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compositionComposition:ZIPRASIDONE-80MG
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Zipsal-80 Capsule is used to treat schizophrenia and bipolar disorder. It contains Ziprasidone which works by blocking the effects of chemical messengers (dopamine and serotonin) in the brain and improves thinking mood, and behaviour. In some cases, this medicine may cause side effects such as drowsiness, dizziness, light-headedness, weakness, nausea, vomiting, runny nose, and cough. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ZIPRASIDONE-80MG

Manufacturer/Marketer :

Bioapoyo

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zipsal-80 Capsule

Zipsal-80 Capsule is a prescription medicine used to treat symptoms of mental health conditions, specifically schizophrenia and bipolar I disorder. It helps rebalance naturally occurring chemicals in the brain to reduce episodes of mania, hallucinations, or severe mood swings. By targeting these symptoms, this medication supports a more stable, clear, and balanced daily life.

For this medicine to work effectively, it must be taken consistently, usually twice every day. It is highly important to take each dose with a main meal, as food significantly helps your body absorb the medication. Incorporating structured routines, prioritising regular sleep, and keeping a daily mood journal can further support your progress during treatment.

While taking Zipsal-80 Capsule , you may experience common side effects such as drowsiness, dizziness, or a dry mouth. However, you must contact your doctor immediately if you experience serious side effects like an irregular heartbeat, extreme muscle stiffness, or sudden confusion. Monitoring these signs closely helps keep your treatment safe and effective.

Do not take this if you have a history of certain heart rhythm issues, a recent heart attack, or uncompensated heart failure. Before starting, talk to your doctor if you have kidney or liver damage, low blood potassium or magnesium levels, or a history of seizures. Your doctor will evaluate these factors to ensure this medication is safe for your specific health profile.

Certain medicines, alcohol, and tobacco use can change how Zipsal-80 Capsule works or increase your risk of dangerous side effects, such as severe drowsiness or heart rhythm issues. Please consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are caring for an elderly individual, as special precautions are required for these groups.

Uses of Zipsal-80 Capsule

Zipsal-80 Capsule used in the treatment of Schizophrenia and Manic depression (bipolar disorder). The detailed uses of Zipsal-80 Capsule are as follows:

  • Schizophrenia: Zipsal-80 Capsule helps reduce distressing symptoms such as hearing voices, seeing things that are not there, or having strong beliefs that are not true, allowing for clearer thoughts.
  • Bipolar I Disorder (Manic or Mixed Episodes): It controls periods of extreme excitement, high energy, rapid talking, or irritability, helping to restore emotional balance.
  • Maintenance of Bipolar I Disorder: Taken long-term, it helps keep your mood stable and prevents future episodes of mania or depression from returning.

Key Benefits

Zipsal-80 Capsule helps manage symptoms of schizophrenia and bipolar disorder, making it easier to think clearly, maintain emotional balance, and carry out everyday activities.

The following are the benefits of Zipsal-80 Capsule :

  • By calming overactive brain pathways, it helps you think more clearly, focus on daily tasks, and feel more connected to those around you.
  • It smooths out intense emotional peaks and valleys, helping you feel more in control of your reactions and daily moods.
  • Relief from persistent symptoms makes it easier to maintain relationships, attend work or school, and complete daily routines.
  • Consistent use lowers the likelihood of severe symptom flare-ups, which means fewer disruptions to your life and fewer hospital visits.
Side effects of Zipsal-80 Capsule
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

  • Zipsal-80 Capsule should be taken with food. If taken on an empty stomach, your body will only absorb about half of the medication, making it much less effective.
  • Take your doses at the same times every day to maintain a steady level of medicine in your body.
  • Swallow Zipsal-80 Capsule as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Zipsal-80 Capsule Works

Zipsal-80 Capsule contains Ziprasidone, which works by targeting specific chemical messengers, or neurotransmitters, in the brain. In conditions like schizophrenia and bipolar disorder, certain chemicals, mainly dopamine and serotonin, are out of balance. This imbalance can lead to symptoms like hallucinations, mood shifts, or disorganised thinking. This medicine binds to dopamine and serotonin receptors in the brain to block excessive chemical signals, which helps calm hyperactive thoughts and stabilise intense moods. At the same time, it gently stimulates other specific serotonin receptors to help lift a flat mood and improve mental clarity. It also slightly prevents the brain from reabsorbing serotonin and norepinephrine, further supporting emotional stability.
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Alcohol

Unsafe

It is advised to avoid alcohol consumption while taking Zipsal-80 Capsule . Alcohol intake, along with Zipsal-80 Capsule , may cause increased dizziness and drowsiness. Please consult your doctor for more information.

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Pregnancy

Caution

Using antipsychotic drugs during the third trimester of pregnancy may cause muscle problems in newborns. Please consult your doctor before taking Zipsal-80 Capsule if you are pregnant or planning to conceive.

