Apollo
logo

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
Select Delivery Location
compositionComposition:MILNACIPRAN-25MG
prescription
Prescription Medicine
info
image icons

Zesnil 25mg Tablet is indicated for the management of fibromyalgia, a long-lasting condition that causes pain and tenderness throughout the body. It contains Milnacipran, which works by increasing the amount of natural substances, such as serotonin and norepinephrine, that help stop the movement of pain signals in the brain. Thereby it helps manage fibromyalgia. Sometimes, Zesnil 25mg Tablet may cause side effects such as nausea, vomiting, headache, constipation, dizziness, and dry mouth.

Read more
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
OffersOffers & Discounts

Get Free delivery (₹99) with circle icon

Join Circle
coupon
Get Extra 18% Off with Coupons
coupon
Extra 10% Off with Bank Offers
bank offer
bank offer
bank offer

More about the Product

Composition :

MILNACIPRAN-25MG

Manufacturer/Marketer :

Consern Pharma Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Zesnil 25mg Tablet

Zesnil 25mg Tablet is a prescription medication primarily used to manage the symptoms of fibromyalgia, a chronic condition characterised by widespread muscle pain, fatigue, and sleep disturbances. By targeting chemical pathways in the nervous system, it helps to lower pain sensitivity and improve daily physical function. This medicine is designed for ongoing daily management rather than immediate pain relief.

To achieve the best results, you must take Zesnil 25mg Tablet consistently every single day as directed by your doctor. It can be taken either with or without food, though taking it alongside a meal can help reduce potential stomach discomfort. Incorporating gentle daily physical activities, such as stretching or low-impact walking, and maintaining a regular sleep routine can further support your treatment plan.

While taking Zesnil 25mg Tablet, some people may experience mild side effects like nausea, headaches, or dry mouth as their bodies adjust. However, you should contact your doctor immediately if you notice serious symptoms, such as a rapid heart rate, severe chest pain, or sudden changes in your mood. Your healthcare provider can help monitor these symptoms and adjust your plan safely.

Before starting this medicine, tell your doctor if you have a history of high blood pressure, heart problems, kidney disease, liver issues, or glaucoma. Do not take this if you are currently using monoamine oxidase inhibitors (MAOIs) or have uncontrolled narrow-angle glaucoma. Sharing your complete medical history ensures this treatment is safe for you.

This medication can interact with other substances, including blood thinners, certain antidepressants, and alcohol, which may increase your risk of bleeding or severe drowsiness. Pregnant women, breastfeeding mothers, and elderly individuals should consult their doctor to carefully weigh the risks and benefits before starting Zesnil 25mg Tablet.

Uses of Zesnil 25mg Tablet

Your doctor may prescribe Zesnil 25mg Tablet to help manage specific medical conditions. The primary uses include:

  • Fibromyalgia: Zesnil 25mg Tablet is effective in reducing the chronic, widespread muscle pain, joint stiffness, and deep fatigue associated with fibromyalgia by balancing chemical signals in the brain.
  • Major Depressive Disorder: In certain regions and cases, doctors may prescribe this medication to treat severe depression, helping to improve mood, energy levels, and overall emotional well-being.

Key Benefits

Taking Zesnil 25mg Tablet as prescribed can bring meaningful improvements to your daily life. Key benefits of this medication include:

  • Significant pain reduction: By modifying how your brain processes pain signals, it helps ease the persistent, aching muscle pain of fibromyalgia, allowing for more comfortable movement.
  • Enhanced physical functioning: Lower pain levels make it easier to perform everyday physical tasks, helping you stay active and maintain your independence.
  • Decreased fatigue and better sleep: When chronic pain is kept under control, you are likely to experience fewer sleep interruptions at night, leaving you feeling more rested and energised during the day.

Directions for Use

  • Zesnil 25mg Tablet can be taken with or without food, but it is preferable to take it with food to reduce the chances of stomach upset.
  • Take Zesnil 25mg Tablet once daily; however, follow your doctor's advice regarding the dosage and duration.
  • Swallow Zesnil 25mg Tablet as a whole with a glass of water.
  • Do not break, crush or chew Zesnil 25mg Tablet.

