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  3. Zolith 250mg Tablet

Zolith 250mg Tablet, Pack of 1 Tablet
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Zolith 250mg Tablet belongs to the class of antipsychotic medicine used in the treatment of bipolar disorder and mania. This medicine suppresses the excess and abnormal activity of nerve cells in the brain by increasing the activity of chemical messengers in the brain. Common side effects include loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination.
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Composition :

LITHIUM CARBONATE-250MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Zolith 250mg Tablet

Zolith 250mg Tablet belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low mood depression.

Zolith 250mg Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Zolith 250mg Tablet as prescribed. Your doctor will advise you on how often you need to take Zolith 250mg Tablet based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Zolith 250mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Zolith 250mg Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Zolith 250mg Tablet. Regular blood tests are recommended while taking Zolith 250mg Tablet to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or had weight loss surgery, please inform your doctor before taking Zolith 250mg Tablet.

Uses of Zolith 250mg Tablet

Treatment of Bipolar disorder and Mania

Directions for Use

• Take Zolith 250mg Tablet with food for better absorption or take it as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow it as a whole with a glass of water.• Do not crush, chew or break it.

Medicinal Benefits

Zolith 250mg Tablet is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Zolith 250mg Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Zolith 250mg Tablet relaxes nerves and calms the mood, which helps in having a better social life and enables to do daily activities comfortably.

How Zolith 250mg Tablet Works

Zolith 250mg Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

• Store in a cool and dry place away from sunlight.• Keep Zolith 250mg Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Zolith 250mg Tablet
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit or eliminate caffeine and alcohol from your diet, as these substances can worsen hand trembling.
  • Practice relaxation techniques like deep breathing, yoga, or mindfulness meditation to reduce stress-induced tremors.
  • Engage in regular exercise to improve muscle control and coordination.
  • Ensure adequate sleep (7-8 hours) to prevent fatigue, which can worsen tremors.
  • Identify and minimize triggers that cause tremors, such as stress or certain activities.
  • Consider occupational therapy for tailored exercises and adaptive tools to manage daily tasks with trembling hands.
  • Consult a doctor if hand trembling interferes with your daily activities or is accompanied by other concerning neurological symptoms such as weakness, numbness, or speech difficulties.

What if I have taken an overdose of Zolith 250mg Tablet

Take Zolith 250mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include vomiting, diarrhoea, muscular weakness, drowsiness, and lack of coordination. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Regular blood tests are recommended while taking Zolith 250mg Tablet to check lithium levels in the blood. If you are pregnant or breastfeeding, please inform your doctor before taking Zolith 250mg Tablet. If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Zolith 250mg Tablet as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

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LithiumCisapride
Critical
LithiumCidofovir
Critical

Drug-Drug Interactions

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LithiumCisapride
Critical
How does the drug interact with Zolith 250mg Tablet:
Taking Cisapride with Zolith 250mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Zolith 250mg Tablet with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumCidofovir
Critical
How does the drug interact with Zolith 250mg Tablet:
Cidofovir can cause higher levels of Zolith 250mg Tablet carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Zolith 250mg Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumAnagrelide
Severe
How does the drug interact with Zolith 250mg Tablet:
Taking Zolith 250mg Tablet together with Anagrelide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Zolith 250mg Tablet and Anagrelide together can evidently cause an interaction, but it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
LithiumPiroxicam
Severe
How does the drug interact with Zolith 250mg Tablet:
Co-administration of Piroxicam and Zolith 250mg Tablet can increase the levels of Zolith 250mg Tablet, which may lead to side effects.

How to manage the interaction:
Co-administration of Zolith 250mg Tablet with Piroxicam can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination. Do not stop using any medications without talking to a doctor.
LithiumPhenylbutazone
Severe
How does the drug interact with Zolith 250mg Tablet:
Taking Zolith 250mg Tablet and Phenylbutazone together may significantly increase the blood levels of Zolith 250mg Tablet.

How to manage the interaction:
Co-administration of Zolith 250mg Tablet with Phenylbutazone can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, or increased urination. Do not stop using any medications without a doctor's advice.
LithiumTacrolimus
Severe
How does the drug interact with Zolith 250mg Tablet:
Taking tacrolimus with Zolith 250mg Tablet may increase risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Zolith 250mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
LithiumFluoxetine
Severe
How does the drug interact with Zolith 250mg Tablet:
Co-administration of Zolith 250mg Tablet with Fluoxetine can result in effects and also Serotonin syndrome (a condition wherein serotonin levels are increased in the body).

How to manage the interaction:
Although there is a interaction between Fluoxetine and Zolith 250mg Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumChloroquine
Severe
How does the drug interact with Zolith 250mg Tablet:
Taking chloroquine with Zolith 250mg Tablet together can increase the risk ofabnormal heart rhythm.