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Breast Feeding

Caution

It is not known if Zipsal-80 Capsule is excreted into the breast milk. Please consult your doctor before taking Zipsal-80 Capsule if you are a breastfeeding mother.

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Driving

Unsafe

Zipsal-80 Capsule may make you feel dizzy or drowsy. Do not drive if you are not mentally alert or experience any symptoms that affect your ability to drive or operate machinery.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Caution

Please consult your doctor before using Zipsal-80 Capsule if you suffer from any severe kidney impairment/disease.

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Children

Unsafe

Zipsal-80 Capsule is not recommended in people below 18 years of age.

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Heart

Unsafe

Zipsal-80 Capsule is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Unsafe

Zipsal-80 Capsule is not safe for use in elderly patients aged 65 or older due to its severe side effects.

What if I have taken an overdose of Zipsal-80 Capsule

Symptoms of overdose may include drowsiness, slurred speech, uncontrolled sudden movements, uncontrollable shaking of a part of the body, and anxiety. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Sync doses with meals: Plan your doses to coincide with your largest meals of the day, ensuring the meal is substantial (at least 500 calories) so the medicine is fully absorbed.
  • Stay hydrated in the heat: This medicine can make it harder for your body to cool down. Drink plenty of water and avoid spending prolonged periods in extreme heat or direct sunlight.
  • Rise slowly to prevent falls: To avoid sudden drops in blood pressure that cause dizziness, take your time when moving from a lying or sitting position to standing.
  • Monitor your blood sugar: Since some atypical antipsychotics can affect how your body processes sugar, focus on a diet rich in fibre, lean proteins, and complex carbohydrates, and monitor for excessive thirst or frequent urination.
  • Limit caffeine intake: High amounts of caffeine can interfere with sleep and worsen feelings of restlessness, which may complicate your treatment.
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Have a query?

How Soon It Starts Working

  • The time required for Zipsal-80 Capsule to start to work: Zipsal-80 Capsule ideally shows its action within 6 to 8 hours after administration.
  • The time for which the effects of Zipsal-80 Capsule last: The effect of Zipsal-80 Capsule lasts for 24 hours.

What if you forget to take Zipsal-80 Capsule

If you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Monitor your heart rhythm: Your doctor may require routine electrocardiograms (ECGs) to check your heart's electrical activity before and during treatment.
  • Avoid alcohol completely: Combining alcohol with this medicine can cause dangerous drowsiness, extreme dizziness, and severely impair your coordination.
  • Do not stop treatment abruptly: Stopping your medicine suddenly can cause your mental health symptoms to return rapidly. Always consult your doctor to discuss a plan for a gradually decreasing dose.
  • Be careful when driving: This medicine can cause drowsiness and slow your reaction times. Avoid driving or operating machinery until you are certain how this medicine affects you.
  • Watch for signs of a severe allergic reaction: Stop taking the medicine and seek immediate help if you experience a skin rash with fever, swollen lymph nodes, or swelling of the face and throat.

Drug-Drug Interactions

verifiedApollotooltip
  • Heart rhythm medicines (e.g., amiodarone, quinidine, sotalol): Taking Zipsal-80 Capsule with heart rhythm medicines may significantly increase the risk of a dangerous irregular heartbeat.
  • Certain antibiotics (e.g., erythromycin, moxifloxacin): These medicines can prolong the QT interval, increasing heart risks when combined with Zipsal-80 Capsule .
  • Drowsiness-causing medications (e.g., diazepam, morphine, zolpidem): Taking certain sleeping aids, anxiety drugs, or opioids alongside Zipsal-80 Capsule can cause extreme, dangerous sleepiness and slowed breathing.
ZiprasidoneHydroxyzine
Critical
ZiprasidoneRilpivirine
Critical