How Zesnil 25mg Tablet Works

To understand how Zesnil 25mg Tablet works, it helps to look at how pain signals travel through your body. The brain and spinal cord use natural chemical messengers, specifically serotonin and norepinephrine, to regulate mood and control pain pathways. In people with fibromyalgia, these chemical messengers are often out of balance, which can cause the nervous system to amplify pain signals, making normal sensations feel painful. Zesnil 25mg Tablet belongs to a class of medications that prevent your brain from reabsorbing serotonin and norepinephrine too quickly. By keeping higher levels of these two key chemicals active in your nervous system, the medication helps block or 'turn down' the pain signals before they reach your brain. This dual action restores chemical balance, effectively reducing both the physical sensation of pain and the emotional distress that often accompanies chronic conditions.
bannner image

Alcohol

Unsafe

Avoid consuming alcohol while on treatment with Zesnil 25mg Tablet.

bannner image

Pregnancy

Caution

Milnacipran belongs to pregnancy category C. Zesnil 25mg Tablet should be used during pregnancy only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Caution should be exercised while administering Zesnil 25mg Tablet to nursing women.

bannner image

Driving

Caution

Zesnil 25mg Tablet may cause drowsiness and may affect your judgment, thinking, and movements. Avoid driving or operating machinery until you know how this medication affects you.

bannner image

Liver

Caution

Please consult your doctor if you have liver problems. Caution should be exercised in patients with severe liver impairment.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with severe renal impairment. It should be used with caution in patients with moderate kidney impairment. This medicine is not recommended for patients with end-stage renal disease.

bannner image

Children

Unsafe

Zesnil 25mg Tablet is not recommended for children below 17 years as the safety and effectiveness have not been established.

bannner image

Heart

Caution

Zesnil 25mg Tablet should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Zesnil 25mg Tablet.

bannner image

Geriatrics

Consult your doctor

Please consult a doctor before administering Zesnil 25mg Tablet to geriatric patients. Your doctor will prescribe Zesnil 25mg Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Zesnil 25mg Tablet

If you suspect an overdose, seek emergency medical care immediately. Symptoms of an overdose may include extreme dizziness, confusion, a rapid heart rate, severe drowsiness, or muscle stiffness.

Diet & Lifestyle Advise

  • Engage in low-impact exercise: Gentle activities like walking, swimming, or water aerobics can help keep your joints flexible and reduce muscle stiffness without triggering a pain flare-up.
  • Prioritise restful sleep: Create a calming bedtime routine and sleep in a dark, quiet room. Managing your sleep environment helps combat the chronic fatigue associated with fibromyalgia.
  • Limit caffeine and alcohol: Both caffeine and alcohol can interfere with your sleep cycle and may worsen side effects like dizziness, dry mouth, or a fast heart rate.
  • Practice pacing: Listen to your body and balance periods of activity with rest. Spacing out your tasks throughout the day prevents overexertion and reduces the risk of pain flare-ups.
health query

Have a query?

How Soon It Starts Working

The time required for Zesnil 25mg Tablet to start to work: Zesnil 25mg Tablet ideally shows its action within 2 to 4 hours after administration. The time for which the effects of Zesnil 25mg Tablet last: The effect of Zesnil 25mg Tablet lasts for 6 to 8 hours.

What if you forget to take Zesnil 25mg Tablet

If you miss a dose of Zesnil 25mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Zesnil 25mg Tablet at room temperature, ideally between 68°F and 77°F (20°C to 25°C). Avoid exposing it to extreme heat or freezing conditions.

Drug Warnings

  • Monitor your blood pressure: Since Zesnil 25mg Tablet can elevate your blood pressure and heart rate, make sure to have these checked regularly by your healthcare provider.
  • Exercise caution when driving: This medicine can cause dizziness or drowsiness, especially when you first start taking it. Avoid driving, operating machinery, or performing dangerous tasks until you know how it affects you.
  • Watch for mood alterations: Pay close attention to any sudden emotional changes, panic attacks, or thoughts of self-harm, particularly during the first few weeks of treatment or after a dose change.
  • Communicate all medications: Always provide your doctor and pharmacist with a complete list of all prescription drugs, over-the-counter medicines, and herbal supplements you take to avoid dangerous interactions.
  • Avoid sudden discontinuation: Never stop taking Zesnil 25mg Tablet without consulting your doctor first, as stopping abruptly can cause withdrawal effects like brain zaps, anxiety, and sleep disturbances.