How to manage the interaction:
Taking chloroquine and Zolith 250mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LithiumBedaquiline
Severe
How does the drug interact with Zolith 250mg Tablet:
Taking amisulpride together with tamoxifen can increase the risk of an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Zolith 250mg Tablet and Bedaquiline, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
LithiumDesvenlafaxine
Severe
How does the drug interact with Zolith 250mg Tablet:
Taking Zolith 250mg Tablet with Desvenlafaxine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Desvenlafaxine and Zolith 250mg Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a constant sodium diet as it may affect lithium levels in the blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Zolith 250mg Tablet.
  • Do regular exercise and maintain a stable weight as Zolith 250mg Tablet may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink the same amount of water every day as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Zolith 250mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Zolith 250mg Tablet as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Zolith 250mg Tablet is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Zolith 250mg Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

bannner image

Driving

Unsafe

Zolith 250mg Tablet may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Zolith 250mg Tablet.

bannner image

Liver

Safe if prescribed

Zolith 250mg Tablet is safe to use in patients with liver diseases/conditions if prescribed by a doctor.

bannner image

Kidney

Caution

Take Zolith 250mg Tablet with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required. Zolith 250mg Tablet is not recommended for patients with severe kidney problems.

bannner image

Children

Caution

Zolith 250mg Tablet is generally not recommended for children below 12 years. However, Zolith 250mg Tablet may be used in children above 7 years for treating bipolar disorder only if prescribed by a doctor.

Have a query?

FAQs

Zolith 250mg Tablet belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder.

Zolith 250mg Tablet helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Zolith 250mg Tablet is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Zolith 250mg Tablet.

Zolith 250mg Tablet may cause weight gain but it is not necessary for everyone taking Zolith 250mg Tablet to experience this side effect. However, in order to avoid gaining weight while taking Zolith 250mg Tablet, you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.

It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.

Zolith 250mg Tablet may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong-smelling urine or a decrease in urination, it indicates that you are dehydrated, and this may affect lithium levels in the blood. Therefore, you are recommended to drink plenty of fluids while taking Zolith 250mg Tablet to avoid dehydration.

You are not recommended to stop taking Zolith 250mg Tablet without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Zolith 250mg Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Zolith 250mg Tablet, please consult your doctor so that the dose may be gradually reduced.

You are not recommended to take Zolith 250mg Tablet with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking, or shivering, please consult a doctor immediately. However, before using Zolith 250mg Tablet with any other medicines, you are advised to contact your doctor.

The effects of Zolith 250mg Tablet can vary from person to person, but it generally takes 1-3 weeks for you to see the full benefits. However, it's important to continue taking the Zolith 250mg Tablet regularly as prescribed by your doctor to maintain its effectiveness.

It's important to inform your doctor about your hypertension and the medications you're taking for it as Zolith 250mg Tablet can interact with certain blood pressure medications, and your doctor may need to adjust your treatment plan to ensure your safety.

No, you should not increase the dose of Zolith 250mg Tablet on your own. It can take 1-3 weeks to feel the full effects, and increasing the dose without medical advice can be dangerous and may lead to adverse effects. However consult your doctor if you have any concerns.

Yes, Zolith 250mg Tablet can cause sleepiness as a side effect. It's important to be cautious when performing activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.

Yes, Zolith 250mg Tablet can affect the kidneys. Long-term use of lithium can lead to kidney problems, and regular monitoring of kidney function is necessary during treatment. It's important to inform your doctor if you have any pre-existing kidney conditions or if you experience any symptoms of kidney problems while taking Zolith 250mg Tablet.

Zolith 250mg Tablet should only be started if adequate facilities for assessing Zolith 250mg Tablet levels are available. Because elevated levels of Zolith 250mg Tablet are linked to Zolith 250mg Tablet toxicity. Zolith 250mg Tablet toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Zolith 250mg Tablet levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.

Zolith 250mg Tablet should be taken as prescribed by your doctor. It is recommended to take with food to reduce nausea. Zolith 250mg Tablet may be taken before or after meals. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Certain medications which decrease the levels of Zolith 250mg Tablet in blood include carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea and herbal medicines. Therefore, before starting Zolith 250mg Tablet, inform your doctor about all the medicines you are taking.

The common side effects of Zolith 250mg Tablet are loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Plot No-208, Industrial Area, Phase 1, Panchkula-134113
Other Info - ZO20335

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 6:59 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.10828.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/017812s033,018421s032,018558s027lbl.pdf
  3. https://www.drugs.com/lithium.html
  4. https://www.nhs.uk/medicines/lithium/
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