly recommend consulting a neurologist or orthopaedic specialist for a proper diagnosis (possibly an MRI). In the meantime, physical therapy focusing on posture and ergonomic desk adjustments can help relieve the pressure on your nerves while sitting.