verifiedApollotooltip

  • Monoamine Oxidase Inhibitors (MAOIs): Combining Zesnil 25mg Tablet with MAOIs can lead to a severe, life-threatening condition called serotonin syndrome. You must wait at least 14 days after stopping an MAOI before starting this medication.
  • Other Serotonergic Medications: Taking this medicine alongside other antidepressants, triptans, tramadol, or St. John's Wort increases the risk of serotonin syndrome.
  • Blood Thinners and NSAIDs: Medications like warfarin, aspirin, ibuprofen, and other nonsteroidal anti-inflammatory drugs can raise the risk of abnormal bleeding or bruising when taken with Zesnil 25mg Tablet.

Login/Sign Up

verifiedApollotooltip
  • Alcohol: Consuming alcohol while taking this medicine can increase the risk of liver damage and significantly worsen side effects like dizziness and extreme drowsiness.

Login/Sign Up

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Zesnil 25mg Tablet is used to treat Fibromyalgia.
Zesnil 25mg Tablet works by increasing the amount of natural substances, such as serotonin and norepinephrine, which help prevent the movement of pain signals in the brain. Thereby, it helps manage fibromyalgia.
Zesnil 25mg Tablet may cause high blood pressure (hypertension). Regular monitoring of pulse rate and blood pressure prior to initiation and during treatment is recommended.
Do not discontinue the medicine without consulting your doctor. The doctor may reduce the dose gradually as stopping Zesnil 25mg Tablet suddenly may cause withdrawal symptoms like mood changes, agitation, irritability, dizziness, confusion, tiredness, headache, numbness or tingling in the hands or feet, anxiety, difficulty falling asleep or staying asleep, abnormal excitement, seizures, or ringing in the ears. Consult the doctor if you experience these symptoms.
Zesnil 25mg Tablet may cause angle-closure glaucoma. The doctor may advise an eye examination before you start taking Zesnil 25mg Tablet. Consult the doctor immediately if you experience eye pain, nausea, swelling or redness in or around the eye, and changes in vision, such as seeing coloured rings around lights.
No, Zesnil 25mg Tablet does not have any habit-forming or addictive potential.
Zesnil 25mg Tablet is generic and not a controlled substance.
Weight loss may occur as a side effect of Zesnil 25mg Tablet. If you experience any unexpected changes or unusual symptoms during treatment, contact your doctor immediately.
Zesnil 25mg Tablet causes side effects such as nausea, vomiting, headache, constipation, dizziness, dry mouth and insomnia (sleep disorder). Most of these side effects do not require any medical requirements as they will gradually reduce over time. Contact a doctor if these side effects persist for longer durations.
It is highly recommended that you avoid drinking alcohol while taking this medicine. Alcohol can worsen side effects like dizziness and drowsiness, and it can increase your risk of developing liver damage. Talk to your doctor if you have concerns about alcohol use.
Weight gain is not a common side effect of Zesnil 25mg Tablet. In fact, some patients experience a mild decrease in appetite, which can sometimes lead to slight weight loss. Talk to your doctor if you experience any unexpected changes in your weight.
Take the missed dose as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and continue with your regular schedule. Never take a double dose to compensate for a missed one, and talk to your doctor or pharmacist if you frequently forget doses.
Serotonin syndrome is a rare but life-threatening condition caused by excess serotonin. Symptoms include severe agitation, shivering, sweating, fast heart rate, muscle twitching, stiffness, loss of coordination, and high fever. Seek emergency medical care immediately if you notice these signs, and talk to your doctor.
No, you should never stop taking this medication suddenly, even if your symptoms have completely improved. Abruptly stopping can cause withdrawal symptoms like intense dizziness, headaches, nausea, and mood changes. Always talk to your doctor, who will help you slowly and safely reduce your dose.
The safety of Zesnil 25mg Tablet during pregnancy and breastfeeding has not been fully established and may carry risks to the baby. If you are pregnant, planning a pregnancy, or breastfeeding, talk to your doctor to determine the safest treatment plan for your condition.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India
Other Info - ZE39310
whatsapp Floating Button
Buy Now
Add to Cart