Drug-Drug Interactions

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ZiprasidoneHydroxyzine
Critical
How does the drug interact with Zipsal-80 Capsule:
Taking Zipsal-80 Capsule with Hydroxyzine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Zipsal-80 Capsule with Hydroxyzine is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
ZiprasidoneRilpivirine
Critical
How does the drug interact with Zipsal-80 Capsule:
Co-administration of Rilpivirine with Zipsal-80 Capsule can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Rilpivirine with Zipsal-80 Capsule together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
ZiprasidoneSorafenib
Critical
How does the drug interact with Zipsal-80 Capsule:
Co-administration of Sorafenib with Zipsal-80 Capsule can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Sorafenib with Zipsal-80 Capsule together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
ZiprasidoneBicalutamide
Critical
How does the drug interact with Zipsal-80 Capsule:
Taking Bicalutamide and Zipsal-80 Capsule can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Bicalutamide with Zipsal-80 Capsule is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
ZiprasidoneAsenapine
Critical
How does the drug interact with Zipsal-80 Capsule:
Co-administration of Asenapine with Zipsal-80 Capsule can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Zipsal-80 Capsule and Asenapine but can be taken together if prescribed by a doctor. Contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
ZiprasidoneAmiodarone
Critical
How does the drug interact with Zipsal-80 Capsule:
Taking Amiodarone and Zipsal-80 Capsule may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Amiodarone with Zipsal-80 Capsule together should be avoided as it can likely result in an interaction, but it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ZiprasidoneProcainamide
Critical
How does the drug interact with Zipsal-80 Capsule:
Co-administration of Procainamide with Zipsal-80 Capsule can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Procainamide with Zipsal-80 Capsule together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
ZiprasidoneClarithromycin
Critical
How does the drug interact with Zipsal-80 Capsule:
Taking Clarithromycin with Zipsal-80 Capsule can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Clarithromycin and Zipsal-80 Capsule can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ZiprasidoneFlutamide
Critical
How does the drug interact with Zipsal-80 Capsule:
Using Zipsal-80 Capsule together with flutamide can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Zipsal-80 Capsule with Flutamide is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
ZiprasidoneTetrabenazine
Critical
How does the drug interact with Zipsal-80 Capsule:
Co-administration of Tetrabenazine with Zipsal-80 Capsule together can raise the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Tetrabenazine with Zipsal-80 Capsule together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Taking without food: Reduces the absorption of this medicine by about 50%, making it significantly less effective. Always take it with a meal of at least 500 calories.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Zipsal-80 Capsule is used to treat schizophrenia and manic depression (bipolar disorder).
Zipsal-80 Capsule works by balancing the chemical messengers like dopamine and serotonin located in the brain, thereby improving mood, behaviour and thoughts.
Zipsal-80 Capsule should be used with caution in the medical history of liver or kidney diseases, heart problems (coronary artery disease, irregular heartbeat), breast cancer, breathing problems (sleep apnoea), stroke, diabetes, dementia, fits, low white blood cells, obesity, and swallowing problems. Please let your doctor know if you have any other medical problems before starting Zipsal-80 Capsule .
Yes, this medicine can interfere with your body's ability to sweat and cool down, which increases the risk of dehydration and heatstroke. Be sure to drink plenty of fluids and limit heavy exercise in hot weather. Talk to your doctor if you feel excessively hot, dizzy, or weak.
Zipsal-80 Capsule may cause dizziness. It is advised to avoid getting up too fast from a sitting or lying position to make you feel dizzy.
Zipsal-80 Capsule can cause a side effect called orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Zipsal-80 Capsule are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.
This medicine requires food to be properly absorbed into your bloodstream. If you take it on an empty stomach, your body only absorbs about half of the dose, which means the medicine will not work as intended. Always take it with a meal of at least 500 calories. Talk to your doctor or pharmacist if you need help planning your meals.
This medication is generally known to have a lower risk of causing weight gain compared to other medicines in the same class. However, some weight changes can still occur. It is helpful to monitor your weight and maintain a balanced diet. Talk to your doctor if you notice any sudden or concerning weight gain.
No, you should avoid drinking alcohol while taking this medicine. Alcohol can worsen side effects like severe drowsiness, confusion, and dizziness, and it can also interfere with how well the medicine manages your symptoms. Talk to your doctor if you have concerns about stopping alcohol.
Taking this medicine during the last three months of pregnancy may cause withdrawal symptoms, breathing issues, or feeding difficulties in the newborn. Do not start or stop this medicine without discussing the risks and benefits with your healthcare provider. Talk to your doctor to find the best plan for you.
A fast, pounding, or irregular heartbeat is a serious medical issue that requires immediate attention, as it can be a sign of a dangerous heart rhythm change. Stop what you are doing and seek emergency medical care right away. Talk to your doctor before taking any more doses.
No, you should never stop taking this medicine suddenly, even if your symptoms have completely gone away. Stopping abruptly can cause your symptoms to return or lead to withdrawal effects. Your doctor must help you by gradually decreasing your dose if you need to stop. Talk to your doctor before making any changes.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Health Service (NHS). Ziprasidone - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Ziprasidone Pregnancy and Lactation Reference Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  4. U.S. Food and Drug Administration (FDA). 020825S035,020919S02Bl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  5. Ziprasidone Ziprasidone. 2001. [Accessed on 23 Jan. 2019]Check here
  6. Miceli JJ, Glue P, Alderman J, Wilner K, et al. The effect of food on the absorption of oral ziprasidone. Psychopharmacol Bull. 2007;40(3):58-68Check here
  7. Ziprasidone Ziprasidone. 2001. [Accessed on 19 Mar. 2019]Check here

Country of origin

India
Other Info - ZIP0118

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